| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baridoo Donatus Dooka, Chinna N Orish, Anthonet N Ezejiofor, Theresa C Umeji, Kpobari W Nkpaa, Ifeoma Okereke, Ana Cirovic, Aleksandar Cirovic, Orish E Orisakw. Rice bran extract ameliorate heavy metal mixture induced hippocampal toxicity via inhibiting oxido-inflammatory damages and modulating Hmox-1/BDNF/Occludin/Aβ40/Aβ42 in rats. Toxicology research. vol 14. issue 2. 2025-04-09. PMID:40201631. |
collectively, rbe ameliorated mm - induced oxidative stress, neuro-inflammation and hippocampal apoptosis via attenuation of oxidative damages of cellular constituents, neuronal inflammation and subsequent down regulation of amyloid precursor proteins aβ40, aβ42 and up regulation of occludin, bdnf, hmox-1 protein expression via nrf-2 dependent pathways to abrogate hippocampal toxicity associated with spatial learning and memory deficits. |
2025-04-09 |
2025-04-11 |
rat |
| Yang Shu, Weishang Zhou, Weixia Zhang, Lingzheng Lu, Yan Gao, Yingying Yu, Conghui Shan, Difei Tong, Xunyi Zhang, Wei Shi, Guangxu Li. Exposure to malathion impairs learning and memory of zebrafish by disrupting cholinergic signal transmission, undermining synaptic plasticity, and aggravating neuronal apoptosis. Journal of hazardous materials. vol 488. 2025-02-01. PMID:39892146. |
exposure to malathion impairs learning and memory of zebrafish by disrupting cholinergic signal transmission, undermining synaptic plasticity, and aggravating neuronal apoptosis. |
2025-02-01 |
2025-02-04 |
zebrafish |
| Yang Shu, Weishang Zhou, Weixia Zhang, Lingzheng Lu, Yan Gao, Yingying Yu, Conghui Shan, Difei Tong, Xunyi Zhang, Wei Shi, Guangxu Li. Exposure to malathion impairs learning and memory of zebrafish by disrupting cholinergic signal transmission, undermining synaptic plasticity, and aggravating neuronal apoptosis. Journal of hazardous materials. vol 488. 2025-02-01. PMID:39892146. |
collectively, our results suggested that malathion at environmentally realistic levels can significantly undermine learning and memory of zebrafish by disrupting cholinergic signal transmission, impairing synaptic plasticity, and aggravating neuronal apoptosis via inducing oxidative stress. |
2025-02-01 |
2025-02-04 |
zebrafish |
| Ming-Xuan Yang, Zhuo-Ran Wang, Yan-Li Zhang, Zhi-Na Zhang, Yan-Li Li, Rui Wang, Qiang Su, Jun-Hong Gu. Albumin antagonizes Alzheimer's disease-related Tau pathology and enhances cognitive performance by inhibiting aberrant Tau aggregation. Experimental neurology. 2025-01-21. PMID:39837459. |
administration of alb intranasally was shown to enhance learning and memory in mapt/p301s transgenic mice, markedly decreasing hyperphosphorylation of tau protein and reducing neuronal apoptosis. |
2025-01-21 |
2025-01-24 |
mouse |
| Sheng-Yow Ho, Chia-Hui Lin, Chien-Cheng Huang, Cheng-Hsien Lin, Mao-Tsun Lin, Ying-Jan Wang, Jui-Ti Ma, Li-Tsun Shieh, Ching-Ping Chang, Hung-Jung Li. Hyperbaric oxygen therapy attenuates brain radiation-induced cognitive deficits in rats. International journal of medical sciences. vol 22. issue 2. 2025-01-09. PMID:39781518. |
compared with the rats with 0 gy wbrt on 28 days, the rats with 10 gy wbrt on 28 days had significantly higher severity of spatial learning and memory dysfunction and hippocampal microgliosis, newborn neuronal apoptosis, and lipid peroxidation. |
2025-01-09 |
2025-01-13 |
rat |
| Jipeng Wen, Feiyu Long, Xiaobo Bi, Xiaoying Wan. circHOMER1 Alleviates Sevoflurane-Induced Hippocampal Neuronal Injury via Targeted Negative Regulation of miR-217. Journal of biochemical and molecular toxicology. vol 39. issue 1. 2025-01-08. PMID:39776010. |
sev treatment significantly reduces cell viability, increases apoptosis, stimulates inflammatory responses and oxidative stress, and induces learning and memory impairments in sd rats. |
2025-01-08 |
2025-01-13 |
mouse |
| Lin Chen, Maozhu Liu, Xinhua Dai, Cuilin He, Kejing Wang, Jinhua Tang, Yang Yan. Untargeted Metabolomics Reveals Metabolic Link Between Histone H3K27 Demethylase UTX and Neurodevelopment. Journal of cellular and molecular medicine. vol 29. issue 1. 2025-01-08. PMID:39779477. |
we found that utx knockout in neurones leads to cell death and apoptosis in the hippocampus and cortex, as well as induces impaired learning and memory functions in mice. |
2025-01-08 |
2025-01-13 |
mouse |
| Yao Tan, Yujing Huang, Weiyan Chen, Tingyuan Lang, Lingqiao Wang, Xiaoling Chen, Haili Yu, Zhiqun Qiu, Ke Cui, Chengwei Guo, Yiqi Wang, Ziyuan Zho. Microcystin-LR induces neuronal damage through mitophagy defects resulted from the downregulated transcription of Scd2 by directly targeting IGF-1R. Environmental pollution (Barking, Essex : 1987). 2024-12-26. PMID:39725202. |
we found that administration of 10 μg/kg body weight (intraperitoneally) mc-lr impaired learning and memory abilities and induced neuronal damage and apoptosis in the ca1 region of the hippocampus in rats. |
2024-12-26 |
2024-12-29 |
rat |
