| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rana Abu-Dahab, Maha R Abdallah, Violet Kasabri, Nizar M Mhaidat, Fatma U Afif. Mechanistic studies of antiproliferative effects of Salvia triloba and Salvia dominica (Lamiaceae) on breast cancer cell lines (MCF7 and T47D). Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 69. issue 11-12. 2015-05-08. PMID:25854764. |
did not enhance p53 levels, and apoptosis induced by them was not caspase-8- or sfas/fasl-dependent. |
2015-05-08 |
2023-08-13 |
Not clear |
| Evguenia M Alexandrova, Natalia D Marchenk. Mutant p53 - Heat Shock Response Oncogenic Cooperation: A New Mechanism of Cancer Cell Survival. Frontiers in endocrinology. vol 6. 2015-05-08. PMID:25954247. |
the main tumor suppressor function of p53 as a "guardian of the genome" is to respond to cellular stress by transcriptional activation of apoptosis, growth arrest, or senescence in damaged cells. |
2015-05-08 |
2023-08-13 |
human |
| Hui Shi, Ting Tao, Delai Huang, Zhao Ou, Jun Chen, Jinrong Pen. A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function. Nucleic acids research. vol 43. issue 2. 2015-05-01. PMID:25550427. |
p53 functions as a tumor suppressor by transcriptionally regulating the expression of genes involved in controlling cell proliferation or apoptosis. |
2015-05-01 |
2023-08-13 |
zebrafish |
| Fahim Atif, Seema Yousuf, Donald G Stei. Anti-tumor effects of progesterone in human glioblastoma multiforme: role of PI3K/Akt/mTOR signaling. The Journal of steroid biochemistry and molecular biology. vol 146. 2015-04-30. PMID:24787660. |
apoptosis in tumor tissue was detected by the expression of cleaved caspase-3, bcl-2, bad and p53 proteins and confirmed by tunel assay. |
2015-04-30 |
2023-08-13 |
mouse |
| Shuhei Sakata, Shinya Hayashi, Takaaki Fujishiro, Kohei Kawakita, Noriyuki Kanzaki, Shingo Hashimoto, Kenjiro Iwasa, Nobuaki Chinzei, Shinsuke Kihara, Masahiko Haneda, Takeshi Ueha, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosak. Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 33. issue 3. 2015-04-30. PMID:25469820. |
epa inhibited snp-induced chondrocyte apoptosis, caspase 3 and poly(adp-ribose) polymerase cleavage, phosphorylation of p38 mapk and p53, and expression of mmp3 and mmp13. |
2015-04-30 |
2023-08-13 |
mouse |
| Le Jiang, Ning Kon, Tongyuan Li, Shang-Jui Wang, Tao Su, Hanina Hibshoosh, Richard Baer, Wei G. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. vol 520. issue 7545. 2015-04-30. PMID:25799988. |
although p53-mediated cell-cycle arrest, senescence and apoptosis serve as critical barriers to cancer development, emerging evidence suggests that the metabolic activities of p53 are also important. |
2015-04-30 |
2023-08-13 |
mouse |
| Le Jiang, Ning Kon, Tongyuan Li, Shang-Jui Wang, Tao Su, Hanina Hibshoosh, Richard Baer, Wei G. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. vol 520. issue 7545. 2015-04-30. PMID:25799988. |
notably, p53(3kr), an acetylation-defective mutant that fails to induce cell-cycle arrest, senescence and apoptosis, fully retains the ability to regulate slc7a11 expression and induce ferroptosis upon reactive oxygen species (ros)-induced stress. |
2015-04-30 |
2023-08-13 |
mouse |
| Yu Qin, Jiangyue Zhao, Xiaojie Min, Mingwu Wang, Wenting Luo, Di Wu, Qichang Yan, Jing Li, Xinwei Wu, Jinsong Zhan. MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract. Biochimica et biophysica acta. vol 1842. issue 12 Pt A. 2015-04-28. PMID:25312242. |
microrna-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract. |
2015-04-28 |
2023-08-13 |
human |
| Yu Qin, Jiangyue Zhao, Xiaojie Min, Mingwu Wang, Wenting Luo, Di Wu, Qichang Yan, Jing Li, Xinwei Wu, Jinsong Zhan. MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract. Biochimica et biophysica acta. vol 1842. issue 12 Pt A. 2015-04-28. PMID:25312242. |
in vitro, mir-125b regulates human lens epithelial cell apoptosis at least in part by directly targeting p53. |
2015-04-28 |
2023-08-13 |
human |
| Hui-fen Zhou, Yu He, Yu-yan Zhang, Jie-hong Yang, Tao Zhao, Wei Fu, Peng Zhou, Hai-tong Wa. [Protective effect of combined administration of active ingredients of Danhong on cerebral micro-vascular endothelial cell injured by hypoxia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 39. issue 22. 2015-04-28. PMID:25850275. |
after hypoxia, the up-regulated p53 mrna expression could cause retardation in g, phase and promote cell apoptosis. |
2015-04-28 |
