| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
the fmr1 ko mice exhibited stereotypical behavior, impaired social ability, and learning and memory impairment, while rapamycin treatment improved behavioral disorders in fmr1 ko mice. |
2024-06-08 |
2024-06-11 |
mouse |
| Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsa. mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS. EMBO molecular medicine. 2024-02-20. PMID:38374465. |
when evaluating the animals' behavior, we showed that treatment of amn082 reduces repetitive behavior and improves learning and memory in fmr1 ko mice. |
2024-02-20 |
2024-02-22 |
mouse |
| Marta Prieto, Alessandra Folci, Stéphane Marti. Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction. Molecular psychiatry. vol 25. issue 8. 2021-03-22. PMID:31822816. |
importantly, fmrp loss-of-function leads to fragile x syndrome (fxs), a rare genetic developmental condition causing a range of neurological alterations including intellectual disability (id), learning and memory impairments, autistic-like features and seizures. here, we also explore the possibility that recently reported missense mutations in the fmr1 gene disrupt the ptm homoeostasis of fmrp, thus participating in the aetiology of fxs. |
2021-03-22 |
2023-08-13 |
Not clear |
| Pamela R Westmark, Alejandra Gutierrez, Aaron K Gholston, Taralyn M Wilmer, Cara J Westmar. Preclinical testing of the ketogenic diet in fragile X mice. Neurochemistry international. vol 134. 2021-02-23. PMID:31958482. |
herein, we tested the effects of chronic ketogenic diet treatment on seizures, body weight, ketone and glucose levels, diurnal activity levels, learning and memory, and anxiety behaviors in fmr1 |
2021-02-23 |
2023-08-13 |
mouse |
| R Michelle Saré, Merlin Levine, Carolyn Beebe Smit. Behavioral Phenotype of Fmr1 Knock-Out Mice during Active Phase in an Altered Light/Dark Cycle. eNeuro. vol 3. issue 2. 2016-12-13. PMID:27294193. |
we report that phase did not alter the fmr1 ko phenotype in open field activity, anxiety, and learning and memory. |
2016-12-13 |
2023-08-13 |
mouse |
| Mei Qin, Zachary Zeidler, Kristen Moulton, Leland Krych, Zengyan Xia, Carolyn B Smit. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. Behavioural brain research. vol 291. 2016-03-28. PMID:25979787. |
in a mouse model (fmr1 knockout (ko)) of fxs, a deficit in performance on the passive avoidance test of learning and memory is a robust phenotype. |
2016-03-28 |
2023-08-13 |
mouse |
| Robert M J Deacon, Larry Glass, Mike Snape, Michael J Hurley, Francisco J Altimiras, Rodolfo R Biekofsky, Patricia Cogra. NNZ-2566, a novel analog of (1-3) IGF-1, as a potential therapeutic agent for fragile X syndrome. Neuromolecular medicine. vol 17. issue 1. 2015-12-09. PMID:25613838. |
nnz-2566, a synthetic analog of a naturally occurring neurotrophic peptide derived from insulin-like growth factor-1 (igf-1), was administered to fmr1 knockout mice correcting learning and memory deficits, abnormal hyperactivity and social interaction, normalizing aberrant dendritic spine density, overactive erk and akt signaling, and macroorchidism. |
2015-12-09 |
2023-08-13 |
mouse |
| Saul S Siller, Kendal Broadi. Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Disease models & mechanisms. vol 4. issue 5. 2011-12-30. PMID:21669931. |
we first treat drosophila fmr1 (dfmr1) null animals with minocycline to assay the effects on mutant synaptic architecture in three disparate locations: the neuromuscular junction (nmj), clock neurons in the circadian activity circuit and kenyon cells in the mushroom body learning and memory center. |
2011-12-30 |
2023-08-12 |
mouse |
| Charles R Tessier, Kendal Broadi. The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20843478. |
