| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie L Baringer, Avraham S Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S Lippmann, Vladimir S Spiegelman, Ian A Simpson, James R Conno. Amyloid-\\xce\\xb2 exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin. Journal of neurochemistry. 2023-09-05. PMID:37667496. |
the mechanism underlying this response begins with increased iron uptake and mitochondrial activity by the astrocytes, which in turn increases levels of apo-transferrin in the amyloid-\xce\xb2 conditioned astrocyte media leading to increased iron transport from endothelial cells. |
2023-09-05 |
2023-09-07 |
Not clear |
| Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corval\\xc3\\xa1n, Estibaliz Ampuero, Sebasti\\xc3\\xa1n Abarz\\xc3\\xbaa, Polett Garc\\xc3\\xa9s, Armando Amaro, Iv\\xc3\\xa1n Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Brigitte van Zunder. Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43 Frontiers in cell and developmental biology. vol 11. 2023-08-30. PMID:37645251. |
there is compelling evidence that mouse and human als and als/ftd astrocytes can reduce the number of healthy wild-type motoneurons (mns) in co-cultures or after treatment with astrocyte conditioned media (acm), independently of their genotype. |
2023-08-30 |
2023-09-07 |
mouse |
| Wei Quan, Cheng-Shi Xu, Xiao-Chong Li, Chao Yang, Tian Lan, Meng-Yue Wang, Dong-Hu Yu, Feng Tang, Ze-Fen Wang, Zhi-Qiang L. Telmisartan inhibits microglia-induced neurotoxic A1 astrocyte conversion via PPAR\\xce\\xb3-mediated NF-\\xce\\xbaB/p65 degradation. International immunopharmacology. vol 123. 2023-08-06. PMID:37544025. |
this conditioned medium induced early, transient a2 astrocyte conversion (within 24\xc2\xa0h) and late, sustained a1 conversion (beginning at 24\xc2\xa0h and lasting up to 7\xc2\xa0days), with a concomitant increase in the production of pro-inflammatory cytokines (interleukin [il]-1\xce\xb2, tumor necrosis factor [tnf]\xce\xb1, and il-6) and phosphorylation of nuclear factor-\xce\xbab (nf-\xce\xbab)/p65. |
2023-08-06 |
2023-08-14 |
Not clear |
| Stephanie L Baringer, Avraham S Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S Lippmann, Vladimir S Spiegelman, Ian A Simpson, James R Conno. Amyloid-\\xce\\xb2 exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292926. |
the mechanism underlying this response begins with increased iron uptake and mitochondrial activity by the astrocytes which in turn increases levels of apo-transferrin in the amyloid-\xce\xb2 conditioned astrocyte media leading to increased iron transport from endothelial cells. |
2023-06-09 |
2023-08-14 |
Not clear |
| Daniela N Rocha, Eva D Carvalho, Liliana R Pires, Chiara Gardin, Ilaria Zanolla, Piotr K Szewczyk, Cl\\xc3\\xa1udia Machado, Rui Fernandes, Urszula Stachewicz, Barbara Zavan, Jo\\xc3\\xa3o B Relvas, Ana P P\\xc3\\xaag. It takes two to remyelinate: A bioengineered platform to study astrocyte-oligodendrocyte crosstalk and potential therapeutic targets in remyelination. Biomaterials advances. vol 151. 2023-05-06. PMID:37148597. |
this platform was then combined with a previously established tissue engineered glial scar model of astrocytes embedded in 1\xc2\xa0% (w/v) alginate matrices, in which astrocyte reactive phenotype was acquired using meningeal fibroblast conditioned medium. |
2023-05-06 |
2023-08-14 |
Not clear |
| Manjusha Thakar, Midrelle E Noumbissi, Monique F Stin. Microvascular Environment Influences Brain Microvascular Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes for the EPCR Expression in the Brain Endothelium. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108071. |
we used in vitro brain endothelial cell cultures and showed that the upregulation of epcr expression was associated with exposure to oligodendrocyte conditioned media (ocm) compared to astrocyte conditioned media (acm). |