2023-08-13 |
mouse |
| Jeyran Shahbazi, Christopher J Scarlett, Murray D Norris, Bing Liu, Michelle Haber, Andrew E Tee, Alice Carrier, Andrew V Biankin, Wendy B London, Glenn M Marshall, Richard B Lock, Tao Li. Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1. Oncotarget. vol 5. issue 12. 2015-04-24. PMID:24952595. |
here we aimed to identify the mechanism through which n-myc overexpressing p53 wild-type neuroblastoma cells acquired resistance to apoptosis. |
2015-04-24 |
2023-08-13 |
human |
| Dong-In Koh, Dohyun Han, Hoon Ryu, Won-Il Choi, Bu-Nam Jeon, Min-Kyeong Kim, Youngsoo Kim, Jin Young Kim, Lee Parry, Alan R Clarke, Albert B Reynolds, Man-Wook Hu. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 42. 2015-04-24. PMID:25288747. |
moreover, the p53 with this particular acetylation pattern shows increased dna binding and potently induces cell cycle arrest and apoptosis by activating transcription of cdkn1a (cyclin-dependent kinase inhibitor 1) and various apoptotic genes. |
2015-04-24 |
2023-08-13 |
mouse |
| D Sorriento, C Del Giudice, A Bertamino, M Ciccarelli, I Gomez-Monterrey, P Campiglia, E Novellino, M Illario, B Trimarco, N De Luca, G Iaccarin. New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53. British journal of cancer. vol 112. issue 1. 2015-04-23. PMID:25422906. |
p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. |
2015-04-23 |
2023-08-13 |
Not clear |
| D Sorriento, C Del Giudice, A Bertamino, M Ciccarelli, I Gomez-Monterrey, P Campiglia, E Novellino, M Illario, B Trimarco, N De Luca, G Iaccarin. New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53. British journal of cancer. vol 112. issue 1. 2015-04-23. PMID:25422906. |
we recently synthesised two new compounds (isa27 and sm13), which block p53-mdm2 interaction and induce apoptosis in p53 wild-type (wt) tumour cells. |
2015-04-23 |
2023-08-13 |
Not clear |
| M Ming, K Soltani, C R Shea, X Li, Y Y H. Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene. vol 34. issue 3. 2015-04-22. PMID:24441046. |
in contrast, homozygous sirt1 deletion in mouse skin augments p53 acetylation and expression of its transcriptional target noxa, and sensitizes the epidermis to uvb-induced apoptosis in vivo, while heterozygous sirt1 deletion has no such effect. |
2015-04-22 |
2023-08-12 |
mouse |
| B C Nair, S R Krishnan, G R Sareddy, M Mann, B Xu, M Natarajan, P Hasty, D Brann, R R Tekmal, R K Vadlamud. Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Cell death and differentiation. vol 21. issue 9. 2015-04-22. PMID:24786831. |
p53 is an important transcription factor and tumor suppressor that has a critical role in dna damage response (ddr) including cell cycle arrest, repair or apoptosis. |
2015-04-22 |
2023-08-13 |
Not clear |
| H Li, Y Zhang, A Ströse, D Tedesco, K Gurova, G Selivanov. Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis. Cell death and differentiation. vol 21. issue 9. 2015-04-22. PMID:24971482. |
in the present study, we performed an integrated analysis of genome-wide short hairpin rna screen and gene expression data and uncovered a previously unrecognized role of sp1 as a central modulator of the transcriptional response induced by p53 that leads to robust induction of apoptosis. |
2015-04-22 |
2023-08-13 |
Not clear |
| Yi Xu, Jin Qi, Xiaoyu Yang, Erxi Wu, Steven Y Qia. Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-γ-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracil's cytotoxicity. Redox biology. vol 2. 2015-04-22. PMID:25114837. |
our study shows that the exclusive dgla׳s free radical derivatives from c-8 oxygenation lead to cell growth inhibition, cell cycle arrest and apoptosis in the human colon cancer cell line hca-7 colony 29, probably by up-regulating the cancer suppressor p53 and the cell cycle inhibitor p27. |
2015-04-22 |
2023-08-13 |
human |
| Ren-Tao Jiang, Chun-Suo Yao, Jin-Ye Bai, Qi Ho. [Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 5. 2015-04-22. PMID:25151729. |
[effects of vam3 on sodium nitroprusside-induced apoptosis and sirt1 and p53 expression in rat articular chondrocytes]. |
2015-04-22 |
2023-08-13 |
rat |
| Ren-Tao Jiang, Chun-Suo Yao, Jin-Ye Bai, Qi Ho. [Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 5. 2015-04-22. PMID:25151729. |
this study indicates vam3 could protect rat articular chondrocytes against snp-induced apoptosis, perhaps through the upregulation of sirt1 and deacetylation of p53. |
2015-04-22 |
2023-08-13 |
rat |