| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lilin Hu, Zilu Cheng, Huikuan Chu, Weijun Wang, Yu Jin, Ling Yan. TRIF-dependent signaling and its role in liver diseases. Frontiers in cell and developmental biology. vol 12. 2024-05-02. PMID:38694821. |
trif plays a pivotal role in regulating interferon beta 1 (ifn-β) response, nuclear factor kappa b (nf-κb) signaling, apoptosis, and necroptosis signaling mediated by tlr3 and tlr4. |
2024-05-02 |
2024-05-04 |
Not clear |
| Yixuan Huang, Chengcheng Jiang, Xiaojie Liu, Wei Tang, Hongya Gui, Tao Sun, Doudou Xu, Maozhang He, Maozhen Han, Huan Qiu, Mingwei Chen, Shenghai Huan. Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-04-29. PMID:38683122. |
furthermore, tlr4 activation induced autophagy and apoptosis in neuronal cells, promoted the formation of the nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome, and increased the secretion of downstream inflammatory cytokines such as interleukin-1β (il-1β), interleukin-18 (il-18) and tumour necrosis factor-α (tnf-α). |
2024-04-29 |
2024-05-02 |
human |
| Yixuan Huang, Chengcheng Jiang, Xiaojie Liu, Wei Tang, Hongya Gui, Tao Sun, Doudou Xu, Maozhang He, Maozhen Han, Huan Qiu, Mingwei Chen, Shenghai Huan. Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-04-29. PMID:38683122. |
interestingly, blockade of tlr4 or treatment with exogenous melatonin significantly suppressed tlr4 activation as well as tlr4-mediated apoptosis, autophagy and immune responses. |
2024-04-29 |
2024-05-02 |
human |
| Xin Qi, Xin Chen, Wen-Bo An, Zhi-Ming Xu, Duo-Xian Wang, Peng-Fei Luo, Yi-Xin Chen, Jiao-Jiao Ma, Zi-Yang Hu, Wei Qi, Jian-Jun Liu, Jun-Xi Li. [Ligusticum cycloprolactam inhibits IL-1β-induced apoptosis and inflammation of rat chondrocytes via HMGB1/TLR4/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621908. |
the modeled chondrocytes showed increased apoptosis rate, promoted expression of cox-2, pge2, and tnf-α, up-regulated protein levels of bax, caspase-3, hmgb1, tlr4, and nf-κb p65 and mrna levels of hmgb1, tlr4, nf-κb p65, and myd88, and down-regulated protein level of bcl-2. |
2024-04-15 |
2024-04-18 |
rat |
| Jing Guo, Qi-Yun Zhang, Lin Xu, Min Li, Qian-Yun Su. Icariin ameliorates LPS-induced acute lung injury in mice via complement C5a-C5aR1 and TLR4 signaling pathways. International immunopharmacology. vol 131. 2024-03-11. PMID:38467082. |
network pharmacology, molecular docking, and in vivo experimental results revealed that ica inhibited the complement c5a-c5ar1 axis, tlr4 mediated nf-κb, mapk, and jak2-stat3 signaling pathways related gene and protein expressions, and decreased inflammatory cytokine, chemokine, adhesion molecule expressions, and mitochondrial apoptosis in lps-induced ali. |
2024-03-11 |
2024-03-14 |
mouse |
| Bei Chen, Ya-Fei Li, Zhang Fang, Wen-Yi Cai, Zhi-Qiang Tian, Dianfu Li, Ze-Mu Wan. Epigallocatechin-3-gallate protects sepsis-induced myocardial dysfunction by inhibiting the nuclear factor-κB signaling pathway. Heliyon. vol 10. issue 5. 2024-03-07. PMID:38449632. |
it can effectively inhibit the upregulation of tlr4 expression induced by lps and inhibit iκb α/nf- κb/p65 signaling pathway, thereby inhibiting cardiomyocyte apoptosis and improving myocarditis. |
2024-03-07 |
2024-03-09 |
Not clear |
| Lixia Hou, Huiqing Zuo, Bo Xiao, Dong Ya. Toll-like receptor 4 mediated autophagy regulates airway smooth muscle cells behavior. The Journal of asthma : official journal of the Association for the Care of Asthma. 2024-02-23. PMID:38349366. |
in this study, we aimed to investigate the influence of toll-like receptor 4 (tlr4) on autophagy and its underlying mechanism in asmc proliferation, apoptosis, and migration. |
