| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lilin Hu, Zilu Cheng, Huikuan Chu, Weijun Wang, Yu Jin, Ling Yan. TRIF-dependent signaling and its role in liver diseases. Frontiers in cell and developmental biology. vol 12. 2024-05-02. PMID:38694821. |
trif plays a pivotal role in regulating interferon beta 1 (ifn-β) response, nuclear factor kappa b (nf-κb) signaling, apoptosis, and necroptosis signaling mediated by tlr3 and tlr4. |
2024-05-02 |
2024-05-04 |
Not clear |
| Fabian Rose, Beate Köberle, Sebastian Honnen, Cindy Bay, Jürgen Burhenne, Johanna Weiss, Walter E Haefeli, Dirk Theil. RNA is a pro-apoptotic target of cisplatin in cancer cell lines and C. elegans. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-19. PMID:38503239. |
assuming rna cross-linking (pseudo double-stranded rna), the contribution of the toll-like receptor 3 (tlr3, a sensor of double-stranded rna) to apoptosis induction in cancer cell lines was investigated by pharmacological tlr3 inhibition and overexpression. |
2024-03-19 |
2024-03-23 |
caenorhabditis_elegans |
| Jian Zeng, Qiong-Qiong Lu, Xiao-Long Du, Ling Yuan, Xiao-Jun Yan. Toll-like receptor 3 signaling drives enteric glial cells against dextran sulfate sodium-induced colitis in mice. Journal of molecular histology. 2024-02-20. PMID:38376631. |
in vitro, tlr3 signaling prevented apoptosis in egcs and drove the secretion of egcs-derived glial cell line-derived neurotrophic factor, 15-hydroxyeicosatetraenoic acid and s-nitrosoglutathione. |
2024-02-20 |
2024-02-22 |
mouse |
| Bin Han, Chao Zhang, Xiaoxiao Wang, Huangqin Song, Lei Zhang, Tao Li, Jiefeng He, Haoliang Zha. The Functional Mechanisms of Toll-Like Receptor 3 and Its Implications in Digestive System Tumors. Frontiers in bioscience (Landmark edition). vol 28. issue 11. 2023-12-08. PMID:38062829. |
additionally, tlr3 is considered an important immune modulator, as it can regulate cell apoptosis and promote anticancer immunity. |
2023-12-08 |
2023-12-17 |
Not clear |
| Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Che. Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-08-06. PMID:37544956. |
importantly, compared to the wild-type (wt) mice, tlr3 knockout (ko) mice and tlr3-specific neuronal knockdown mice both displayed improved cognitive function, reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity. |
2023-08-06 |
2023-08-14 |
mouse |
| Lu Zhao, Jinqiang Huang, Yongjuan Li, Shenji Wu, Yujun Kan. Comprehensive analysis of immune parameters, mRNA and miRNA profiles, and immune genes expression in the gill of rainbow trout infected with infectious hematopoietic necrosis virus (IHNV). Fish & shellfish immunology. 2023-01-16. PMID:36646338. |
the mrna and mirna analysis identified 4343 differentially expressed genes (degs) and 11 differentially expressed mirnas (dems), and numerous immune-related degs involved in the toll-like receptor signaling pathway, apoptosis, dna replication, p53 signaling, rig-i-like receptor signaling pathway, and nod-like receptor signaling pathway and expression were significantly up-regulated in t48gm group, including tlr3, tlr7, tlr8, traf3, ifih1, trim25, dhx58, ddh58, hsp90a.1, nlrc3, nlrc5, socs3, irf3, irf7, casp7, mx1, and vig2. |
2023-01-16 |
2023-08-14 |
cat |
| Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujit. Correction: PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis. Cell death & disease. vol 13. issue 9. 2022-09-19. PMID:36123340. |
correction: pkr and tlr3 trigger distinct signals that coordinate the induction of antiviral apoptosis. |
2022-09-19 |
2023-08-14 |
Not clear |
| Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujit. PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis. Cell death & disease. vol 13. issue 8. 2022-08-15. PMID:35970851. |
pkr and tlr3 trigger distinct signals that coordinate the induction of antiviral apoptosis. |
2022-08-15 |
2023-08-14 |
Not clear |
| Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujit. PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis. Cell death & disease. vol 13. issue 8. 2022-08-15. PMID:35970851. |
however, intracellular long dsrna was sensed by pkr and tlr3, which activate distinct signals, and synergistically induced rapid apoptosis. |
2022-08-15 |
2023-08-14 |
Not clear |
| Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujit. PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis. Cell death & disease. vol 13. issue 8. 2022-08-15. PMID:35970851. |
the present results demonstrated that pkr and tlr3 were both essential for inducing the viral rna-mediated apoptosis of infected cells and the arrest of viral production. |
2022-08-15 |
2023-08-14 |
Not clear |
| Ximena Maria Muresan, Eva Slabáková, Jiřina Procházková, Stanislav Drápela, Radek Fedr, Markéta Pícková, Ondřej Vacek, Ráchel Víchová, Tereza Suchánková, Jan Bouchal, Daniela Kürfürstová, Milan Král, Tereza Hulínová, Radek Paus Sýkora, Vladimír Študent, Václav Hejret, Wytske M van Weerden, Martin Puhr, Václav Pustka, David Potěšil, Zbyněk Zdráhal, Zoran Culig, Karel Souče. Toll-like receptor 3 (TLR3) overexpression induces invasion of prostate cancer cells, whereas its activation triggers apoptosis. The American journal of pathology. 2022-06-24. PMID:35750257. |
