| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Akeno, A L Miller, X Ma, K A Wikenheiser-Brokam. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene. vol 34. issue 5. 2015-04-10. PMID:24469052. |
on the contrary, p53 loss led to increased apoptosis that had to be overcome for tumor progression. |
2015-04-10 |
2023-08-12 |
mouse |
| Xiaoran Yin, Jun Zhang, Xiaoning Li, Dong Liu, Cheng Feng, Rongrui Liang, Kun Zhuang, Chenlei Cai, Xinghuan Xue, Fuchun Jing, Xijing Wang, Jun Wang, Xinlian Liu, Hongbing M. DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways. International journal of molecular sciences. vol 15. issue 7. 2015-04-10. PMID:25026173. |
dads induced apoptosis by activating a mitochondria-dependent pathway with the executor of caspase-3, increasing p53 level and bax/bcl-2 ratio, and downregulating the raf/mek/erk pathway in eca109 xenograft tumosr. |
2015-04-10 |
2023-08-13 |
mouse |
| M V Igotti Abramova, A K Pojidaeva, E A Filippova, O O Gnedina, S B Svetlikova, V A Pospelo. HDAC inhibitors induce apoptosis but not cellular senescence in Gadd45α-deficient E1A+Ras cells. The international journal of biochemistry & cell biology. vol 51. 2015-04-09. PMID:24721210. |
the elevated apoptotic background of gadd45α-/- cells is accompanied by higher levels of ser15-phosphorylated p53 and p21/waf1 proteins that additionally commit the cells to hdis-induced apoptosis. |
2015-04-09 |
2023-08-13 |
Not clear |
| Zhi-Bin Ma, Hong-Yu Xu, Miao Jiang, You-Lin Yang, Lian-Xin Liu, Ying-Hua L. Arsenic trioxide induces apoptosis of human gastrointestinal cancer cells. World journal of gastroenterology. vol 20. issue 18. 2015-04-09. PMID:24833880. |
to investigate the changes in apoptosis in gastrointestinal cancer cells from patients with gastrointestinal cancers treated with arsenic trioxide (as₂o₃); and to study the possible molecular mechanisms of such changes by detecting the expression levels of p53 and bcl-2. |
2015-04-09 |
2023-08-13 |
human |
| Nawaf Al-Taweel, Elizabeth Varghese, Ana-Maria Florea, Dietrich Büsselber. Cisplatin (CDDP) triggers cell death of MCF-7 cells following disruption of intracellular calcium ([Ca(2+)]i) homeostasis. The Journal of toxicological sciences. vol 39. issue 5. 2015-04-09. PMID:25242407. |
beside dna damage and activation of p53 signaling pathway, cddp induces tumor-cell death due to elevation in the intracellular calcium concentration ([ca(2+)]i).however, the role of [ca(2+)]i in cddp induced apoptosis of breast cancer cells (mcf-7) is not well understood. |
2015-04-09 |
2023-08-13 |
Not clear |
| Zhifeng Zhang, Leigang Zheng, Zhenqun Zhao, Jun Shi, Xing Wang, Jian Huan. Grape seed proanthocyanidins inhibit H2O2-induced osteoblastic MC3T3-E1 cell apoptosis via ameliorating H2O2-induced mitochondrial dysfunction. The Journal of toxicological sciences. vol 39. issue 5. 2015-04-09. PMID:25242411. |
moreover, the proanthocyanidins inhibit h2o2-induced apoptosis signaling which is mediated by p53. |
2015-04-09 |
2023-08-13 |
human |
| Joana M Xavier, Ana L Morgado, Susana Solá, Cecília M P Rodrigue. Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress. Antioxidants & redox signaling. vol 21. issue 7. 2015-04-08. PMID:24329038. |
apoptosis regulatory proteins, such as p53, play a pivotal role in neural differentiation, through mechanisms independent of cell death. |
2015-04-08 |
2023-08-12 |
Not clear |
| Chin-Chih Ho, An-Cheng Huang, Chun-Shu Yu, Jin-Cherng Lien, Shin-Hwar Wu, Yi-Ping Huang, Hui-Ying Huang, Jehn-Hwa Kuo, Wen-Yen Liao, Jai-Sing Yang, Po-Yuan Chen, Jing-Gung Chun. Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways. Environmental toxicology. vol 29. issue 11. 2015-04-07. PMID:23554011. |
western blotting assay showed that ellagic acid promoted p21, p53 and decreased cdc2 and wee1 for leading to g0/g1 phase arrest and promoting bad expression, aif and endo g, cytochrome c, caspase-9 and -3 for leading to apoptosis in tsgh8301 cells. |
2015-04-07 |
2023-08-12 |
human |
| Mei-Juan Xie, Yi-Hua Ma, Lin Miao, Yan Wang, Hai-Zhen Wang, Ying-Ying Xing, Tao Xi, Yuan-Yuan L. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 13. 2015-04-07. PMID:25040975. |
pretreatment with the antioxidant nac diminished apoptosis and p53 overexpression induced by emodin. |
2015-04-07 |
2023-08-13 |
human |
| Mei-Juan Xie, Yi-Hua Ma, Lin Miao, Yan Wang, Hai-Zhen Wang, Ying-Ying Xing, Tao Xi, Yuan-Yuan L. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 13. 2015-04-07. PMID:25040975. |
transfecting p53 sirna also attenuated apoptosis induced by emodin, bax expression and mitochondrial translocation being reduced compared to treatment with emodin alone. |
2015-04-07 |
2023-08-13 |
human |
