| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaebin Kim, Edwin Bustamante, Peter Sotonyi, Nicholas Maxwell, Pooja Parameswaran, Julie K Kent, William C Wetsel, Erik J Soderblom, Bence Rácz, Scott H Soderlin. Presynaptic Rac1 in the hippocampus selectively regulates working memory. eLife. vol 13. 2024-07-24. PMID:39046788. |
previous studies have shown that rac1-mediated signaling is associated with hippocampal-dependent working memory and longer-term forms of learning and memory and that rac1 can modulate forms of both pre- and postsynaptic plasticity. |
2024-07-24 |
2024-07-26 |
mouse |
| Jaebin Kim, Edwin Bustamante, Peter Sotonyi, Nicholas D Maxwell, Pooja Parameswaran, Julie K Kent, William C Wetsel, Erik J Soderblom, Bence Rácz, Scott H Soderlin. Presynaptic Rac1 in the hippocampus selectively regulates working memory. bioRxiv : the preprint server for biology. 2024-04-02. PMID:38562715. |
previous studies have shown that rac1-mediated signaling is associated with hippocampal-dependent working memory and longer-term forms of learning and memory and that rac1 can modulate forms of both pre- and postsynaptic plasticity. |
2024-04-02 |
2024-04-04 |
Not clear |
| Vikram Joshi, Shivakumar Subbanna, Madhu Shivakumar, Balapal S Basavarajapp. CB1R regulates CDK5 signaling and epigenetically controls Rac1 expression contributing to neurobehavioral abnormalities in mice postnatally exposed to ethanol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 3. 2019-12-18. PMID:30143782. |
together, these findings propose that the postnatal ethanol-induced cb1r-mediated activation of cdk5 suppresses arc and rac1 expression in the mouse brain and is responsible for persistent synaptic plasticity and learning and memory defects in adult mice. |
2019-12-18 |
2023-08-13 |
mouse |
| Luis A Martinez, Maria Victoria Tejada-Simo. Pharmacological Rescue of Hippocampal Fear Learning Deficits in Fragile X Syndrome. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29128904. |
we have previously shown that fxs mouse models exhibit learning and memory deficits as well as hyperactive rac1 in the hippocampus. |
2019-02-04 |
2023-08-13 |
mouse |
| Luis A Martinez, Maria Victoria Tejada-Simo. Pharmacological Rescue of Hippocampal Fear Learning Deficits in Fragile X Syndrome. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29128904. |
modulation of rac1 activity is critical during synaptic plasticity as well as learning and memory. |
2019-02-04 |
2023-08-13 |
mouse |
| Chih-Ming Chen, Lauren L Orefice, Shu-Ling Chiu, Tara A LeGates, Samer Hattar, Richard L Huganir, Haiqing Zhao, Baoji Xu, Rejji Kuruvill. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 4. 2018-04-12. PMID:28069946. |
wnt5a expression in hippocampal neurons begins postnatally, and its deletion attenuated camkii and rac1 activity, reduced glun1 glutamate receptor expression, and impaired synaptic plasticity and spatial learning and memory in 3-mo-old mice. |
2018-04-12 |
2023-08-13 |
mouse |
| Nathan G Hedrick, Stephen C Harward, Charles E Hall, Hideji Murakoshi, James O McNamara, Ryohei Yasud. Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. Nature. vol 538. issue 7623. 2017-03-07. PMID:27680697. |
the rho gtpase proteins rac1, rhoa and cdc42 have a central role in regulating the actin cytoskeleton in dendritic spines, thereby exerting control over the structural and functional plasticity of spines and, ultimately, learning and memory. |
2017-03-07 |
2023-08-13 |
Not clear |
| Luis A Martinez, Maria V Tejada-Simo. Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21569781. |
additionally rac1 has been seen to play a role in activation of signal transduction pathways associated with hippocampal learning and memory. |
2012-04-17 |
2023-08-12 |
mouse |
| Luis A Martinez, Maria V Tejada-Simo. Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21569781. |
