| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason M Beckta, Syed Farhan Ahmad, Hu Yang, Kristoffer Valeri. Revisiting p53 for cancer-specific chemo- and radiotherapy: ten years after. Cell cycle (Georgetown, Tex.). vol 13. issue 5. 2015-05-11. PMID:24526114. |
several studies have reported that mutant or null p53 tumor cells undergo apoptosis more easily than genetically matched, normal p53 counterparts when inhibiting a specific stress kinase in combination with standard chemotherapy or when exposed to an ataxia-telangiectasia mutated (atm) kinase inhibitor and radiation, thus achieving true cancer specificity in animal tumor models. |
2015-05-11 |
2023-08-12 |
Not clear |
| Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Sha. Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the proliferation of hepatoma cells. Mutation research. vol 763-764. 2015-05-11. PMID:24657251. |
moreover, this increase of apoptosis was associated with the activation of p53 and p21 accompanied by a decreased ratio of bcl-2/bax and up-regulation of phosphorylated c-jun n-terminal kinase (jnk) and caspase-3 activity. |
2015-05-11 |
2023-08-12 |
Not clear |
| Mingyuan He, Chen Dong, Yuexia Xie, Jitao Li, Dexiao Yuan, Yang Bai, Chunlin Sha. Reciprocal bystander effect between α-irradiated macrophage and hepatocyte is mediated by cAMP through a membrane signaling pathway. Mutation research. vol 763-764. 2015-05-11. PMID:24657252. |
moreover, the bystander apoptosis in hl-7702 cells was aggravated by camp inhibition but it could not be evoked when p53 of hl-7702 cells was knocked down no matter of forskolin and kh-7 treatment. |
2015-05-11 |
2023-08-12 |
human |
| Lanlan Wei, Anastacia M Griego, Ming Chu, Michelle A Ozbu. Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes. Carcinogenesis. vol 35. issue 10. 2015-05-11. PMID:25064354. |
as expected from loss of p53 activity in tobacco-exposed cells, dna strand breaks were significantly higher but apoptosis was minimal compared with cells containing integrated viral genomes. |
2015-05-11 |
2023-08-13 |
human |
| Hui-Ching Chuang, Liang Peng Yang, Alison L Fitzgerald, Abdullah Osman, Sang Hyeok Woo, Jeffrey N Myers, Heath D Skinne. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells. PloS one. vol 9. issue 8. 2015-05-11. PMID:25119136. |
restoring normal p53 function has previously been investigated via the use of rita (reactivation of p53 and induction of tumor cell apoptosis), a small molecule that induces a conformational change in p53, leading to activation of its downstream targets. |
2015-05-11 |
2023-08-13 |
Not clear |
| Kemal Alpay, Mehdi Farshchian, Johanna Tuomela, Jouko Sandholm, Kaappo Aittokallio, Elina Siljamäki, Marko Kallio, Veli-Matti Kähäri, Sakari Hietane. Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone. PloS one. vol 9. issue 8. 2015-05-11. PMID:25148385. |
the combination treatment resulted in caspase activation and apoptosis, but this effect did not depend on either p53 or p73 activity. |
2015-05-11 |
2023-08-13 |
human |
| Ying Shen, Shuilian Zhang, Xiaobin Huang, Kailin Chen, Jing Shen, Zhengyang Wan. Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells. BioMed research international. vol 2014. 2015-05-11. PMID:25215298. |
we further reintroduced the wild-type p53 into the transformed cells, and the malignant proliferation can be abrogated by inducing cell cycle arrest and apoptosis. |
2015-05-11 |
2023-08-13 |
human |
| Avinashnarayan Venkatanarayan, Payal Raulji, William Norton, Deepavali Chakravarti, Cristian Coarfa, Xiaohua Su, Santosh K Sandur, Marc S Ramirez, Jaehuk Lee, Charles V Kingsley, Eliot F Sananikone, Kimal Rajapakshe, Katherine Naff, Jan Parker-Thornburg, James A Bankson, Kenneth Y Tsai, Preethi H Gunaratne, Elsa R Flore. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. vol 517. issue 7536. 2015-05-11. PMID:25409149. |
the p53 family interacts extensively in cellular processes that promote tumour suppression, such as apoptosis and autophagy, thus a clear understanding of this interplay in cancer is needed to treat tumours with alterations in the p53 pathway. |
2015-05-11 |
2023-08-13 |
mouse |
| Daniela Montariello, Annaelena Troiano, Daniela Di Girolamo, Sascha Beneke, Viola Calabrò, Piera Quesad. Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells. Biochemical pharmacology. vol 94. issue 3. 2015-05-11. PMID:25667043. |
depending on their genetic background (p53(wt) versus p53(null)), carcinoma cells are more or less sensitive to drug-induced cell cycle arrest and/or apoptosis. |
2015-05-11 |
2023-08-13 |
Not clear |
| Daniela Montariello, Annaelena Troiano, Daniela Di Girolamo, Sascha Beneke, Viola Calabrò, Piera Quesad. Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells. Biochemical pharmacology. vol 94. issue 3. 2015-05-11. PMID:25667043. |
