| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing-Yu Lu, Jun-Fei Teng, Juan Yao, Xuan Li, Bing Wu, Xue-Qiang Hu, Ping Wang, Xiao-Qian Jiang, Jian-Feng Sui, Ke-Hui Hu, Yue-Ming Xu, Shu-Lei Li. The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats. Brain research bulletin. 2025-03-02. PMID:40024398. |
direct and indirect evidence suggests that the prelimbic cortex (prl) and the ventral tegmental area (vta) are the key brain regions involved in the regulation of itch sensation and itch-related emotions. |
2025-03-02 |
2025-03-05 |
rat |
| Xing-Yu Lu, Jun-Fei Teng, Juan Yao, Xuan Li, Bing Wu, Xue-Qiang Hu, Ping Wang, Xiao-Qian Jiang, Jian-Feng Sui, Ke-Hui Hu, Yue-Ming Xu, Shu-Lei Li. The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats. Brain research bulletin. 2025-03-02. PMID:40024398. |
however, the differential roles of the prl-vta pathway in the regulation of itch sensation and itch-related emotion remain unclear. |
2025-03-02 |
2025-03-05 |
rat |
| Xing-Yu Lu, Jun-Fei Teng, Juan Yao, Xuan Li, Bing Wu, Xue-Qiang Hu, Ping Wang, Xiao-Qian Jiang, Jian-Feng Sui, Ke-Hui Hu, Yue-Ming Xu, Shu-Lei Li. The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats. Brain research bulletin. 2025-03-02. PMID:40024398. |
gabaergic and daergic neurons in the vta are potentially responsible for mediating the opposite regulatory effects of prl-vta projections on itch sensation and emotion, respectively. |
2025-03-02 |
2025-03-05 |
rat |
| Jun-Fei Teng, Xing-Yu Lu, Jun-Hui Long, Ying Shi, Xue-Qiang Hu, Jian-Feng Sui, Ping Wang, Lian-Lin Zeng, Xuan Li, Jin-He Xu, Zu-Zhen Ou, Ke-Hui Hu, Shu-Lei Li. The projection from the rostral anterior cingulate cortex to the ventral tegmental area regulates 5-HT-induced itch aversion and scratching in rats. Neurobiology of disease. 2025-02-16. PMID:39956463. |
the current findings contribute to a better understanding of the circuit mechanisms underlying the processing of different components of itch, such as sensation and emotion. |
2025-02-16 |
2025-02-23 |
rat |
| Syed Minhaj Rahman, Fatema Esaa, Suephy C Chen, Alice P Pentland, Julie Ryan Wol. ItchyQoL reveals differences in itch symptom experience in routine dermatologic care. Archives of dermatological research. vol 316. issue 7. 2024-06-07. PMID:38847876. |
correlative analyses showed mild itch associated with emotional impacts on qol (p < 0.01), while severe itch associated with functional and emotional impacts on qol (p < 0.01). |
2024-06-07 |
2024-06-10 |
Not clear |
| Syed Minhaj Rahman, Fatema Esaa, Suephy C Chen, Alice P Pentland, Julie Ryan Wol. ItchyQoL reveals differences in itch symptom experience in routine dermatologic care. Archives of dermatological research. vol 316. issue 7. 2024-06-07. PMID:38847876. |
itchyqol demonstrated an emotional impact on qol by mild itch, but a functional and emotional impact on qol by severe itch. |
2024-06-07 |
2024-06-10 |
Not clear |
| Maryam Shayan, Nazgol-Sadat Haddadi, Maryam Shokrian Zeini, Mohadese Shokrian Zeini, Hasti Tashak Golroudbari, Arya Afrooghe, Elham Ahmadi, Asma Rashki, Ahmad-Reza Dehpou. Social interactions and olfactory cues are required for contagious itch in mice. Scientific reports. vol 14. issue 1. 2024-05-17. PMID:38760368. |
in line with these behavioral findings, our study reveals increased activity in brain regions associated with olfaction, emotion, and memory during contagious itch, including the olfactory bulb, the amygdala, the hypothalamus, and the hippocampus, with this activity diminished in anosmic mice. |
