| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yahong Wang, Ziying Lin, Haili Huang, Huijuan He, Lawei Yang, Ting Chen, Teng Yang, Nina Ren, Yun Jiang, Wenya Xu, David W Kamp, Tie Liu, Gang Li. AMPK is required for PM2.5-induced autophagy in human lung epithelial A549 cells. International journal of clinical and experimental medicine. vol 8. issue 1. 2015-03-18. PMID:25784975. |
the effects of phosphorylation of ampk, mtor, akt, erk, jnk, and p53 on lc3ii in a549 were observed following pm2.5 exposure; the role of autophagy in pm2.5-induced apoptosis was examined using 3-methyladenine and rapamycin. |
2015-03-18 |
2023-08-13 |
human |
| Yun-Han Lee, Daekwan Seo, Kyung-Ju Choi, Jesper B Andersen, Min-Ah Won, Mitsuteru Kitade, Luis E Gómez-Quiroz, Adam D Judge, Jens U Marquardt, Chiara Raggi, Elizabeth A Conner, Ian MacLachlan, Valentina M Factor, Snorri S Thorgeirsso. Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2. Cancer research. vol 74. issue 17. 2015-03-17. PMID:24958469. |
these effects were associated with deregulation of hdac-regulated genes that control cell cycle, apoptosis, and lipid metabolism, specifically, by upregulation of p27 and acetylated p53 and by downregulation of cdk6 and bcl2. |
2015-03-17 |
2023-08-13 |
human |
| Jufeng Xia, Jialu Chen, Zhongmin Zhang, Peipei Song, Wei Tang, Norihiro Kokud. A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo. Drug discoveries & therapeutics. vol 8. issue 4. 2015-03-16. PMID:25262593. |
among these components, there are three sets: i) mainly apoptosis-related groups, such as, alkaloids, diterpenoids, anthraquinones, berbamines, and xanthones, target pathways like the mitochondrial pathway, nf-κb pathway, p53 pathway and so on; ii) mainly proliferation, invasion and metastasis-related groups, such as, triterpenes, sesquiterpenes, polysaccharides, and glycosides, target pathways like the mtor pathway, β-catenin pathway, erk pathway and so on; iii) both apoptosis and proliferation, invasion and metastasis-related groups, such as benzoquinones, flavonoids, saponins, and steroids, target the pathways in i) and ii) synchronously. |
2015-03-16 |
2023-08-13 |
Not clear |
| Q-L Jiang, S Zhang, M Tian, S-Y Zhang, T Xie, D-Y Chen, Y-J Chen, J He, J Liu, L Ouyang, X Jian. Plant lectins, from ancient sugar-binding proteins to emerging anti-cancer drugs in apoptosis and autophagy. Cell proliferation. vol 48. issue 1. 2015-03-16. PMID:25488051. |
it has been widely accepted that plant lectins affect both apoptosis and autophagy by modulating representative signalling pathways involved in bcl-2 family, caspase family, p53, pi3k/akt, erk, bnip3, ras-raf and atg families, in cancer. |
2015-03-16 |
2023-08-13 |
Not clear |
| Roel Quintens, Tine Verreet, Ann Janssen, Mieke Neefs, Liselotte Leysen, Arlette Michaux, Mieke Verslegers, Nada Samari, Giuseppe Pani, Joris Verheyde, Sarah Baatout, Mohammed A Benotman. Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Biology open. vol 4. issue 3. 2015-03-16. PMID:25681390. |
ionizing radiation is a potent activator of the tumor suppressor gene p53, which itself regulates the transcription of genes involved in canonical pathways such as the cell cycle, dna repair and apoptosis as well as other biological processes like metabolism, autophagy, differentiation and development. |
2015-03-16 |
2023-08-13 |
mouse |
| Jihong Zhang, Marc Hummersone, Charles S Matthews, Malcolm F G Stevens, Tracey D Bradsha. N3-substituted temozolomide analogs overcome methylguanine-DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death. Oncology. vol 88. issue 1. 2015-03-14. PMID:25277441. |
analogs 1 and 2 inhibited mmr-deficient colorectal carcinoma cell growth (irrespective of p53); g2/m cell cycle arrest preceded apoptosis. |
2015-03-14 |
2023-08-13 |
Not clear |
| Rupninder Sandhu, Jessica Rein, Monica D'Arcy, Jason I Herschkowitz, Katherine A Hoadley, Melissa A Troeste. Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status. Carcinogenesis. vol 35. issue 11. 2015-03-13. PMID:25123132. |
kd of mir-146a caused decreased proliferation and increased apoptosis, effectively ablating the effects of p53 loss. |
2015-03-13 |
2023-08-13 |
human |
| Meiyu Peng, Bingqing Huang, Qi Zhang, Shuyu Fu, Dan Wang, Xixi Cheng, Xi Wu, Zhenyi Xue, Lijuan Zhang, Da Zhang, Yurong Da, Yun Dai, Qing Yang, Zhi Yao, Liang Qiao, Rongxin Zhan. Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. Cancer letters. vol 354. issue 2. 2015-03-13. PMID:25128650. |
embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of stat3 and activation of p53 signaling pathways. |
2015-03-13 |
2023-08-13 |
Not clear |
| Roberta Cotugno, Anna Basile, Elena Romano, Dario Gallotta, Maria Antonietta Belisari. BAG3 down-modulation sensitizes HPV18(+) HeLa cells to PEITC-induced apoptosis and restores p53. Cancer letters. vol 354. issue 2. 2015-03-13. PMID:25175321. |
