| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Liu, Cen Zhang, Wenwei Hu, Zhaohui Fen. Tumor suppressor p53 and its mutants in cancer metabolism. Cancer letters. vol 356. issue 2 Pt A. 2015-03-03. PMID:24374014. |
as a transcription factor, p53 transcriptionally regulates its target genes to initiate different biological processes in response to stress, including apoptosis, cell cycle arrest or senescence, to exert its function in tumor suppression. |
2015-03-03 |
2023-08-12 |
human |
| Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ramesh C Gupt. Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25304375. |
mechanistically in hpv positive caski cells, tan iia was found to (i) downregulate expression of hpv e6 and e7 genes and modulate associated proteins e6ap and e2f1, (ii) cause s phase cell cycle arrest, (iii) induce accumulation of p53 and alter expression of p53-dependent targets, (iv) modulate prb and related proteins, and (v) cause p53-mediated apoptosis by moderating bcl2, bax, caspase-3, and parp cleavage expressions. |
2015-03-03 |
2023-08-13 |
mouse |
| Bo Li, Ying Gao, Gary O Rankin, Yon Rojanasakul, Stephen J Cutler, Youying Tu, Yi Charlie Che. Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent pathway in cisplatin-resistant ovarian cancer cells. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25304379. |
chk induced apoptosis through a p53-dependent caspase-8 activation extrinsic pathway, and caused g2 cell cycle arrest via cyclin b1 by increasing p53 expression and p38 phosphorylation in ovcar-3 and a2780/cp70 cells. |
2015-03-03 |
2023-08-13 |
Not clear |
| Shi Qiu, Yun Cai, Xing Gao, Shou-Zhi Gu, Ze-Jun Li. A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25444901. |
one of the most important tumor suppression functions of p53 is its ability to induce apoptosis. |
2015-03-03 |
2023-08-13 |
Not clear |
| Shi Qiu, Yun Cai, Xing Gao, Shou-Zhi Gu, Ze-Jun Li. A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25444901. |
we therefore use a34, a small peptide derived from p53 linker region, to investigate the possibility of resuming the apoptosis activity of p53 by sequestering iaspp with p53 and derepressing p53. |
2015-03-03 |
2023-08-13 |
Not clear |
| Shi Qiu, Yun Cai, Xing Gao, Shou-Zhi Gu, Ze-Jun Li. A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25444901. |
the results show that a34 can competitively combine with iaspp and therefore release p53 from iaspp; a34 can enhance the transcriptional activity of p53 on the promoters of bax and puma; a34 can increase cell apoptosis and slow tumor growth in vitro and vivo. |
2015-03-03 |
2023-08-13 |
Not clear |
| Xinli Shi, Jingli Liu, Laifeng Ren, Nan Mao, Fang Tan, Nana Ding, Jing Yang, Mingyuan L. Nutlin-3 downregulates p53 phosphorylation on serine392 and induces apoptosis in hepatocellular carcinoma cells. BMB reports. vol 47. issue 4. 2015-03-02. PMID:24286312. |
nutlin-3 downregulates p53 phosphorylation on serine392 and induces apoptosis in hepatocellular carcinoma cells. |
2015-03-02 |
2023-08-12 |
human |
| Yanhong Luo, Yaodong Wei, Taizhong Wang, Dongzhu Chen, Tiansheng Lu, Ruibo Wu, Keke S. Pine pollen inhibits cell apoptosis-related protein expression in the cerebral cortex of mice with arsenic poisoning. Neural regeneration research. vol 7. issue 12. 2015-02-27. PMID:25722672. |
results indicated that pine pollen suppressed cell apoptosis in the cerebral cortex of arsenic-poisoned mice by reducing bax, bcl-2 protein expression and increasing p53 protein expression. |
2015-02-27 |
2023-08-13 |
mouse |
| In-Ja Park, Woo Kyeom Yang, Sang-Hee Nam, Jongki Hong, Ki Ryeol Yang, Joungmok Kim, Sung Soo Kim, Wonchae Choe, Insug Kang, Joohun H. Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24173372. |
in addition, ampk also induces cell cycle arrest or apoptosis through several tumor suppressors including lkb1, tsc2, and p53. |
2015-02-26 |
2023-08-12 |
human |
| K Rudolf, M Cervinka, E Rudol. Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24375172. |
sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. |
2015-02-26 |
2023-08-12 |
Not clear |
| K Rudolf, M Cervinka, E Rudol. Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24375172. |
conversely, decreased apoptosis in sf-exposed melanoma cultivates might be attributed to akt-mediated suppression of p38 as well as p53 activity. |
2015-02-26 |
2023-08-12 |
Not clear |
