| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Misa Ariyoshi, Ryo Yuge, Yuki Kitadai, Daisuke Shimizu, Ryo Miyamoto, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Yuji Urabe, Shiro Ok. WEE1 Inhibitor Adavosertib Exerts Antitumor Effects on Colorectal Cancer, Especially in Cases with Cancers. vol 16. issue 18. 2024-09-28. PMID:39335109. |
wee1 inhibitor adavosertib exerts antitumor effects on colorectal cancer, especially in cases with inhibition of wee1, a key regulator of the g2/m checkpoint of the cell cycle, induces apoptosis by initiating mitosis without repairing dna damage. |
2024-09-28 |
2024-10-01 |
mouse |
| Christoph Hieber, Al-Hassan M Mustafa, Sarah Neuroth, Sven Henninger, Hans-Peter Wollscheid, Joanna Zabkiewicz, Michelle Lazenby, Caroline Alvares, Siavosh Mahboobi, Falk Butter, Walburgis Brenner, Matthias Bros, Oliver H Kräme. Inhibitors of the tyrosine kinases FMS-like tyrosine kinase-3 and WEE1 induce apoptosis and DNA damage synergistically in acute myeloid leukemia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-06. PMID:38971011. |
inhibitors of the tyrosine kinases fms-like tyrosine kinase-3 and wee1 induce apoptosis and dna damage synergistically in acute myeloid leukemia cells. |
2024-07-06 |
2024-07-12 |
human |
| Christoph Hieber, Al-Hassan M Mustafa, Sarah Neuroth, Sven Henninger, Hans-Peter Wollscheid, Joanna Zabkiewicz, Michelle Lazenby, Caroline Alvares, Siavosh Mahboobi, Falk Butter, Walburgis Brenner, Matthias Bros, Oliver H Kräme. Inhibitors of the tyrosine kinases FMS-like tyrosine kinase-3 and WEE1 induce apoptosis and DNA damage synergistically in acute myeloid leukemia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-06. PMID:38971011. |
we reveal that promising clinical grade and preclinical inhibitors of flt3 and wee1 synergistically trigger apoptosis in leukemic cells that express flt3-itd. |
2024-07-06 |
2024-07-12 |
human |
| Wenhao Zhang, Qingli Li, Rutie Yi. Targeting WEE1 Kinase in Gynecological Malignancies. Drug design, development and therapy. vol 18. 2024-06-25. PMID:38915863. |
targeted inhibition of wee1 kinase may cause tumor cell apoptosis, primarily, in the p53-deficient tumor, via bypassing the g2/m checkpoint without properly repairing dna damage, resulting in genome instability and chromosomal deletion. |
2024-06-25 |
2024-06-27 |
Not clear |
| Koji Fukuda, Shinji Takeuchi, Sachiko Arai, Shigeki Nanjo, Shigeki Sato, Hiroshi Kotani, Kenji Kita, Akihiro Nishiyama, Hiroyuki Sakaguchi, Koshiro Ohtsubo, Seiji Yan. Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations. Cell reports. Medicine. 2024-05-22. PMID:38776912. |
through crispr-cas9 knockout screening using a library of 746 crrnas and drug screening with a custom library of 432 compounds, we discover that wee1 kinase inhibitors are potent enhancers of apoptosis, particularly in kras-mutant nsclc cells harboring tp53 mutations. |
2024-05-22 |
2024-05-27 |
rat |
| Koji Fukuda, Shinji Takeuchi, Sachiko Arai, Shigeki Nanjo, Shigeki Sato, Hiroshi Kotani, Kenji Kita, Akihiro Nishiyama, Hiroyuki Sakaguchi, Koshiro Ohtsubo, Seiji Yan. Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations. Cell reports. Medicine. 2024-05-22. PMID:38776912. |
mechanistically, wee1 inhibition promotes g2/m transition and reduces checkpoint kinase 2 (chk2) and rad51 expression in the dna damage response (ddr) pathway, which is associated with apoptosis and the repair of dna double-strand breaks, leading to mitotic catastrophe. |
