| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Liu, Rui Chen, Nan Zhang, Xianlong Ye, Yin Bai, Yuquan Wei, Guiping Ren, Deshan L. [Anti-tumor efficacy of P53 with 9R cell-penetrating peptides]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 29. issue 7. 2015-05-16. PMID:24195362. |
the apoptosis experiment showed that p53 could induce apoptosis of tumor cells. |
2015-05-16 |
2023-08-12 |
Not clear |
| Yuan Liu, Rui Chen, Nan Zhang, Xianlong Ye, Yin Bai, Yuquan Wei, Guiping Ren, Deshan L. [Anti-tumor efficacy of P53 with 9R cell-penetrating peptides]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 29. issue 7. 2015-05-16. PMID:24195362. |
compared with the p53, cpps-p53 had a more significant effect in inducing cell apoptosis (**p < 0.01). |
2015-05-16 |
2023-08-12 |
Not clear |
| Yuan Liu, Rui Chen, Nan Zhang, Xianlong Ye, Yin Bai, Yuquan Wei, Guiping Ren, Deshan L. [Anti-tumor efficacy of P53 with 9R cell-penetrating peptides]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 29. issue 7. 2015-05-16. PMID:24195362. |
the cpps-p53 shows more significant effects than p53 in inhibiting cell growth and inducing apoptosis on tumor cells. |
2015-05-16 |
2023-08-12 |
Not clear |
| Bernat Crosa. Deubiquitinating enzyme inhibitors and their potential in cancer therapy. Current cancer drug targets. vol 14. issue 6. 2015-05-15. PMID:25088039. |
very active research in this field in the last decade shows that deubiquitinating enzymes play important regulatory roles in aspects relevant to cancer, such as proteasome activity, p53 stability, the regulation of fanconi anemia related proteins, tumor cell apoptosis induction, to mention a few. |
2015-05-15 |
2023-08-13 |
Not clear |
| WenLi Mu, QingJun Zhang, XiaoQiang Tang, WenYan Fu, Wei Zheng, YunBiao Lu, HongLiang Li, YuSheng Wei, Li Li, ZhiGang She, HouZao Chen, DePei Li. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. Science China. Life sciences. vol 57. issue 9. 2015-05-15. PMID:25104317. |
furthermore, we show that cardiomyocyte apoptosis caused by suppression of sirt1 activity is, at least in part, due to increased p53 acetylation and upregulated bax expression. |
2015-05-15 |
2023-08-13 |
mouse |
| Jiao Wang, Rongrong Zhu, Xiaoyu Sun, Yanjing Zhu, Hui Liu, Shi-Long Wan. Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria-mediated apoptosis pathway. International journal of nanomedicine. vol 9. 2015-05-15. PMID:25187702. |
moreover, results demonstrated that the mechanisms of vp16-slns were similar to those claimed for free vp16, including induction of cellular apoptosis by activation of p53, release of cytochrome c, loss of membrane potential, and activation of caspases. |
2015-05-15 |
2023-08-13 |
Not clear |
| Jing Li, Weixing Qu, Yongyi Cheng, Yi Sun, Yazhuo Jiang, Tiejun Zou, Zhiping Wang, Yonggang Xu, Huacai Zha. The inhibitory effect of intravesical fisetin against bladder cancer by induction of p53 and down-regulation of NF-kappa B pathways in a rat bladder carcinogenesis model. Basic & clinical pharmacology & toxicology. vol 115. issue 4. 2015-05-14. PMID:24646039. |
we found that fisetin-induced apoptosis in bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of nf-κb pathway activity, causing changes in the ratio of pro- and antiapoptotic proteins. |
2015-05-14 |
2023-08-12 |
rat |
| Jing Li, Weixing Qu, Yongyi Cheng, Yi Sun, Yazhuo Jiang, Tiejun Zou, Zhiping Wang, Yonggang Xu, Huacai Zha. The inhibitory effect of intravesical fisetin against bladder cancer by induction of p53 and down-regulation of NF-kappa B pathways in a rat bladder carcinogenesis model. Basic & clinical pharmacology & toxicology. vol 115. issue 4. 2015-05-14. PMID:24646039. |
our study suggests that the activation of p53 and inhibition of the nf-κb pathway may play important roles in the fisetin-induced apoptosis in bladder cancer. |
2015-05-14 |
2023-08-12 |
rat |
| Yan Ma, Dan Liu, Dun Wang, Yongjun Wang, Qiang Fu, John K Fallon, Xinggang Yang, Zhonggui He, Feng Li. Combinational delivery of hydrophobic and hydrophilic anticancer drugs in single nanoemulsions to treat MDR in cancer. Molecular pharmaceutics. vol 11. issue 8. 2015-05-14. PMID:24712391. |
the improvements in therapeutic response over either ptx-ve or 5-fu-tpgs therapy alone were demonstrated by the ability to effectively induce the apoptosis of tumor cells via up-regulation of tumor suppressor p53 and β-tubulin and by the significant inhibition of cell cycle progression. |