bag3 down-modulation sensitizes hpv18(+) hela cells to peitc-induced apoptosis and restores p53. |
2015-03-13 |
2023-08-13 |
Not clear |
| Hongling Zhang, Yong Huang, Qian Du, Xiaomao Luo, Liang Zhang, Xiaomin Zhao, Dewen Ton. Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25499817. |
porcine parvovirus infection induces apoptosis in pk-15 cells through activation of p53 and mitochondria-mediated pathway. |
2015-03-13 |
2023-08-13 |
Not clear |
| Hongling Zhang, Yong Huang, Qian Du, Xiaomao Luo, Liang Zhang, Xiaomin Zhao, Dewen Ton. Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25499817. |
taken together, our results demonstrated that ppv infection induced apoptosis in pk-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway. |
2015-03-13 |
2023-08-13 |
Not clear |
| Mireille Happy, Jordan Dejoie, Cynthia K Zajac, Briseida Cortez, Karabi Chakraborty, Joseph Aderemi, Moira Sauan. Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25511708. |
while p53 is a promising antitumor therapeutic agent, antagonists of sigma 1 receptor also inhibit tumor cell survival and induce apoptosis. |
2015-03-13 |
2023-08-13 |
human |
| Chih-Chun Lee, Bong-Suk Kim, Ching Ching Wu, Tsang Long Li. Bursal transcriptome of chickens protected by DNA vaccination versus those challenged with infectious bursal disease virus. Archives of virology. vol 160. issue 1. 2015-03-11. PMID:25267176. |
the expression levels of genes related to immune cell regulation, apoptosis and glucose transport, including cd4, cd8, il-2, ifn-γ, il-12(p40), il-18, gm-csf, gata-3, p53, glucose transporter-2 and glucose transporter-3, were upregulated or significantly (p < 0.05) upregulated at 3 dpc and later in unvaccinated chickens challenged with ibdv. |
2015-03-11 |
2023-08-13 |
Not clear |
| Sylvanie Surget, Géraldine Descamps, Carole Brosseau, Vincent Normant, Sophie Maïga, Patricia Gomez-Bougie, Nadège Gouy-Colin, Catherine Godon, Marie C Béné, Philippe Moreau, Steven Le Gouill, Martine Amiot, Catherine Pellat-Deceunync. RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway. BMC cancer. vol 14. 2015-03-09. PMID:24927749. |
rita (reactivating p53 and inducing tumor apoptosis) is efficient against tp53abnormal myeloma cells independently of the p53 pathway. |
2015-03-09 |
2023-08-13 |
Not clear |
| William N Pappano, Qian Zhang, Lora A Tucker, Chris Tse, Jieyi Wan. Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells. BMC cancer. vol 14. 2015-03-09. PMID:24927813. |
genetic inhibition of the atypical kinase wee1 selectively drives apoptosis of p53 inactive tumor cells. |
2015-03-09 |
2023-08-13 |
Not clear |
| Jung Ok Lee, Ji Wook Moon, Soo Kyung Lee, So Mi Kim, Nami Kim, Seong-Gyu Ko, Hyeon Soo Kim, Sun Hwa Par. Rhus verniciflua extract modulates survival of MCF-7 breast cancer cells through the modulation of AMPK-pathway. Biological & pharmaceutical bulletin. vol 37. issue 5. 2015-03-06. PMID:24553147. |
the inhibition of ampk blocked rvs-induced p53 phosphorylation and bax expression, which suggests that ampk is involved in rvs-induced cancer apoptosis. |
2015-03-06 |
2023-08-12 |
human |
| Matthew D Cheeseman, Amir Faisal, Sydonia Rayter, Olivier R Barbeau, Andrew Kalusa, Maura Westlake, Rosemary Burke, Michael Swan, Rob van Montfort, Spiros Linardopoulos, Keith Jone. Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorganic & medicinal chemistry letters. vol 24. issue 15. 2015-03-05. PMID:24953599. |
these compounds cause growth inhibition at nanomolar concentrations, induce apoptosis, activate p53 and display impressive cell-line selectivity. |
2015-03-05 |
2023-08-13 |
Not clear |
| Krishna Kumar L Samaga, Gudapati Venkateshwara Rao, G Chandrashekara Reddy, Anil Kumar Kush, Latha Diwaka. Synthetic racemates of abyssinone I and II induces apoptosis through mitochondrial pathway in human cervix carcinoma cells. Bioorganic chemistry. vol 56. 2015-03-04. PMID:25019692. |
abyssinones promoted apoptosis by up regulation of p53 and bax, along with down regulation of bcl-2. |
2015-03-04 |
2023-08-13 |
human |
| Yueh-Chiao Yeh, Tsun-Jui Liu, Hui-Chin La. Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-04. PMID:25737737. |
shikonin induces apoptosis, necrosis, and premature senescence of human a549 lung cancer cells through upregulation of p53 expression. |
2015-03-04 |
2023-08-13 |
human |
| Yueh-Chiao Yeh, Tsun-Jui Liu, Hui-Chin La. Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-04. PMID:25737737. |
treatment of cells with pifithrin-α, a specific inhibitor of p53, suppressed shikonin-induced apoptosis and premature senescence, suggesting the role of p53 in mediating the actions of shikonin on regulation of lung cancer cell proliferation. |
2015-03-04 |
2023-08-13 |
human |