2024-05-22 |
2024-05-27 |
rat |
| Yongxu Su, Yanjia Hu, Binbin Qu, Rongchang Lei, Ge Gu. METTL3 Promotes OSCC Progression by Down-Regulating WEE1 in a m6A-YTHDF2-Dependent Manner. Molecular biotechnology. 2024-05-14. PMID:38744787. |
wee1 overexpression inhibited proliferation, invasion, and migration while promoting apoptosis in oscc cells. |
2024-05-14 |
2024-05-27 |
mouse |
| Christina Pfeiffer, Alexander M Grandits, Hélène Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| Kaiping Liu, Ling Wang, Zhiyuan Lou, Lijuan Guo, Yuanling Xu, Hongyan Qi, Zejun Fang, Lingming Mei, Xiang Chen, Xiaomin Zhang, Jimin Shao, Xueping Xian. E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma. Biochemical pharmacology. 2023-10-20. PMID:37863324. |
we further showed here that the combination of e2f8 knockdown with mk-1775, an inhibitor of wee1 being evaluated in clinical trials, synergistically suppressed proliferation and promoted apoptosis of luad cells in vitro and in vivo. |
2023-10-20 |
2023-11-08 |
Not clear |
| Chiao-Ping Chen, Chun-Nan Yeh, Yi-Ru Pan, Wen-Kuan Huang, Yu-Tien Hsiao, Chih-Hong Lo, Chiao-En W. Wee1 inhibition by MK1775 potentiates gemcitabine through accumulated replication stress leading to apoptosis in biliary tract cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-09-02. PMID:37659202. |
wee1 inhibition by mk1775 potentiates gemcitabine through accumulated replication stress leading to apoptosis in biliary tract cancer. |
2023-09-02 |
2023-09-07 |
mouse |
| Vignesh Sundararajan, Tuan Zea Tan, Diana Lim, Yanfen Peng, Antje Margret Wengner, Natalie Yan Li Ngoi, Anand D Jeyasekharan, David Shao Peng Ta. Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition. The Journal of pathology. 2022-11-14. PMID:36373784. |
rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention toward targeting cell cycle checkpoint kinases (such as atr, chk1, wee1 and others) along the dna damage response and replicative stress response pathways, thereby allowing unrepaired dna damage to be carried forward towards mitotic catastrophe and apoptosis. |
2022-11-14 |
2023-08-14 |
Not clear |
| Jeffrey C Martin, Jennie R Sims, Ajay Gupta, Andrei V Bakin, Joyce E Oh. WEE1 inhibition augments CDC7 (DDK) inhibitor-induced cell death in Ewing sarcoma by forcing premature mitotic entry and mitotic catastrophe. Cancer research communications. vol 2. issue 6. 2022-11-07. PMID:36338546. |
to overcome this, we combined the inhibition of ddk with the inhibition of wee1 and found that this results in elevated levels of premature mitotic entry, mitotic catastrophe, and apoptosis. |
2022-11-07 |
2023-08-14 |
Not clear |
| He Tong, Li Wang, Jing Shi, Haowei Jin, Kefan Zhang, Yulong Bao, Yongshuai Wu, Yipeng Cheng, Pengxia Liu, Changshan Wan. Upregulated miR-322-5p regulates cell cycle and promotes cell proliferation and apoptosis by directly targeting Wee1 in mice liver injury. Cell cycle (Georgetown, Tex.). 2022-08-12. PMID:35957539. |
upregulated mir-322-5p regulates cell cycle and promotes cell proliferation and apoptosis by directly targeting wee1 in mice liver injury. |
2022-08-12 |
2023-08-14 |
mouse |
| Vishnu Kumarasamy, Ram Nambiar, Jianxin Wang, Hanna Rosenheck, Agnieszka K Witkiewicz, Erik S Knudse. RB loss determines selective resistance and novel vulnerabilities in ER-positive breast cancer models. Oncogene. 2022-06-08. PMID:35676324. |