all together our results suggest that in cancer cells parp inhibitor(s) can operate in the choice between growth arrest and apoptosis by modulating p53 family-dependent signal. |
2015-05-11 |
2023-08-13 |
Not clear |
| Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Lia. Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25511237. |
overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents. |
2015-05-09 |
2023-08-13 |
mouse |
| Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Lia. Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25511237. |
the ankrd1 (ankyrin repeat domain 1) gene is known to be up-regulated in heart failure and acts as a co-activator of p53, modulating its transcriptional activity, but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. |
2015-05-09 |
2023-08-13 |
mouse |
| Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Lia. Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25511237. |
in the presence of angii in nrcs, infection with a recombinant adenovirus containing rat ankrd1 cdna (ad-ankrd1) enhanced the mitochondrial translocation of bax and phosphorylated p53, increased mitochondrial permeability and cardiomyocyte apoptosis, and reduced cell viability, whereas these effects were antagonized by silencing of ankrd1. |
2015-05-09 |
2023-08-13 |
mouse |
| Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Lia. Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25511237. |
cardiomyocyte apoptosis and the expression of phosphorylated p53 were also significantly increased in ad-ankrd1-infected tac mice, whereas knockdown of ankrd1 significantly inhibited the apoptotic signal pathway as well as cardiomyocyte apoptosis in pressure-overload mice. |
2015-05-09 |
2023-08-13 |
mouse |
| Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Lia. Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25511237. |
these findings indicate that overexpression of ankrd1 exacerbates pathological cardiac dysfunction through enhancement of cardiomyocyte apoptosis mediated by the up-regulation of p53. |
2015-05-09 |
2023-08-13 |
mouse |
| Ines Müller, Stefan Beissert, Dagmar Kulm. Anti-apoptotic NF-κB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production. The Journal of investigative dermatology. vol 135. issue 3. 2015-05-08. PMID:25380350. |
using the non-transformed keratinocyte cell line hacat, we shed light on the interplay between p53 and nf-κb by providing clear evidence that chronically activated nf-κb together with designated "gain of function" mutp53 promotes apoptosis via cooperative tumor necrosis factor (tnf) production in response to uvb+il-1. |
2015-05-08 |
2023-08-13 |
human |
| Carlotta Giorgi, Massimo Bonora, Giovanni Sorrentino, Sonia Missiroli, Federica Poletti, Jan M Suski, Fabian Galindo Ramirez, Rosario Rizzuto, Francesco Di Virgilio, Ester Zito, Pier Paolo Pandolfi, Mariusz R Wieckowski, Fabio Mammano, Giannino Del Sal, Paolo Pinto. p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 6. 2015-05-08. PMID:25624484. |
p53 at the endoplasmic reticulum regulates apoptosis in a ca2+-dependent manner. |
2015-05-08 |
2023-08-13 |
Not clear |
| Carlotta Giorgi, Massimo Bonora, Giovanni Sorrentino, Sonia Missiroli, Federica Poletti, Jan M Suski, Fabian Galindo Ramirez, Rosario Rizzuto, Francesco Di Virgilio, Ester Zito, Pier Paolo Pandolfi, Mariusz R Wieckowski, Fabio Mammano, Giannino Del Sal, Paolo Pinto. p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 6. 2015-05-08. PMID:25624484. |
activated by a variety of stimuli, p53 regulates cell-cycle arrest and apoptosis. |
2015-05-08 |
2023-08-13 |
Not clear |
| Carlotta Giorgi, Massimo Bonora, Giovanni Sorrentino, Sonia Missiroli, Federica Poletti, Jan M Suski, Fabian Galindo Ramirez, Rosario Rizzuto, Francesco Di Virgilio, Ester Zito, Pier Paolo Pandolfi, Mariusz R Wieckowski, Fabio Mammano, Giannino Del Sal, Paolo Pinto. p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 6. 2015-05-08. PMID:25624484. |
these findings define a critical nonnuclear function of p53 in regulating ca(2+) signal-dependent apoptosis. |
2015-05-08 |
2023-08-13 |
Not clear |
| Rana Abu-Dahab, Maha R Abdallah, Violet Kasabri, Nizar M Mhaidat, Fatma U Afif. Mechanistic studies of antiproliferative effects of Salvia triloba and Salvia dominica (Lamiaceae) on breast cancer cell lines (MCF7 and T47D). Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 69. issue 11-12. 2015-05-08. PMID:25854764. |
the mechanism of apoptosis was further investigated by determining the levels of p53, p21/waf1, fasl (fas ligand), and sfas (fas/apo-1). |
2015-05-08 |
2023-08-13 |
Not clear |