| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
in cardiomyocytes, nicotine significantly increased nadph oxidase 4 (nox4), which coincided with increased reactive oxygen species (ros) and increased cardiomyocyte apoptosis which were dependent on phlpp1 expression. |
2024-06-08 |
2024-06-11 |
Not clear |
| Xiaohui Zhang, Ye Lu, Na He, Feng Wan. Downregulation of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation. Experimental cell research. vol 397. issue 2. 2021-04-27. PMID:33164862. |
additionally, upregulation of phlpp1 lowered cell viability and increased cell apoptosis and ros production in hg-exposed rgcs. |
2021-04-27 |
2023-08-13 |
rat |
| Xiaohui Zhang, Ye Lu, Na He, Feng Wan. Downregulation of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation. Experimental cell research. vol 397. issue 2. 2021-04-27. PMID:33164862. |
downregulation of phlpp1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of nrf2 activation. |
2021-04-27 |
2023-08-13 |
rat |
| Xiaohui Zhang, Ye Lu, Na He, Feng Wan. Downregulation of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation. Experimental cell research. vol 397. issue 2. 2021-04-27. PMID:33164862. |
in conclusion, our findings demonstrate that downregulation of phlpp1 activates nrf2/are signaling to protect rgcs from hg-induced apoptosis and oxidative stress. |
2021-04-27 |
2023-08-13 |
rat |
| Xiaohui Zhang, Ye Lu, Na He, Feng Wan. Downregulation of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation. Experimental cell research. vol 397. issue 2. 2021-04-27. PMID:33164862. |
our functional assay elucidated that knockdown of phlpp1 improved cell viability and decreased cell apoptosis and reactive oxygen species (ros) production in hg-exposed rgcs. |
2021-04-27 |
2023-08-13 |
rat |
| Genshen Cai, Jing Zhang, Rupeng Wan. [Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 1. 2021-02-01. PMID:33441223. |
conclusion phlpp1 is highly expressed in renal tissue of patients with dn, and the down-regulated expression of phlpp1 in podocytes can promote the autophagy of podocytes and reduced the apoptosis of podocytes by activating pi3k/akt/mtor pathway. |
2021-02-01 |
2023-08-13 |
human |
| Genshen Cai, Jing Zhang, Rupeng Wan. [Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 1. 2021-02-01. PMID:33441223. |
[down-regulation of phlpp1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating pi3k/akt/mtor pathway]. |
2021-02-01 |
2023-08-13 |
human |
| Genshen Cai, Jing Zhang, Rupeng Wan. [Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 1. 2021-02-01. PMID:33441223. |
objective to investigate the expression of pleckstrin homology(ph) domain leucine-rich repeats protein phosphatase 1 (phlpp1) in renal tissue of patients with diabetic nephropathy (dn) and its effect on podocyte autophagy and apoptosis, and to explore its related mechanism. |
2021-02-01 |
2023-08-13 |
human |
| Tehreem Anwar, Mirza Jawad Ul Hasnain, Amina Sarwar, Hajra Kanwal, Bakhtawar Afzal, Masroor Ellahi Babar, Muhammad Tariq Parve. Insilico modeling and analysis of small molecules binding to the PHLPP1 protein by molecular dynamics simulation. Pakistan journal of pharmaceutical sciences. vol 33. issue 1(Supplementary). 2020-12-04. PMID:32122860. |
the phlpp (pleckstrin homology domain leucine-rich repeat protein phosphatases) is a newly discovered group of genes which includes phlpp1 and phlpp2 and plays an integral part in several cellular processes like apoptosis, cell signaling cell survival, and cell proliferation etc. |
2020-12-04 |
2023-08-13 |
Not clear |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
in human ivds, phlpp1 expression was positively correlated with idd and the apoptosis marker cleaved caspase-3, suggesting a key role of phlpp1 in the progression of idd. |
2020-08-20 |
2023-08-13 |
mouse |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
in mice, 3 days after ivd needle puncture injury, phlpp1 knockout (ko) promoted akt phosphorylation and cell proliferation, with less apoptosis. |
2020-08-20 |
2023-08-13 |
mouse |
| Minggang Peng, Jingjing Wang, Zhongxian Tian, Dongyun Zhang, Honglei Jin, Claire Liu, Jiawei Xu, Jingxia Li, Xiaohui Hua, Jiheng Xu, Chao Huang, Chuanshu Huan. Autophagy-mediated Autophagy. vol 15. issue 9. 2020-07-06. PMID:30821592. |
autophagy-mediated phlpp1 (ph domain and leucine rich repeat protein phosphatase 1) is a newly identified family of ser/thr phosphatases that catalyzes the dephosphorylation of a conserved regulatory motif of the agc kinases resulting in a tumor suppressive function, while cdkn1b/p27 also acts as a tumor suppressor by regulating cell cycle, senescence, apoptosis, and cell motility. |
2020-07-06 |
2023-08-13 |
Not clear |
| Zhenya Shao, Gang Lv, Pushuai Wen, Yang Cao, Deshui Yu, Yanyan Lu, Gang Li, Zichen Su, Peng Teng, Kang Gao, Yansong Wang, Xifan Me. Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice. Life sciences. vol 209. 2018-10-15. PMID:30114409. |
silencing of phlpp1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice. |
2018-10-15 |
2023-08-13 |
mouse |
| Zhenya Shao, Gang Lv, Pushuai Wen, Yang Cao, Deshui Yu, Yanyan Lu, Gang Li, Zichen Su, Peng Teng, Kang Gao, Yansong Wang, Xifan Me. Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice. Life sciences. vol 209. 2018-10-15. PMID:30114409. |
in this study, we investigated the effects of the progression of sci and potential regulation of apoptosis after the pleckstrin homology (ph) domain and leucine rich repeat protein phosphatase 1 (phlpp1) gene was silenced. |
2018-10-15 |
2023-08-13 |
mouse |
| Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudr. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell reports. vol 16. issue 1. 2017-11-21. PMID:27320912. |
enhanced apoptosis is due to absence of calpain-1-mediated cleavage of ph domain and leucine-rich repeat protein phosphatase 1 (phlpp1), which results in inhibition of the akt pro-survival pathway in developing granule cells. |
2017-11-21 |
2023-08-13 |
mouse |
| Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudr. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell reports. vol 16. issue 1. 2017-11-21. PMID:27320912. |
injection of neonatal mice with the indirect akt activator, bisperoxovanadium, or crossing calpain-1 ko mice with phlpp1 ko mice prevented increased postnatal cerebellar granule cell apoptosis and restored granule cell density and motor coordination in adult mice. |
2017-11-21 |
2023-08-13 |
mouse |
| Narmadha Reddy Gangula, Subbareddy Maddik. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). The Journal of biological chemistry. vol 288. issue 48. 2014-02-21. PMID:24145035. |
similar to phlpp1 function, wdr48 and usp12 negatively regulate akt activation and thus promote cellular apoptosis. |
2014-02-21 |
2023-08-12 |
Not clear |