| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Shen, Wenwen Han, Xiangrong Tan, Kyle J Gu, Danial F Naseem, Guibin Zheng, Guojun Li, Jianlin Lou, Chao Che. Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA-mediated modulation of the RIPK1-FADD-Caspase 8 complex. Molecular carcinogenesis. 2024-05-02. PMID:38695620. |
moreover, tan iia reduced the expression of ripk1 and fadd in hnscc chemoresistant cell lines, which could increase the chemosensitivity of cisplatin and promote apoptosis. |
2024-05-02 |
2024-05-04 |
Not clear |
| Hong Tri Tran, Tobias Kratina, Auriane Coutansais, Dominika Michalek, Benjamin M Hogan, Kate E Lawlor, James E Vince, John Silke, Najoua Lalaou. RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation. Cell death and differentiation. 2024-03-22. PMID:38514849. |
however, recent studies have shown that mice expressing uncleavable ripk1 die during embryogenesis due to excessive apoptosis, while uncleavable cyld mice are viable. |
2024-03-22 |
2024-03-24 |
mouse |
| Yue Xu, Feng Lin, Guolei Liao, Jiaxing Sun, Wenli Chen, Lei Zhan. Ripks and Neuroinflammation. Molecular neurobiology. 2024-02-13. PMID:38349514. |
ripk1 and ripk3 are responsible for the control of cell death, including apoptosis, necrosis, and inflammation. |
2024-02-13 |
2024-02-15 |
human |
| Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhan. Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage. Experimental neurology. 2024-01-30. PMID:38290652. |
ripk1, a receptor-interacting serine/threonine protein kinase, plays a crucial role in maintaining cellular and tissue homeostasis by integrating inflammatory responses and cell death signaling pathways including apoptosis and necroptosis, which have been implicated in diverse physiological and pathological processes. |
2024-01-30 |
2024-02-02 |
mouse |
| Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhan. Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage. Experimental neurology. 2024-01-30. PMID:38290652. |
we observed the correlation between ripk1 kinase activity and microglia-mediated inflammation as well as neuronal apoptosis. |
2024-01-30 |
2024-02-02 |
mouse |
| Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhan. Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage. Experimental neurology. 2024-01-30. PMID:38290652. |
we then investigated whether inhibition of ripk1 could alleviate neuroinflammation and neuronal apoptosis following sah, thereby reducing brain edema and ameliorating neurobehavioral deficits. |
2024-01-30 |
2024-02-02 |
mouse |
| Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhan. Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage. Experimental neurology. 2024-01-30. PMID:38290652. |
consequently, inhibition of ripk1 resulted in a downregulation of inflammatory cytokines and chemokines and attenuation of neuronal apoptosis after sah in vitro. |
2024-01-30 |
2024-02-02 |
mouse |
| Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhan. Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage. Experimental neurology. 2024-01-30. PMID:38290652. |
our findings suggest that inhibiting ripk1 kinase represents a promising therapeutic strategy for mitigating brain injury after sah by attenuating ripk1-driven neuroinflammation and neuronal apoptosis. |
2024-01-30 |
2024-02-02 |
mouse |
| Yinliang Bai, Yujun Qiao, Mingming Li, Wenzhen Yang, Haile Chen, Yanqing Wu, Honghua Zhan. RIPK1 inhibitors: A key to unlocking the potential of necroptosis in drug development. European journal of medicinal chemistry. vol 265. 2024-01-10. PMID:38199165. |
receptor-interacting protein kinase 1 (ripk1), an essential regulator in the cell death receptor signalling pathway, has been shown to be involved in the regulation of important events, including necrosis, inflammation, and apoptosis. |
2024-01-10 |
2024-01-13 |
Not clear |
| Mariano Prado-Acosta, Seihwan Jeong, Alberto Utrero-Rico, Tatiana Goncharov, Joshua D Webster, Ernst Holler, George Morales, Sergio Dellepiane, John E Levine, Michael E Rothenberg, Domagoj Vucic, James L M Ferrar. Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects. Science translational medicine. vol 15. issue 727. 2023-12-20. PMID:38117900. |
inflammatory cytokines mediate damage to key gvhd targets such as intestinal stem cells (iscs) and also activate receptor interacting protein kinase 1 (rip1; ripk1), a critical regulator of apoptosis and necroptosis. |
2023-12-20 |
2023-12-23 |
mouse |
| Xiaodan Wang, Jiatong Sun, Tong Xu, Yutian Lei, Meichen Gao, Hongjin Li. Resveratrol alleviates imidacloprid-induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway. Environmental toxicology. 2023-12-14. PMID:38095043. |
