| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Hua Xu, Xiao-Yan Liu, Jin Su, Dao-Jun Li, Qiao Huang, Ming-Qian Lu, Fang Yi, Jing-Hua Ren, Wei-Hong Che. ShRNA targeting Bmi-1 sensitizes CD44⁺ nasopharyngeal cancer stem-like cells to radiotherapy. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24927072. |
we found that bmi-1 knockdown prolonged g1 and enhanced the radiation-induced g2/m arrest, inhibited dna damage repair, elevated protein p16, p14 and p53 expression, leading to increased apoptosis in the radiated cd44+ cells. |
2015-02-12 |
2023-08-13 |
Not clear |
| Peng Chen, Haibin Wang, Zhijian Duan, June X Zou, Hongwu Chen, Wei He, Junjian Wan. Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. BioMed research international. vol 2014. 2015-02-12. PMID:24967384. |
estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and p53 mediated apoptosis in osteosarcoma cells. |
2015-02-12 |
2023-08-13 |
Not clear |
| Peng Chen, Haibin Wang, Zhijian Duan, June X Zou, Hongwu Chen, Wei He, Junjian Wan. Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. BioMed research international. vol 2014. 2015-02-12. PMID:24967384. |
our further studies demonstrated that err α suppressed ros induction of tumor suppressor p53 and its target genes noxa and xaf1 which are mediators of p53-dependent apoptosis. |
2015-02-12 |
2023-08-13 |
Not clear |
| Peng Chen, Haibin Wang, Zhijian Duan, June X Zou, Hongwu Chen, Wei He, Junjian Wan. Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. BioMed research international. vol 2014. 2015-02-12. PMID:24967384. |
in conclusion, this study demonstrated that err α plays an important role in the development of mtx resistance through blocking mtx-induced ros production and attenuating the activation of p53 mediated apoptosis signaling pathway, and points to err α as a novel target for improving osteosarcoma therapy. |
2015-02-12 |
2023-08-13 |
Not clear |
| Brandon A Vara, Anand Mayasundari, John C Tellis, Michael W Danneman, Vanessa Arredondo, Tyler A Davis, Jaeki Min, Kristin Finch, R Kiplin Guy, Jeffrey N Johnsto. Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition. The Journal of organic chemistry. vol 79. issue 15. 2015-02-12. PMID:25017623. |
the finding by scientists at hoffmann-la roche that cis-imidazolines could disrupt the protein-protein interaction between p53 and mdm2, thereby inducing apoptosis in cancer cells, raised considerable interest in this scaffold over the past decade. |
2015-02-12 |
2023-08-13 |
Not clear |
| Xiang Ling, Chao Xu, Chuandong Fan, Kai Zhong, Fengzhi Li, Xinjiang Wan. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. Cancer research. vol 74. issue 24. 2015-02-10. PMID:25512388. |
however, in the absence of p53 or in the presence of mdmx overexpression, fl118 promotes p53-independent apoptosis. |
2015-02-10 |
2023-08-13 |
human |
| Pavel Starha, Jan Hošek, Ján Vančo, Zdeněk Dvořák, Pavel Suchý, Igor Popa, Gabriela Pražanová, Zdeněk Trávníče. Pharmacological and molecular effects of platinum(II) complexes involving 7-azaindole derivatives. PloS one. vol 9. issue 3. 2015-02-07. PMID:24603594. |
the results of ex vivo assays revealed that the complexes 1-3 were able to modulate the levels of active forms of caspases 3 and 8, and the transcription factor p53, and thus activate the intrinsic (mitochondrial) pathway of apoptosis. |
2015-02-07 |
2023-08-12 |
mouse |
| Adam L Cohen, Howard Colma. Glioma biology and molecular markers. Cancer treatment and research. vol 163. 2015-02-05. PMID:25468223. |