2024-05-17 |
2024-05-27 |
mouse |
| Jun-Hui Long, Pu-Jun Wang, Li Xuan, Yao Juan, Guang-Yan Wu, Jun-Fei Teng, Jian-Feng Sui, Ya-Min Li, Liu Yang, Hong-Li Li, Shu-Lei Li. Prelimbic Cortex-Nucleus Accumbens Core Projection Positively Regulates Itch and Itch-Related Aversion. Behavioural brain research. 2024-04-14. PMID:38615978. |
itch is one of the most common clinical symptoms in patients with diseases of the skin, liver, or kidney, and it strongly triggers aversive emotion and scratching behavior. |
2024-04-14 |
2024-04-17 |
rat |
| Jieyan Zheng, Xiao Min Zhang, Wenting Tang, Yonglin Li, Pei Wang, Jianhua Jin, Zhengyi Luo, Shunchang Fang, Shana Yang, Zicheng Wei, Kexin Song, Zihan Huang, Zihao Wang, Ziyu Zhu, Naizhen Shi, Diyun Xiao, Linyu Yuan, Hualin Shen, Lianyan Huang, Boxing L. An insular cortical circuit required for itch sensation and aversion. Current biology : CB. 2024-03-14. PMID:38484733. |
itch encompasses both sensory and emotional dimensions, with the two dimensions reciprocally exacerbating each other. |
2024-03-14 |
2024-03-17 |
Not clear |
| Jieyan Zheng, Xiao Min Zhang, Wenting Tang, Yonglin Li, Pei Wang, Jianhua Jin, Zhengyi Luo, Shunchang Fang, Shana Yang, Zicheng Wei, Kexin Song, Zihan Huang, Zihao Wang, Ziyu Zhu, Naizhen Shi, Diyun Xiao, Linyu Yuan, Hualin Shen, Lianyan Huang, Boxing L. An insular cortical circuit required for itch sensation and aversion. Current biology : CB. 2024-03-14. PMID:38484733. |
the activation of aic elicits aversive emotion and exacerbates pruritogen-induced itch sensation and aversion. |
2024-03-14 |
2024-03-17 |
Not clear |
| Jieyan Zheng, Xiao Min Zhang, Wenting Tang, Yonglin Li, Pei Wang, Jianhua Jin, Zhengyi Luo, Shunchang Fang, Shana Yang, Zicheng Wei, Kexin Song, Zihan Huang, Zihao Wang, Ziyu Zhu, Naizhen Shi, Diyun Xiao, Linyu Yuan, Hualin Shen, Lianyan Huang, Boxing L. An insular cortical circuit required for itch sensation and aversion. Current biology : CB. 2024-03-14. PMID:38484733. |
our study discovers the shared neural circuit (aic → dbnst pathway) underlying the itch sensation and aversion, highlights the critical role of the aic as a central hub for the itch processing, and provides a framework to understand the neural mechanisms underlying the sensation and emotion interaction. |
2024-03-14 |
2024-03-17 |
Not clear |
| Juan Yao, Xuan Li, Guang-Yan Wu, Bing Wu, Jun-Hui Long, Pu-Jun Wang, Shu-Lei Liu, Jie Gao, Jian-Feng Su. The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch. Neuroscience bulletin. 2023-08-08. PMID:37553505. |
these findings provide preliminary evidence that the aic is involved, at least partially via aversive emotion mediation, in the regulation of 5-ht-, but not compound 48/80-induced itch. |
2023-08-08 |
2023-08-16 |
Not clear |
| Hideki Funahashi, Darya Pavlenko, Kent Sakai, Rebecca Verpile, Kristen Sanders, Tasuku Akiyam. Dynorphinergic projections from the central amygdala to the parabrachial nucleus regulate itch. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-03. PMID:37399333. |
the amygdala plays a key role in the processing of itch and pain signals as well as emotion. |
2023-07-03 |
2023-08-14 |
mouse |
| Rui Chen, Xiang Xu, Xin-Yue Wang, Wen-Bin Jia, De-Shan Zhao, Na Liu, Zhen Pang, Xiao-Qing Liu, Yan Zhan. The lateral habenula nucleus regulates pruritic sensation and emotion. Molecular brain. vol 16. issue 1. 2023-06-27. PMID:37370111. |