| Malgorzata Frik, Alberto Martínez, Benelita T Elie, Oscar Gonzalo, Daniel Ramírez de Mingo, Mercedes Sanaú, Roberto Sánchez-Delgado, Tanmoy Sadhukha, Swayam Prabha, Joe W Ramos, Isabel Marzo, María Conte. In vitro and in vivo evaluation of water-soluble iminophosphorane ruthenium(II) compounds. A potential chemotherapeutic agent for triple negative breast cancer. Journal of medicinal chemistry. vol 57. issue 23. 2015-02-26. PMID:25409416. |
initial mechanistic studies indicate that the cell death type for these compounds is mainly through canonical or caspase-dependent apoptosis, nondependent on p53, and that the compounds do not interact with dna or inhibit protease cathepsin b. |
2015-02-26 |
2023-08-13 |
mouse |
| Weiwei Sun, Lulu Chen, Wei Zhang, Rong Wang, David Goltzman, Dengshun Mia. Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 1. 2015-02-25. PMID:25370849. |
the proliferation of spermatogenic cells was decreased with downregulation of cyclin e and cdk2 and upregulation of p53 and p21 expression, whereas apoptosis of spermatogenic cells was increased with upregulation of bax and p-caspase 3 expression and downregulation of bcl-xl expression. |
2015-02-25 |
2023-08-13 |
mouse |
| Li Mai, Faping Yi, Xiaoyan Gou, Ji Zhang, Changdong Wang, Geli Liu, Youquan Bu, Chengfu Yuan, Linman Deng, Fangzhou Son. The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancer. Molecular and cellular biochemistry. vol 392. issue 1-2. 2015-02-24. PMID:24633962. |
moreover, the overexpression of mcph1 activated mitochondrial apoptosis through regulating several apoptosis-related proteins such as p53, bcl-2, bax, cytochrome c, caspase-3, and parp-1. |
2015-02-24 |
2023-08-12 |
Not clear |
| Fei Zhao, Weiwei Huang, Tamgue Ousman, Bin Zhang, Yangyang Han, Daguia Zambe John Clotaire, Chen Wang, Huanhuan Chang, Huanan Luo, Xiaoyong Ren, Ming Le. Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation. PloS one. vol 8. issue 11. 2015-02-23. PMID:24244715. |
triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing e6-mediated p53 degradation. |
2015-02-23 |
2023-08-12 |
human |
| Fei Zhao, Weiwei Huang, Tamgue Ousman, Bin Zhang, Yangyang Han, Daguia Zambe John Clotaire, Chen Wang, Huanhuan Chang, Huanan Luo, Xiaoyong Ren, Ming Le. Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation. PloS one. vol 8. issue 11. 2015-02-23. PMID:24244715. |
increased p53 transactivates down-stream target genes to initiate apoptosis. |
2015-02-23 |
2023-08-12 |
human |
| Fei Zhao, Weiwei Huang, Tamgue Ousman, Bin Zhang, Yangyang Han, Daguia Zambe John Clotaire, Chen Wang, Huanhuan Chang, Huanan Luo, Xiaoyong Ren, Ming Le. Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation. PloS one. vol 8. issue 11. 2015-02-23. PMID:24244715. |
in conclusion, our results demonstrated that triptolide inhibits cell proliferation and induces apoptosis in laryngocarcinoma cells by enhancing p53 expression and activating p53 functions through induction of dna damage and suppression of e6 mediated p53 degradation. |
2015-02-23 |
2023-08-12 |
human |
| Yuan Ying, Jinu Kim, Sherry N Westphal, Kelly E Long, Babu J Padanila. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. Journal of the American Society of Nephrology : JASN. vol 25. issue 12. 2015-02-23. PMID:24854277. |
apoptosis and expression of proapoptotic p53 targets, including bid and siva, were also significantly reduced, and cell cycle arrest at the g2/m phase was attenuated in p53 ko ischemic kidneys. |
2015-02-23 |
2023-08-13 |
mouse |
| Yuan Ying, Jinu Kim, Sherry N Westphal, Kelly E Long, Babu J Padanila. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. Journal of the American Society of Nephrology : JASN. vol 25. issue 12. 2015-02-23. PMID:24854277. |
in conclusion, specific deletion of p53 in the ptc protects kidneys from functional and histologic deterioration after iri by decreasing necrosis, apoptosis, and inflammation and modulates the long-term sequelae of iri by preventing interstitial fibrogenesis. |
2015-02-23 |
2023-08-13 |
mouse |
| Zuoren Yu, Zengguang Xu, Gabriele Disante, Jennifer Wright, Min Wang, Yuan Li, Qian Zhao, Tao Ren, Xiaoming Ju, Ellen Gutman, Guangxue Wang, Sankar Addya, Tieyan Li, Zhendong Xiang, Chenguang Wang, Xiongfei Yang, Xiaolai Yang, Richard Pestel. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. vol 5. issue 4. 2015-02-21. PMID:24658544. |
mir-17/20 mediates apoptosis via increased p53 expression which promotes akt degradation. |
2015-02-21 |
2023-08-12 |
mouse |