null drosophila fmr1 (dfmr1) mutants exhibit reduced learning and loss of protein synthesis-dependent memory consolidation, which is dependent on the brain mushroom body (mb) learning and memory center. |
2011-09-27 |
2023-08-12 |
drosophila_melanogaster |
| K B Baker, S P Wray, R Ritter, S Mason, T H Lanthorn, K V Saveliev. Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments. Genes, brain, and behavior. vol 9. issue 6. 2010-12-27. PMID:20398059. |
our results suggest that procedural factors, such as the use of albino mice, may help to reliably detect spatial learning and memory impairments in both sexes of fmr1 ko mice, making it more useful for understanding fxs and a platform for evaluating potential therapeutics. |
2010-12-27 |
2023-08-12 |
mouse |
| K B Baker, S P Wray, R Ritter, S Mason, T H Lanthorn, K V Saveliev. Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments. Genes, brain, and behavior. vol 9. issue 6. 2010-12-27. PMID:20398059. |
male and female fmr1 knockout mice on c57 albino background exhibit spatial learning and memory impairments. |
2010-12-27 |
2023-08-12 |
mouse |
| Yuze Shang, Hansen Wang, Valentina Mercaldo, Xiangyao Li, Tao Chen, Min Zhu. Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19659572. |
however, results for synaptic long-term potentiation (ltp), a key cellular model for learning and memory, remain inconclusive in the hippocampus of fmr1 knockout mice. |
2009-11-06 |
2023-08-12 |
mouse |
| Yuze Shang, Hansen Wang, Valentina Mercaldo, Xiangyao Li, Tao Chen, Min Zhu. Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19659572. |
the animal model of fxs, fmr1 knockout mice, have deficits in the morris water maze and trace fear memory tests, showing impairment in hippocampus-dependent learning and memory. |
2009-11-06 |
2023-08-12 |
mouse |
| Lata Mahishi, Karen Usdi. NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2). The Biochemical journal. vol 400. issue 2. 2006-11-28. PMID:16886907. |
disruption of fxr2 in mice produces learning and memory deficits, and fmr1 and fxr2 double-knockout mice have exaggerated impairments in certain neurobehavioral phenotypes relative to the single gene knockouts. |
2006-11-28 |
2023-08-12 |
mouse |
| F X Brennan, D S Albeck, R Paylo. Fmr1 knockout mice are impaired in a leverpress escape/avoidance task. Genes, brain, and behavior. vol 5. issue 6. 2006-11-01. PMID:16923151. |
unfortunately, a number of studies have found no consistent, robust learning and memory impairment in the fmr1 ko mice. |
2006-11-01 |
2023-08-12 |
mouse |
| Mei Qin, Julia Kang, Carolyn Beebe Smit. Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 24. 2003-01-14. PMID:12427968. |
our finding of impaired performance of fmr1 ko mice on a passive avoidance task is suggestive of a deficit in learning and memory. |
2003-01-14 |
2023-08-12 |
mouse |
| William T O'Donnell, Stephen T Warre. A decade of molecular studies of fragile X syndrome. Annual review of neuroscience. vol 25. 2002-10-10. PMID:12052912. |
as synaptic plasticity has been implicated in learning and memory, analysis of synapse abnormalities in patients and fmr1 knockout mice should prove useful in studying the pathogenesis of fragile x syndrome and understanding learning and cognition in general. |
2002-10-10 |
2023-08-12 |
mouse |
| G S Fisch, H K Hao, C Bakker, B A Oostr. Learning and memory in the FMR1 knockout mouse. American journal of medical genetics. vol 84. issue 3. 1999-06-24. PMID:10331607. |
learning and memory in the fmr1 knockout mouse. |
1999-06-24 |
2023-08-12 |
mouse |
| G S Fisch, H K Hao, C Bakker, B A Oostr. Learning and memory in the FMR1 knockout mouse. American journal of medical genetics. vol 84. issue 3. 1999-06-24. PMID:10331607. |
thus, we examined learning and memory in male fmr1 knockout mice crossbred from fvb and e129 strains, and in male fvb control mice, using operant conditioning techniques. |
1999-06-24 |
2023-08-12 |
mouse |