| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathleen Hatch, Fritz Lischka, Mengfan Wang, Xiufen Xu, Cheryl D Stimpson, Tara Barvir, Nathan P Cramer, Daniel P Perl, Guoqiang Yu, Caroline A Browne, Dara L Dickstein, Zygmunt Galdzick. The role of microglia in neuronal and cognitive function during high altitude acclimatization. Scientific reports. vol 14. issue 1. 2024-08-16. PMID:39152179. |
our findings revealed that microglia depletion decreased ltp and reduced glucose levels by 25% at sl but did not affect fear memory recall. |
2024-08-16 |
2024-08-20 |
mouse |
| Kathleen Hatch, Fritz Lischka, Mengfan Wang, Xiufen Xu, Cheryl D Stimpson, Tara Barvir, Nathan P Cramer, Daniel P Perl, Guoqiang Yu, Caroline A Browne, Dara L Dickstein, Zygmunt Galdzick. The role of microglia in neuronal and cognitive function during high altitude acclimatization. Scientific reports. vol 14. issue 1. 2024-08-16. PMID:39152179. |
to explore these interactions at ha, pharmacological depletion of microglia with the colony-stimulating factor-1 receptor inhibitor, plx5622, was employed in male c57bl/6j mice maintained at ha or sea level (sl) for 3-weeks, followed by assessment of ex-vivo hippocampal long-term potentiation (ltp), fear memory recall and microglial dynamics/physiology. |
2024-08-16 |
2024-08-20 |
mouse |
| Kathleen Hatch, Fritz Lischka, Mengfan Wang, Xiufen Xu, Cheryl D Stimpson, Tara Barvir, Nathan P Cramer, Daniel P Perl, Guoqiang Yu, Caroline A Browne, Dara L Dickstein, Zygmunt Galdzick. The role of microglia in neuronal and cognitive function during high altitude acclimatization. Scientific reports. vol 14. issue 1. 2024-08-16. PMID:39152179. |
at ha, the absence of microglia did not significantly alter ha associated deficits in fear memory or ha mediated decreases in peripheral glucose levels. |
2024-08-16 |
2024-08-20 |
mouse |
| Guang-Jing Zou, Zhao-Rong Chen, Xue-Qin Wang, Yan-Hui Cui, Fang Li, Chang-Qi Li, Lai-Fa Wang, Fu-Lian Huan. Microglial activation in the medial prefrontal cortex after remote fear recall participates in the regulation of auditory fear extinction. European journal of pharmacology. 2024-06-20. PMID:38901527. |
in this study, we investigated the activated profiles of microglia after the recall of remote-cued fear memory and the role of activated microglia in the extinction of remote-cued fear in adult male c57bl/6 mice. |
2024-06-20 |
2024-06-23 |
mouse |
| Guang-Jing Zou, Zhao-Rong Chen, Xue-Qin Wang, Yan-Hui Cui, Fang Li, Chang-Qi Li, Lai-Fa Wang, Fu-Lian Huan. Microglial activation in the medial prefrontal cortex after remote fear recall participates in the regulation of auditory fear extinction. European journal of pharmacology. 2024-06-20. PMID:38901527. |
however, the role of microglia in fear memory recall remains unclear. |
2024-06-20 |
2024-06-23 |
mouse |
| Ruyan Chen, Zhilin Wang, Qing Lin, Xutian Hou, Yan Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wan. Destabilization of fear memory by Rac1-driven engram-microglia communication in hippocampus. Brain, behavior, and immunity. 2024-04-26. PMID:38670239. |
these results indicate that rac1-driven communications between engram cells and microglia contributes to contextual fear memory destabilization, and is mediated by atg7 and tlr2/4, and suggest a novel mechanistic framework for cytoskeletal regulator in fear memory interference. |
2024-04-26 |
2024-04-29 |
mouse |
| Ethan J Goodman, Rebecca G Biltz, Jonathan M Packer, Damon J DiSabato, Samuel P Swanson, Braeden Oliver, Ning Quan, John F Sheridan, Jonathan P Godbou. Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons. Molecular psychiatry. 2024-03-08. PMID:38459193. |
the purpose of this study was to determine the influence of microglia and il-1r1 signaling in neurons in the development of sensitization and increased fear memory after rsd. |
2024-03-08 |
2024-03-11 |
mouse |
| Hiroko Ikeda, Aimi Yamagishi, Naomi Yonemochi, Shogo Yamamoto, Takatsune Shimizu, Akihiro Muto, John L Waddington, Junzo Kame. Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice. Molecular neurobiology. 2024-02-03. PMID:38308664. |
the microglia inhibitor minocycline, but not the astrocyte inhibitor fluorocitrate, alleviated disruption in extinction of conditioned fear memory in tb mice. |
2024-02-03 |
2024-02-06 |
mouse |
