| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenqing Tang, Ruyi Xue, Shuqiang Weng, Jian Wu, Ying Fang, Yi Wang, Lingling Ji, Tingting Hu, Taotao Liu, Xiaowu Huang, She Chen, Xizhong Shen, Si Zhang, Ling Don. BIRC6 promotes hepatocellular carcinogenesis: interaction of BIRC6 with p53 facilitating p53 degradation. International journal of cancer. vol 136. issue 6. 2015-04-22. PMID:25196217. |
birc6 knockdown remarkably suppressed cell proliferation, caused g1/s arrest and sensitized hepatoma cells to sorafenib-induced apoptosis in hepatoma cells, which was partly reversed by rna interference targeting p53. |
2015-04-22 |
2023-08-13 |
mouse |
| Xiandan Cui, Hyo-Kyoung Choi, Young-Seok Choi, Soo-Yeon Park, Gi-Jun Sung, Yoo-Hyun Lee, Jeongmin Lee, Woo Jin Jun, Kyungsup Kim, Kyung-Chul Choi, Ho-Geun Yoo. DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis. Cancer letters. vol 357. issue 1. 2015-04-21. PMID:25444898. |
because this function was p53 dependent, dnajb1 depletion increased the expression of p53-targeted apoptosis genes. |
2015-04-21 |
2023-08-13 |
human |
| Abdelouahid El-Khattouti, Natale T Sheehan, Jesus Monico, Heather A Drummond, Youssef Haikel, Robert T Brodell, Mosaad Megahed, Mohamed Hassa. CD133⁺ melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: significance for melanoma treatment. Cancer letters. vol 357. issue 1. 2015-04-21. PMID:25449786. |
the functional analysis of e2f1 in cd133(+) melanoma subpopulation demonstrated the ability of e2f1 gene transfer to trigger apoptosis of cd133(+) cells and to enhance the activation of apoptosis signal-regulating kinase (ask1), c-jun n-terminal kinase and p38, and the dna-binding activities of the transcription factors ap-1 and p53. |
2015-04-21 |
2023-08-13 |
Not clear |
| Nader AbuSara, Seyd Razavi, Leena Derwish, Yumiko Komatsu, Maria Licursi, Kensuke Hirasaw. Restoration of IRF1-dependent anticancer effects by MEK inhibition in human cancer cells. Cancer letters. vol 357. issue 2. 2015-04-21. PMID:25497010. |
restoration of the expression of antitumor genes, p27 and p53 upregulated modulator of apoptosis (puma), by mek inhibition was less in irf1 shrna knockdown cancer cells than in vector control cancer cells, suggesting that ras/mek targets irf1 for the downregulation of the antitumor genes. |
2015-04-21 |
2023-08-13 |
human |
| Lina Yang, Yunjiao Zhou, Yinghua Li, Juan Zhou, Yougen Wu, Yunqing Cui, Gong Yang, Yang Hon. Mutations of p53 and KRAS activate NF-κB to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells. Cancer letters. vol 357. issue 2. 2015-04-21. PMID:25499080. |
mutations of p53 and kras activate nf-κb to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells. |
2015-04-21 |
2023-08-13 |
Not clear |
| Paola Indovina, Eleonora Marcelli, Domenico Di Marzo, Nadia Casini, Iris Maria Forte, Francesca Giorgi, Luigi Alfano, Francesca Pentimalli, Antonio Giordan. Abrogating G₂/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma. Cancer biology & therapy. vol 15. issue 4. 2015-04-20. PMID:24365782. |
consistently, we also observed a decrease in g 2/m accumulation and an increase in mitotic entry of dna-damaged cells and apoptosis, probably due to the loss of the cell ability to arrest cell cycle in response to dna damage, irrespectively of p53 mutational status. |
2015-04-20 |
2023-08-12 |
Not clear |
| Bo Wu, Xiaoyu Chu, Cong Feng, Junwei Hou, Hongxia Fan, Ningning Liu, Changfei Li, Xianping Kong, Xin Ye, Songdong Men. Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. Cancer letters. vol 359. issue 2. 2015-04-20. PMID:25637791. |
overexpression and knockdown studies both demonstrated that gp96 decreases p53 protein levels, and gp96 regulated cell apoptosis in a p53-dependent manner. |
2015-04-20 |
2023-08-13 |
Not clear |
| Hailing Liu, Ling Zhou, Songshan Shi, Ying Wang, Xinyan Ni, Fei Xiao, Shunchun Wang, Ping Li, Kan Din. Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling. Glycobiology. vol 24. issue 8. 2015-04-17. PMID:24799378. |
the downregulation of mdm2 with stabilizing p53 and the nuclear location of p21 were induced by g19 to cause cell cycle arrest and apoptosis to some extent. |
2015-04-17 |
2023-08-13 |
mouse |
| Antonella Scalera, Giovanni Tarantin. Could metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease? World journal of gastroenterology. vol 20. issue 28. 2015-04-17. PMID:25071314. |
in in vitro studies, pparγ inhibited various carcinomas including hcc, most probably by regulating apoptosis via the p21, p53 and p27 pathways. |
2015-04-17 |
2023-08-13 |
human |
| Min-Goo Lee, Jikhyon Han, Seong-In Jeong, Nam-Gu Her, Jin-Hee Lee, Tae-Kyu Ha, Min-Ju Kang, Byung-Kyu Ryu, Sung-Gil Ch. XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 43. 2015-04-17. PMID:25313037. |
here, we report that xaf1 forms a positive feedback loop with p53 and acts as a molecular switch in p53-mediated cell-fate decisions favoring apoptosis over cell-cycle arrest. |