common pathways in glioma biology include growth factor receptor tyrosine kinases and their downstream signaling via the map kinase cascade or pi3k signaling, loss of apoptosis through p53, cell cycle regulation, angiogenesis via vegf signaling, and invasion. |
2015-02-05 |
2023-08-13 |
Not clear |
| Caroline Dayan, Barbara F Hale. Effects of ethylene glycol monomethyl ether and its metabolite, 2-methoxyacetic acid, on organogenesis stage mouse limbs in vitro. Birth defects research. Part B, Developmental and reproductive toxicology. vol 101. issue 3. 2015-02-04. PMID:24798094. |
murine gestation day 12 embryonic forelimbs were exposed to 3, 10, or 30 mm egme or 2-maa in culture for 6 days to examine effects on limb morphology; limbs were cultured for 1 to 24 hr to monitor effects on the acetylation of histones (h3k9 and h4k12), a nonhistone protein, p53 (p53k379), and markers for cell cycle arrest (p21) and apoptosis (cleaved caspase-3). |
2015-02-04 |
2023-08-13 |
mouse |
| Caroline Dayan, Barbara F Hale. Effects of ethylene glycol monomethyl ether and its metabolite, 2-methoxyacetic acid, on organogenesis stage mouse limbs in vitro. Birth defects research. Part B, Developmental and reproductive toxicology. vol 101. issue 3. 2015-02-04. PMID:24798094. |
egme had little effect on limb morphology and no significant effects on the acetylation of histones or p53 or on biomarkers for cell cycle arrest or apoptosis. |
2015-02-04 |
2023-08-13 |
mouse |
| Miguel Mendivil-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pard. Response to rotenone is glucose-sensitive in a model of human acute lymphoblastic leukemia: involvement of oxidative stress mechanism, DJ-1, Parkin, and PINK-1 proteins. Oxidative medicine and cellular longevity. vol 2014. 2015-02-04. PMID:24949116. |
we demonstrated that rot induces apoptosis in jurkat cells cultured in g11 by oxidative stress (os) mechanism involving the generation of anion superoxide radical (o2(∙-), 68%)/hydrogen peroxide (h2o2, 54%), activation of nf-κb (32%), p53 (25%), c-jun (17%) transcription factors, and caspase-3 (28%), apoptosis-inducing factor (aif, 36%) nuclei translocation, c-jun n-terminal kinase (jnk) activation, and loss of mitochondria transmembrane potential (ΔΨm, 62%) leading to nuclei fragmentation (~10% and ~40% stage i-ii fragmented nuclei, resp.). |
2015-02-04 |
2023-08-13 |
human |
| Nancy Carolina Andrés, María Eugenia Fermento, Norberto Ariel Gandini, Alejandro López Romero, Alejandro Ferro, Lucila Gonzalez Donna, Alejandro Carlos Curino, María Marta Facchinett. Heme oxygenase-1 has antitumoral effects in colorectal cancer: involvement of p53. Experimental and molecular pathology. vol 97. issue 3. 2015-02-04. PMID:25236576. |
our investigation of the mechanisms involved in ho-1 action in crc demonstrates that the protein reduces cell viability through induction of cell cycle arrest and apoptosis and, importantly, that a functional p53 tumor suppressor protein is required for these effects. |
2015-02-04 |
2023-08-13 |
human |
| Józefa Węsierska-Gądek, Eva Walzi, Iva Dolečkova, Gerald Schmi. Oncogenes do not Fully Override Cell-intrinsic Traits: Pronounced Impact of the Cellular Programme. Cancer microenvironment : official journal of the International Cancer Microenvironment Society. vol 2. issue Suppl 1. 2015-02-03. PMID:19731086. |
overexpression of p53 tumor suppressor protein in malignant cells induces cell cycle arrest, or alternatively, apoptosis thereby indicating that additional factors may contribute to the p53-mediated outcome. |
2015-02-03 |
2023-08-12 |
rat |