| Zhenkun Xiong, Zhenhua Li, Xueqin Sima, Zhi Zen. Astaxanthin reduces TBPH-induced neurobehavioral deficits in mice by the ROS-ERK1/2-FOS pathway. Ecotoxicology and environmental safety. vol 281. 2024-07-04. PMID:38964056. |
the results indicate that exposure to tbph can lead to a decline in learning and memory abilities and abnormal behaviors in mice, which may be associated with oxidative stress responses and apoptosis in the hippocampus. |
2024-07-04 |
2024-07-11 |
mouse |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zha. Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis. International journal of biological macromolecules. vol 271. issue Pt 2. 2024-05-29. PMID:38801850. |
the results showed that, compared to the vehicle group, the l-lactate-treated mice displayed learning and memory performance impairments, as well as reduced hippocampal atp and nadh levels, but increased oxidative stress, mitochondrial dysfunction, and apoptosis, which suggesting inhibited l-lactate-pyruvate conversion in the brain. |
2024-05-29 |
2024-05-31 |
mouse |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
intracerebroventricular injection of msa into the brains of c57bl/6j mice to a similar concentration as in patient brains induced neuronal apoptosis, neuroinflammation, increased tau phosphorylation, and decreased the spatial learning and memory abilities, while elovl1 knockdown significantly prevented the deleterious effect of msa. |
2024-04-23 |
2024-04-26 |
mouse |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
these data suggest that tan iia may upregulate the expression of the creb-bdnf-trkb signaling pathway in the hippocampus of brain tissue, produce anti-neuroinflammatory, antioxidant stress, inhibit neuronal apoptosis effects, and improve cholinergic neurotransmitter disorder induced by stz, reduce the neuronal damage and learning and memory impairment caused by stz in rats, and improve the cognitive function of rats. |
2024-04-14 |
2024-04-17 |
rat |
| Xi Zhang, Hong Zheng, Zhitao Ni, Yuyin Shen, Die Wang, Wenqing Li, Liangcai Zhao, Chen Li, Hongchang Ga. Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline. Cerebral cortex (New York, N.Y. : 1991). 2024-01-14. PMID:38220573. |
results revealed that i.c.v fgf21 infusion effectively improved learning and memory performance of dicd mice; neuron loss and apoptosis in hippocampus and cortex were significantly blocked, suggesting a potential neuroprotective role of fgf21 in dicd. |
2024-01-14 |
2024-01-17 |
mouse |
| Charlene P Poore, Nurul A M N Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Lia. TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia. Neurobiology of disease. 2024-01-10. PMID:38199274. |
using a rat model of chronic hypoxia with both common carotid arteries occluded, we found that m4p treatment could reduce apoptosis in the neurons within the hippocampus, attenuate long-term potentiation impairment and improve the functions of learning and memory in this rat model. |
2024-01-10 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Jingjing Ge, Xiaoling Jiao, Hui L. MicroRNA-126-3P targets PIK3R2 to ameliorate autophagy and apoptosis of cortex in hypoxia-reoxygenation treated neonatal rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063094. |
injection of mir-126-3p mimic raised the learning and memory abilities through down-regulating the cerebral ischemic area, improving pathological damage of the cortex, reducing the neurons apoptosis of the cortex and down-regulating the autophagy-related and apoptosis-related proteins. |
2023-12-08 |
2023-12-17 |
rat |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the rats fed with copper-laden diet for 12 weeks, and the effect of chr on the copper content in liver and 24-h urine, the learning and memory ability, the morphological changes and the apoptosis level of neurons in hippocampal ca1 region, the expression level of bax, bcl-2, cleaved caspase-3, p-pi3k, pi3k, p-akt, and akt proteins were detected. |
2023-11-24 |
2023-11-29 |
human |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the experiments showed that chr could reduce the copper content in liver, increase the copper content in 24-h urine, improve the ability of the learning and memory, alleviate the damage and apoptosis level of hippocampal neurons, down-regulate the expression of bax, cleaved caspase-3, and up-regulate the expressions of bcl-2, p-pi3k/pi3k, p-akt/akt. |
2023-11-24 |
2023-11-29 |
human |
| Meng-Nan Zeng, Bing Cao, Ao-Zi Feng, Peng-Li Guo, Meng Liu, Yu-Han Zhang, Meng Li, Xiao-Ke Zhen. [Platycladi Semen oil ameliorates Aβ_(25-35)-induced brain injury in mice based on network pharmacology and gut microbiota]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 15. 2023-10-06. PMID:37802772. |
learning and memory ability, neuronal damage, levels of aβ_(1-42)/aβ_(1-40), p-tau, related indicators of apoptosis and oxidative stress, and immune cells, and protein and mrna expression related to the sphingosine kinase 1(sphk1)/sphingosine-1-phosphate(s1p)/sphingosine-1-phosphate receptor 5(s1pr5) signaling pathway of mice in each group were determined. |
2023-10-06 |
2023-10-15 |
mouse |