the combination of aurk and wee1 inhibitors, yields synergistic cell death selectively in rb-deleted er+ breast cancer cells via apoptosis and yields profound disease control in vivo. |
2022-06-08 |
2023-08-14 |
Not clear |
| Sajjad Vakili-Samiani, Omid Joodi Khanghah, Elham Gholipour, Fatemeh Najafi, Elham Zeinalzadeh, Parisa Samadi, Parisa Sarvarian, Shiva Pourvahdani, Shohre Karimi Kelaye, Michael R Hamblin, Abbas Ali Hosseinpour Feiz. Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy. Mutation research. vol 824. 2022-03-05. PMID:35247630. |
however, damaged cells can activate wee1 kinase (as a part of the ddr and rsr pathways), which prevents apoptosis and cell death by inducing cell cycle arrest at g2 phase. |
2022-03-05 |
2023-08-13 |
Not clear |
| Manuela Mancini, Cecilia Monaldi, Sara De Santis, Michela Rondoni, Cristina Papayannidis, Chiara Sartor, Antonio Curti, Samantha Bruno, Michele Cavo, Simona Soverin. Combined Inhibition of Polo-Like Kinase-1 and Wee1 as a New Therapeutic Strategy to Induce Apoptotic Cell Death in Neoplastic Mast Cells. Cancers. vol 14. issue 3. 2022-02-15. PMID:35159005. |
wee1 inhibition by mk1775 after 24 h treatment with danusertib or volasertib, when cells were arrested in g2 phase and wee1, was overexpressed and hyper-activated, resulting in a significantly higher rate of apoptosis than that obtained from concomitant treatment with danusertib or volasertib + mk1775 for 48 h. in conclusion, plk1 and aka, alone or together with wee1, are attractive therapeutic targets in neoplastic mcs. |
2022-02-15 |
2023-08-13 |
Not clear |
| Lin Sun, Huangxing Cai, Tengchao Zhou, Hua Xiang, Lin Lon. Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR-101-3p/Wee1 axis. Drug development research. 2022-01-26. PMID:35080031. |
then, cck-8 and flow cytometry assays were used to detect the proliferation and apoptosis of hcc cells after verbascoside and x-ray combined treatment, and the expressions of wee1 and apoptosis-related proteins bax and bcl-2 were detected by western blot. |
2022-01-26 |
2023-08-13 |
human |
| Lin Sun, Huangxing Cai, Tengchao Zhou, Hua Xiang, Lin Lon. Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR-101-3p/Wee1 axis. Drug development research. 2022-01-26. PMID:35080031. |
mir-101-3p inhibition or wee1 overexpression could reverse the effect of verbascoside on the viability and apoptosis of hcc cells. |
2022-01-26 |
2023-08-13 |
human |
| Yeliz Aka, Bahriye Karakas, Ufuk Acikbas, Huveyda Basaga, Ozgur Gul, Ozgur Kutu. Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target. The international journal of biochemistry & cell biology. vol 137. 2021-09-27. PMID:34171479. |
bh3-only proteins puma and bim functionally contribute to apoptosis signaling following co-targeting bcl-2 and wee1. |
2021-09-27 |
2023-08-13 |
Not clear |
| Antje Lindemann, Ameeta A Patel, Lin Tang, Noriaki Tanaka, Frederico O Gleber-Netto, Mason D Bartels, Li Wang, Daniel J McGrail, Shiaw-Yih Lin, Steven J Frank, Mitchell J Frederick, Jeffrey N Myers, Abdullah A Osma. Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress. Molecular cancer therapeutics. vol 20. issue 7. 2021-08-19. PMID:33947685. |
combined inhibition of rad51 and wee1 enhances cell killing in hnscc through induction of apoptosis associated with excessive dna damage and replication stress. |
2021-08-19 |
2023-08-13 |
Not clear |