| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Xiang Liao, Jin-Min Zeng, Jia-Jie Zhou, Guang-Hua Yang, Kun Ding, Xian-Jue Zhan. [Retracted] Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells. Molecular medicine reports. vol 30. issue 2. 2024-06-09. PMID:38818834. |
[retracted] silencing of rtkn2 by sirna suppresses proliferation, and induces g1 arrest and apoptosis in human bladder cancer cells. |
2024-06-09 |
2024-06-11 |
human |
| Xiaomei Zhang, Jian Wang, Haiying L. RTKN2 knockdown alleviates the malignancy of breast cancer cells by regulating the Wnt/β-catenin pathway. Scientific reports. vol 13. issue 1. 2023-12-28. PMID:38155217. |
fcm and western blot assay were performed to measure the function of rtkn2 silencing on bc cell apoptosis. |
2023-12-28 |
2023-12-31 |
Not clear |
| Xiaomei Zhang, Jian Wang, Haiying L. RTKN2 knockdown alleviates the malignancy of breast cancer cells by regulating the Wnt/β-catenin pathway. Scientific reports. vol 13. issue 1. 2023-12-28. PMID:38155217. |
down-regulation of rtkn2 restrained bc cell progression by suppressing cell proliferation, migratory ability, invasive ability, and inducing apoptosis. |
2023-12-28 |
2023-12-31 |
Not clear |
| H-G Zhao, J-J Yin, X Chen, J Wu, W Wang, L-W Tan. RTKN2 Enhances Radioresistance in Gastric Cancer through Regulating the Wnt/β-Catenin Signalling Pathway. Folia biologica. vol 68. issue 1. 2022-10-06. PMID:36201856. |
a series of functional assays revealed that overexpression of rtkn2 induced gc cell proliferation, promoted gc cell migration and invasion, while inhibiting gc cell apoptosis. |
2022-10-06 |
2023-08-14 |
Not clear |
| H-G Zhao, J-J Yin, X Chen, J Wu, W Wang, L-W Tan. RTKN2 Enhances Radioresistance in Gastric Cancer through Regulating the Wnt/β-Catenin Signalling Pathway. Folia biologica. vol 68. issue 1. 2022-10-06. PMID:36201856. |
gc cells were exposed to irradiation, and data from cell survival and apoptotic assays showed that knock-down of rtkn2 enhanced radiosensitivity of gc through up-regulation of apoptosis and down-regulation of proliferation in irradiation-exposed gc cells. |
2022-10-06 |
2023-08-14 |
Not clear |
| H-G Zhao, J-J Yin, X Chen, J Wu, W Wang, L-W Tan. RTKN2 Enhances Radioresistance in Gastric Cancer through Regulating the Wnt/β-Catenin Signalling Pathway. Folia biologica. vol 68. issue 1. 2022-10-06. PMID:36201856. |
however, silence of rtkn2 promoted gc cell apoptosis, while repressing gc cell proliferation, invasion and migration. |
2022-10-06 |
2023-08-14 |
Not clear |
| Xueqin Pang, Rui Li, Dongtao Shi, Xudong Pan, Chen Ma, Guangbo Zhang, Chuanyong Mu, Weichang Che. Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells. Oncology letters. vol 14. issue 6. 2020-10-01. PMID:29250187. |
furthermore, the silencing of rtkn2 in the cells induced apoptosis by reducing the expression level of bax and increasing the expression level of bcl2. |
2020-10-01 |
2023-08-13 |
human |
| Wei Wei, Huabing Chen, Sibin Li. Knockdown of Rhotekin 2 expression suppresses proliferation and invasion and induces apoptosis in hepatocellular carcinoma cells. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27081789. |
additionally, it was identified that downregulation of rtkn2 in hcc cells notably induced cell apoptosis, while significantly repressing cell invasion. |
2017-04-06 |
2023-08-13 |
Not clear |
