| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francis Atim Akanyibah, Yi Zhu, Aijun Wan, Dickson Kofi Wiredu Ocansey, Yuxuan Xia, An-Ning Fang, Fei Ma. Effects of DNA methylation and its application in inflammatory bowel disease (Review). International journal of molecular medicine. vol 53. issue 6. 2024-05-02. PMID:38695222. |
dnam is one of the most common areas that has drawn increasing attention recently, with studies revealing that the interleukin (il)‑23/il‑12, wingless‑related integration site, il‑6‑associated signal transducer and activator of transcription 3, suppressor of cytokine signaling 3 and apoptosis signaling pathways are involved in dnam and in the pathogenesis of ibd. |
2024-05-02 |
2024-05-04 |
Not clear |
| Juan Liu, Ye Huang, Zhong Li. [Curcumin Combined with Thalidomide Inhibits Proliferation of KG-1 Cells and Its Related Mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 32. issue 2. 2024-04-25. PMID:38660846. |
to investigate the effects of curcumin combined with thalidomide on the proliferation and apoptosis of acute myeloid leukemia kg-1 cells, and its correlation with b-cell lymphoma-xl (bcl-xl), signal transducer and activator of transcription 3 (stat3). |
2024-04-25 |
2024-04-28 |
Not clear |
| Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Don. Enhanced STAT3/PIK3R1/mTOR Signaling Triggers Tubular Cell Inflammation and Apoptosis in Septic-Induced Acute Kidney Injury: Implications for Therapeutic Intervention. Clinical science (London, England : 1979). 2024-02-27. PMID:38411015. |
in these models, renal inflammation and tubular cell apoptosis were accompanied by the aberrant activation of the mechanistic target of rapamycin (mtor) and the signal transducer and activator of transcription 3 (stat3) signaling pathways. |
2024-02-27 |
2024-03-02 |
mouse |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Sung Eun Kim, Dong-Yun Lee, DooSeok Cho. Dienogest attenuates STAT3 activation in ovarian endometriotic cysts. European journal of obstetrics, gynecology, and reproductive biology. vol 294. 2024-02-01. PMID:38301500. |
recent studies have suggested that endometriosis could be the result of excessive activation of signal transducer and activator of transcription 3 (stat3), which is associated with the regulation of essential cellular mechanisms such as proliferation, invasion, and apoptosis. |
2024-02-01 |
2024-02-04 |
Not clear |
| Songxian Zhu, Jingjing Guo, Li Yu, Jun Liu, Jixiang Chen, Jinxin Xin, Yuqiang Zhang, Jie Luo, Chao Dua. Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells. Scientific reports. vol 13. issue 1. 2023-12-09. PMID:38071213. |
furthermore, cell viability, dna damage, apoptosis rate, and signal transducer and activator of transcription 3 (stat3) protein were measured using cytotoxic assay, comet assay, flow cytometry, and western blotting analysis, respectively. |
2023-12-09 |
2023-12-17 |
human |
| J Arévalo, I Campoy, M Durán, S Nemours, A Areny, M Vall-Palomar, C Martínez, G Cantero-Recasens, A Mesegue. STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness. Scientific reports. vol 13. issue 1. 2023-11-09. PMID:37945711. |
the signal transducer and activator of transcription 3 (stat3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (y705) or serine 727 (s727) residues that regulates essential processes such as cell differentiation, apoptosis inhibition, or cell survival. |
2023-11-09 |
2023-11-20 |
human |
| Shuangxia Zhang, Zhangxiu Liao, Shubo Li, Ying Lu. Non-metabolic enzyme function of PKM2 in hepatocellular carcinoma: A review. Medicine. vol 102. issue 42. 2023-10-20. PMID:37861491. |
studies have shown that pkm2 is highly expressed in hcc and can be translocated to the nucleus, where it interacts with various transcription factors and proteins such as hypoxia-inducible factor-1α, sterol regulatory element-binding protein 1a, signal transducer and activator of transcription 3, nuclear factor erythroid 2-like 2 and histone h3, exerting non-metabolic enzyme functions to regulate the cell cycle, proliferation, apoptosis, immune escape, migration, and invasion, as well as hcc angiogenesis and tumor microenvironment. |
