| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angelo Gismondi, Sara Caldarola, Gaia Lisi, Giada Juli, Lidia Chellini, Valentina Iadevaia, Christopher G Proud, Fabrizio Loren. Ribosomal stress activates eEF2K-eEF2 pathway causing translation elongation inhibition and recruitment of terminal oligopyrimidine (TOP) mRNAs on polysomes. Nucleic acids research. vol 42. issue 20. 2015-03-31. PMID:25332393. |
it has been shown that defect in ribosome biogenesis (ribosomal stress) induces apoptosis or cell cycle arrest through activation of the tumor suppressor p53. |
2015-03-31 |
2023-08-13 |
Not clear |
| Kazufumi Toume, Tadashi Habu, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibash. Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance. Journal of natural products. vol 78. issue 1. 2015-03-31. PMID:25537111. |
artonin e (5) induced caspase-dependent apoptosis in combination with trail, increased caspase 3/7 activity, and enhanced the protein levels of p53 and dr5. |
2015-03-31 |
2023-08-13 |
Not clear |
| Qingyuan Yang, Zhao Zhang, Wenjie Mei, Fenyong Su. A novel ruthenium(II)-polypyridyl complex inhibits cell proliferation and induces cell apoptosis by impairing DNA damage repair. Journal of chemotherapy (Florence, Italy). vol 26. issue 4. 2015-03-30. PMID:24070188. |
in addition, this complex induced cell apoptosis by upregulating both p21 and p53. |
2015-03-30 |
2023-08-12 |
Not clear |
| Jeong Eun Lee, Mi Sun Lim, Jae Hyeon Park, Chang Hwan Park, Hyun Chul Ko. Nuclear NF-κB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells. Neurotoxicology. vol 42. 2015-03-30. PMID:24727577. |
nuclear nf-κb contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells. |
2015-03-30 |
2023-08-13 |
human |
| Cui Yang, Jinyan Yang, Xiangting Xu, Sanmei Yan, Shitian Pan, Xiaoxia Pan, Changhong Zhang, George Pakheng Leun. Vasodilatory effect of 14,15-epoxyeicosatrienoic acid on mesenteric arteries in hypertensive and aged rats. Prostaglandins & other lipid mediators. vol 112. 2015-03-30. PMID:24880050. |
furthermore, expression of the p53 protein, an indicator of cell senescence and apoptosis, was elevated in adult and old shr as well as in old wky. |
2015-03-30 |
2023-08-13 |
rat |
| Juan Liao, Zhi Ye, Guoqing Huang, Chang Xu, Qulian Guo, E Wan. Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. Neuropharmacology. vol 85. 2015-03-30. PMID:24953831. |
delayed treatment with nsc23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. |
2015-03-30 |
2023-08-13 |
rat |
| Juan Liao, Zhi Ye, Guoqing Huang, Chang Xu, Qulian Guo, E Wan. Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. Neuropharmacology. vol 85. 2015-03-30. PMID:24953831. |
in addition, the mitochondrial translocation of p53 and the expression of p53-upregulated modulator of apoptosis (puma) in the mitochondria of the cerebral ischemic cortex were determined by western blotting. |
2015-03-30 |
2023-08-13 |
rat |
| Juan Liao, Zhi Ye, Guoqing Huang, Chang Xu, Qulian Guo, E Wan. Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. Neuropharmacology. vol 85. 2015-03-30. PMID:24953831. |
nsc23766 not only ameliorated post-ischemic neuronal apoptosis but also decreased cerebral ischemia-induced mitochondrial p53 translocation and the expression of puma in mitochondria in diabetic rats. |
2015-03-30 |
2023-08-13 |
rat |
| Juan Liao, Zhi Ye, Guoqing Huang, Chang Xu, Qulian Guo, E Wan. Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. Neuropharmacology. vol 85. 2015-03-30. PMID:24953831. |
thus, our data indicate that nsc23766 has therapeutic potential against cerebral ischemic reperfusion injury and that nsc23766 significantly ameliorates neuronal apoptosis by suppressing mitochondrial p53 translocation in streptozotocin-induced diabetic rats. |
2015-03-30 |
2023-08-13 |
rat |
| Tsui-Hwa Tseng, Chien-Heng Shen, Wen-Shih Huang, Cheng-Nan Chen, Wen-Hai Liang, Tseng-Hsi Lin, Hsing-Chun Ku. Activation of neutral-sphingomyelinase, MAPKs, and p75 NTR-mediating caffeic acid phenethyl ester-induced apoptosis in C6 glioma cells. Journal of biomedical science. vol 21. 2015-03-30. PMID:24997497. |
previously, our laboratory demonstrated the in vitro and in vivo bioactivity of cape and addressed the role of p53 and the p38 mitogen-activated protein kinase (mapk) pathway in regulating cape-induced apoptosis in c6 glioma cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Kazunari Iwamoto, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamot. Stochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damage. PloS one. vol 9. issue 7. 2015-03-30. PMID:25003668. |
