| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Liu, Xuying Ding, Xiao Guo, Meijun Zhao, Xiaojun Zhang, Ziqing Li, Risheng Zhao, Yuyan Cao, Jiaying Xin. Recombinant human HspB5-ACD structural domain inhibits neurotoxicity by regulating pathological \\xce\\xb1-Syn aggregation. International journal of biological macromolecules. 2023-11-22. PMID:37992927. |
in vitro experiments showed that ahspb5 could inhibit the formation of \xce\xb1-syn oligomers and fibrils; in cellular experiments, ahspb5 could prevent \xce\xb1-syn-induced neuronal cell dysfunction, oxidative stress damage and apoptosis, and its mechanism of action was related to the th-da pathway and mitochondria-dependent apoptotic pathway; in animal experiments, ahspb5 could inhibit behavioural abnormalities, oxidative stress damage and loss of dopaminergic neurons. |
2023-11-22 |
2023-11-29 |
human |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Saud A Alnaaim, Hebatallah M Saad, Gaber El-Saber Batih. The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson's Disease: The Way of New Inroads. Molecular neurobiology. 2023-10-28. PMID:37897634. |
of note, p75ntr plays a critical role in the regulation of dopaminergic neuronal survival and apoptosis in the cns. |
2023-10-28 |
2023-11-08 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Saud A Alnaaim, Hebatallah M Saad, Gaber El-Saber Batih. The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson's Disease: The Way of New Inroads. Molecular neurobiology. 2023-10-28. PMID:37897634. |
particularly, p75ntr can induce selective apoptosis of dopaminergic neurons and progression of pd. |
2023-10-28 |
2023-11-08 |
Not clear |
| Sara Mostafalou, Mohammad Abdollah. The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides. Archives of toxicology. 2023-10-03. PMID:37787774. |
apart from inhibiting the cholinesterase enzyme, op compounds are believed to cause other pathological mechanisms at both the extracellular level (cholinergic, serotonergic, dopaminergic, glutamatergic, and gabaergic synapses) and the intracellular level (oxidative stress, mitochondrial dysfunction, inflammation, autophagy, and apoptosis) that contribute to these disorders. |
2023-10-03 |
2023-10-07 |
human |
| Xu Liu, Qingqing Wu, Jingwen Wu, Jianxi Liu, Fuli Zheng, Guangxia Yu, Hong Hu, Zhenkun Guo, Siying Wu, Huangyuan Li, Wenya Sha. Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p. Ecotoxicology and environmental safety. vol 263. 2023-08-17. PMID:37591128. |
it can lead to the activation of microglia and apoptosis of dopaminergic neurons. |
2023-08-17 |
2023-09-07 |
Not clear |
| Xiyu Gao, Dewei He, Yanting Liu, Mingchi Cui, Zhe Li, Jie Li, Yuan He, Hefei Wang, Bojian Ye, Shoupeng Fu, Dianfeng Li. Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats. International immunopharmacology. vol 123. 2023-08-03. PMID:37536186. |
the excessive autophagy of neurons and hyperactivation of microglia were shown to be involved in the apoptosis of dopaminergic neurons. |
2023-08-03 |
2023-08-14 |
rat |
| Rohit Bhatt, Devendra Vaishnav, Vishal Airao, Tejas Sharma, Mahesh Rachamalla, Shalini Mani, Ashish Kumar Gupta, Vijay Upadhye, Saurabh Kumar Jha, Niraj Kumar Jha, Sachin Parma. Neuroprotective potential of saroglitazar in 6-OHDA induced Parkinson's disease in rats. Chemical biology & drug design. 2023-07-30. PMID:37518817. |
consequently, interleukin-6, tumour necrosis-\xce\xb1, interferon-\xce\xb3 and cyclooxygenase-2 mediated neuroinflammation leads to mitochondrial dysfunction, involving inhibition of complex-ii and iv activities, followed by apoptosis and degeneration of striatal dopaminergic neurons. |
2023-07-30 |
2023-08-14 |
rat |
| Rohit Bhatt, Devendra Vaishnav, Vishal Airao, Tejas Sharma, Mahesh Rachamalla, Shalini Mani, Ashish Kumar Gupta, Vijay Upadhye, Saurabh Kumar Jha, Niraj Kumar Jha, Sachin Parma. Neuroprotective potential of saroglitazar in 6-OHDA induced Parkinson's disease in rats. Chemical biology & drug design. 2023-07-30. PMID:37518817. |
saroglitazar (sg) being dual ppar-\xce\xb1/\xce\xb3 agonist activates both ppar-\xce\xb1 and ppar-\xce\xb3 receptors and provide neuroprotection by reducing oxidative stress, neuroinflammation, mitochondrial dysfunction and apoptosis of dopaminergic cells in 6-ohda induced pd in rats. |
2023-07-30 |
2023-08-14 |
rat |
| Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Khatija Ayoob, Seenipandi Arunachalam, Shreesh Ojha, Rami Beira. Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373023. |
tannic acid mitigates rotenone-induced dopaminergic neurodegeneration by inhibiting inflammation, oxidative stress, apoptosis, and glutamate toxicity in rats. |
2023-06-28 |
2023-08-14 |
human |
| Ling Chen, Xuejie Huan, Fengju Jia, Zhen Zhang, Mingxia Bi, Lin Fu, Xixun Du, Xi Chen, Chunling Yan, Qian Jiao, Hong Jian. Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis. Antioxidants (Basel, Switzerland). vol 12. issue 4. 2023-04-28. PMID:37107185. |
deubiquitylase otud3 mediates endoplasmic reticulum stress through regulating fortilin stability to restrain dopaminergic neurons apoptosis. |