| Yi-Xiang Liao, Jin-Min Zeng, Jia-Jie Zhou, Guang-Hua Yang, Kun Ding, Xian-Jue Zhan. Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27082503. |
therefore, the present study investigated the expression levels of rhotekin 2 (rtkn2), a rho effector protein, in human bladder cancer tissues and cell lines, and examined the effect of rtkn2 on the proliferation, cell cycle, apoptosis and invasion of human bladder cancer cell lines. |
2017-04-06 |
2023-08-13 |
human |
| Yi-Xiang Liao, Jin-Min Zeng, Jia-Jie Zhou, Guang-Hua Yang, Kun Ding, Xian-Jue Zhan. Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27082503. |
silencing of rtkn2 by sirna suppresses proliferation, and induces g1 arrest and apoptosis in human bladder cancer cells. |
2017-04-06 |
2023-08-13 |
human |
| Yi-Xiang Liao, Jin-Min Zeng, Jia-Jie Zhou, Guang-Hua Yang, Kun Ding, Xian-Jue Zhan. Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27082503. |
furthermore, rtkn2 knockdown in the cells led to cell apoptosis and the suppression of invasion. |
2017-04-06 |
2023-08-13 |
human |
| Wei Li, Ya-Fen Wu, Rong-Hua Xu, Hui Lu, Cui Hu, Hua Qia. miR-1246 releases RTKN2-dependent resistance to UVB-induced apoptosis in HaCaT cells. Molecular and cellular biochemistry. vol 394. issue 1-2. 2015-10-26. PMID:24880483. |
these findings suggested that mir-1246 promotes uvb-induced apoptosis by downregulating rtkn2 expression and that uvb-upregulated mir-1246 released rtkn2-dependent resistance to uvb-induced apoptosis by targeting rtkn2 post-transcriptionally in keratinocyte cells. |
2015-10-26 |
2023-08-13 |
Not clear |
| Wei Li, Ya-Fen Wu, Rong-Hua Xu, Hui Lu, Cui Hu, Hua Qia. miR-1246 releases RTKN2-dependent resistance to UVB-induced apoptosis in HaCaT cells. Molecular and cellular biochemistry. vol 394. issue 1-2. 2015-10-26. PMID:24880483. |
moreover, rtkn2 was observed to be resistant to uvb-induced apoptosis and rtkn2 antagonized the pro-apoptotic effects of mir-1246 during uvb-induced apoptosis in hacat cells. |
2015-10-26 |
2023-08-13 |
Not clear |
| Fiona M Collier, Andrea Loving, Adele J Baker, Janet McLeod, Ken Walder, Mark A Kirklan. RTKN2 Induces NF-KappaB Dependent Resistance to Intrinsic Apoptosis in HEK Cells and Regulates BCL-2 Genes in Human CD4(+) Lymphocytes. Journal of cell death. vol 2. 2015-06-30. PMID:26124677. |
the gene for rhotekin 2 (rtkn2) was originally identified in a promyelocytic cell line resistant to oxysterol-induced apoptosis. |
2015-06-30 |
2023-08-13 |
human |
| Fiona M Collier, Andrea Loving, Adele J Baker, Janet McLeod, Ken Walder, Mark A Kirklan. RTKN2 Induces NF-KappaB Dependent Resistance to Intrinsic Apoptosis in HEK Cells and Regulates BCL-2 Genes in Human CD4(+) Lymphocytes. Journal of cell death. vol 2. 2015-06-30. PMID:26124677. |
rtkn2 induces nf-kappab dependent resistance to intrinsic apoptosis in hek cells and regulates bcl-2 genes in human cd4(+) lymphocytes. |
2015-06-30 |
2023-08-13 |
human |
| Fiona M Collier, Andrea Loving, Adele J Baker, Janet McLeod, Ken Walder, Mark A Kirklan. RTKN2 Induces NF-KappaB Dependent Resistance to Intrinsic Apoptosis in HEK Cells and Regulates BCL-2 Genes in Human CD4(+) Lymphocytes. Journal of cell death. vol 2. 2015-06-30. PMID:26124677. |
in both cell models rtkn2 played a role in the process of intrinsic apoptosis and this was dependent on either nf-kappab signaling or expression of downstream bcl-2 genes. |
2015-06-30 |
2023-08-13 |
human |