because of the established role of ltp and ltd in learning and memory processes, in this study we investigate whether rac1 plays also an active and critical role in these types of long-term synaptic plasticity. |
2012-04-17 |
2023-08-12 |
mouse |
| Gutiérrez-Vargas Johanna, Castro-Alvarez John Fredy, Velásquez-Carvajal David, Montañez-Velásquez Maria Natalia, Céspedes-Rubio Angel, Cardona-Gómez Gloria Patrici. Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817060. |
however, in the in vivo model an inactive state of rac1, and its cellular localization remained one month after ischemia, with still decreased survival signaling, significant tauopathy, and learning and memory alterations. |
2011-09-07 |
2023-08-12 |
rat |
| Gutiérrez-Vargas Johanna, Castro-Alvarez John Fredy, Velásquez-Carvajal David, Montañez-Velásquez Maria Natalia, Céspedes-Rubio Angel, Cardona-Gómez Gloria Patrici. Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817060. |
these neuropathological hallmarks were reversed two months post-ischemia, related with a rac1 activity state similar to control, as well as a "normalization" of the learning and memory tasks in the ischemic rats. |
2011-09-07 |
2023-08-12 |
rat |
| Daeyoung Oh, Seungnam Han, Jinsoo Seo, Jae-Ran Lee, Jeonghoon Choi, John Groffen, Karam Kim, Yi Sul Cho, Han-Saem Choi, Hyewon Shin, Jooyeon Woo, Hyejung Won, Soon Kwon Park, Soo-Young Kim, Jihoon Jo, Daniel J Whitcomb, Kwangwook Cho, Hyun Kim, Yong Chul Bae, Nora Heisterkamp, Se-Young Choi, Eunjoon Ki. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 42. 2010-11-16. PMID:20962234. |
regulation of synaptic rac1 activity, long-term potentiation maintenance, and learning and memory by bcr and abr rac gtpase-activating proteins. |
2010-11-16 |
2023-08-12 |
mouse |
| Daeyoung Oh, Seungnam Han, Jinsoo Seo, Jae-Ran Lee, Jeonghoon Choi, John Groffen, Karam Kim, Yi Sul Cho, Han-Saem Choi, Hyewon Shin, Jooyeon Woo, Hyejung Won, Soon Kwon Park, Soo-Young Kim, Jihoon Jo, Daniel J Whitcomb, Kwangwook Cho, Hyun Kim, Yong Chul Bae, Nora Heisterkamp, Se-Young Choi, Eunjoon Ki. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 42. 2010-11-16. PMID:20962234. |
these results suggest that bcr and abr have novel roles in the regulation of synaptic rac1 signaling, synaptic plasticity, and learning and memory, and that excessive rac1 activity negatively affects synaptic and cognitive functions. |
2010-11-16 |
2023-08-12 |
mouse |
| Ursula Haditsch, Dino P Leone, Mélissa Farinelli, Anna Chrostek-Grashoff, Cord Brakebusch, Isabelle M Mansuy, Susan K McConnell, Theo D Palme. A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molecular and cellular neurosciences. vol 41. issue 4. 2009-09-07. PMID:19394428. |
a central role for the small gtpase rac1 in hippocampal plasticity and spatial learning and memory. |
2009-09-07 |
2023-08-12 |
Not clear |
| Giovanni Diana, Giovanni Valentini, Sara Travaglione, Loredana Falzano, Massimo Pieri, Cristina Zona, Stefania Meschini, Alessia Fabbri, Carla Fiorentin. Enhancement of learning and memory after activation of cerebral Rho GTPases. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 2. 2007-02-16. PMID:17202256. |
here, we show that the modulation of cerebral rhoa and rac1 activity induced by cnf1 in mice leads to (i) rearrangement of cerebral actin cytoskeleton, (ii) enhanced neurotransmission and synaptic plasticity, and (iii) improved learning and memory in various behavioral tasks. |
2007-02-16 |
2023-08-12 |
mouse |
| Huibin Yang, Raymond R Mattingl. The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology. Molecular biology of the cell. vol 17. issue 5. 2006-08-08. PMID:16481401. |
both h-ras and rac1 activation have been linked to synaptic plasticity and thus could contribute to the function of ras-grf1 in neuronal signal transduction pathways that underlie learning and memory. |
2006-08-08 |
2023-08-12 |
Not clear |