| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Jiang, Kuldeep Sachdeva, Chris N Goulbourne, Martin J Berg, James Peddy, Philip H Stavrides, Anna Pensalfini, Monika Pawlik, Lauren Whyte, Basavaraj S Balapal, Subbanna Shivakumar, Cynthia Bleiwas, John F Smiley, Paul M Mathews, Ralph A Nixo. Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345644. |
we additionally demonstrate pathological consequences of appl1 overexpression, including functional changes in hippocampal long-term potentiation (ltp) and long-term depression (ltd), as well as degeneration of the large projection cholinergic neurons of the basal forebrain and impairment of hippocampal-dependent memory. |
2024-09-30 |
2024-10-02 |
mouse |
| Qian-Yun Wu, Lian-Hong Lin, Kun Lu, Si-Fu Deng, Wei-Min Li, Yuan Xu, Bin Zhang, Ji-Hong Li. Astrocytic 5-HT Experimental & molecular medicine. 2024-07-31. PMID:39085354. |
astrocytic 5-ht nmda receptor-dependent long-term depression (ltd) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. |
2024-07-31 |
2024-08-03 |
mouse |
| Ji-Woon Kim, Benjamin Kleinfelter, Ege T Kavalali, Lisa M Monteggi. Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-07-02. PMID:38956176. |
we observed that physostigmine induces acute stress in tandem with long term depression of glutamate release in the hippocampus of mice. |
2024-07-02 |
2024-07-06 |
mouse |
| Hardy Hagena, Denise Manahan-Vaugha. Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 379. issue 1906. 2024-06-10. PMID:38853558. |
interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations. |
2024-06-10 |
2024-06-14 |
Not clear |
| Hardy Hagena, Denise Manahan-Vaugha. Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 379. issue 1906. 2024-06-10. PMID:38853558. |
hippocampal long-term potentiation (ltp) and long-term depression (ltd) are hebbian forms of synaptic plasticity that are widely believed to comprise the physiological correlates of associative learning. |
2024-06-10 |
2024-06-14 |
Not clear |
| Ana Belén Sanz-Martos, María Roca, Mariano Ruiz-Gayo, Nuria Del Olm. TRIBUTYRIN REVERSES THE DELETERIOUS EFFECT OF SATURATED FAT ON WORKING MEMORY AND SYNAPTIC PLASTICITY IN JUVENILE MICE: DIFFERENTIAL EFFECTS IN MALES AND FEMALES. European journal of pharmacology. 2024-06-09. PMID:38852700. |
hippocampal expression of genes involved in glutamatergic transmission as well as synaptic plasticity (long-term potentiation -ltp- and long-term depression -ltd-) were also analyzed. |
2024-06-09 |
2024-06-14 |
mouse |
| Amrita Benoy, Lik-Wei Wong, Niha Ather, Sreedharan Sajikuma. Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats. Oxford open neuroscience. vol 1. 2024-04-10. PMID:38596711. |
here, we show that bath-application of serotonin facilitates the persistence of long-term depression (ltd) at the ca3 schaffer collateral inputs to ca2 neurons (sc-ca2) when coupled to a weak low frequency electrical stimulation, in acute rat hippocampal slices. |
2024-04-10 |
2024-04-12 |
rat |
| Naoya Atarashi, Misaki Morishita, Shinji Matsud. Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons. The Journal of biological chemistry. 2024-02-14. PMID:38354781. |
activation of innate immune receptor tlr9 by mitochondrial dna plays essential roles in the chemical long-term depression of hippocampal neurons. |
2024-02-14 |
2024-02-17 |
Not clear |
| Liam T Ralph, John Georgiou, Graham L Collingridge, Patrick Tidbal. Sex-dependence of synaptic depression induced by activation of metabotropic glutamate receptors in rat hippocampus. Brain and neuroscience advances. vol 8. 2024-02-01. PMID:38298523. |
we studied dhpg-induced long-term depression at the schaffer collateral-commissural pathway in area ca1 of hippocampal slices prepared from three separate age groups of sprague dawley rats. |
2024-02-01 |
2024-02-03 |
rat |
| Hayuma Otsuka, Sachie Sasaki-Hamada, Hitoshi Ishibashi, Jun-Ichiro Ok. Hippocampal acetylcholine receptor activation-dependent long-term depression in streptozotocin-induced diabetic rats. Neuroscience letters. 2024-01-22. PMID:38253285. |
hippocampal acetylcholine receptor activation-dependent long-term depression in streptozotocin-induced diabetic rats. |
2024-01-22 |
2024-01-25 |
rat |
| Priyanka D Pinky, Jenna Bloemer, Warren D Smith, Yifeng Du, Ryan T Heslin, Sharay E Setti, Jeremiah C Pfitzer, Kawsar Chowdhury, Hao Hong, Subhrajit Bhattacharya, Muralikrishnan Dhanasekaran, Alexander Dityatev, Miranda N Reed, Vishnu Suppiramania. Prenatal Cannabinoid Exposure Elicits Memory Deficits Associated with Reduced PSA-NCAM Expression, Altered Glutamatergic Signaling, and Adaptations in Hippocampal Synaptic Plasticity. Cells. vol 12. issue 21. 2023-11-10. PMID:37947603. |
