| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fanny Wulkan, Rocco Romagnuolo, Beiping Qiang, Tamilla Valdman Sadikov, Kyung-Phil Kim, Elya Quesnel, Wenlei Jiang, Naaz Andharia, Jill J Weyers, Nilesh R Ghugre, Bilgehan Ozcan, Faisal J Alibhai, Michael A Laflamm. Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias. Frontiers in cardiovascular medicine. vol 11. 2024-07-24. PMID:39045008. |
our group previously reported that these arrhythmias arise from a focal mechanism whereby graft tissue functions as an ectopic pacemaker; therefore, we hypothesized that hpsc-cms engineered with a dominant negative form of the pacemaker ion channel hcn4 (dnhcn4) would exhibit reduced automaticity and arrhythmogenic risk following transplantation. |
2024-07-24 |
2024-07-26 |
human |
| Silvia Marchiano, Kenta Nakamura, Hans Reinecke, Lauren Neidig, Michael Lai, Shin Kadota, Filippo Perbellini, Xiulan Yang, Jordan M Klaiman, Leslie P Blakely, Elaheh Karbassi, Paul A Fields, Aidan M Fenix, Kevin M Beussman, Anu Jayabalu, Faith A Kalucki, Akiko Futakuchi-Tsuchida, Gerhard J Weber, Sarah Dupras, Hiroshi Tsuchida, Lil Pabon, Lili Wang, Björn C Knollmann, Steven Kattman, R Scott Thies, Nathan Sniadecki, W Robb MacLellan, Alessandro Bertero, Charles E Murr. Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy. Cell stem cell. vol 30. issue 4. 2023-04-07. PMID:37028405. |
abolishing depolarization-associated genes hcn4, cacna1h, and slc8a1, along with overexpressing hyperpolarization-associated kcnj2, creates hpsc-cms that lack automaticity but contract when externally stimulated. |
2023-04-07 |
2023-08-14 |
human |
| Trevor Henley, Julie Goudy, Marietta Easterling, Carrie Donley, Robert Wirka, Michael Bressa. Local tissue mechanics control cardiac pacemaker cell embryonic patterning. Life science alliance. vol 6. issue 6. 2023-03-27. PMID:36973005. |
in addition, we demonstrate that subjecting embryonic cpcs to substrate stiffnesses higher than those measured in vivo results in loss of coherent electrical oscillation and dysregulation of the hcn4 and ncx1 ion channels required for cpc automaticity. |
2023-03-27 |
2023-08-14 |
Not clear |
| Donghai Liu, Andrew Taehun Song, Xiaoyan Qi, Patrick Piet van Vliet, Jiening Xiao, Feng Xiong, Gregor Andelfinger, Stanley Natte. Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Nature communications. vol 12. issue 1. 2021-05-24. PMID:33953173. |
cohesin-protein shugoshin-1 controls cardiac automaticity via hcn4 pacemaker channel. |
2021-05-24 |
2023-08-13 |
human |
| Xin Huang, Pei Yang, Zhao Yang, Hong Zhang, Aiqun M. Age-associated expression of HCN channel isoforms in rat sinoatrial node. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 3. 2016-06-06. PMID:26341471. |
during the senescent process, the hcn2 and hcn4 protein levels declined, which was accompanied with a decreased effect of ivabradine on rat san automaticity. |
2016-06-06 |
2023-08-13 |
rat |
| Jinfeng Liu, Ruxiu Liu, Jie Peng, Yanli Wan. Effects of Yiqi Tongyang on HCN4 Protein Phosphorylation in Damaged Rabbit Sinoatrial Node Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-04-12. PMID:27069490. |
here, we speculated that these effects could be associated with upregulation of hcn4 protein phosphorylation, which consequently improved cell automaticity, increased heart rate, and had treatment effects on sss. |
2016-04-12 |
2023-08-13 |
rabbit |
| Rajan Sah, Pietro Mesirca, Marjolein Van den Boogert, Jonathan Rosen, John Mably, Matteo E Mangoni, David E Clapha. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 32. 2013-11-04. PMID:23878236. |
we conclude that trpm7 influences diastolic membrane depolarization and automaticity in san indirectly via regulation of hcn4 expression. |
2013-11-04 |
2023-08-12 |
mouse |
| Vasanth Vedantham, Melissa Evangelista, Yu Huang, Deepak Srivastav. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Developmental biology. vol 373. issue 1. 2013-01-25. PMID:23085412. |
to understand regional variation in cardiac automaticity, we carried out an in vivo analysis of cis-regulatory elements that control expression of the hyperpolarization-activated cyclic-nucleotide gated ion channel 4 (hcn4). |
2013-01-25 |
2023-08-12 |
mouse |
| Yoshimichi Kudo, Mariko Kaneko, Makoto Nakazawa, Sachiko Tomit. A case of cor triatriatum with an abnormal P wave: the pacemaker action from the specialized tissue in the abnormal septum. Pediatric cardiology. vol 32. issue 8. 2012-04-12. PMID:21823032. |
the authors confirmed the existence of cells positive to hcn4, indicating that they were sinoatrial node cells or at least cells with electrical automaticity. |
2012-04-12 |
2023-08-12 |
Not clear |
| Xiaobin Luo, Huixian Lin, Zhengwei Pan, Jiening Xiao, Yong Zhang, Yanjie Lu, Baofeng Yang, Zhiguo Wan. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. The Journal of biological chemistry. vol 283. issue 29. 2008-09-03. PMID:18458081. |
the pacemaker current i(f), carried by the hyperpolarization-activated channels encoded mainly by the hcn2 and hcn4 genes in the heart, plays an important role in determining cardiac automaticity. |
2008-09-03 |
2023-08-12 |
rat |
| Kazuo Ueda, Kazufumi Nakamura, Takeharu Hayashi, Natsuko Inagaki, Megumi Takahashi, Takuro Arimura, Hiroshi Morita, Yasushi Higashiuesato, Yuji Hirano, Michio Yasunami, Shuichi Takishita, Akira Yamashina, Tohru Ohe, Makoto Sunamori, Masayasu Hiraoka, Akinori Kimur. Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. The Journal of biological chemistry. vol 279. issue 26. 2004-08-13. PMID:15123648. |
hyperpolarization-activated cyclic nucleotide-gated channel 4 gene hcn4 is a pacemaker channel that plays a key role in automaticity of sinus node in the heart, and an hcn4 mutation was reported in a patient with sinus node dysfunction. |
2004-08-13 |
2023-08-12 |
Not clear |