Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Rajesh Basnet, Buddha Bahadur Basnet, Obed Boadi Amissah, Rongqi Huang, Yirong Sun, Zhiyuan Li, Jean de Dieu Habiman. Network Pharmacology-Based Virtual Screening of Chemical Constituents from Vitexnegundo Linn's Discovered Novel Molecular Targets for Breast Cancer Treatment. Current cancer drug targets. 2024-07-30. PMID:39075939. |
the chinese chaste tree vitexnegundo (vn) is a popular herb in south and southeast asia that has several health benefits, including the ability to inhibit tumor growth and induce apoptosis in multiple tumors. |
2024-07-30 |
2024-08-02 |
Not clear |
Ying Luo, Dan Zhang, Leping Hou, Nengming Li. Vernodalin suppresses tumor proliferation and increases apoptosis of gastric cancer cells through attenuation of FAK/PI3K/AKT/mTOR and MAPKs signaling pathways. Current pharmaceutical biotechnology. 2022-08-01. PMID:35909270. |
vernodalin (vn) induced apoptosis has been reported in various types of human cancer cells. |
2022-08-01 |
2023-08-14 |
human |
Marina Pisano, Claudia Arru, Maria Serra, Grazia Galleri, Daniele Sanna, Eugenio Garribba, Giuseppe Palmieri, Carla Rozz. Antiproliferative activity of vanadium compounds: effects on the major malignant melanoma molecular pathways. Metallomics : integrated biometal science. vol 11. issue 10. 2020-06-15. PMID:31490510. |
the inorganic anion vanadate(v) (vn) and the oxidovanadium(iv) complex [vo(dhp)2] (vs2), where dhp is 1,2-dimethyl-3-hydroxy-4(1h)-pyridinonate, showed ic50 values of 4.7 and 2.6 μm, respectively, against the a375 mm cell line, causing apoptosis and cell cycle arrest. |
2020-06-15 |
2023-08-13 |
Not clear |
Balraj Singh Gill, Richa Mehra, Navgeet, Sanjeev Kuma. Vitex negundo and its medicinal value. Molecular biology reports. vol 45. issue 6. 2019-04-25. PMID:30311123. |
vn is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. |
2019-04-25 |
2023-08-13 |
Not clear |
Byeong Tak Jeon, Rok Won Heo, Hyun Joo Shin, Chin-Ok Yi, Yu Hee Lee, Han-Nah Joung, Jung Hwa Jung, Jaehoon Jung, Soo Kyoung Kim, Jong Ryeal Hahm, Byong Won Lee, Jong Min Ko, In Youl Baek, Sang Soo Kang, Gu Seob Ro. Attenuation by a Vigna nakashimae extract of nonalcoholic fatty liver disease in high-fat diet-fed mice. Bioscience, biotechnology, and biochemistry. vol 78. issue 3. 2015-04-02. PMID:25036839. |
thus, these data indicate that a chronic vn extract prevented nafld through multiple mechanisms, including inflammation, er stress, and apoptosis in the liver. |
2015-04-02 |
2023-08-13 |
mouse |
Henning Petersen, Zhongfang Wang, Eva Lenz, Stephan Pleschka, Silke Rautenschlei. Reassortment of NS segments modifies highly pathogenic avian influenza virus interaction with avian hosts and host cells. Journal of virology. vol 87. issue 10. 2013-06-21. PMID:23468508. |
in the present study, we show that the ns segment of a/vietnam/1203/2004 (fpv ns vn, h5n1) hpaiv significantly altered the characteristics of the h7 prototype hpaiv in tracheal organ cultures (toc) of chicken and turkey in vitro, with decreased replication efficiency accompanied by increased induction of type i interferon (ifn) and apoptosis. |
2013-06-21 |
2023-08-12 |
human |
Donald R Staine. Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides? Medical hypotheses. vol 70. issue 2. 2008-05-02. PMID:17582695. |
vn receptors are class ii g protein-coupled receptors (gpcrs) which couple primarily to the adenylate cyclase (ac)-cyclic amp (camp) pathway and camp has a central role in neurological metabolism including influencing blood-brain barrier (bbb) and blood-spinal barrier (bsb) permeability, coordinating neuroregulatory pathways, and protecting against neuronal apoptosis. |