2015-04-17 |
2023-08-13 |
human |
| Joseph M Rogers, Vladimiras Oleinikovas, Sarah L Shammas, Chi T Wong, David De Sancho, Christopher M Baker, Jane Clark. Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 43. 2015-04-17. PMID:25313042. |
here we examine a typical system, where a small disordered protein (puma, p53 upregulated modulator of apoptosis) folds to an α-helix when bound to a groove on the surface of a folded protein (mcl-1, induced myeloid leukemia cell differentiation protein). |
2015-04-17 |
2023-08-13 |
Not clear |
| Yashodhar P Bhandary, Shwetha K Shetty, Amarnath S Marudamuthu, Jian Fu, Barbara M Pinson, Jeffrey Levin, Sreerama Shett. Role of p53-fibrinolytic system cross-talk in the regulation of quartz-induced lung injury. Toxicology and applied pharmacology. vol 283. issue 2. 2015-04-17. PMID:25596429. |
lung tissues and aecs isolated from wild-type (wt) mice exposed to silica exhibit increased apoptosis, p53 and pai-1, and suppression of upa expression. |
2015-04-17 |
2023-08-13 |
mouse |
| Yashodhar P Bhandary, Shwetha K Shetty, Amarnath S Marudamuthu, Jian Fu, Barbara M Pinson, Jeffrey Levin, Sreerama Shett. Role of p53-fibrinolytic system cross-talk in the regulation of quartz-induced lung injury. Toxicology and applied pharmacology. vol 283. issue 2. 2015-04-17. PMID:25596429. |
treatment of wt mice with csp inhibits pai-1, restores upa expression and prevents aec apoptosis by suppressing p53, which is otherwise induced in mice exposed to silica. |
2015-04-17 |
2023-08-13 |
mouse |
| Ewelina Wawryk-Gawda, Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Katarzyna Chłapek, Kamila Bulak, Marian Jędrych, Barbara Jodłowska-Jędryc. P53 protein in proliferation, repair and apoptosis of cells. Protoplasma. vol 251. issue 3. 2015-04-16. PMID:24043441. |
p53 protein in proliferation, repair and apoptosis of cells. |
2015-04-16 |
2023-08-12 |
rat |
| Ewelina Wawryk-Gawda, Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Katarzyna Chłapek, Kamila Bulak, Marian Jędrych, Barbara Jodłowska-Jędryc. P53 protein in proliferation, repair and apoptosis of cells. Protoplasma. vol 251. issue 3. 2015-04-16. PMID:24043441. |
we compared the activity of p53 protein in cells with a high apoptosis index and in cells with active repair mechanisms and high proliferation index. |
2015-04-16 |
2023-08-12 |
rat |
| Ewelina Wawryk-Gawda, Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Katarzyna Chłapek, Kamila Bulak, Marian Jędrych, Barbara Jodłowska-Jędryc. P53 protein in proliferation, repair and apoptosis of cells. Protoplasma. vol 251. issue 3. 2015-04-16. PMID:24043441. |
we observed stronger p53 protein expression in the epithelial cells of the materials taken 24 h after the last dose of 2-cda associated with the active process of apoptosis and inhibition of proliferation. |
2015-04-16 |
2023-08-12 |
rat |
| Heidi W-S Wong, Zeeshan Shaukat, Jianbin Wang, Robert Saint, Stephen L Gregor. JNK signaling is needed to tolerate chromosomal instability. Cell cycle (Georgetown, Tex.). vol 13. issue 4. 2015-04-16. PMID:24335260. |
here we identify components upstream and downstream of jnk that are able to mediate this effect, and test the involvement of p53 and dna damage in causing apoptosis when jnk signaling is reduced in cin cells. |
2015-04-16 |
2023-08-12 |
Not clear |
| Minakshi Nihal, Nihal Ahmad, Gary S Woo. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell cycle (Georgetown, Tex.). vol 13. issue 4. 2015-04-16. PMID:24343700. |
a combination of class i/ii and class iii hdacis (vorinostat and tenovin-1) produced significantly greater growth inhibition, cell death via apoptosis, as well as superior p53 promoter upregulation in wtp53 myla cells as compared with either agent alone. |
2015-04-16 |
2023-08-12 |
Not clear |
| Domenico Di Marzo, Iris Maria Forte, Paola Indovina, Elena Di Gennaro, Valeria Rizzo, Francesca Giorgi, Eliseo Mattioli, Carmelina Antonella Iannuzzi, Alfredo Budillon, Antonio Giordano, Francesca Pentimall. Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma. Cell cycle (Georgetown, Tex.). vol 13. issue 4. 2015-04-16. PMID:24345738. |
rita triggered robust caspase-dependent apoptosis specifically in epithelioid and biphasic mesothelioma cell lines, both through wild-type and mutant p53, concomitant to p21 downregulation. |
2015-04-16 |
2023-08-12 |
Not clear |
| Domenico Di Marzo, Iris Maria Forte, Paola Indovina, Elena Di Gennaro, Valeria Rizzo, Francesca Giorgi, Eliseo Mattioli, Carmelina Antonella Iannuzzi, Alfredo Budillon, Antonio Giordano, Francesca Pentimall. Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma. Cell cycle (Georgetown, Tex.). vol 13. issue 4. 2015-04-16. PMID:24345738. |
our data indicate that reactivation of p53 and concomitant p21 downregulation effectively induce cell death in mesothelioma, a tumor characterized by a high intrinsic resistance to apoptosis. |
2015-04-16 |
2023-08-12 |
Not clear |