All Relations between long term depression and appl1
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Ying Jiang, Kuldeep Sachdeva, Chris N Goulbourne, Martin J Berg, James Peddy, Philip H Stavrides, Anna Pensalfini, Monika Pawlik, Lauren Whyte, Basavaraj S Balapal, Subbanna Shivakumar, Cynthia Bleiwas, John F Smiley, Paul M Mathews, Ralph A Nixo. Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345644. | we additionally demonstrate pathological consequences of appl1 overexpression, including functional changes in hippocampal long-term potentiation (ltp) and long-term depression (ltd), as well as degeneration of the large projection cholinergic neurons of the basal forebrain and impairment of hippocampal-dependent memory. | 2024-09-30 | 2024-10-02 | mouse |
| Mónica Fernández-Monreal, Carla Sánchez-Castillo, José A Esteba. APPL1 gates long-term potentiation through its plekstrin homology domain. Journal of cell science. vol 129. issue 14. 2017-08-04. PMID:27257087. | we show that appl1 knockdown specifically impairs pi3k-dependent forms of synaptic plasticity, such as long-term potentiation (ltp) and metabotropic-glutamate-receptor-dependent long-term depression (mglur-ltd). | 2017-08-04 | 2023-08-13 | Not clear |