2024-02-23 |
2024-02-25 |
Not clear |
| Hongwang Cui, Ji Li, Xiangtao Li, Tian Su, Peng Wen, Chuanling Wang, Xiaozhong Deng, Yonghua Fu, Weijie Zhao, Changjia Li, Pengbing Hua, Yongjun Zhu, Wei Wa. TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis. Bone. 2024-02-17. PMID:38367924. |
previous studies have shown that tnf-α-induced osteocyte necroptosis might exert a stronger effect on pmop than apoptosis, and tlr4 can also induce cell necroptosis, as confirmed by recent studies. |
2024-02-17 |
2024-02-20 |
Not clear |
| Guan Wang, Yu-Lin Xu, Xi-Hai Zhang, Lian Tang, Yao L. LncRNA HOTTIP regulates TLR4 promoter methylation by recruiting H3K4 methyltransferase MLL1 to affect apoptosis and inflammatory response of fibroblast-like synoviocyte in rheumatoid arthritis. The Kaohsiung journal of medical sciences. 2024-02-16. PMID:38363110. |
lncrna hottip regulates tlr4 promoter methylation by recruiting h3k4 methyltransferase mll1 to affect apoptosis and inflammatory response of fibroblast-like synoviocyte in rheumatoid arthritis. |
2024-02-16 |
2024-02-18 |
mouse |
| Guan Wang, Yu-Lin Xu, Xi-Hai Zhang, Lian Tang, Yao L. LncRNA HOTTIP regulates TLR4 promoter methylation by recruiting H3K4 methyltransferase MLL1 to affect apoptosis and inflammatory response of fibroblast-like synoviocyte in rheumatoid arthritis. The Kaohsiung journal of medical sciences. 2024-02-16. PMID:38363110. |
hottip regulates tlr4 expression by recruiting mll1, leading to tlr4 promoter methylation, thereby suppressing ra-fls proliferation and inducing cell apoptosis and inflammatory response in ra. |
2024-02-16 |
2024-02-18 |
mouse |
| Linyu Wu, Zixuan Tan, Lei Su, Fang Dong, Guangyu Xu, Feng Zhan. Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway. Frontiers in cellular neuroscience. vol 17. 2024-01-26. PMID:38273974. |
wb analysis was performed to assess the levels of tlr4, myd88, p-nf-κb p65/nf-κb p65, and inflammation, apoptosis, pyroptosis-related proteins. |
2024-01-26 |
2024-01-28 |
Not clear |
| Zhaowei Cai, Liqun Deng, Yingying Fan, Yujie Ren, Yun Ling, Jue Tu, Yueqin Cai, Xiaoping Xu, Minli Che. Dysregulation of Ceramide Metabolism Is Linked to Iron Deposition and Activation of Related Pathways in the Aorta of Atherosclerotic Miniature Pigs. Antioxidants (Basel, Switzerland). vol 13. issue 1. 2024-01-26. PMID:38275624. |
furthermore, c16 ceramide could promote iron deposition in raw264.7 cells, leading to increased intracellular reactive oxygen species (ros) production, apoptosis, and activation of the toll-like receptor 4 (tlr4)/nuclear factor-kappa b (nf-қb) inflammatory pathway, which could be mitigated by deferoxamine. |
2024-01-26 |
2024-01-28 |
human |
| Kangfeng Jiang, Jinyin Cai, Qianming Jiang, Juan J Loor, Ganzhen Deng, Xiaobing Li, Jing Yan. Interferon-tau protects bovine endometrial epithelial cells against inflammatory injury by regulating the PI3K/AKT/β-catenin/FoxO1 signaling axis. Journal of dairy science. vol 107. issue 1. 2024-01-14. PMID:38220437. |
results revealed that the knockdown of foxo1 blocked the upregulation of tlr4 and p-p65 induced by ly294002, and enhanced the inhibition of ifn-τ on tlr4, p-p65, and cell apoptosis. |
2024-01-14 |
2024-01-17 |
cattle |
| Lei Yang, Zhao-Yong Li, Lu Ma, Yan-Tao Guo, Shao-Feng Yang, Hui Xiong, Bo-Yu Wu, Jia-Hao Duan, En-Xu Liu, Chao Zhang, Ying Nie, Long Chen, Lin-Quan Li. [Aucubin combined with ADSCs-exos protects TBHP-induced nucleus pulposus cells via TLR4/NF-κB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 19. 2023-12-19. PMID:38114119. |