2023-04-28 |
2023-08-14 |
mouse |
| Ling Chen, Xuejie Huan, Fengju Jia, Zhen Zhang, Mingxia Bi, Lin Fu, Xixun Du, Xi Chen, Chunling Yan, Qian Jiao, Hong Jian. Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis. Antioxidants (Basel, Switzerland). vol 12. issue 4. 2023-04-28. PMID:37107185. |
we found that the er thickness and the expression of protein disulphide isomerase (pdi) were increased, and the apoptosis level was elevated in the dopaminergic neurons of otud3 knockout mice. |
2023-04-28 |
2023-08-14 |
mouse |
| Feng Qiu, Yue Wu, Guojin Xie, Hui Cao, Mingyang Du, Haibo Jian. MiRNA-1976 Regulates the Apoptosis of Dopaminergic Neurons by Targeting the Journal of integrative neuroscience. vol 22. issue 2. 2023-03-30. PMID:36992582. |
mirna-1976 regulates the apoptosis of dopaminergic neurons by targeting the parkinson's disease (pd), which is a neurodegenerative disease, requires urgently needed biomarkers to explore its mechanism. |
2023-03-30 |
2023-08-14 |
Not clear |
| Lujain Bader Eddin, Sheikh Azimullah, Niraj Kumar Jha, Mohamed Fizur Nagoor Meeran, Rami Beiram, Shreesh Ojh. Limonene, a Monoterpene, Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Modulating Neuroinflammation, Hippo Signaling and Apoptosis in Rats. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982297. |
limonene, a monoterpene, mitigates rotenone-induced dopaminergic neurodegeneration by modulating neuroinflammation, hippo signaling and apoptosis in rats. |
2023-03-29 |
2023-08-14 |
rat |
| Yufang Yao, Zhiyue Zhao, Fubo Zhang, Na Miao, Nan Wang, Xin Xu, Chaoping Yan. microRNA-221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease. Brain and behavior. 2023-02-16. PMID:36795044. |
several studies verified that microrna (mirnas) targeting the bim/bax/caspase-3 signaling axis is involved in the apoptosis of dopaminergic neurons in substantia nigra. |
2023-02-16 |
2023-08-14 |
mouse |
| Mei-Chou Lai, Wayne-Young Liu, Shorong-Shii Liou, I-Min Li. Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP Nutrients. vol 15. issue 3. 2023-02-11. PMID:36771255. |
hispidin in the medicinal fungus protects dopaminergic neurons from jnk activation-regulated mitochondrial-dependent apoptosis in an mpp degenerative diseases of the brain include parkinson's disease (pd), which is associated with moveable signs and is still incurable. |
2023-02-11 |
2023-08-14 |
Not clear |
| Richa Singh, Walia Zahra, Saumitra Sen Singh, Hareram Birla, Aaina Singh Rathore, Priyanka Kumari Keshri, Hagera Dilnashin, Shekhar Singh, Surya Pratap Sing. Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway. Scientific reports. vol 13. issue 1. 2023-02-11. PMID:36774383. |
major pathological features of parkinson's disease (pd) include increase in oxidative stress leading to the aggregation of \xce\xb1-synuclein, mitochondrial dysfunction and apoptosis of dopaminergic neurons. |
2023-02-11 |
2023-08-14 |
mouse |
| Tsz Ki K. Does Drinking Coffee Reduce the Incidence of Parkinson's Disease? Cureus. vol 15. issue 1. 2023-02-01. PMID:36721713. |
the inhibition of inflammation and microglial cell activation to reduce reactive oxygen species (ros)-induced cellular damage and the resultant mitochondrial dysfunction of the dopaminergic neurons appears to be the main pathway, inducing neuronal loss via the activation of the intrinsic pathway to apoptosis. |
2023-02-01 |
2023-08-14 |
mouse |
| Wesley Zhi Chung See, Rakesh Naidu, Kim San Tan. Paraquat and Parkinson's disease: The molecular crosstalk of upstream signal transduction pathways leading to apoptosis. Current neuropharmacology. 2023-01-27. PMID:36703582. |
the underlying mechanisms of the dopaminergic lesion are primarily driven by the generation of reactive oxygen species, decrease in antioxidant enzyme levels, neuroinflammation, mitochondrial dysfunction, and er stress, leading to a cascade of molecular crosstalks that result in the initiation of apoptosis. |
2023-01-27 |
2023-08-14 |
Not clear |
| Nuria Acero, Teresa Ortega, Victoria Villagrasa, Gemma Leon, Dolores Mu\\xc3\\xb1oz-Mingarro, Encarna Castillo, M Eugenia Gonz\\xc3\\xa1lez-Rosende, Silvia Borr\\xc3\\xa1s, Jose Luis Rios, Francisco Bosch-Morell, Isabel Mart\\xc3\\xadnez-Sol\\xc3\\xad. Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal. Phytotherapy research : PTR. 2023-01-23. PMID:36690605. |
there are preclinical and clinical scientific evidences on their properties against protein aggregates in the central nervous system and their effects on neuroinflammation, apoptosis dysregulation, mitochondrial dysfunction, gabaergic, glutamatergic and dopaminergic systems alterations, monoamine oxidase alterations, serotonin depletion and oestrogenic protection. |
2023-01-23 |
2023-08-14 |
Not clear |
| Sheikh Azimullah, Richard L Jayaraj, Mohamed Fizur Nagoor Meeran, Fakhreya Y Jalal, Abdu Adem, Shreesh Ojha, Rami Beira. Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677744. |
myrcene salvages rotenone-induced loss of dopaminergic neurons by inhibiting oxidative stress, inflammation, apoptosis, and autophagy. |
2023-01-21 |
2023-08-14 |
Not clear |