a massive integrative mathematical model of dna double-strand break (dsb) generation, dsb repair system, p53 signaling network, and apoptosis induction pathway was constructed to explore the dominant factors of unknown criteria of cell fate decision. |
2015-03-30 |
2023-08-13 |
human |
| Kazunari Iwamoto, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamot. Stochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damage. PloS one. vol 9. issue 7. 2015-03-30. PMID:25003668. |
statistical analysis of the simulated results shows that the generation of multiple p53 pulses is a prerequisite for apoptosis induction. |
2015-03-30 |
2023-08-13 |
human |
| Kazunari Iwamoto, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamot. Stochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damage. PloS one. vol 9. issue 7. 2015-03-30. PMID:25003668. |
furthermore, cells exhibited considerable individual variability in p53 dynamics, which correlated with intrinsic apoptosis induction. |
2015-03-30 |
2023-08-13 |
human |
| Shashi Kiran, Vineesha Oddi, Gayatri Ramakrishn. Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response. Experimental cell research. vol 331. issue 1. 2015-03-26. PMID:25445786. |
when treated with higher dose of doxorubicin (>1 µm), sirt7 conferred resistance to apoptosis by attenuating stress activated kinases (sapk viz., p38 and jnk) and p53 response thereby shifting the cellular fate towards senescence. |
2015-03-26 |
2023-08-13 |
Not clear |
| Shashi Kiran, Vineesha Oddi, Gayatri Ramakrishn. Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response. Experimental cell research. vol 331. issue 1. 2015-03-26. PMID:25445786. |
sirt7 mediated resistance to doxorubicin induced apoptosis and senescence was lost when p53 level was restored by nutlin treatment. |
2015-03-26 |
2023-08-13 |
Not clear |
| Sue Haupt, Dinesh Raghu, Ygal Haup. p53 Calls upon CIA (Calcium Induced Apoptosis) to Counter Stress. Frontiers in oncology. vol 5. 2015-03-25. PMID:25806354. |
p53 calls upon cia (calcium induced apoptosis) to counter stress. |
2015-03-25 |
2023-08-13 |
Not clear |
| Ying Zhou, Shu-yu Wang, Xiao-kui Yang, Hong-mei Wan. [Relationship between the Akt-regulated direct p53 mitochondrial translocation and the resistance to cisplatin of ovarian cancer cells]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 33. issue 2. 2015-03-24. PMID:21575475. |
to explore akt-regulated direct p53 mitochondrial translocation in cisplatin-induced apoptosis in ovarian cancer cells and the relationship between this and chemoresistance in ovarian cancer. |
2015-03-24 |
2023-08-12 |
Not clear |
| Haiyan Dong, Xiang Yang, Jingjing Xie, Liping Xiang, Yuanfang Li, Minrui Ou, Ting Chi, Zhenhua Liu, Suhong Yu, Yu Gao, Jianzhong Chen, Jingwei Shao, Lee Ji. UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. Biochemical pharmacology. vol 93. issue 2. 2015-03-20. PMID:25522955. |
the combination selectively down-regulated the expression of bcl-2 and hkii proteins, up-regulated the expression of bax and p53, and collectively resulted in enhanced apoptosis related to caspase-3, -8, and -9 activities, in addition to inhibition on the cell mitochondrial membrane potential. |
2015-03-20 |
2023-08-13 |
Not clear |
| b' Marie Tosolini, Fr\\xc3\\xa9d\\xc3\\xa9ric Pont, Delphine B\\xc3\\xa9tous, Emmanuel Ravet, Laetitia Ligat, Fr\\xc3\\xa9d\\xc3\\xa9ric Lopez, Mary Poupot, Marc Poirot, \\xc3\\x89ric P\\xc3\\xa9rouzel, G\\xc3\\xa9rard Tiraby, Els Verhoeyen, Jean-Jacques Fourni\\xc3\\xa. Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a G\\xce\\xb1s protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Molecular and cellular biology. vol 35. issue 2. 2015-03-19. PMID:25384972.' |
the blockade of basal (adenosine-free) signaling from a2a inhibits protein kinase a (pka) activity, thereby recruiting cytosolic p53, which opens the mitochondrial permeability transition pore and impairs mitochondrial respiration, resulting in apoptosis. |
2015-03-19 |
2023-08-13 |
mouse |
| Daniel Talmasov, Zhang Xinjun, Bing Yu, Mandayam O Nandan, Agnieszka B Bialkowska, Enas Elkarim, Jes Kuruvilla, Vincent W Yang, Amr M Ghale. Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 308. issue 2. 2015-03-18. PMID:25414097. |
also, the irradiated klf4(Δis) mice had a significantly higher number of crypt cells positive for apoptosis, p53, and p21 compared with irradiated klf4(fl/fl) mice. |
2015-03-18 |
2023-08-13 |
mouse |