| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuhong Pan, Wenjun Cai, Anchun Cheng, Mingshu Wang, Juan Huang, Shun Chen, Qiao Yang, Ying Wu, Di Sun, Sai Mao, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Qun Gao, Xumin Ou, Bin Tian, Zhongqiong Yin, Renyong Ji. Duck Tembusu virus NS3 protein induces apoptosis by activating the PERK/PKR pathway and mitochondrial pathway. Journal of virology. 2023-10-25. PMID:37877719. |
on the other hand, ns3 interacts with voltage-dependent anion channel 2 (vdac2) and inhibits the anti-apoptotic protein vdac2 to induce apoptosis, which is accompanied by the depolarization of mitochondrial membrane potential and accumulation of intracellular reactive oxygen species. |
2023-10-25 |
2023-11-08 |
Not clear |
| Collins Waguia Kontchou, Ian E Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich, Georg H\\xc3\\xa4cke. Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak. Cell death and differentiation. 2022-04-10. PMID:35397654. |
infection further inhibited apoptosis induced conformational changes of bak, as evidenced by changes to protease sensitivity, oligomerization and release from the mitochondrial porin vdac2. |
2022-04-10 |
2023-08-13 |
human |
| Zheng Yuan, Grant Dewson, Peter E Czabotar, Richard W Birkinsha. VDAC2 and the BCL-2 family of proteins. Biochemical Society transactions. 2021-12-16. PMID:34913469. |
voltage dependent anion channel 2 (vdac2) can regulate apoptosis. |
2021-12-16 |
2023-08-13 |
Not clear |
| Zheng Yuan, Grant Dewson, Peter E Czabotar, Richard W Birkinsha. VDAC2 and the BCL-2 family of proteins. Biochemical Society transactions. 2021-12-16. PMID:34913469. |
notably, vdac2 is required for efficient bax-mediated apoptosis, but conversely inhibits bak-mediated apoptosis. |
2021-12-16 |
2023-08-13 |
Not clear |
| Zheng Yuan, Grant Dewson, Peter E Czabotar, Richard W Birkinsha. VDAC2 and the BCL-2 family of proteins. Biochemical Society transactions. 2021-12-16. PMID:34913469. |
this review focuses on the role of vdac2 in apoptosis, discussing the current knowledge of the interaction between vdac2 and bcl-2 family proteins and the recent development of an apoptosis inhibitor that targets the vdac2-bak interaction. |
2021-12-16 |
2023-08-13 |
Not clear |
| Thirupura S Shankar, Dinesh K A Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, Aspasia Thodou Krokidi, Dallen Calder, Sutip Navankasattusas, Paulina Sander, Oh Sung Kwon, Aishwarya Aravamudhan, Jing Ling, Andreas Dendorfer, Changmin Xie, Ohyun Kwon, Emily H Y Cheng, Kevin J Whitehead, Thomas Gudermann, Russel S Richardson, Frank B Sachse, Johann Schredelseker, Kenneth W Spitzer, Dipayan Chaudhuri, Stavros G Drako. Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Nature communications. vol 12. issue 1. 2021-08-04. PMID:34321484. |
voltage dependent anion channel 2 (vdac2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. |
2021-08-04 |
2023-08-13 |
mouse |
| Leilei Zhang, Danyelle M Townsend, Morgan Morris, Eduardo N Maldonado, Yu-Lin Jiang, Ann-Marie Broome, Jennifer R Bethard, Lauren E Ball, Kenneth D Te. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. The Journal of pharmacology and experimental therapeutics. vol 374. issue 2. 2020-11-12. PMID:32546528. |
in h460 cells, depletion of vdac1 and vdac2 by small interfering rna impacted me-344 effects by diminishing generation of reactive oxygen species (ros), preventing mitochondrial membrane potential dissipation, and moderating me-344-induced cytotoxicity and mitochondrial-mediated apoptosis. |
2020-11-12 |
2023-08-13 |
Not clear |
| Leilei Zhang, Danyelle M Townsend, Morgan Morris, Eduardo N Maldonado, Yu-Lin Jiang, Ann-Marie Broome, Jennifer R Bethard, Lauren E Ball, Kenneth D Te. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. The Journal of pharmacology and experimental therapeutics. vol 374. issue 2. 2020-11-12. PMID:32546528. |
mechanistically, vdac1 and vdac2 knockdown prevented me-344-induced apoptosis by inhibiting bax mitochondrial translocation and cytochrome c release as well as apoptosis in these h460 cells. |
2020-11-12 |
2023-08-13 |
Not clear |
| Mark F van Delft, Stephane Chappaz, Yelena Khakham, Chinh T Bui, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, Laure Peilleron, Thao Nguyen, Caroline Miles, Soo San Wan, Rachael M Lane, Ahmad Wardak, Kurt Lackovic, Peter M Colman, Jarrod J Sandow, Andrew I Webb, Peter E Czabotar, Grant Dewson, Keith G Watson, David C S Huang, Guillaume Lessene, Benjamin T Kil. A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature chemical biology. vol 15. issue 11. 2020-02-14. PMID:31591564. |
a small molecule interacts with vdac2 to block mouse bak-driven apoptosis. |
2020-02-14 |
2023-08-13 |
mouse |
| Mark F van Delft, Stephane Chappaz, Yelena Khakham, Chinh T Bui, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, Laure Peilleron, Thao Nguyen, Caroline Miles, Soo San Wan, Rachael M Lane, Ahmad Wardak, Kurt Lackovic, Peter M Colman, Jarrod J Sandow, Andrew I Webb, Peter E Czabotar, Grant Dewson, Keith G Watson, David C S Huang, Guillaume Lessene, Benjamin T Kil. A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature chemical biology. vol 15. issue 11. 2020-02-14. PMID:31591564. |
