| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Joana Pinto, Lucy Bizien, Julie M J Fabre, Nina Ðukanović, Valentin Lepetz, Fiona Henderson, Marine Pujol, Romain W Sala, Thibault Tarpin, Daniela Popa, Antoine Triller, Clément Léna, Véronique Fabre, Alain Bessi. Microglial TNFα controls daily changes in synaptic GABAARs and sleep slow waves. The Journal of cell biology. vol 223. issue 7. 2024-05-02. PMID:38695719. |
together, our results reveal that microglia orchestrate sleep-intrinsic plasticity of synaptic gabaars, sculpt sleep slow waves, and support memory consolidation. |
2024-05-02 |
2024-05-04 |
Not clear |
| Zheng Liang, Xiaokang Gong, Yang Zhao, Yanna Zhao, Jing Yu, Tiantian Huang, Chaoqing Yang, Liangwei Wu, Mengbing Huang, Xiaochuan Wang, Xiji Shu, Jian Ba. Long-Term High-Fat Diet Consumption Aggravates β-Amyloid Deposition and Tau Pathology Accompanied by Microglial Activation in an Alzheimer's Disease Model. Molecular nutrition & food research. 2024-03-16. PMID:38491393. |
these lipid-droplet-accumulating microglia exhibit diminished migratory capacity and compromise plaque consolidation, thereby exacerbating the accumulation of β-amyloid. |
2024-03-16 |
2024-03-19 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
compared with those in control mice microglia, the most significantly induced genes were synapse-related, whereas immune-related genes were reduced due to fear memory consolidation. |
2022-08-20 |
2023-08-14 |
mouse |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
furthermore, in the hippocampal microglia, we found that the expression of neurotransmitter release regulators, γ-aminobutyric acid (gaba) receptor gabrb3 and synapsin 1/2, increased under fear memory consolidation and restored (decreased) after extinction. |
2022-08-20 |
2023-08-14 |
mouse |
| Conrad Kiyoshi, Andrea Tedesch. Axon growth and synaptic function: A balancing act for axonal regeneration and neuronal circuit formation in CNS trauma and disease. Developmental neurobiology. vol 80. issue 7-8. 2021-10-06. PMID:32902152. |
not only immature neurons are able to precisely control the expression of a plethora of genes necessary for axon extension and pathfinding, synapse formation and function, but also non-neuronal cells such as astrocytes and microglia actively participate in sculpting the nervous system through refinement, consolidation, and elimination of synaptic contacts. |
2021-10-06 |
2023-08-13 |
Not clear |
| Phi T Nguyen, Leah C Dorman, Simon Pan, Ilia D Vainchtein, Rafael T Han, Hiromi Nakao-Inoue, Sunrae E Taloma, Jerika J Barron, Ari B Molofsky, Mazen A Kheirbek, Anna V Molofsk. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell. vol 182. issue 2. 2021-04-01. PMID:32615087. |
these data define a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation. |
2021-04-01 |
2023-08-13 |
mouse |
| Mark E Gurney, Emily C D'Amato, Alex B Burgi. Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 1. 2016-01-19. PMID:25371167. |
pde4b-nams have the potential to reduce neuroinflammation by dampening microglia cytokine production triggered by brain amyloid, while pde4d-nams have potent cognitive benefit by augmenting signaling through the camp/protein kinase a/camp response element-binding protein (creb) pathway for memory consolidation. |
2016-01-19 |
2023-08-13 |
human |