| Mei-Juan Xie, Yi-Hua Ma, Lin Miao, Yan Wang, Hai-Zhen Wang, Ying-Ying Xing, Tao Xi, Yuan-Yuan L. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 13. 2015-04-07. PMID:25040975. |
taken together, these results indicate that ros is a trigger of emodin-induced apoptosis in hct116 cells, and p53 expression increases under oxidative stress, leading to bax-mediated mitochondrial apoptosis. |
2015-04-07 |
2023-08-13 |
human |
| Claudia Alva-Sanchez, Adair Rodriguez, Ivan Villanueva, Brenda Anguiano, Carmen Aceves, Jorge Pacheco-Rosad. The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat. Acta neurobiologiae experimentalis. vol 74. issue 1. 2015-04-06. PMID:24718050. |
in this work we measured the expression of specific proteins that control cell proliferation (cycline-d1), cell arrest (p21), damage (p53) or apoptosis (bax and bcl2) in the hippocampus of hypothyroid rats treated with the nmda receptor (nmdar) blocker mk-801 during the induction of hypothyroidism. |
2015-04-06 |
2023-08-13 |
rat |
| Jerson L Silva, Claudia V De Moura Gallo, Danielly C F Costa, Luciana P Range. Prion-like aggregation of mutant p53 in cancer. Trends in biochemical sciences. vol 39. issue 6. 2015-04-06. PMID:24775734. |
p53 is a master regulatory protein that participates in cellular processes such as apoptosis, dna repair, and cell cycle control. |
2015-04-06 |
2023-08-13 |
human |
| Fuping Gao, Qing Yuan, Liang Gao, Pengju Cai, Huarui Zhu, Ru Liu, Yaling Wang, Yueteng Wei, Guodong Huang, Jian Liang, Xueyun Ga. Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles. Biomaterials. vol 35. issue 31. 2015-04-06. PMID:25064805. |
the combination of nano se and irinotecan showed increased cytotoxic effect with hct-8 tumor cells likely by p53 mediated apoptosis. |
2015-04-06 |
2023-08-13 |
Not clear |
| D B Korma. [Alternative means of drug therapy for cancer: antineoplastons--antitumor properties and mechanisms of action]. Voprosy onkologii. vol 60. issue 4. 2015-04-03. PMID:25552063. |
in experimental studies it was showed that synthetic antineoplastons (a10-3-phenyl-acetyl-amino-2,6-piperidinedione and as2-1--a mixture of phenylacetic acid and phenylacetylglutamine) were able to prevent the introduction of glutamine into the cell, to block the action of bcl-2, to activate p53 and p21, to inhibit histone deacetylase, to induce apoptosis. |
2015-04-03 |
2023-08-13 |
human |
| S-M Ju, H-O Pae, W-S Kim, D-G Kang, H-S Lee, B-H Jeo. Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells. European review for medical and pharmacological sciences. vol 18. issue 8. 2015-04-02. PMID:24817286. |
role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells. |
2015-04-02 |
2023-08-13 |
rat |
| Y Li, Y-J Liu, G Lv, D-L Zhang, L Zhang, D L. Propofol protects against hydrogen peroxide-induced apoptosis in cardiac H9c2 cells is associated with the NF-κB activation and PUMA expression. European review for medical and pharmacological sciences. vol 18. issue 10. 2015-04-02. PMID:24899612. |
previous studies showed nf-κb (nf-κb) could be activated after oxidative stress in cardiac cells, and p53 up-regulated modulator of apoptosis (puma) is a direct target of nf-κb and mediates oxidative stress -induced apoptosis. |
2015-04-02 |
2023-08-13 |
rat |
| Xin Zhao, Liang Pang, Jing Li, Jia-Le Song, Li-Hua Qi. Apoptosis inducing effects of Kuding tea polyphenols in human buccal squamous cell carcinoma cell line BcaCD885. Nutrients. vol 6. issue 8. 2015-04-01. PMID:25100434. |
by rt-pcr and western blot assays, kuding tea polyphenol significantly induced apoptosis in bcacd885 cancer cells (p < 0.05) by upregulating caspase-3, caspase-8, caspase-9, fas/fasl, bax, p53, p21, e2f1, p73 and downregulating bcl-2, bcl-xl, hiap-1, and hiap-2 mrna and protein expressions. |
2015-04-01 |
2023-08-13 |
human |
| Lin Li, Po Sing Leun. Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer. The international journal of biochemistry & cell biology. vol 53. 2015-03-31. PMID:24875648. |
in pancreatic cancer, significant mutations of k-ras and p53, constitutive activation of nfκb, over-expression of heat shock proteins (hsp90, hsp70), histone deacetylase (hdacs) and the activities of other proteins (cox-2, nrf2 and bcl-2 family members) are closely linked with resistance to apoptosis and invasion. |
2015-03-31 |
2023-08-13 |
Not clear |
| Jonas Bethuyne, Steven De Gieter, Olivier Zwaenepoel, Abel Garcia-Pino, Kaat Durinck, Adriaan Verhelle, Gholamreza Hassanzadeh-Ghassabeh, Frank Speleman, Remy Loris, Jan Getteman. A nanobody modulates the p53 transcriptional program without perturbing its functional architecture. Nucleic acids research. vol 42. issue 20. 2015-03-31. PMID:25324313. |
to perform this task, p53 regulates the transcription of genes promoting various cellular outcomes including cell cycle arrest, apoptosis or senescence. |
2015-03-31 |
2023-08-13 |
Not clear |