| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pontsho Moela, Mpho M S Choene, Lesetja R Motad. Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death. Immunobiology. vol 219. issue 8. 2015-04-16. PMID:24703106. |
degradation of p53 by rbbp6 may compromise p53-mediated apoptosis in breast cancer. |
2015-04-16 |
2023-08-13 |
Not clear |
| Pontsho Moela, Mpho M S Choene, Lesetja R Motad. Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death. Immunobiology. vol 219. issue 8. 2015-04-16. PMID:24703106. |
our studies indicate that the knockdown of rbbp6 by sirna modulates p53 gene expression involved in cell death pathways and apoptosis, showing statistically significant gene expression differences. |
2015-04-16 |
2023-08-13 |
Not clear |
| Daniel Salgado Küpper, Fabiana C P Valera, Rafael Malinsky, Cristiane Maria Milanezi, João S Silva, Edwin Tamashiro, Wilma T Anselmo-Lim. Expression of apoptosis mediators p53 and caspase 3, 7, and 9 in chronic rhinosinusitis with nasal polyposis. American journal of rhinology & allergy. vol 28. issue 3. 2015-04-16. PMID:24980229. |
expression of apoptosis mediators p53 and caspase 3, 7, and 9 in chronic rhinosinusitis with nasal polyposis. |
2015-04-16 |
2023-08-13 |
Not clear |
| Qin Li, Yun Zhang, Adel K El-Naggar, Shunbin Xiong, Peirong Yang, James G Jackson, Gilda Chau, Guillermina Lozan. Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors. Molecular cancer research : MCR. vol 12. issue 6. 2015-04-15. PMID:24598047. |
finally, it was determined that restored p53 suppressed cell proliferation but did not elicit apoptosis in the mdm2-overexpressing angiosarcomas. |
2015-04-15 |
2023-08-12 |
human |
| Negar Azarpira, Koorosh Kazemi, Masumeh Dara. Influence of p53 (rs1625895) polymorphism in kidney transplant recipients. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. vol 25. issue 6. 2015-04-15. PMID:25394431. |
although rejection is a complex immunologic event and functional importance of snps has not been confirmed yet, we suggest that wild type p53 may promote apoptosis during inflammation. |
2015-04-15 |
2023-08-13 |
Not clear |
| Lin Yuan, Zhongbin Chen, Shanshan Song, Shan Wang, Chunyan Tian, Guichun Xing, Xiaojuan Chen, Zhi-Xiong Xiao, Fuchu He, Lingqiang Zhan. p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling. The Journal of biological chemistry. vol 290. issue 5. 2015-04-15. PMID:25505178. |
by promoting p53 degradation, plp2 inhibits the p53-mediated antiviral response and apoptosis to ensure viral growth in infected cells. |
2015-04-15 |
2023-08-13 |
human |
| C Bersani, L-D Xu, A Vilborg, W-O Lui, K G Wima. Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ. Oncogene. vol 33. issue 35. 2015-04-14. PMID:24469038. |
our results suggest a role of wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of fas and 14-3-3σ mrna levels. |
2015-04-14 |
2023-08-12 |
Not clear |
| I Gañán-Gómez, M C Estañ-Omaña, P Sancho, P Aller, M C Boyano-Adáne. Mechanisms of resistance to apoptosis in the human acute promyelocytic leukemia cell line NB4. Annals of hematology. vol 94. issue 3. 2015-04-14. PMID:25322811. |
more importantly, we also demonstrated that high basal autophagy levels and the gain-of-function of mutant p53 are intrinsic mechanisms of resistance to apoptosis in this cell line. |
2015-04-14 |
2023-08-13 |
human |
| I Gañán-Gómez, M C Estañ-Omaña, P Sancho, P Aller, M C Boyano-Adáne. Mechanisms of resistance to apoptosis in the human acute promyelocytic leukemia cell line NB4. Annals of hematology. vol 94. issue 3. 2015-04-14. PMID:25322811. |
according to our results, the pharmacological inhibition of autophagy and p53 mutants are useful tools to explore resistance to apoptosis in apl and other types of cancer and could be the bases of new therapeutic approaches that improve the efficiency and allow dose reduction of the current treatments. |
2015-04-14 |
2023-08-13 |
human |
| Daotong Li, Haoran Ma, Yaqiong Ye, Changyun Ji, Xiaohong Tang, Dan Ouyang, Jian Chen, Yugu Li, Yongjiang M. Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway. Environmental toxicology and pharmacology. vol 38. issue 1. 2015-04-13. PMID:24952344. |