hippocampal-dependent memory deficits in adolescent pce animals were associated with decreased long-term potentiation (ltp) and enhanced long-term depression (ltd) at hippocampal schaffer collateral-ca1 synapses, as well as an imbalance between glun2a- and glun2b-mediated signaling. |
2023-11-10 |
2023-11-20 |
rat |
| Marc Dahlmanns, Maria Jesus Valero-Aracama, Jana Katharina Dahlmanns, Fang Zheng, Christian Alzheime. Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus. iScience. vol 26. issue 10. 2023-10-13. PMID:37829200. |
using transgenic mice with a forebrain-specific disruption of activin receptor signaling, we identified the pronounced dorsal-ventral gradient of activin a as a major factor determining the distinct neurophysiologic signatures of dorsal and ventral hippocampus, ranging from pyramidal cell firing, tuning of frequency-dependent synaptic facilitation, to long-term potentiation (ltp), long-term depression (ltd), and de-potentiation. |
2023-10-13 |
2023-10-15 |
mouse |
| Thu-Huong Hoang, Denise Manahan-Vaugha. Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning. Brain structure & function. 2023-09-10. PMID:37690045. |
spatial content learning promotes the expression of hippocampal synaptic plasticity, particularly long-term depression (ltd). |
2023-09-10 |
2023-10-07 |
rat |
| Jill Rocchetti, Caroline Fasano, Gregory Dal-Bo, Elisa Guma, Salah El Mestikawy, Tak-Pan Wong, Gohar Fakhfouri, Bruno Giro. Persistent extrasynaptic hyperdopaminergia in the mouse hippocampus induces plasticity and recognition memory deficits reversed by the atypical antipsychotic sulpiride. PloS one. vol 18. issue 8. 2023-08-25. PMID:37624765. |
in vitro application of gbr on hippocampal slices abolished long-term depression (ltd) of fepsp in temporal ca1. |
2023-08-25 |
2023-09-07 |
mouse |
| Luisa Di Menna, Rosamaria Orlando, Giovanna D'Errico, Roxana Paula Ginerete, Agata Machaczka, Carmela M Bonaccorso, Andrea Arena, Michela Spatuzza, Roberta Celli, Marika Alborghetti, Eleonora Ciocca, Anna Rita Zuena, Maria Rosaria Scioli, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Maria Vincenza Catani. Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism. Neuropharmacology. 2023-07-01. PMID:37392820. |
the involvement of the mglu5 receptors in the pathophysiology of several forms of monogenic autism has been supported by numerous studies following the seminal observation that mglu5 receptor-dependent long-term depression was enhanced in the hippocampus of mice modeling the fragile-x syndrome (fxs). |
2023-07-01 |
2023-08-14 |
mouse |
| Price Obot, Galadu Subah, Antonia Schonwald, Jian Pan, Libor Velíšek, Jana Velíšková, Patric K Stanton, Eliana Sceme. Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice. ASN neuro. vol 15. 2023-06-27. PMID:37365910. |
field potential recordings in hippocampal slices of panx1-null mice revealed an attenuation of both long-term potentiation (ltp) of synaptic strength and long-term depression (ltd) at schaffer collateral-ca1 synapses without alterations of basal synaptic transmission or pre-synaptic paired-pulse facilitation. |
2023-06-27 |
2023-08-14 |
mouse |
| Suhel Parvez, Binu Ramachandran, Medha Kaushik, Heena Tabassum, Julietta U Fre. Long-term depression induction and maintenance across regions of the apical branch of CA1 dendrites. Hippocampus. 2023-05-31. PMID:37254828. |
well known as the center for learning and memory, hippocampus is the crucial brain region to study synaptic plasticity in the context of cellular fundamental mechanisms such as long-term depression (ltd) and long-term potentiation (ltp). |
2023-05-31 |
2023-08-14 |
rat |
| Ela Mishra, Mahendra Kumar Thaku. Mitophagy: A promising therapeutic target for neuroprotection during aging and age-related diseases. British journal of pharmacology. 2023-02-15. PMID:36792062. |
besides the maintenance of brain homeostasis, hippocampal mitophagy also helps in synapse formation, axonal development, dopamine release, and long-term depression. |
2023-02-15 |
2023-08-14 |
Not clear |
| Price Obot, Galadu Subah, Antonia Schonwald, Jian Pan, Libor Velíšek, Jana Velíšková, Patric K Stanton, Eliana Sceme. Astrocyte and neuronal Panx1 support long-term reference memory in mice. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711845. |
field potential recordings in hippocampal slices of panx1-null mice revealed an attenuation of both long-term potentiation (ltp) of synaptic strength and long-term depression (ltd) at schaffer collateral - ca1 synapses without alterations basal synaptic transmission or pre-synaptic paired-pulse facilitation. |
2023-01-30 |
2023-08-14 |
mouse |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of alzheimer's disease? |
2022-12-01 |
2023-08-14 |
Not clear |