2023-10-20 |
2023-11-08 |
Not clear |
| Xinzhe Fang, Weiyi Huang, Qiang Sun, Yang Zhao, Rui Sun, Fang Liu, Danmei Huang, Yanmei Zhang, Fenfei Gao, Bin Wan. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life sciences. 2023-09-22. PMID:37739161. |
to discover the possible mechanism by which melatonin prevents dn, we investigated the potential effects of melatonin on signal transducer and activator of transcription 3 (stat3) on the progression of cellular senescence and apoptosis. |
2023-09-22 |
2023-10-07 |
Not clear |
| Ning Liu, Lei Huang, Hu Xu, Xinyu He, Xueqing He, Jun Cao, Wenjun Xu, Yaoxing Wang, Hongquan Wei, Sheng Wang, Hong Zheng, Shan Gao, Youzhi Xu, Wenjie L. Phosphatidylserine decarboxylase downregulation in uric acid‑induced hepatic mitochondrial dysfunction and apoptosis. MedComm. vol 4. issue 4. 2023-07-28. PMID:37502610. |
high ua levels also inhibited signal transducer and activator of transcription 3 （stat3） phosphorylation as well as mitochondrial respiration, while inducing apoptosis both in vivo and in vitro. |
2023-07-28 |
2023-08-14 |
mouse |
| Zhongbo Xu, Manyang Shen, Lin L. Exploring the active components and mechanism of modified bazhen decoction in treatment of chronic cerebral circulation insufficiency based on network pharmacology and molecular docking. Medicine. vol 102. issue 29. 2023-07-21. PMID:37478218. |
the central core targets were il6, mapk14, signal transducer and activator of transcription 3, rela, vegfa, ccnd1, casp3, ar, fos, jun, egfr, mapk1, akt1, myc, and esr1; gene ontology functional enrichment analysis yielded 911 gene ontology items (p < .01), while kyoto encyclopedia of genes and genomes pathway enrichment yielded 138 signal pathways (p < .01), primarily including oxidative reactions, vascular regulation, apoptosis, and pi3k-akt signaling pathway. |
2023-07-21 |
2023-08-14 |
Not clear |
| P Kurowska, K Gazdzik, A Jasinska, E Mlyczynska, D Wachowska, A Ra. Resistin as a new player in the regulation of porcine corpus luteum luteolysis: in vitro effect on proliferation/viability, apoptosis and autophagy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 1. 2023-05-28. PMID:37245230. |
thus, the aim of the present study was to examine the in vitro effect of resistin on the proliferation/viability, apoptosis and autophagy of porcine luteal cells as well as the involvement of mitogen-activated kinase (map3/1), protein kinase b (akt) and signal transducer and activator of transcription 3 (stat3) in these processes. |
2023-05-28 |
2023-08-14 |
Not clear |
| Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Ki. Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238935. |
the expression levels of proteins regulating cell apoptosis, cell cycle, and the signal transducer and activator of transcription 3 (stat3) signaling pathways were examined using western blotting analysis. |
2023-05-27 |
2023-08-14 |
human |
| Jayoung Song, Ahreum Kim, Intaek Hong, Sangji Kim, Woong Sub Byun, Hyun Soo Lee, Hyung Sik Kim, Sang Kook Lee, Yongseok Kwo. Synthesis and biological evaluation of atropisomeric tetrahydroisoquinolines overcoming docetaxel resistance in triple-negative human breast cancer cells. Bioorganic chemistry. vol 137. 2023-05-25. PMID:37229969. |
further biological studies suggested that the (r)-enantiomer overcomes docetaxel resistance via the downregulation of signal transducer and activator of transcription 3 activation and consequently induces cellular apoptosis in docetaxel-resistant triple-negative breast cancer cell lines. |
2023-05-25 |
2023-08-14 |
human |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
in order to experimentally evaluate the apoptosis of pro-b type lymphocytes, induced as a result of the known activation of orphan nuclear receptor 4a1 (nr4a1), through cytosporone b (csn-b, 10 μm), in the presence or absence of exosomes derived from gingival fibroblasts, we administered as a treatment: 1 μm r-7050 [functional inhibitor of tumor necrosis factor alpha (tnfα)], 1 μm z-ietd-fmk (functional inhibitor of caspase 8), 1 μm gsk690693 (functional inhibitor of akt 1∕2∕3 pathways) and, last but not least, 1 μm scutellarin [functional inhibitor of receptor activator of nuclear factor-kappa b ligand (rankl)] and therefore of the signal transducer and activator of transcription 3 (stat3) pathway. |
