| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| Kaiping Liu, Ling Wang, Zhiyuan Lou, Lijuan Guo, Yuanling Xu, Hongyan Qi, Zejun Fang, Lingming Mei, Xiang Chen, Xiaomin Zhang, Jimin Shao, Xueping Xian. E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma. Biochemical pharmacology. 2023-10-20. PMID:37863324. |
we further showed here that the combination of e2f8 knockdown with mk-1775, an inhibitor of wee1 being evaluated in clinical trials, synergistically suppressed proliferation and promoted apoptosis of luad cells in vitro and in vivo. |
2023-10-20 |
2023-11-08 |
Not clear |
| Chiao-Ping Chen, Chun-Nan Yeh, Yi-Ru Pan, Wen-Kuan Huang, Yu-Tien Hsiao, Chih-Hong Lo, Chiao-En W. Wee1 inhibition by MK1775 potentiates gemcitabine through accumulated replication stress leading to apoptosis in biliary tract cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-09-02. PMID:37659202. |
wee1 inhibition by mk1775 potentiates gemcitabine through accumulated replication stress leading to apoptosis in biliary tract cancer. |
2023-09-02 |
2023-09-07 |
mouse |
| Vignesh Sundararajan, Tuan Zea Tan, Diana Lim, Yanfen Peng, Antje Margret Wengner, Natalie Yan Li Ngoi, Anand D Jeyasekharan, David Shao Peng Ta. Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition. The Journal of pathology. 2022-11-14. PMID:36373784. |
rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention toward targeting cell cycle checkpoint kinases (such as atr, chk1, wee1 and others) along the dna damage response and replicative stress response pathways, thereby allowing unrepaired dna damage to be carried forward towards mitotic catastrophe and apoptosis. |
2022-11-14 |
2023-08-14 |
Not clear |
| Jeffrey C Martin, Jennie R Sims, Ajay Gupta, Andrei V Bakin, Joyce E Oh. WEE1 inhibition augments CDC7 (DDK) inhibitor-induced cell death in Ewing sarcoma by forcing premature mitotic entry and mitotic catastrophe. Cancer research communications. vol 2. issue 6. 2022-11-07. PMID:36338546. |
to overcome this, we combined the inhibition of ddk with the inhibition of wee1 and found that this results in elevated levels of premature mitotic entry, mitotic catastrophe, and apoptosis. |
2022-11-07 |
2023-08-14 |
Not clear |
| He Tong, Li Wang, Jing Shi, Haowei Jin, Kefan Zhang, Yulong Bao, Yongshuai Wu, Yipeng Cheng, Pengxia Liu, Changshan Wan. Upregulated miR-322-5p regulates cell cycle and promotes cell proliferation and apoptosis by directly targeting Wee1 in mice liver injury. Cell cycle (Georgetown, Tex.). 2022-08-12. PMID:35957539. |
upregulated mir-322-5p regulates cell cycle and promotes cell proliferation and apoptosis by directly targeting wee1 in mice liver injury. |
2022-08-12 |
2023-08-14 |
mouse |
| Vishnu Kumarasamy, Ram Nambiar, Jianxin Wang, Hanna Rosenheck, Agnieszka K Witkiewicz, Erik S Knudse. RB loss determines selective resistance and novel vulnerabilities in ER-positive breast cancer models. Oncogene. 2022-06-08. PMID:35676324. |
the combination of aurk and wee1 inhibitors, yields synergistic cell death selectively in rb-deleted er+ breast cancer cells via apoptosis and yields profound disease control in vivo. |
2022-06-08 |
2023-08-14 |
Not clear |
| Sajjad Vakili-Samiani, Omid Joodi Khanghah, Elham Gholipour, Fatemeh Najafi, Elham Zeinalzadeh, Parisa Samadi, Parisa Sarvarian, Shiva Pourvahdani, Shohre Karimi Kelaye, Michael R Hamblin, Abbas Ali Hosseinpour Feiz. Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy. Mutation research. vol 824. 2022-03-05. PMID:35247630. |