2023-04-28 |
2023-08-14 |
Not clear |
| Yuan Hu, Miao Zhang, Bihan Liu, Yingying Tang, Zhuo Wang, Tao Wang, Jiaxin Zheng, Junjian Zhan. Honokiol prevents chronic cerebral hypoperfusion induced astrocyte A1 polarization to alleviate neurotoxicity by targeting SIRT3-STAT3 axis. Free radical biology & medicine. 2023-03-30. PMID:36997099. |
we found that hnk was able to inhibit the phosphorylation and nuclear translocation of stat3, a1 polarization, and reduce conditioned medium's neuronal toxicity of astrocyte under chronic hypoxia induced by cobalt chloride; stat3 phosphorylation inhibitor c188-9 was able to mimic the above effects of hnk, suggesting that hnk may inhibit chronic hypoxia-induced a1 polarization in astrocytes via stat3. |
2023-03-30 |
2023-08-14 |
rat |
| Omid Alavi, Aliakbar Alizadeh, Farzaneh Dehghani, Hamed Alipour, Nader Tanide. Anti-inflammatory effects of umbilical cord mesenchymal stem cell and Autologous conditioned serum on oligodendrocyte, astrocyte, and microglial specific gene in cuprizone animal model. Current stem cell research & therapy. 2023-02-28. PMID:36852798. |
anti-inflammatory effects of umbilical cord mesenchymal stem cell and autologous conditioned serum on oligodendrocyte, astrocyte, and microglial specific gene in cuprizone animal model. |
2023-02-28 |
2023-08-14 |
Not clear |
| Rebecca M Fleeman, Madison K Kuhn, Dennis C Chan, Elizabeth A Procto. Apolipoprotein E \\xce\\xb54 modulates astrocyte neuronal support functions in the presence of amyloid-\\xce\\xb2. Journal of neurochemistry. 2023-02-10. PMID:36762973. |
to determine whether apoe4 alters astrocyte neuronal support functions, we measured glycolytic and oxidative metabolism of neurons treated with conditioned media from apoe4 or apoe3 (the common, risk-neutral variant) primary astrocyte cultures. |
2023-02-10 |
2023-08-14 |
Not clear |
| Emily Welby, Allison D Eber. Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery. Glia. 2023-01-19. PMID:36655314. |
while healthy astrocyte conditioned media did not improve sma motor neuron activity, sma motor neurons robustly responded to healthy astrocyte neuromodulation in direct contact cultures. |
2023-01-19 |
2023-08-14 |
human |
| Rino Takei, Mari Nakashima, Mari Gotoh, Misaki Endo, Kei Hashimoto, Yasunori Miyamoto, Kimiko Murakami-Murofush. 2-carba-cyclic phosphatidic acid modulates astrocyte-to-microglia communication and influences microglial polarization towards an anti-inflammatory phenotype. Neuroscience letters. 2023-01-12. PMID:36634888. |
in this study, to elucidate the 2ccpa behavior in glial communication, we collected the astrocyte conditioned media (acm) from primary astrocyte cultures that were treated by lipopolysaccharide (lps) and 2ccpa and analyzed the alteration of microglial inflammation caused by the acm treatment. |
2023-01-12 |
2023-08-14 |
Not clear |
| Callie M Weber, Bilal Moiz, Sophia M Zic, Viviana Alp\\xc3\\xadzar Vargas, Andrew Li, Alisa Morss Clyn. Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism. Fluids and barriers of the CNS. vol 19. issue 1. 2022-12-10. PMID:36494870. |
treatment with astrocyte conditioned media and high glucose increased glycolysis in both hpbmec and hibmec, though hpbmec decreased glycolysis in response to fluvastatin while hibmec did not. |
2022-12-10 |
2023-08-14 |
human |
| Genilso Gava-Junior, Susana A Ferreira, Cl\\xc3\\xa1udio Roque, Julieta Mendes-Oliveira, In\\xc3\\xaas Serrenho, Nuno Pinto, Maria Vaz Patto, Gra\\xc3\\xa7a Baltaza. High-frequency repetitive magnetic stimulation rescues ischemia-injured neurons through modulation of glial-derived neurotrophic factor present in the astrocyte's secretome. Journal of neurochemistry. 2022-12-08. PMID:36477745. |
