| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuoren Yu, Zengguang Xu, Gabriele Disante, Jennifer Wright, Min Wang, Yuan Li, Qian Zhao, Tao Ren, Xiaoming Ju, Ellen Gutman, Guangxue Wang, Sankar Addya, Tieyan Li, Zhendong Xiang, Chenguang Wang, Xiongfei Yang, Xiaolai Yang, Richard Pestel. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. vol 5. issue 4. 2015-02-21. PMID:24658544. |
these results demonstrated a novel pathway through which mir17/20 regulate p53 and akt controlling breast cancer cell apoptosis. |
2015-02-21 |
2023-08-12 |
mouse |
| Nadia Danilova, Elena Bibikova, Todd M Covey, David Nathanson, Elizabeth Dimitrova, Yoan Konto, Anne Lindgren, Bertil Glader, Caius G Radu, Kathleen M Sakamoto, Shuo Li. The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia. Disease models & mechanisms. vol 7. issue 7. 2015-02-21. PMID:24812435. |
therefore, we treated rp-deficient zebrafish embryos with exogenous nucleosides and observed decreased activation of p53 and ampk, reduced apoptosis, and rescue of hematopoiesis. |
2015-02-21 |
2023-08-13 |
human |
| Valérie Lang, Chiara Pallara, Amaia Zabala, Sofia Lobato-Gil, Fernando Lopitz-Otsoa, Rosa Farrás, Roland Hjerpe, Monica Torres-Ramos, Lorea Zabaleta, Christine Blattner, Ronald T Hay, Rosa Barrio, Arkaitz Carracedo, Juan Fernandez-Recio, Manuel S Rodríguez, Fabienne Aille. Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity. Molecular oncology. vol 8. issue 5. 2015-02-21. PMID:24816189. |
the tumor suppressor p53 regulates the expression of genes involved in cell cycle progression, senescence and apoptosis. |
2015-02-21 |
2023-08-13 |
Not clear |
| Shweta Thakur, Bibekananda Sarkar, Ravi P Cholia, Nandini Gautam, Monisha Dhiman, Anil K Manth. APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions. Experimental & molecular medicine. vol 46. 2015-02-20. PMID:25033834. |
for example, ape1 activates activator protein-1, nuclear factor kappa b, hypoxia-inducible factor 1α, paired box gene 8, signal transducer activator of transcription 3 and p53, which are involved in apoptosis, inflammation, angiogenesis and survival pathways. |
2015-02-20 |
2023-08-13 |
human |
| Michelle Myers, F Hamish Morgan, Seng H Liew, Nadeen Zerafa, Thilini Upeksha Gamage, Mai Sarraj, Michele Cook, Ileana Kapic, Antony Sutherland, Clare L Scott, Andreas Strasser, Jock K Findlay, Jeffrey B Kerr, Karla J Hut. PUMA regulates germ cell loss and primordial follicle endowment in mice. Reproduction (Cambridge, England). vol 148. issue 2. 2015-02-19. PMID:24859845. |
in this study, we identified bbc3 (puma) (p53 upregulated modulator of apoptosis, also known as bcl2-binding component 3), a pro-apoptotic bh3-only protein belonging to the bcl2 family, as a critical determinant of the number of germ cells during ovarian development. |
2015-02-19 |
2023-08-13 |
mouse |
| Richard I Christopherson, Swetlana Mactier, Juhura G Almazi, Philippa L Kohnke, O Giles Best, Stephen P Mulliga. Mechanisms of action of fludarabine nucleoside against human Raji lymphoma cells. Nucleosides, nucleotides & nucleic acids. vol 33. issue 4-6. 2015-02-19. PMID:24940695. |
it is clear that 2-faraamp has multiple mechanisms of action that may collectively result in strand breaks in dna, accumulation of phosphorylated p53 and apoptosis. |
2015-02-19 |
2023-08-13 |
human |
| Stephen Lyle, Kathleen Hoover, Cansu Colpan, Zhiqing Zhu, Zdenka Matijasevic, Stephen N Jone. Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice. PloS one. vol 9. issue 6. 2015-02-19. PMID:24979267. |
furthermore, our findings reveal that loss of dicer in the epidermis induces extensive dna damage, activation of the dna damage response and p53-dependent apoptosis, and that dicer and p53 cooperate to suppress mammalian skin carcinogenesis. |
2015-02-19 |
2023-08-13 |
mouse |
| Mariana Leão, Sara Gomes, Cláudia Bessa, Joana Soares, Liliana Raimundo, Paola Monti, Gilberto Fronza, Clara Pereira, Lucília Saraiv. Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules. Experimental cell research. vol 330. issue 1. 2015-02-19. PMID:25265062. |
on the contrary, none of the tested p53 family members induced apoptosis either per se or after apoptotic stimuli. |
2015-02-19 |
2023-08-13 |
human |
| Chunhua Wan, Xa Ma, Shangshi Shi, Jianya Zhao, Xiaoke Nie, Jingling Han, Jing Xiao, Xiaoke Wang, Shengyang Jiang, Junkang Jian. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. Toxicology and applied pharmacology. vol 281. issue 3. 2015-02-17. PMID:25448048. |
pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. |
2015-02-17 |
2023-08-13 |
human |
| Chunhua Wan, Xa Ma, Shangshi Shi, Jianya Zhao, Xiaoke Nie, Jingling Han, Jing Xiao, Xiaoke Wang, Shengyang Jiang, Junkang Jian. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. Toxicology and applied pharmacology. vol 281. issue 3. 2015-02-17. PMID:25448048. |
however, the role of p53 in mn-induced neuronal apoptosis and neurological deficits remains obscure. |
