| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian C Ruyle, Sarah Masud, Rohith Kesaraju, Mubariz Tahirkheli, Juhi Modh, Sofia Angulo-Lopera, Tania Lintz, Jessica A Higginbotham, Nicolas Massaly, Jose A Moro. Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive effects. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345613. |
furthermore, selective peripheral mor antagonism could be a promising therapeutic strategy for managing oird by sparing cns-driven acute opioid-associated withdrawal and aversion observed after nlx. |
2024-09-30 |
2024-10-02 |
Not clear |
| Julie Bailly, Florence Allain, Eric Schwartz, Chloé Tirel, Charles Dupuy, Florence Petit, Marco A Diana, Emmanuel Darcq, Brigitte L Kieffe. Habenular Neurons Expressing Mu Opioid Receptors Promote Negative Affect in a Projection-Specific Manner. Biological psychiatry. 2022-12-10. PMID:36496267. |
mor signaling may also influence aversion centers, notably the habenula (hb), where the receptor is highly dense. |
2022-12-10 |
2023-08-14 |
Not clear |
| Julie Bailly, Florence Allain, Eric Schwartz, Chloé Tirel, Charles Dupuy, Florence Petit, Marco A Diana, Emmanuel Darcq, Brigitte L Kieffe. Habenular Neurons Expressing Mu Opioid Receptors Promote Negative Affect in a Projection-Specific Manner. Biological psychiatry. 2022-12-10. PMID:36496267. |
our previous data suggest that the inhibitory activity of mor in the hb may limit aversive states. |
2022-12-10 |
2023-08-14 |
Not clear |
| Florence Allain, Michelle Carter, Sylvie Dumas, Emmanuel Darcq, Brigitte L Kieffe. The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula. Scientific reports. vol 12. issue 1. 2022-11-24. PMID:36424418. |
the mu opioid receptor (mor) and the orphan gpr151 receptor are inhibitory g protein coupled receptors that are enriched in the habenula, a small brain region involved in aversion processing, addiction and mood disorders. |
2022-11-24 |
2023-08-14 |
Not clear |
| Khatereh Kharazmi, Behrang Alani, Azhdar Heydari, Abolfazl Ardjman. Protection against Morphine-Induced Inhibitory Avoidance Memory Impairment in Rat by Curcumin: Possible Role of Nitric Oxide/ cAMP-Response Element Binding Protein Pathway. Iranian journal of medical sciences. vol 47. issue 6. 2022-11-16. PMID:36380970. |
this study employs an inhibitory avoidance (ia) model to investigate whether cur can prevent morphine (mor)-induced memory impairment as well as the possible role of camp-response element binding (creb) protein, and nitric oxide (no) signaling in this mechanism. |
2022-11-16 |
2023-08-14 |
rat |
| Maggie W Waung, Kayla A Maanum, Thomas J Cirino, Joseph R Driscoll, Chris O'Brien, Svetlana Bryant, Kasra A Mansourian, Marisela Morales, David J Barker, Elyssa B Margoli. A diencephalic circuit in rats for opioid analgesia but not positive reinforcement. Nature communications. vol 13. issue 1. 2022-02-10. PMID:35140231. |
critically, optogenetic stimulation of lhb-projecting lpo neurons produces an aversive state that is relieved by lhb mor activation, and optogenetic inhibition of lhb-projecting lpo neurons relieves the aversiveness of ongoing pain. |
2022-02-10 |
2023-08-13 |
rat |
| Bradley K Taylor, Gregory Corde. Endogenous analgesia, dependence, and latent pain sensitization. Current topics in behavioral neurosciences. vol 20. 2021-10-21. PMID:25227929. |
disruption with mor inverse agonists reinstates pain and precipitates cellular, somatic, and aversive signs of physical withdrawal; this phenomenon requires n-methyl-d-aspartate receptor-mediated activation of calcium-sensitive adenylyl cyclase type 1 (ac1). |
2021-10-21 |
2023-08-13 |
Not clear |
| Manuella Machado Godoi, Hélio Zangrossi Junior, Joice Maria da Cunha, Janaina Menezes Zanovel. Mu-opioid and CB1 cannabinoid receptors of the dorsal periaqueductal gray interplay in the regulation of fear response, but not antinociception. Pharmacology, biochemistry, and behavior. vol 194. 2021-03-30. PMID:32376258. |
the activation of cannabinoid type-1 (cb1) or mu-opioid (mor) receptors in the dorsal region of this structure (dpag) inhibits fear and facilitates antinociception induced by different aversive stimuli. |
2021-03-30 |
2023-08-13 |
Not clear |
| Megan E Fo. Aversion No MOR: Mu-opioid receptors in habenular β4 neurons are key for naloxone aversion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-29. PMID:31055593. |
aversion no mor: mu-opioid receptors in habenular β4 neurons are key for naloxone aversion. |
2020-12-29 |
2023-08-13 |
Not clear |
| L J Boulos, S Ben Hamida, J Bailly, M Maitra, A T Ehrlich, C Gavériaux-Ruff, E Darcq, B L Kieffe. Mu opioid receptors in the medial habenula contribute to naloxone aversion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31005059. |