the results showed that compared with the model group, the aucubin or adscs-exos group showed enhanced viability and proliferation of npcs, decreased proportion of g_0/g_1 phase cells, increased proportion of s phase cells, reduced apoptosis and proportion of cells in senescence, lowered il-1β and tnf-α levels, elevated il-10 level, down-regulated mrna and protein levels of tlr4 and nf-κb, and up-regulated mrna and protein levels of aggrecan and col2a1. |
2023-12-19 |
2023-12-23 |
Not clear |
| Lei Yang, Zhao-Yong Li, Lu Ma, Yan-Tao Guo, Shao-Feng Yang, Hui Xiong, Bo-Yu Wu, Jia-Hao Duan, En-Xu Liu, Chao Zhang, Ying Nie, Long Chen, Lin-Quan Li. [Aucubin combined with ADSCs-exos protects TBHP-induced nucleus pulposus cells via TLR4/NF-κB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 19. 2023-12-19. PMID:38114119. |
compared with the aucubin or adscs-exos group, the aucubin+adscs-exos combination further increased the viability and proliferation of npcs, decreased the proportion of g_0/g_1 phase cells, increased the proportion of s phase cells, reduced the apoptosis and proportion of cells in senescence, lowered the il-1β and tnf-α levels, elevated the il-10 level, down-regulated the mrna and protein levels of tlr4 and nf-κb, and up-regulated the mrna and protein levels of aggrecan and col2a1. |
2023-12-19 |
2023-12-23 |
Not clear |
| Tong Xu, Chaozhuang Zhu, Feifeng Song, Wanli Zhang, Mengnan Yuan, Zongfu Pan, Ping Huan. Immunological characteristics of immunogenic cell death genes and malignant progression driving roles of TLR4 in anaplastic thyroid carcinoma. BMC cancer. vol 23. issue 1. 2023-11-24. PMID:37990304. |
eventually, silence of tlr4 synergistically enhanced paclitaxel-induced proliferation inhibition, apoptosis, calr exposure and release of atp. |
2023-11-24 |
2023-11-28 |
Not clear |
| Xin Liu, Wei Wei, Yue-Zhang Wu, Yuan Wang, Wei-Wei Zhang, Yong-Ping Wang, Xiao-Ping Dong, Qi Sh. Emodin treatment of papillary thyroid cancer cell lines Oncology letters. vol 26. issue 6. 2023-11-06. PMID:37927413. |
emodin could inhibit proliferation and promote apoptosis of ptc cells, which is dependent on the downregulation of cellular nf-κb and the tlr4 signaling pathway. |
2023-11-06 |
2023-11-08 |
Not clear |
| Journal Of Healthcare Engineerin. Retracted: miR-195 Inhibits Proliferation and Enhances Apoptosis of OSCC Cells via Targeting TLR4. Journal of healthcare engineering. vol 2023. 2023-10-20. PMID:37860323. |
retracted: mir-195 inhibits proliferation and enhances apoptosis of oscc cells via targeting tlr4. |
2023-10-20 |
2023-11-08 |
Not clear |
| Jia Zheng, Cui-Cui Wu, Wei Liu, Xi-Xin Jiang, Lan Luo, Yi-Yuan Deng, Guang L. [Inhibition of Ferulic Acid on U937 Cell Growth and Its Related Mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 31. issue 5. 2023-10-17. PMID:37846672. |
to investigate the effects of ferulic acid (fa) on proliferation, apoptosis and toll-like receptor 4 (tlr4)/nuclear factor-κb (nf-κb) signaling pathway of human acute myeloid leukemia (aml) u937 cells. |
2023-10-17 |
2023-11-08 |
human |
| Hanan A Fahmy, Marwa A Mohamed, Mai H Mekkawy, Eman F S Tah. Role of TLR4 signaling pathway in the mitigation of damaged lung by low-dose gamma irradiation. Cell biochemistry and function. 2023-09-21. PMID:37732723. |
additionally, exposure to ldr decreased tlr4, irak4, and mapk levels, decreased apoptosis, and restored all the alterations in the histopathological, hematological parameters, and dna fragmentation, indicating its protective effects on the lung when compared with untreated rats. |
2023-09-21 |
2023-10-07 |
rat |