2008-05-02 |
2023-08-12 |
Not clear |
Foudil Lamari, Francoise Braut-Boucher, Nushjira Pongnimitprasert, Maguy Bernard, Marie-Jose Foglietti, Christian Derappe, Michele Auber. Cell adhesion and integrin expression are modulated by oxidative stress in EA.hy 926 cells. Free radical research. vol 41. issue 7. 2007-09-18. PMID:17577742. |
cell adhesion onto vitronectin (vn) and fibronectin (fn) was increased at low concentrations of hx/xo (up to 5 mu/ml) or t-bhp (up to 125 microm) and prevented ros-induced apoptosis. |
2007-09-18 |
2023-08-12 |
Not clear |
Karen Meerovitch, Frédéric Bergeron, Lorraine Leblond, Brigitte Grouix, Cathy Poirier, Monica Bubenik, Laval Chan, Henriette Gourdeau, Terry Bowlin, Giorgio Attard. A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen. Vascular pharmacology. vol 40. issue 2. 2003-12-15. PMID:12646396. |
both compounds were potent inducers of endothelial cell apoptosis when plated on rgd-dependent ecm (vitronectin, vn), which was dependent on the ability to induce cell detachment. |
2003-12-15 |
2023-08-12 |
chicken |
Yan-Lin Guo, Shujie Wang, Dian J Cao, Robert W Colma. Apoptotic effect of cleaved high molecular weight kininogen is regulated by extracellular matrix proteins. Journal of cellular biochemistry. vol 89. issue 3. 2003-11-12. PMID:12761895. |
hka induced apoptosis of endothelial cells grown on vn and gel but not cells grown on fn which closely parallels with its anti-adhesive potency. |
2003-11-12 |
2023-08-12 |
Not clear |
J Wu, W Liu, K Koenig, S Idell, V C Broaddu. Vitronectin adsorption to chrysotile asbestos increases fiber phagocytosis and toxicity for mesothelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 279. issue 5. 2000-11-09. PMID:11053028. |
vn coating of both chrysotile and crocidolite, but not of glass beads, increased intracellular oxidation and apoptosis of mesothelial cells. |
2000-11-09 |
2023-08-12 |
Not clear |
J H Uhm, N P Dooley, A P Kyritsis, J S Rao, C L Gladso. Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 5. issue 6. 1999-09-30. PMID:10389948. |
results of the study were: (a) vn coatings, in a dose-dependent manner, inhibited topoisomerase (topo)-induced apoptosis by up to 50% (optimal coating density, 500 ng/cm2); in contrast, fibronectin (fn), an ecm protein present in abundance in the brain, demonstrated no protection; (b) in a dose-response study, vn clearly conferred a survival advantage (ld50 of topo: on vn, 120 ng/ml; on fn, 35 ng/ml); (c) the protective effect of vn was not due to enhanced cell adhesion or alterations in the cell cycle distribution; (d) both of the classic integrin receptors that bind vn (alpha(v)beta3, alpha(v)beta5) were capable of mediating this protective effect, because ligation of either of the two classic integrins conferred chemoresistance to topo; and (e) chemoresistance observed with vn was associated with an increase in expression of two antiapoptotic proteins, bcl-2 and bcl-x(l), with a consequent increase in the ratios for bcl-2:bax and bcl-x(l):bax. |
1999-09-30 |
2023-08-12 |
human |
J H Uhm, N P Dooley, A P Kyritsis, J S Rao, C L Gladso. Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 5. issue 6. 1999-09-30. PMID:10389948. |
by using an in vitro assay of dna fragmentation as a quantitative measure of apoptotic cell death, we sought to determine whether the sensitivity of two human glioma cell lines (d54 and u251) to drug-induced apoptosis could be inhibited by vn. |
1999-09-30 |
2023-08-12 |
human |