2015-02-17 |
2023-08-13 |
human |
| Chunhua Wan, Xa Ma, Shangshi Shi, Jianya Zhao, Xiaoke Nie, Jingling Han, Jing Xiao, Xiaoke Wang, Shengyang Jiang, Junkang Jian. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. Toxicology and applied pharmacology. vol 281. issue 3. 2015-02-17. PMID:25448048. |
in the present study, we showed that p53 was critically involved in mn-induced neuronal apoptosis in rat striatum through both transcription-dependent and -independent mechanisms. |
2015-02-17 |
2023-08-13 |
human |
| Chunhua Wan, Xa Ma, Shangshi Shi, Jianya Zhao, Xiaoke Nie, Jingling Han, Jing Xiao, Xiaoke Wang, Shengyang Jiang, Junkang Jian. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. Toxicology and applied pharmacology. vol 281. issue 3. 2015-02-17. PMID:25448048. |
the cytoplasmic p53 had a remarkable distribution in mitochondria, suggesting an involvement of p53 mitochondrial translocation in mn-induced neuronal apoptosis. |
2015-02-17 |
2023-08-13 |
human |
| Venkateshwar Madka, Altaf Mohammed, Qian Li, Yuting Zhang, Jagan M R Patlolla, Laura Biddick, Stan Lightfoot, Xue-Ru Wu, Vernon Steele, Levy Kopelovich, Chinthalapally V Ra. Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 7. 2015-02-13. PMID:24795386. |
urothelial tumors of the licofelone-fed mice showed an increase in apoptosis (p53, p21, bax, and caspase3) with a decrease in proliferation, inflammation, and angiogenesis markers (proliferating cell nuclear antigen, cox-2, 5-lox, prostaglandin e synthase 1, flap, and vegf). |
2015-02-13 |
2023-08-13 |
mouse |
| Susanne Schuster, Melanie Penke, Theresa Gorski, Stefanie Petzold-Quinque, Georg Damm, Rolf Gebhardt, Wieland Kiess, Antje Garte. Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes. PloS one. vol 9. issue 3. 2015-02-12. PMID:24603648. |
resveratrol induced cell cycle arrest in the s- and g2/m- phase and apoptosis was mediated by activation of p53 and caspase-3 in hepg2 cells. |
2015-02-12 |
2023-08-12 |
human |
| Alberto Izzotti, Roumen Balansky, Francesco D'Agostini, Mariagrazia Longobardi, Cristina Cartiglia, Rosanna T Micale, Sebastiano La Maestra, Anna Camoirano, Gancho Ganchev, Marietta Iltcheva, Vernon E Steele, Silvio De Flor. Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice. Cancer medicine. vol 3. issue 3. 2015-02-12. PMID:24683044. |
modulation by metformin of 42 of 1281 pulmonary micrornas in smoke-free mice highlighted a variety of mechanisms, including modulation of ampk, stress response, inflammation, nfκb, tlr9, tgf, p53, cell cycle, apoptosis, antioxidant pathways, ras, myc, dicer, angiogenesis, stem cell recruitment, and angiogenesis. |
2015-02-12 |
2023-08-12 |
mouse |
| Sukriti Goyal, Sonam Grover, Jaspreet Kaur Dhanjal, Chetna Tyagi, Manisha Goyal, Abhinav Grove. Group-based QSAR and molecular dynamics mechanistic analysis revealing the mode of action of novel piperidinone derived protein-protein inhibitors of p53-MDM2. Journal of molecular graphics & modelling. vol 51. 2015-02-12. PMID:24858256. |
tumour suppressor p53 is known to play a central role in prevention of tumour development, dna repair, senescence and apoptosis which is in normal cells maintained by negative feedback regulator mdm2 (murine double minute 2). |
2015-02-12 |
2023-08-13 |
Not clear |
| H Matsumoto, Y Murakami, K Kataoka, H Lin, K M Connor, J W Miller, D Zhou, J Avruch, D G Vavva. Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment. Cell death & disease. vol 5. 2015-02-12. PMID:24874741. |
the transcription of p53 upregulated modulator of apoptosis (puma) and fas was also reduced in mst2(-/-) mice post-rd. |
2015-02-12 |
2023-08-13 |
mouse |
| Bo Liu, Yue-Qiu Gao, Xiao-Min Wang, Yu-Chun Wang, Li-Qi F. Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest. Molecular medicine reports. vol 10. issue 2. 2015-02-12. PMID:24889088. |
flow cytometric analysis and dna fragmentation revealed that germacrone promoted apoptosis of glioma cells, associated with an increased expression of p53 and bax and decreased expression of bcl‑2. |
2015-02-12 |
2023-08-13 |
human |
| J Wu, S Liang, J Bergholz, H He, E M Walsh, Y Zhang, Z-X Xia. ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell death & disease. vol 5. 2015-02-12. PMID:24901051. |
p63 is a p53 family member involved in multiple facets of biology, including embryonic development, cell proliferation, differentiation, survival, apoptosis, senescence and aging. |
2015-02-12 |
2023-08-13 |
Not clear |
| Ou Huang, Zuoquan Xie, Weili Zhang, Ying Lou, Yan Mao, Hongchun Liu, Min Jiang, Kunwei She. A771726, an anti-inflammatory drug, exerts an anticancer effect and reverses tamoxifen resistance in endocrine-resistant breast cancer cells. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24919713. |
cell cycle, apoptosis, mapk, metabolism and p53 signaling pathway) and cellular processes (e.g. |
2015-02-12 |
2023-08-13 |
Not clear |