| Hiroko Ikeda, Aimi Yamagishi, Naomi Yonemochi, Shogo Yamamoto, Takatsune Shimizu, Akihiro Muto, John L Waddington, Junzo Kame. Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice. Molecular neurobiology. 2024-02-03. PMID:38308664. |
these findings indicate that tb mice show an increase in serum cytokines, including il-1β, that increases kc production in microglia of the hippocampus, which then disrupts extinction of fear memory. |
2024-02-03 |
2024-02-06 |
mouse |
| Hongrui Zhu, Ao Guan, Jiayuan Liu, Li Peng, Zhi Zhang, Sheng Wan. Noteworthy perspectives on microglia in neuropsychiatric disorders. Journal of neuroinflammation. vol 20. issue 1. 2023-10-04. PMID:37794488. |
numerous studies have demonstrated a pivotal involvement of microglia in neuropsychiatric disorders, including negative affection, social deficit, compulsive behavior, fear memory, pain and other symptoms associated with major depression disorder, anxiety disorder, autism spectrum disorder and schizophrenia. |
2023-10-04 |
2023-10-07 |
human |
| Yanan Wu, Kaiyi Zhou, Baiyang Liu, Jindong Xu, Liming Lei, Jiaqi Hu, Xiao Cheng, Feng Zhong, Sheng Wan. Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice. Neurotoxicity research. 2023-09-05. PMID:37668877. |
hf group cued fear memory, spatial memory, and learning impairment, accompanied by activation of glial cells (astrocytes, microglia, and oligodendrocytes) in the hippocampus. |
2023-09-05 |
2023-09-07 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
compared with those in control mice microglia, the most significantly induced genes were synapse-related, whereas immune-related genes were reduced due to fear memory consolidation. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
furthermore, in the hippocampal microglia, we found that the expression of neurotransmitter release regulators, γ-aminobutyric acid (gaba) receptor gabrb3 and synapsin 1/2, increased under fear memory consolidation and restored (decreased) after extinction. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
microglia have been suggested to be involved in the underlying mechanism of conditional fear memory formation by regulating inflammatory cytokines. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
whilst the increased expression of synapse-related genes was reversed after fear memory extinction, that of immunological genes was not, strongly suggesting a connection between microglia, neurons, and a dysregulated immune response following contextual fear conditioning. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
this study characterized the transcription profile of microglia in a fear memory conditional mouse model. |
2022-08-20 |
2023-08-14 |
mouse |
| Bu-Fang Fan, Bo Hao, Yun-Da Dai, Li Xue, Yan-Wei Shi, Lu Liu, Shou-Min Xuan, Ning Yang, Xiao-Guang Wang, Hu Zha. Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice. Brain pathology (Zurich, Switzerland). 2022-05-25. PMID:35612904. |
notably, knockdown of tet3 in nac activates microglia and cd39-p2y12r signaling pathway, and inhibition of cd39 reverses the effects of tet3 knockdown on the fear memory generalization and anxiety. |
2022-05-25 |
2023-08-13 |
mouse |
| Marta Celorrio, Miguel A Abellanas, James Rhodes, Victoria Goodwin, Jennie Moritz, Sangeetha Vadivelu, Leran Wang, Rachel Rodgers, Sophia Xiao, Ilakkia Anabayan, Camryn Payne, Alexandra M Perry, Megan T Baldridge, Maria S Aymerich, Ashley Steed, Stuart H Fries. Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33691793. |
antibiotic-induced gut microbial dysbiosis established prior to tbi significantly worsened neuronal loss and reduced microglia activation in the injured hippocampus with concomitant changes in fear memory response. |
2021-11-18 |
2023-08-13 |
Not clear |
| Shingo Enomoto, Takahiro A Kat. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder. Neurochemistry international. vol 142. 2021-10-27. PMID:33232758. |
several preclinical studies using pavlovian fear conditioning have suggested that microglia are involved in fear memory dysregulation and altered fear neuronal networks. |
2021-10-27 |
2023-08-13 |
Not clear |
| Shingo Enomoto, Takahiro A Kat. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder. Neurochemistry international. vol 142. 2021-10-27. PMID:33232758. |
involvement of microglia in disturbed fear memory regulation: possible microglial contribution to the pathophysiology of posttraumatic stress disorder. |
2021-10-27 |
2023-08-13 |
Not clear |