itch is a complex aversive sensory and emotional experience. |
2023-06-27 |
2023-08-14 |
Not clear |
| Jia-Ni Li, Xue-Mei Wu, Liu-Jie Zhao, Han-Xue Sun, Jie Hong, Feng-Ling Wu, Si-Hai Chen, Tao Chen, Hui Li, Yu-Lin Dong, Yun-Qing L. Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice. Nature communications. vol 14. issue 1. 2023-05-03. PMID:37137899. |
itch is an annoying sensation consisting of both sensory and emotional components. |
2023-05-03 |
2023-08-14 |
mouse |
| Guang-Yan Wu, Xiao-Xia Zheng, Shan-Lan Zhao, Yi Wang, Shan Jiang, Yi-Song Wang, Yi-Lun Yi, Juan Yao, Hui-Zhong Wen, Ju Liu, Hong-Li Li, Jian-Feng Su. The prelimbic cortex regulates itch processing by controlling attentional bias. iScience. vol 26. issue 1. 2023-01-09. PMID:36619983. |
recent studies have begun to investigate the neural mechanisms underlying the modulation of sensory and emotional components of itch in the brain. |
2023-01-09 |
2023-08-14 |
Not clear |
| Sheera F Lerman, Michael A Owens, Tony Liu, Joseph Puthumana, C Scott Hultman, Julie A Caffrey, Michael T Smit. Sleep after burn injuries: A systematic review and meta-analysis. Sleep medicine reviews. vol 65. 2022-09-10. PMID:36087455. |
results from the systematic review demonstrate that a variety of sleep disturbances are common in burn survivors, persisting years after the injury and are associated with pain, itch, emotional distress and reduction in quality of life. |
2022-09-10 |
2023-08-14 |
Not clear |
| Mariana Spetea, Helmut Schmidhamme. Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands. Handbook of experimental pharmacology. vol 271. 2021-11-26. PMID:33454858. |
the endogenous kappa opioid system is expressed in the central and peripheral nervous systems, and has a key role in modulating pain in central and peripheral neuronal circuits and a wide array of physiological functions and neuropsychiatric behaviors (e.g., stress, reward, emotion, motivation, cognition, epileptic seizures, itch, and diuresis). |
2021-11-26 |
2023-08-13 |
human |
| Hideki Mochizuki, Loren Hernandez, Gil Yosipovitch, Norihiro Sadato, Ryusuke Kakig. The Amygdala Network for Processing Itch in Human Brains. Acta dermato-venereologica. vol 100. issue 19. 2021-06-23. PMID:33236767. |
during itch stimuli the amygdala exhibited increased functional connectivity with key brain regions of the serotonergic system responsible for negative emotions (the medial habenula and the median raphe nucleus) and with the memory system, which is responsible for consolidating emotional experiences (the parahippocampus and perirhinal cortex). |
2021-06-23 |
2023-08-13 |
human |
| Takao Setsu, Yusuke Hamada, Daisuke Oikawa, Tomohisa Mori, Yozo Ishiuji, Daisuke Sato, Michiko Narita, Shogo Miyazaki, Eri Furuta, Yukari Suda, Hiroyasu Sakai, Takahiro Ochiya, Hiroyuki Tezuka, Masako Iseki, Eiichi Inada, Akihiro Yamanaka, Naoko Kuzumaki, Minoru Narit. Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch. Biochemical and biophysical research communications. vol 534. 2021-04-19. PMID:33220930. |
these findings suggest that repetitive abnormal scratching behaviors under acute and chronic itch stimuli may activate mesolimbic dopamine neurons along with pleasant emotions, while the restriction of such scratching behaviors may initially induce the activation of pvn-crh neurons associated with stress. |
2021-04-19 |
2023-08-13 |
mouse |