however, damaged cells can activate wee1 kinase (as a part of the ddr and rsr pathways), which prevents apoptosis and cell death by inducing cell cycle arrest at g2 phase. |
2022-03-05 |
2023-08-13 |
Not clear |
| Manuela Mancini, Cecilia Monaldi, Sara De Santis, Michela Rondoni, Cristina Papayannidis, Chiara Sartor, Antonio Curti, Samantha Bruno, Michele Cavo, Simona Soverin. Combined Inhibition of Polo-Like Kinase-1 and Wee1 as a New Therapeutic Strategy to Induce Apoptotic Cell Death in Neoplastic Mast Cells. Cancers. vol 14. issue 3. 2022-02-15. PMID:35159005. |
wee1 inhibition by mk1775 after 24 h treatment with danusertib or volasertib, when cells were arrested in g2 phase and wee1, was overexpressed and hyper-activated, resulting in a significantly higher rate of apoptosis than that obtained from concomitant treatment with danusertib or volasertib + mk1775 for 48 h. in conclusion, plk1 and aka, alone or together with wee1, are attractive therapeutic targets in neoplastic mcs. |
2022-02-15 |
2023-08-13 |
Not clear |
| Lin Sun, Huangxing Cai, Tengchao Zhou, Hua Xiang, Lin Lon. Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR-101-3p/Wee1 axis. Drug development research. 2022-01-26. PMID:35080031. |
then, cck-8 and flow cytometry assays were used to detect the proliferation and apoptosis of hcc cells after verbascoside and x-ray combined treatment, and the expressions of wee1 and apoptosis-related proteins bax and bcl-2 were detected by western blot. |
2022-01-26 |
2023-08-13 |
human |
| Lin Sun, Huangxing Cai, Tengchao Zhou, Hua Xiang, Lin Lon. Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR-101-3p/Wee1 axis. Drug development research. 2022-01-26. PMID:35080031. |
mir-101-3p inhibition or wee1 overexpression could reverse the effect of verbascoside on the viability and apoptosis of hcc cells. |
2022-01-26 |
2023-08-13 |
human |
| Yeliz Aka, Bahriye Karakas, Ufuk Acikbas, Huveyda Basaga, Ozgur Gul, Ozgur Kutu. Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target. The international journal of biochemistry & cell biology. vol 137. 2021-09-27. PMID:34171479. |
bh3-only proteins puma and bim functionally contribute to apoptosis signaling following co-targeting bcl-2 and wee1. |
2021-09-27 |
2023-08-13 |
Not clear |
| Antje Lindemann, Ameeta A Patel, Lin Tang, Noriaki Tanaka, Frederico O Gleber-Netto, Mason D Bartels, Li Wang, Daniel J McGrail, Shiaw-Yih Lin, Steven J Frank, Mitchell J Frederick, Jeffrey N Myers, Abdullah A Osma. Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress. Molecular cancer therapeutics. vol 20. issue 7. 2021-08-19. PMID:33947685. |
combined inhibition of rad51 and wee1 enhances cell killing in hnscc through induction of apoptosis associated with excessive dna damage and replication stress. |
2021-08-19 |
2023-08-13 |
Not clear |
| Yassi Fallah, Diane M Demas, Lu Jin, Wei He, Ayesha N Shajahan-Ha. Targeting WEE1 Inhibits Growth of Breast Cancer Cells That Are Resistant to Endocrine Therapy and CDK4/6 Inhibitors. Frontiers in oncology. vol 11. 2021-07-20. PMID:34277427. |
indeed, inhibition of wee1, a crucial g2 checkpoint regulator, with azd1775 (adavosertib), significantly decreased cell proliferation and increased g2/m arrest, apoptosis and gamma-h2ax levels (a marker for dna double stranded breaks) in resistant cells compared with sensitive cells. |