taken together, our results suggest that don causes the activation of p53, increased levels of ros and the induction of mitochondrial dysfunction, which may contribute to don-induced apoptosis in mtec1 cells. |
2015-04-13 |
2023-08-13 |
mouse |
| Xuyi Wang, Maria M Docanto, Hironobu Sasano, Camden Lo, Evan R Simpson, Kristy A Brow. Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer. Cancer research. vol 75. issue 4. 2015-04-13. PMID:25634217. |
the tumor-suppressor p53 is a key regulator of cell-cycle arrest and apoptosis and is frequently mutated in breast cancer. |
2015-04-13 |
2023-08-13 |
human |
| Zaki A Sheri. Caspase Activation and Aberrant Cell Growth in a p53(+/+) Cell Line from a Li-Fraumeni Syndrome Family. Genetics research international. vol 2015. 2015-04-13. PMID:25866679. |
wild-type p53 is well known to induce cell cycle arrest and apoptosis to block aberrant cell growth. |
2015-04-13 |
2023-08-13 |
Not clear |
| Zaki A Sheri. Caspase Activation and Aberrant Cell Growth in a p53(+/+) Cell Line from a Li-Fraumeni Syndrome Family. Genetics research international. vol 2015. 2015-04-13. PMID:25866679. |
however, p53's unique role in apoptosis and cell proliferation in li-fraumeni syndrome (lfs) has not been well elucidated. |
2015-04-13 |
2023-08-13 |
Not clear |
| Zaki A Sheri. Caspase Activation and Aberrant Cell Growth in a p53(+/+) Cell Line from a Li-Fraumeni Syndrome Family. Genetics research international. vol 2015. 2015-04-13. PMID:25866679. |
this is important because apoptosis inducers acting through the mitochondrial death pathway are emerging as promising drugs against tumors where the role of p53 is not only to target gene regulation but also to block cell proliferation. |
2015-04-13 |
2023-08-13 |
Not clear |
| Qingsheng Hou, Hongwei Zhao, Weipeng Gong, Zhenyu Zhu, Yue Han, Dexi Chen, Hongliang Gu. [Phosphorylation status of ASPP2 modulates p53 apoptotic function in oxaliplatin-induced apoptosis of colorectal cancer HCT116 cells]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 36. issue 6. 2015-04-11. PMID:25241782. |
[phosphorylation status of aspp2 modulates p53 apoptotic function in oxaliplatin-induced apoptosis of colorectal cancer hct116 cells]. |
2015-04-11 |
2023-08-13 |
Not clear |
| Qingsheng Hou, Hongwei Zhao, Weipeng Gong, Zhenyu Zhu, Yue Han, Dexi Chen, Hongliang Gu. [Phosphorylation status of ASPP2 modulates p53 apoptotic function in oxaliplatin-induced apoptosis of colorectal cancer HCT116 cells]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 36. issue 6. 2015-04-11. PMID:25241782. |
to investigate the role of apoptosis stimulating protein 2 of p53 (aspp2) phosphorylation status in the regulation of aspp2-p53 apoptotic pathway activity. |
2015-04-11 |
2023-08-13 |
Not clear |
| P Chudasama, A Konrad, R Jochmann, B Lausen, P Holz, E Naschberger, F Neipel, N Britzen-Laurent, M Stürz. Structural proteins of Kaposi's sarcoma-associated herpesvirus antagonize p53-mediated apoptosis. Oncogene. vol 34. issue 5. 2015-04-10. PMID:24469037. |
the tumor suppressor p53 is a central regulatory molecule of apoptosis and is commonly mutated in tumors. |
2015-04-10 |
2023-08-12 |
Not clear |
| P B Essers, T D Klasson, T C Pereboom, D A Mans, M Nicastro, K Boldt, R H Giles, A W MacInne. The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Oncogene. vol 34. issue 6. 2015-04-10. PMID:24469044. |
despite the subsequent hyperstabilization and normal transcriptional activity of p53, we find that zebrafish vhl(-/-) cells are still as highly resistant to dna damage-induced cell cycle arrest and apoptosis as human ccrcc cells. |
2015-04-10 |
2023-08-12 |
human |
| N Akeno, A L Miller, X Ma, K A Wikenheiser-Brokam. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene. vol 34. issue 5. 2015-04-10. PMID:24469052. |
rb inactivation is the initiating lesion in retinoblastoma and current models propose that induction of apoptosis is a key p53 tumor suppressive function. |
2015-04-10 |
2023-08-12 |
mouse |
| N Akeno, A L Miller, X Ma, K A Wikenheiser-Brokam. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene. vol 34. issue 5. 2015-04-10. PMID:24469052. |
p53 suppressed tumorigenesis by inhibiting cell cycle progression, but did not induce apoptosis. |
2015-04-10 |
2023-08-12 |
mouse |