| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Jiang, Kuldeep Sachdeva, Chris N Goulbourne, Martin J Berg, James Peddy, Philip H Stavrides, Anna Pensalfini, Monika Pawlik, Lauren Whyte, Basavaraj S Balapal, Subbanna Shivakumar, Cynthia Bleiwas, John F Smiley, Paul M Mathews, Ralph A Nixo. Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345644. |
we additionally demonstrate pathological consequences of appl1 overexpression, including functional changes in hippocampal long-term potentiation (ltp) and long-term depression (ltd), as well as degeneration of the large projection cholinergic neurons of the basal forebrain and impairment of hippocampal-dependent memory. |
2024-09-30 |
2024-10-02 |
mouse |
| Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Rohit Sharm. Revisiting Licorice as a functional food in the management of neurological disorders: bench to trend. Neuroscience and biobehavioral reviews. 2023-11-04. PMID:37925093. |
network pharmacology analysis reveals that these compounds protect against long-term depression, aging-associated diseases, alzheimer's disease, and other addictions through interactions with cholinergic, dopaminergic, and serotonergic proteins, validated in animal studies only. |
2023-11-04 |
2023-11-08 |
Not clear |
| Linh T Pham, Ko Yamanaka, Yasunori Miyamoto, Hidefumi Waki, Sabine S S Gourau. Estradiol-dependent gene expression profile in the amygdala of young ovariectomized spontaneously hypertensive rats. Physiological genomics. 2022-01-31. PMID:35100063. |
in the amygdala of ovariectomized rats, estradiol treatment downregulated the expression of genes associated with estrogen signaling, cholinergic synapse, dopaminergic synapse, and long-term depression pathways. |
2022-01-31 |
2023-08-13 |
rat |
| Irene A Samengo, Diego Currò, Maria Martir. Nicotinic receptors modulate the function of presynaptic AMPA receptors on glutamatergic nerve terminals in the trigeminal caudal nucleus. Neurochemistry international. vol 90. 2016-09-20. PMID:26277383. |
dynamic control of ampa receptors by the nicotinic cholinergic system has been observed under other experimental conditions, and it can contribute to the control of synaptic plasticity such as long-term depression and potentiation. |
2016-09-20 |
2023-08-13 |
rat |
| Weixing Shen, Joshua L Plotkin, Veronica Francardo, Wai Kin D Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jürgen Wess, Richard R Neubig, Craig W Lindsley, P Jeffrey Conn, Paul Greengard, Erwan Bezard, M Angela Cenci, D James Surmeie. M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron. vol 88. issue 4. 2016-03-01. PMID:26590347. |
our studies show that in dspns, endogenous cholinergic signaling through m4 muscarinic receptors (m4rs) promoted long-term depression of corticostriatal glutamatergic synapses, by suppressing regulator of g protein signaling type 4 (rgs4) activity, and blocked d1 dopamine receptor dependent long-term potentiation (ltp). |
2016-03-01 |
2023-08-13 |
mouse |
| Sakura Nakauchi, Katumi Sumikaw. Endogenous ACh suppresses LTD induction and nicotine relieves the suppression via different nicotinic ACh receptor subtypes in the mouse hippocampus. Life sciences. vol 111. issue 1-2. 2014-10-20. PMID:25046735. |
however, it is largely unknown how nicotinic cholinergic systems regulate the induction of long-term depression (ltd). |
2014-10-20 |
2023-08-13 |
mouse |
| Amy R Nelson, Krystyna Kolasa, Lori L McMaho. Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AβPP. Journal of Alzheimer's disease : JAD. vol 38. issue 4. 2014-08-17. PMID:24081376. |
previously we reported that coincident with noradrenergic sprouting is the partial reinnervation of hippocampus with cholinergic fibers and the maintenance of a m1 muscarinic acetylcholine receptor (m1 machr) dependent long-term depression at ca3-ca1 synapses that is lost in the absence of sprouting. |
2014-08-17 |
2023-08-12 |
human |
| Lorenzo Rinaldo, Christian Hanse. Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 27. 2013-09-26. PMID:23776234. |
our findings allow for the possibility that cholinergic signaling in the cerebellum--which may result from long-term depression (ltd)-related disinhibition of cholinergic neurons in the vestibular nuclei--suppresses presynaptic ltp to prevent an up-regulation of transmitter release that opposes the reduction of postsynaptic responsiveness. |
2013-09-26 |
2023-08-12 |
mouse |
| Lei An, Zhuo Yang, Tao Zhan. Melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiology of learning and memory. vol 100. 2013-07-23. PMID:23231966. |
melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in wistar rats. |
2013-07-23 |
2023-08-12 |
rat |
| Keri Martinowich, Robert J Schloesser, Yuan Lu, Dennisse V Jimenez, Daniel Paredes, Joshua S Greene, Nigel H Greig, Husseini K Manji, Bai L. Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping. Biological psychiatry. vol 71. issue 1. 2012-03-30. PMID:21978521. |
roles of p75(ntr), long-term depression, and cholinergic transmission in anxiety and acute stress coping. |
2012-03-30 |
2023-08-12 |
Not clear |
| Douglas A Caruana, E Clea Warburton, Zafar I Bashi. Induction of activity-dependent LTD requires muscarinic receptor activation in medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 50. 2012-02-09. PMID:22171048. |
to investigate whether acetylcholine regulates synaptic function in the rat mpfc, whole-cell voltage-clamp recordings were made from pyramidal neurons in layer v. bath application of the cholinergic agonist carbachol caused a potent and long-term depression (ltd) of synaptic responses that was blocked by the muscarinic receptor antagonist scopolamine and was mimicked, in part, by the m(1) receptor agonists mcn-a-343 or af102b. |
2012-02-09 |
2023-08-12 |
rat |
| Yanjun Zhao, Thanos Tzounopoulo. Physiological activation of cholinergic inputs controls associative synaptic plasticity via modulation of endocannabinoid signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 9. 2011-05-13. PMID:21368027. |
however, the mechanistic interaction of cholinergic, neuromodulatory inputs with signaling pathways underlying long-term potentiation (ltp) and long-term depression (ltd) remains poorly understood. |
2011-05-13 |
2023-08-12 |
Not clear |
| P A McCoy, L L McMaho. Sympathetic sprouting in visual cortex stimulated by cholinergic denervation rescues expression of two forms of long-term depression at layer 2/3 synapses. Neuroscience. vol 168. issue 3. 2010-09-21. PMID:20412838. |
sympathetic sprouting in visual cortex stimulated by cholinergic denervation rescues expression of two forms of long-term depression at layer 2/3 synapses. |
2010-09-21 |
2023-08-12 |
Not clear |
| Cary L Scheiderer, Eve McCutchen, Erin E Thacker, Krystyna Kolasa, Matthew K Ward, Dee Parsons, Lindy E Harrell, Lynn E Dobrunz, Lori L McMaho. Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 14. 2006-04-26. PMID:16597728. |
sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at ca3-ca1 synapses. |
2006-04-26 |
2023-08-12 |
Not clear |
| A Kral, R Hartmann, J Tillein, S Heid, R Klink. Delayed maturation and sensitive periods in the auditory cortex. Audiology & neuro-otology. vol 6. issue 6. 2002-05-24. PMID:11847463. |
the functional role of long-term potentiation and long-term depression, inhibition, cholinergic modulation and neurotrophins in auditory development and sensitive periods are discussed. |
2002-05-24 |
2023-08-12 |
Not clear |