2021-07-20 |
2023-08-13 |
Not clear |
| Bin Wang, Lin Sun, Zhiyong Yuan, Zhen Ta. Wee1 kinase inhibitor AZD1775 potentiates CD8+\\xe2\\x80\\x89T cell-dependent antitumour activity via dendritic cell activation following a single high dose of irradiation. Medical oncology (Northwood, London, England). vol 37. issue 8. 2021-06-24. PMID:32696094. |
wee1, a kinase associated with the cell cycle, causes g2/m cell cycle arrest to allow repair of injured dna in cancer cells, and a wee1 inhibitor has been confirmed to lead to apoptosis in cancer cells. |
2021-06-24 |
2023-08-13 |
mouse |
| Xinyu Li, Yongwei Su, Katie Hege, Gerard Madlambayan, Holly Edwards, Tristan Knight, Lisa Polin, Juiwanna Kushner, Sijana H Dzinic, Kathryn White, Jay Yang, Regan Miller, Guan Wang, Lijing Zhao, Yue Wang, Hai Lin, Jeffrey W Taub, Yubin G. The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia. Haematologica. vol 106. issue 5. 2021-05-27. PMID:32165486. |
cudc-907 downregulates chk1, wee1, rrm1, and c-myc, which were found to play a role in venetoclax-induced apoptosis. |
2021-05-27 |
2023-08-13 |
mouse |
| S-T Suo, P Gong, X-J Peng, D Niu, Y-T Gu. Knockdown of long non-coding RNA VIM-AS1 inhibits glioma cell proliferation and migration, and increases the cell apoptosis via modulation of WEE1 targeted by miR-105-5p. European review for medical and pharmacological sciences. vol 24. issue 12. 2021-05-03. PMID:32633376. |
knockdown of long non-coding rna vim-as1 inhibits glioma cell proliferation and migration, and increases the cell apoptosis via modulation of wee1 targeted by mir-105-5p. |
2021-05-03 |
2023-08-13 |
Not clear |
| Cheng Hu, Hongyan Xia, Shanshan Bai, Jianlei Zhao, Holly Edwards, Xinyu Li, Yanrong Yang, Jing Lyu, Guan Wang, Yang Zhan, Yan Dong, Yubin G. CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action. Journal of cellular and molecular medicine. vol 24. issue 13. 2021-04-28. PMID:32459381. |
further, down-regulation of wee1, chk1, rrm1 and rrm2 contributed to cudc-907-induced dna damage and apoptosis. |
2021-04-28 |
2023-08-13 |
mouse |
| Fuxia Li, Ensong Guo, Jia Huang, Funian Lu, Bin Yang, Rourou Xiao, Chen Liu, Xue Wu, Yu Fu, Zizhuo Wang, Shaohua Peng, Yu Lei, Zhongzhen Guo, Lei Li, Ling Xi, Chaoyang Sun, Si Liu, Gang Che. mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers. American journal of cancer research. vol 10. issue 3. 2021-04-21. PMID:32266099. |
moreover, we found that the addition of nucleotide metabolic substrate dntps alleviated replication stress, restored the cell cycle and reduced apoptosis to some extent, supporting dntps depletion is necessary for the synergy between wee1 and mtor inhibits. |
2021-04-21 |
2023-08-13 |
Not clear |
| Daniel C Moreira, Sujatha Venkataraman, Apurva Subramanian, John Desisto, Ilango Balakrishnan, Eric Prince, Angela Pierce, Andrea Griesinger, Adam Green, Charles G Eberhardt, Nicholas K Foreman, Rajeev Vibhaka. Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine. Journal of neuro-oncology. vol 147. issue 3. 2021-03-15. PMID:32180106. |
we identified that targeting replication stress through wee1 inhibition to suppress the s-phase replication checkpoint, combined with the attenuation of nucleotide synthesis with gemcitabine, is an effective strategy to induce apoptosis in myc-driven medulloblastoma that could be rapidly translated into early phase clinical trials in children. |
2021-03-15 |
2023-08-13 |
Not clear |