toll-like receptor 3 (tlr3) overexpression induces invasion of prostate cancer cells, whereas its activation triggers apoptosis. |
2022-06-24 |
2023-08-14 |
Not clear |
| Ximena Maria Muresan, Eva Slabáková, Jiřina Procházková, Stanislav Drápela, Radek Fedr, Markéta Pícková, Ondřej Vacek, Ráchel Víchová, Tereza Suchánková, Jan Bouchal, Daniela Kürfürstová, Milan Král, Tereza Hulínová, Radek Paus Sýkora, Vladimír Študent, Václav Hejret, Wytske M van Weerden, Martin Puhr, Václav Pustka, David Potěšil, Zbyněk Zdráhal, Zoran Culig, Karel Souče. Toll-like receptor 3 (TLR3) overexpression induces invasion of prostate cancer cells, whereas its activation triggers apoptosis. The American journal of pathology. 2022-06-24. PMID:35750257. |
furthermore, tlr3-ligand induced apoptosis via cleavage of caspase-3/7 and parp, predominantly in tlr3 overexpressing cells. |
2022-06-24 |
2023-08-14 |
Not clear |
| Daniela Lobenwein, Rosalie Huber, Lars Kerbler, Alexandra Gratl, Sabine Wipper, Can Gollmann-Tepeköylü, Johannes Holfel. Neuronal Pre- and Postconditioning via Toll-like Receptor 3 Agonist or Extracorporeal Shock Wave Therapy as New Treatment Strategies for Spinal Cord Ischemia: An In Vitro Study. Journal of clinical medicine. vol 11. issue 8. 2022-04-23. PMID:35456206. |
pre- and post-ischemic direct tlr3 activation as well as post-ischemic swt can decrease apoptosis and proinflammatory cytokine expression significantly in vitro and might therefore pose possible new treatment strategies for ischemic spinal cord injury. |
2022-04-23 |
2023-08-13 |
Not clear |
| Josef Stolberg-Stolberg, Annika Boettcher, Meike Sambale, Sina Stuecker, Joanna Sherwood, Michael Raschke, Thomas Pap, Jessica Bertran. Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis. Cell death & disease. vol 13. issue 3. 2022-03-12. PMID:35277480. |
immunohistochemistry was performed to examine tlr3 expression and apoptosis in human and murine oa cartilage. |
2022-03-12 |
2023-08-13 |
human |
| Manuel Nico Dold, Xiulin Ng, Claudia Alber, Ian Edward Gentle, Georg Häcker, Arnim Webe. The deubiquitinase Usp27x as a novel regulator of cFLIP Apoptosis : an international journal on programmed cell death. 2022-01-19. PMID:35044632. |
here, we report that enhanced expression of usp27x in human melanoma cells leads to the loss of cellular flice-like inhibitory protein (cflip) and sensitizes to tumor necrosis factor receptor 1 (tnf-r1) or toll-like receptor 3 (tlr3)-induced extrinsic apoptosis through enabling enhanced processing of caspase-8. |
2022-01-19 |
2023-08-13 |
human |
| Gamze Guney Eskiler, Asuman Deveci Özka. The relationship between the efficacy of talazoparib and the functional toll-like receptors 3 and 9 in triple negative breast cancer. Molecular immunology. vol 141. 2021-12-15. PMID:34906906. |
the stimulation of tlr3 or tlr9 and tal treatment caused significantly more apoptosis in tnbc cells through the over-expression of caspase-3 and caspase-8. |
2021-12-15 |
2023-08-13 |
Not clear |
| Marie-Anaïs Locquet, Gabriel Ichim, Joseph Bisaccia, Aurelie Dutour, Serge Lebecque, Marie Castets, Kathrin Webe. Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma. Scientific reports. vol 11. issue 1. 2021-10-28. PMID:34011952. |
caspase-8 deficiency induces a switch from tlr3 induced apoptosis to lysosomal cell death in neuroblastoma. |
2021-10-28 |
2023-08-13 |
Not clear |
| Marie-Anaïs Locquet, Gabriel Ichim, Joseph Bisaccia, Aurelie Dutour, Serge Lebecque, Marie Castets, Kathrin Webe. Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma. Scientific reports. vol 11. issue 1. 2021-10-28. PMID:34011952. |
in cancer cells only, tlr3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with caspase-8 as apical protease. |
2021-10-28 |
2023-08-13 |
Not clear |
| Marie-Anaïs Locquet, Gabriel Ichim, Joseph Bisaccia, Aurelie Dutour, Serge Lebecque, Marie Castets, Kathrin Webe. Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma. Scientific reports. vol 11. issue 1. 2021-10-28. PMID:34011952. |
here, we demonstrate that in the absence of caspase-8, activation of tlr3 can trigger a form of programmed cell death, which is distinct from classical apoptosis. |
2021-10-28 |
2023-08-13 |
Not clear |
| Jiangqi Zhao, Xuyan Huang, Patrick Mcleod, Jifu Jiang, Winnie Liu, Aaron Haig, Anthony M Jevnikar, Zhenyu Jiang, Zhu-Xu Zhan. Toll-like receptor 3 is an endogenous sensor of cell death and a potential target for induction of long-term cardiac transplant survival. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 21. issue 10. 2021-10-18. PMID:33784431. |
we demonstrated that tlr3 interacting with dsrna or self-rna triggered apoptosis and necroptosis in ecs. |
2021-10-18 |
2023-08-13 |
mouse |