the levels of growth factors in the astrocyte conditioned medium (cm) were assessed through a growth factor array and glial-derived neurotrophic factor (gdnf) expression was analyzed by rt-pcr and western blot. |
2022-12-08 |
2023-08-14 |
human |
| Elizabeth R Sharlow, Danielle C Llaneza, William E Grever, Garnett A Mingledorff, Anna J Mendelson, George S Bloom, John S Laz. High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons. SLAS discovery : advancing life sciences R & D. 2022-10-23. PMID:36273809. |
incorporation of astrocyte conditioned medium during differentiation and maturation periods significantly increased the percentage (i.e., \xe2\x88\xbc10% to \xe2\x88\xbc30%) of mature neurons (i.e., neun+) detected at 4-weeks post-differentiation. |
2022-10-23 |
2023-08-14 |
human |
| Ling-Yu Yang, Yong-Ren Chen, Jing-Er Lee, Kuo-Wei Chen, Hui-Tzung Luh, Yi-Tzu Chen, Kuo-Chuan Wang, Sung-Tsang Hsie. Dental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling. Translational stroke research. 2022-10-01. PMID:36181630. |
dental pulp stem cell-derived conditioned medium alleviates subarachnoid hemorrhage-induced microcirculation impairment by promoting m2 microglia polarization and reducing astrocyte swelling. |
2022-10-01 |
2023-08-14 |
rat |
| Wen Zhang, Fanghua Ye, Juan Xiong, Fang He, Li Yang, Fei Yin, Jing Peng, Xiaole Wan. Silencing of miR-132-3p protects against neuronal injury following status epilepticus by inhibiting IL-1\\xce\\xb2-induced reactive astrocyte (A1) polarization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 10. 2022-09-16. PMID:36111973. |
in vitro, the neuronal cell viability and axon length were reduced by additional treatment with a1 astrocyte conditioned media (acm), and downregulation of astrocyte mir-132 rescued the inhibition of cell activity by a1 acm, while the length of axons was further inhibited. |
2022-09-16 |
2023-08-14 |
rat |
| Qasim M Alhadidi, Lijun Xu, Xiaoyun Sun, Yusuf S Althobaiti, Atiah Almalki, Hashem O Alsaab, Creed M Star. MiR-182 Inhibition Protects Against Experimental Stroke in vivo and Mitigates Astrocyte Injury and Inflammation in vitro via Modulation of Cortactin Activity. Neurochemical research. 2022-08-11. PMID:35951202. |
in parallel, lipopolysaccharide (lps)-induced nitric-oxide release in astrocyte cultures was significantly reduced by mir-182 inhibition, translating to reduced injury in primary neuronal cultures subjected to conditioned medium from lps-treated astrocytes. |
2022-08-11 |
2023-08-14 |
mouse |
| Gergana G Nestorova, Chukwumaobim D Nwokwu, Saif Mohammad Ishraq Bar. Microprobe-based technology for antigen-specific purification of exosomes for OMICS analysis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556581. |
microneedles (300\xce\xbcm \xc3\x97 30 mm), functionalized with anti- cd63 antibodies, were incubated under various experimental conditions in conditioned astrocyte medium and astrocyte-derived exosome suspension. |
2022-05-13 |
2023-08-13 |
Not clear |
| James Hong, Rachel Dragas, Mohammad Khazaei, Christopher S Ahuja, Michael G Fehling. Hepatocyte Growth Factor-Preconditioned Neural Progenitor Cells Attenuate Astrocyte Reactivity and Promote Neurite Outgrowth. Frontiers in cellular neuroscience. vol 15. 2021-12-27. PMID:34955750. |
we then assessed the capacity of this modified conditioned media (cm) to attenuate astrocyte reactivity and promote neurite outgrowth |
2021-12-27 |
2023-08-13 |
Not clear |
| Subhalakshmi Guha, Paidi Ramesh Kumar, Soumita Goswami, Pampa Saha, Subhas C Biswa. ICAM-1 protects neurons against Amyloid-\\xce\\xb2 and improves cognitive behaviors in 5xFAD mice by inhibiting NF-\\xce\\xbaB. Brain, behavior, and immunity. 2021-12-07. PMID:34875346. |
here, we identified soluble intercellular adhesion molecule-1 (icam-1) which is rapidly increased in astrocyte conditioned medium derived from a\xce\xb2 |
2021-12-07 |
2023-08-13 |
mouse |