| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanan Wu, Kaiyi Zhou, Baiyang Liu, Jindong Xu, Liming Lei, Jiaqi Hu, Xiao Cheng, Feng Zhong, Sheng Wan. Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice. Neurotoxicity research. 2023-09-05. PMID:37668877. |
hf group cued fear memory, spatial memory, and learning impairment, accompanied by activation of glial cells (astrocytes, microglia, and oligodendrocytes) in the hippocampus. |
2023-09-05 |
2023-09-07 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
compared with those in control mice microglia, the most significantly induced genes were synapse-related, whereas immune-related genes were reduced due to fear memory consolidation. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
microglia have been suggested to be involved in the underlying mechanism of conditional fear memory formation by regulating inflammatory cytokines. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
furthermore, in the hippocampal microglia, we found that the expression of neurotransmitter release regulators, \xce\xb3-aminobutyric acid (gaba) receptor gabrb3 and synapsin 1/2, increased under fear memory consolidation and restored (decreased) after extinction. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
whilst the increased expression of synapse-related genes was reversed after fear memory extinction, that of immunological genes was not, strongly suggesting a connection between microglia, neurons, and a dysregulated immune response following contextual fear conditioning. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
this study characterized the transcription profile of microglia in a fear memory conditional mouse model. |
2022-08-20 |
2023-08-14 |
mouse |
| Bu-Fang Fan, Bo Hao, Yun-Da Dai, Li Xue, Yan-Wei Shi, Lu Liu, Shou-Min Xuan, Ning Yang, Xiao-Guang Wang, Hu Zha. Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice. Brain pathology (Zurich, Switzerland). 2022-05-25. PMID:35612904. |
notably, knockdown of tet3 in nac activates microglia and cd39-p2y12r signaling pathway, and inhibition of cd39 reverses the effects of tet3 knockdown on the fear memory generalization and anxiety. |
2022-05-25 |
2023-08-13 |
mouse |
| Marta Celorrio, Miguel A Abellanas, James Rhodes, Victoria Goodwin, Jennie Moritz, Sangeetha Vadivelu, Leran Wang, Rachel Rodgers, Sophia Xiao, Ilakkia Anabayan, Camryn Payne, Alexandra M Perry, Megan T Baldridge, Maria S Aymerich, Ashley Steed, Stuart H Fries. Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33691793. |
antibiotic-induced gut microbial dysbiosis established prior to tbi significantly worsened neuronal loss and reduced microglia activation in the injured hippocampus with concomitant changes in fear memory response. |
2021-11-18 |
2023-08-13 |
Not clear |
| Shingo Enomoto, Takahiro A Kat. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder. Neurochemistry international. vol 142. 2021-10-27. PMID:33232758. |
several preclinical studies using pavlovian fear conditioning have suggested that microglia are involved in fear memory dysregulation and altered fear neuronal networks. |
2021-10-27 |
2023-08-13 |
Not clear |
| Shingo Enomoto, Takahiro A Kat. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder. Neurochemistry international. vol 142. 2021-10-27. PMID:33232758. |
involvement of microglia in disturbed fear memory regulation: possible microglial contribution to the pathophysiology of posttraumatic stress disorder. |
2021-10-27 |
2023-08-13 |
Not clear |
| Chun Wang, Xu Cao, Jing Yin, Wen-Rui Gao, Wei-Ran Li, Jin-Shun Qi, Mei-Na W. [Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 3. 2021-07-08. PMID:34230948. |
these results indicate that chronic sleep deprivation exacerbates the impairments of recognition memory, working memory and conditioned fear memory in 3xtg-ad mice by aggravating a\xce\xb2 deposition and the excessive activation of microglia in the hippocampus. |
2021-07-08 |
2023-08-13 |
mouse |
| Zhiqian Yu, Hotaka Fukushima, Chiaki Ono, Mai Sakai, Yoshiyuki Kasahara, Yoshie Kikuchi, Nicole Gunawansa, Yuta Takahashi, Hiroo Matsuoka, Satoshi Kida, Hiroaki Tomit. Microglial production of TNF-alpha is a key element of sustained fear memory. Brain, behavior, and immunity. vol 59. 2018-08-23. PMID:27562421. |
on the other hand, expression levels of m2-type microglia-specific cell adhesion molecules, cd206 and cd209, were decreased in microglia from mice representing retention of fear memory, and returned to basal levels in microglia from mice representing extinction of fear memory. |
2018-08-23 |
2023-08-13 |
mouse |
| Zhiqian Yu, Hotaka Fukushima, Chiaki Ono, Mai Sakai, Yoshiyuki Kasahara, Yoshie Kikuchi, Nicole Gunawansa, Yuta Takahashi, Hiroo Matsuoka, Satoshi Kida, Hiroaki Tomit. Microglial production of TNF-alpha is a key element of sustained fear memory. Brain, behavior, and immunity. vol 59. 2018-08-23. PMID:27562421. |
levels of tumor necrosis factor (tnf)-\xce\xb1, but not of other proinflammatory cytokines produced by m1-type microglia, increased in microglia from mice representing retention of fear memory, and returned to basal levels in microglia from mice representing extinction of fear memory. |
2018-08-23 |
2023-08-13 |
mouse |