additionally, imi resulted in upregulation of mitochondrial apoptosis (caspase 3, caspase 9, bax, and cyt-c) and necroptosis (caspase 8, ripk1, ripk3, and mlkl) related factors expression, downregulation of bcl-2 expression, induction of upregulation of cytokine il-6 and tnf-α expression, and downregulation of ifn-γ expression. |
2023-12-14 |
2023-12-17 |
cat |
| Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Elizabeth A Dudley, Elizabeth A Leadbette. RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development. Frontiers in immunology. vol 14. 2023-11-15. PMID:37965338. |
receptor interacting protein kinase 1 (ripk1) and caspase-8 (casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing t cells which have autoreactive or improperly arranged t cell receptors. |
2023-11-15 |
2023-11-20 |
Not clear |
| Fabian Schorn, J Paul Werthenbach, Mattes Hoffmann, Mila Daoud, Johanna Stachelscheid, Lars M Schiffmann, Ximena Hildebrandt, Su Ir Lyu, Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashka. cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. The EMBO journal. 2023-10-04. PMID:37789765. |
cellular inhibitor of apoptosis proteins (ciaps) are ring-containing e3 ubiquitin ligases that ubiquitylate receptor-interacting protein kinase 1 (ripk1) to regulate tnf signalling. |
2023-10-04 |
2023-10-07 |
mouse |
| Pengcheng Zhang, Xinglong Zhang, Yongfu Zhu, Yiyi Cui, Jing Xu, Weiping Zhan. Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis. Oncology research. vol 31. issue 6. 2023-09-25. PMID:37744268. |
silencing of plk1 using mirna transfection in la cells reduced cell proliferation and increased apoptosis, as well as upregulating the expression of necroptosis-related proteins, such as ripk1, ripk3, and mlkl. |
2023-09-25 |
2023-10-07 |
mouse |
| Weimin Sun, Guowei Wu, Xinyu Tian, Chunting Qi, Jingli Liu, Yilun Tong, Mengmeng Zhang, Jiayang Gao, Ze Cao, Yuchao Zhang, Zhijun Liu, Xiaoxu Tian, Ping Wu, Chao Peng, Jingwen Li, Li Tan, Bing Shan, Jianping Liu, Ying Li, Junying Yua. Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 39. 2023-09-21. PMID:37733743. |
treatment with r406 sensitized cells to tnf-mediated necroptosis and ripk1-dependent apoptosis by promoting sustained ripk1 activation. |
2023-09-21 |
2023-10-07 |
mouse |
| Xin Cao, Sisi Peng, Ying Yan, Jun Li, Jianping Zhou, Hongwei Dai, Jie X. Alleviation of temporomandibular joint osteoarthritis by targeting RIPK1-mediated inflammatory signalling. Journal of cellular and molecular medicine. 2023-08-29. PMID:37643315. |
herein, inhibition of ripk1 suppressed the elevated levels of inflammatory factors, nuclear factor kappa b (nf-κb), along with markers of apoptosis and necroptosis after tumour necrosis factor (tnf)-α/cycloheximide (chx) treatment in synoviocytes. |
2023-08-29 |
2023-09-07 |
Not clear |
| Xin Cao, Sisi Peng, Ying Yan, Jun Li, Jianping Zhou, Hongwei Dai, Jie X. Alleviation of temporomandibular joint osteoarthritis by targeting RIPK1-mediated inflammatory signalling. Journal of cellular and molecular medicine. 2023-08-29. PMID:37643315. |
ripk1 regulates nf-κb activation via cellular inhibitor of apoptosis proteins (ciap), apoptosis via caspase-8, and necroptosis via ripk3/mixed lineage kinase domain-like (mlkl) in synoviocytes, which in turn facilitates tmjoa inflammation progression. |
2023-08-29 |
2023-09-07 |
Not clear |
| Chaonan Yang, Yongjiao Wang, Xiaohui Wu, Min Gong, Ying L. Reduced levels of A20 protein prompted RIPK1-dependent apoptosis and blood-brain barrier breakdown during cerebral ischemia reperfusion injury. PloS one. vol 18. issue 8. 2023-08-14. PMID:37578944. |
it was found that the ciri resulted in ripk1 activation and subsequent ripk1-dependent apoptosis (rda). |
2023-08-14 |
2023-09-07 |
Not clear |
| Chanchal Chauhan, Andreas Kraemer, Stefan Knapp, Mark Windheim, Alexey Kotlyarov, Manoj B Menon, Matthias Gaeste. 5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling. Cell death discovery. vol 9. issue 1. 2023-07-26. PMID:37495567. |
while ripk1 inhibitors can rescue mk2-deficient cells from necroptosis, inhibiting ripk3 seems to switch the process to apoptosis. |
2023-07-26 |
2023-08-14 |
Not clear |
| Jianjia Huang, Xiaoyue Pang, Xinting Zhang, Wenyue Qiu, Xuluan Zhang, Rongmei Wang, Wenting Xie, Yuman Bai, Shuilian Zhou, Jianzhao Liao, Zhaojun Xiong, Zhaoxin Tang, Rongsheng S. N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF-α-mediated apoptotic pathways and affecting linear ubiquitination. Translational research : the journal of laboratory and clinical medicine. 2023-07-08. PMID:37422055. |
this study confirmed that nac combined with insulin can promote the linear ubiquitination of ripk1, nemo and c-flip and regulate the apoptosis pathway mediated by tnf-α to attenuate the myocardial injury caused by type 1 dm. |
2023-07-08 |
2023-08-14 |
Not clear |