2023-05-02 |
2023-08-14 |
Not clear |
| Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Zishun Zhan, Yisu Li, Shiqi Pan, Jishi Liu, Juan Tan. Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. Biochemical pharmacology. 2023-04-01. PMID:37003346. |
here, we found that lyn protected against renal tubular injury in cecal ligation and puncture (clp) induced aki mouse model by inhibition of signal transducer and activator of transcription 3 (stat3) phosphorylation and cell apoptosis. |
2023-04-01 |
2023-08-14 |
mouse |
| Wenliang Gong, Xinyu Li, Yuliang Feng, Ming Ji, Dianjun Zhang, Binjie Chen, Siman Wang, Xiafang Wu, Lulu Cui, Baoman Li, Maosheng Xi. Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice. Journal of psychiatric research. vol 161. 2023-03-18. PMID:36933445. |
additionally, leptin attenuated neuronal apoptosis by increasing the phosphorylation of signal transducer and activator of transcription 3 (stat3), which further elevated the expression of ucp2 and inhibited the mitochondrial production of ros induced by ptsd, thus reducing neuronal apoptosis and ameliorating ptsd-related behaviors. |
2023-03-18 |
2023-08-14 |
mouse |
| Young Song, Joseph Leem, Mehul Dhanani, M Dan McKirnan, Yasuhiro Ichikawa, Julie Braza, Elizabeth O Harrington, H Kirk Hammond, David M Roth, Hemal H Pate. Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models. PloS one. vol 18. issue 2. 2023-02-13. PMID:36780477. |
apoptosis and necrosis were increased in cells incubated with dauno-hf plasma for 24 h. down-regulation of voltage-dependent anion-selective channel (vdac)-1, translocase of outer membrane 20 (tom20), and mitochondrial fission factor (mff) in cells exposed to dauno-hf plasma and mitochondrial signal transducer and activator of transcription 3 (stat3) and mff in cells exposed to mi-hf plasma were observed. |
2023-02-13 |
2023-08-14 |
mouse |
| Minxiao Chen, Chenchen Qian, Bo Jin, Chenghong Hu, Lingxi Zhang, Minshan Wang, Bin Zhou, Wei Zuo, Lijiang Huang, Yi Wan. Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma. Cancer biology & therapy. vol 24. issue 1. 2023-01-16. PMID:36647192. |
treatment of wz26 increased reactive oxygen species (ros) generation, subsequently decreased mitochondrial membrane potential and inhibited the phosphorylation of signal transducer and activator of transcription 3 (stat3), thereby inducing g2/m cell cycle arrest and cell apoptosis. |
2023-01-16 |
2023-08-14 |
mouse |
| Song Gao, Xiao-Qing Zhou, Qi Wu, Xue-Dong Chen, Peng Li, Ye-Min Qi. Effects of Holliday Junction-Recognition Protein-Mediated C-Jun N-Terminal Kinase/ Signal Transducer and Activator of Transcription 3 Signaling Pathway on Cell Proliferation, Cell Cycle and Cell Apoptosis in Bladder Urothelial Carcinoma. The Tohoku journal of experimental medicine. 2022-12-21. PMID:36543245. |
effects of holliday junction-recognition protein-mediated c-jun n-terminal kinase/ signal transducer and activator of transcription 3 signaling pathway on cell proliferation, cell cycle and cell apoptosis in bladder urothelial carcinoma. |
2022-12-21 |
2023-08-14 |
Not clear |
| Antonella Di Sotto, Marco Gullì, Marco Minacori, Romina Mancinelli, Stefania Garzoli, Ester Percaccio, Alessio Incocciati, Donatella Romaniello, Gabriela Mazzanti, Margherita Eufemi, Silvia Di Giacom. β-Caryophyllene Counteracts Chemoresistance Induced by Cigarette Smoke in Triple-Negative Breast Cancer MDA-MB-468 Cells. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140359. |
β-caryophyllene was found to be able to increase the csc-induced death of mda-mb-468 cells, likely triggering oxidative stress, cell cycle arrest and apoptosis; moreover, it hindered cell recovery, autophagy activation and cell migration; at last, a marked inhibition of the signal transducer and activator of transcription 3 (stat3) activation was highlighted: this could represent a key mechanism of the chemoprevention by β-caryophyllene. |
2022-09-23 |
2023-08-14 |
human |