| Xiaonan Lv, Peng Wang, Ru Bai, Yingying Cong, Siqingaowa Suo, Xiaofeng Ren, Chunying Che. Inhibitory effect of silver nanomaterials on transmissible virus-induced host cell infections. Biomaterials. vol 35. issue 13. 2015-02-02. PMID:24524838. |
tgev infection induced the occurring of apoptosis in swine testicle (st) cells, down-regulated the expression of bcl-2, up-regulated the expression of bax, altered mitochondrial membrane potential, activated p38 mapk signal pathway, and increased expression of p53 as evidenced by immunofluorescence assays, real-time pcr, flow cytometry and western blot. |
2015-02-02 |
2023-08-12 |
Not clear |
| C Balachandran, B Sangeetha, V Duraipandiyan, M Karunai Raj, S Ignacimuthu, N A Al-Dhabi, K Balakrishna, K Parthasarathy, N M Arulmozhi, M Valan Aras. A flavonoid isolated from Streptomyces sp. (ERINLG-4) induces apoptosis in human lung cancer A549 cells through p53 and cytochrome c release caspase dependant pathway. Chemico-biological interactions. vol 224. 2015-01-30. PMID:25289772. |
(erinlg-4) induces apoptosis in human lung cancer a549 cells through p53 and cytochrome c release caspase dependant pathway. |
2015-01-30 |
2023-08-13 |
human |
| Guoyou Zhang, Ming Li, Xiaodong Zhu, Yushu Bai, Changwei Yan. Knockdown of Akt sensitizes osteosarcoma cells to apoptosis induced by cisplatin treatment. International journal of molecular sciences. vol 12. issue 5. 2015-01-29. PMID:21686164. |
knockdown of akt2, together with cisplatin treatment, promoted the expression of p53 up-regulated modulator of apoptosis (puma). |
2015-01-29 |
2023-08-12 |
Not clear |
| Md Ahsanur Reza, Md Akil Hossain, Seung-Jin Lee, Sileshi Belew Yohannes, Dereje Damte, Man-hee Rhee, Woo-Sik Jo, Joo-Won Suh, Seung-Chun Par. Dichlormethane extract of the jelly ear mushroom Auricularia auricula-judae (higher Basidiomycetes) inhibits tumor cell growth in vitro. International journal of medicinal mushrooms. vol 16. issue 1. 2015-01-29. PMID:24940903. |
semiquantitative reverse transcription polymerase chain reaction analysis demonstrated that dcmf induced cytotoxicity or tumor cell apoptosis as a result of the downregulation of bcl-2 expression and p53 overexpression. |
2015-01-29 |
2023-08-13 |
Not clear |
| Claudia Fiorini, Marco Cordani, Chiara Padroni, Giovanni Blandino, Silvia Di Agostino, Massimo Donadell. Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine. Biochimica et biophysica acta. vol 1853. issue 1. 2015-01-29. PMID:25311384. |
despite the adverse activation of mutant p53 by gemcitabine, simultaneous treatment of pdac cells with gemcitabine and p53-reactivating molecules (cp-31398 and rita) reduced growth rate and induced apoptosis. |
2015-01-29 |
2023-08-13 |
Not clear |
| Claudia Fiorini, Marco Cordani, Chiara Padroni, Giovanni Blandino, Silvia Di Agostino, Massimo Donadell. Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine. Biochimica et biophysica acta. vol 1853. issue 1. 2015-01-29. PMID:25311384. |
the combination drug treatment induced p53 phosphorylation on ser15, apoptosis and autophagosome formation. |
2015-01-29 |
2023-08-13 |
Not clear |
| Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Ho Jeoung, Young-Keun Choi, Younghoon Go, Keun-Gyu Park, In-Kyu Le. Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms. Redox biology. vol 2. 2015-01-28. PMID:25009787. |
in conclusion, dmf prevented abnormal proliferation in vsmcs by g1 cell cycle arrest via p21 upregulation driven by nrf2 and p53 activity, and had a beneficial effect on tnf-α-induced apoptosis and dysfunction in endothelial cells through nrf2-nqo1 activity suggesting that dmf might be a therapeutic drug for patients with vascular disease. |
2015-01-28 |
2023-08-13 |
rat |