mors are inhibitory receptors, therefore we propose that endogenous mor signaling normally inhibits chnrb4-neurons of the mhb and moderates their known aversive activity, which is unmasked upon receptor blockade. |
2020-12-28 |
2023-08-13 |
mouse |
| L J Boulos, S Ben Hamida, J Bailly, M Maitra, A T Ehrlich, C Gavériaux-Ruff, E Darcq, B L Kieffe. Mu opioid receptors in the medial habenula contribute to naloxone aversion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31005059. |
here we tested the hypothesis that mor in the mhb (mhb-mor) also regulates aversion processing. |
2020-12-28 |
2023-08-13 |
mouse |
| L J Boulos, S Ben Hamida, J Bailly, M Maitra, A T Ehrlich, C Gavériaux-Ruff, E Darcq, B L Kieffe. Mu opioid receptors in the medial habenula contribute to naloxone aversion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31005059. |
thus, in addition to facilitating reward at several brain sites, tonic mor activity may also limit aversion within the mhb circuitry. |
2020-12-28 |
2023-08-13 |
mouse |
| F Dadam, F Zádor, X Caeiro, E Szűcs, A I Erdei, R Samavati, R Gáspár, A Borsodi, L Viva. The effect of increased NaCl intake on rat brain endogenous μ-opioid receptor signalling. Journal of neuroendocrinology. vol 30. issue 4. 2019-10-03. PMID:29486102. |
the increased mor g-protein activity following acute sodium overconsumption may participate in the maintenance of normal blood pressure levels and/or in enhancing sodium taste aversion and sodium overload-induced anorexia. |
2019-10-03 |
2023-08-13 |
rat |
| Camila Marroni Roncon, Rafael Carvalho Almada, Jhonatan Christian Maraschin, Elisabeth Aparecida Audi, Hélio Zangrossi, Frederico Guilherme Graeff, Norberto Cysne Coimbr. Pharmacological evidence for the mediation of the panicolytic effect of fluoxetine by dorsal periaqueductal gray matter μ-opioid receptors. Neuropharmacology. vol 99. 2016-08-30. PMID:26320545. |
in addition, the combined administration of sub-effective doses of the selective mor agonist damgo (intra-dpag) and sub-effective doses of chronic as well as subchronic (7 days) fluoxetine increased avoidance and escape latencies, suggesting that the activation of mors may facilitate and accelerate the effects of fluoxetine. |
2016-08-30 |
2023-08-13 |
Not clear |
| Lauri Nummenmaa, Sandra Manninen, Lauri Tuominen, Jussi Hirvonen, Kari K Kalliokoski, Pirjo Nuutila, Iiro P Jääskeläinen, Riitta Hari, Robin I M Dunbar, Mikko Sam. Adult attachment style is associated with cerebral μ-opioid receptor availability in humans. Human brain mapping. vol 36. issue 9. 2016-05-09. PMID:26046928. |
the avoidance dimension of attachment correlated negatively with mor availability in the thalamus and anterior cingulate cortex, as well as the frontal cortex, amygdala, and insula. |
2016-05-09 |
2023-08-13 |
human |
| Caitlin E Johnston, Daniel J Herschel, Amy W Lasek, Ronald P Hammer, Ella M Nikulin. Knockdown of ventral tegmental area mu-opioid receptors in rats prevents effects of social defeat stress: implications for amphetamine cross-sensitization, social avoidance, weight regulation and expression of brain-derived neurotrophic factor. Neuropharmacology. vol 89. 2015-07-15. PMID:25446676. |
social stress exposure induced social avoidance and attenuated weight gain in animals with non-manipulated vta mors, but both these effects were prevented by vta mor knockdown. |
2015-07-15 |
2023-08-13 |
rat |
| Nicole R Kinzeler, Susan P Traver. μ-Opioid modulation in the rostral solitary nucleus and reticular formation alters taste reactivity: evidence for a suppressive effect on consummatory behavior. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 3. 2011-10-24. PMID:21697523. |
indeed, forebrain damgo injections increase sucrose-elicited licking but reduce aversive responding (gaping) to quinine, suggesting that mor activation may enhance taste palatability. |
2011-10-24 |
2023-08-12 |
rat |
| J R Shoblock, N T Maidmen. Enkephalin release promotes homeostatic increases in constitutively active mu opioid receptors during morphine withdrawal. Neuroscience. vol 149. issue 3. 2008-01-16. PMID:17905519. |
taken together, the data suggest that a compensatory increase in enkephalin release during spontaneous morphine withdrawal promotes a second period of mor constitutive activity in wt mice that is responsible for the enhanced naloxone aversion observed in such animals even when naloxone is administered 20 h after morphine. |
2008-01-16 |
2023-08-12 |
mouse |
| P K Olszewski, Q Shi, C J Billington, A S Levin. Opioids affect acquisition of LiCl-induced conditioned taste aversion: involvement of OT and VP systems. American journal of physiology. Regulatory, integrative and comparative physiology. vol 279. issue 4. 2000-11-07. PMID:11004021. |
mor alleviated but did not eliminate the aversive effects. |
2000-11-07 |
2023-08-12 |
rat |