here we show that wehi-9625, a novel tricyclic sulfone small molecule, binds to vdac2 and promotes its ability to inhibit apoptosis driven by mouse bak. |
2020-02-14 |
2023-08-13 |
mouse |
| Mark F van Delft, Stephane Chappaz, Yelena Khakham, Chinh T Bui, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, Laure Peilleron, Thao Nguyen, Caroline Miles, Soo San Wan, Rachael M Lane, Ahmad Wardak, Kurt Lackovic, Peter M Colman, Jarrod J Sandow, Andrew I Webb, Peter E Czabotar, Grant Dewson, Keith G Watson, David C S Huang, Guillaume Lessene, Benjamin T Kil. A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature chemical biology. vol 15. issue 11. 2020-02-14. PMID:31591564. |
our findings expand on the key role of vdac2 in regulating apoptosis and demonstrate that blocking apoptosis at an early stage is both advantageous and pharmacologically tractable. |
2020-02-14 |
2023-08-13 |
mouse |
| Jian He, Shu Mi, Xiao-Wei Qin, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo H. Tiger frog virus ORF104R interacts with cellular VDAC2 to inhibit cell apoptosis. Fish & shellfish immunology. vol 92. 2019-11-22. PMID:31299465. |
tiger frog virus orf104r interacts with cellular vdac2 to inhibit cell apoptosis. |
2019-11-22 |
2023-08-13 |
Not clear |
| Jian He, Shu Mi, Xiao-Wei Qin, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo H. Tiger frog virus ORF104R interacts with cellular VDAC2 to inhibit cell apoptosis. Fish & shellfish immunology. vol 92. 2019-11-22. PMID:31299465. |
this study elucidated the molecular mechanism underlying the interaction of tfv orf104r with the vdac2 protein to regulate cell apoptosis. |
2019-11-22 |
2023-08-13 |
Not clear |
| Shashank Dadsena, Svenja Bockelmann, John G M Mina, Dina G Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar M\\xc3\\xbcller, Markus Schneider, Fikadu G Tafesse, Siewert J Marrink, Manuel N Melo, Joost C M Holthui. Ceramides bind VDAC2 to trigger mitochondrial apoptosis. Nature communications. vol 10. issue 1. 2019-06-10. PMID:31015432. |
ceramides bind vdac2 to trigger mitochondrial apoptosis. |
2019-06-10 |
2023-08-13 |
human |
| Shashank Dadsena, Svenja Bockelmann, John G M Mina, Dina G Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar M\\xc3\\xbcller, Markus Schneider, Fikadu G Tafesse, Siewert J Marrink, Manuel N Melo, Joost C M Holthui. Ceramides bind VDAC2 to trigger mitochondrial apoptosis. Nature communications. vol 10. issue 1. 2019-06-10. PMID:31015432. |
unlike vdac1 removal, loss of vdac2 or replacing its membrane-facing glutamate with glutamine renders human colon cancer cells largely resistant to ceramide-induced apoptosis. |
2019-06-10 |
2023-08-13 |
human |
| Hui San Chin, Mark X Li, Iris K L Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, Ruth M Kluck, Philippe Bouillet, Marco J Herold, Daniel H D Gray, David C S Huang, Mark F van Delft, Grant Dewso. VDAC2 enables BAX to mediate apoptosis and limit tumor development. Nature communications. vol 9. issue 1. 2018-12-31. PMID:30478310. |
vdac2 enables bax to mediate apoptosis and limit tumor development. |
2018-12-31 |
2023-08-13 |
Not clear |
| Hui San Chin, Mark X Li, Iris K L Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, Ruth M Kluck, Philippe Bouillet, Marco J Herold, Daniel H D Gray, David C S Huang, Mark F van Delft, Grant Dewso. VDAC2 enables BAX to mediate apoptosis and limit tumor development. Nature communications. vol 9. issue 1. 2018-12-31. PMID:30478310. |
together, our studies show that efficient bax-mediated apoptosis depends on vdac2, and reveal a striking difference in how bax and bak are functionally impacted by their interactions with vdac2. |
2018-12-31 |
2023-08-13 |
Not clear |
| Elise Petit, Pierre-Fran\\xc3\\xa7ois Cartron, Lisa Oliver, Fran\\xc3\\xa7ois M Vallett. The phosphorylation of Metaxin 1 controls Bak activation during TNF\\xce\\xb1 induced cell death. Cellular signalling. vol 30. 2017-12-01. PMID:27845183. |
here, we show that, after the induction of apoptosis, bak switches from its association with mtx2 and vdac2 to a closer association with mtx1. |
2017-12-01 |
2023-08-13 |
Not clear |
| Jerry Edward Chipuk, Mark P A Luna-Varga. The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family. The Journal of cell biology. vol 216. issue 3. 2017-05-26. PMID:28193702. |
within the mitochondrial pathway of apoptosis, vdac2 controls both the localization and proapoptotic activity of bak. |
2017-05-26 |
2023-08-13 |
Not clear |
| Alessandra Leone, Maria Serena Roca, Chiara Ciardiello, Manuela Terranova-Barberio, Carlo Vitagliano, Gennaro Ciliberto, Rita Mancini, Elena Di Gennaro, Francesca Bruzzese, Alfredo Budillo. Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway. Free radical biology & medicine. vol 89. 2016-09-22. PMID:26409771. |
significantly, we also observed the attenuation of the expression of both the enzyme hexokinase1, a negative vdac1 regulator, and the anti-apoptotic porin vdac2, only in the combination setting, suggesting convergent mechanisms that enhanced mitochondria-dependent apoptosis by targeting vdac protein functions. |
2016-09-22 |
2023-08-13 |
Not clear |