2015-05-14 |
2023-08-13 |
mouse |
| Periyasamy Giridharan, Shilpa A Verekar, Akash R Gohil, Prabhu Dutt Mishra, Amit Khanna, Sunil Kumar Deshmuk. Antiproliferative activity of hamigerone and radicinol isolated from Bipolaris papendorfii. BioMed research international. vol 2014. 2015-05-14. PMID:25184147. |
furthermore we have also noted that both compounds showed increase in apoptosis by favorably modulating both tumor suppressor protein (p53) and antiapoptic protein (bcl-2), and in turn increase caspase-3 expression in cancer cells. |
2015-05-14 |
2023-08-13 |
Not clear |
| Sui Hu, Baoping Cao, Meiying Zhang, Enqiang Linghu, Qimin Zhan, Malcolm V Brock, James G Herman, Gaoping Mao, Mingzhou Gu. Epigenetic silencing BCL6B induced colorectal cancer proliferation and metastasis by inhibiting P53 signaling. American journal of cancer research. vol 5. issue 2. 2015-05-14. PMID:25973304. |
bcl6b activated p53 signaling and induced apoptosis, re-expression of bcl6b sensitized rko and ht29 cells to 5-fluorouracil. |
2015-05-14 |
2023-08-13 |
human |
| Fabian Schumacher, Simone Florian, Anke Schnapper, Bernhard H Monien, Inga Mewis, Monika Schreiner, Albrecht Seidel, Wolfram Engst, Hansruedi Glat. A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells. Archives of toxicology. vol 88. issue 3. 2015-05-12. PMID:24154822. |
adduct formation in caecum was associated with massive apoptosis, p53 activation and p21 induction, in particular after treatment with 1-mim alcohol. |
2015-05-12 |
2023-08-12 |
mouse |
| Ivanildce C Ireno, Cindy Baumann, Regina Stöber, Jan G Hengstler, Lisa Wiesmülle. Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells. Archives of toxicology. vol 88. issue 5. 2015-05-12. PMID:24671466. |
using this substrate, we screened various human tumor and non-transformed cell types differing in the dna damage response, which revealed that detection of genotoxic carcinogens was independent of the p53 status but abrogated by apoptosis. |
2015-05-12 |
2023-08-12 |
human |
| Meriam Haoues, Amira Refai, Aude Mallavialle, M Ridha Barbouche, Nizar Laabidi, Marcel Deckert, Makram Essaf. Forkhead box O3 (FOXO3) transcription factor mediates apoptosis in BCG-infected macrophages. Cellular microbiology. vol 16. issue 9. 2015-05-12. PMID:24712562. |
finally, real-time quantitative pcr (qrt-pcr) analysis of the expression profile of bcg-infected macrophages showed an upregulation of two pro-apoptotic targets of foxo3, noxa and p53 upregulated modulator of apoptosis (puma). |
2015-05-12 |
2023-08-13 |
human |
| Hao Liu, Jiang Yin, Chengkun Wang, Yixue Gu, Min Deng, Zhimin H. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anti-cancer drugs. vol 25. issue 8. 2015-05-12. PMID:24814195. |
furthermore, activation of foxo3a induced cell apoptosis irrespective of p53 status, whereas p53 may act as foxo3a downstream molecules involved in cisplatin-induced cell apoptosis. |
2015-05-12 |
2023-08-13 |
human |
| Aijaz Rashid, Guddekoppa S Ananthnag, Susmita Naik, Joel T Mague, Dulal Panda, Maravanji S Balakrishn. Dinuclear Cu(I) complexes of pyridyl-diazadiphosphetidines and aminobis(phosphonite) ligands: synthesis, structural studies and antiproliferative activity towards human cervical, colon carcinoma and breast cancer cells. Dalton transactions (Cambridge, England : 2003). vol 43. issue 29. 2015-05-12. PMID:24922341. |
the experimental evidence clearly indicated that these compounds initiated apoptosis, which is mediated through the p53 pathway. |
2015-05-12 |
2023-08-13 |
human |
| Hyunji Lee, Hyunjung Lee, Hyunjung Chin, Kyoungmi Kim, Daekee Le. ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:24970817. |
in addition, erbb3 knockdown-induced cell cycle arrest was observed in most colon cancer cells but was accompanied by apoptosis in p53 wild-type cells. |
2015-05-12 |
2023-08-13 |
Not clear |
| Christopher L Daige, Jason F Wiggins, Leslie Priddy, Terri Nelligan-Davis, Jane Zhao, David Brow. Systemic delivery of a miR34a mimic as a potential therapeutic for liver cancer. Molecular cancer therapeutics. vol 13. issue 10. 2015-05-12. PMID:25053820. |
mir34a is a tumor-suppressor mirna that functions within the p53 pathway to regulate cell-cycle progression and apoptosis. |
2015-05-12 |
2023-08-13 |
Not clear |
| Yuanyuan Zhang, Yuqi Wang, Youheng Wei, Jian Ma, Jingtao Peng, Reziya Wumaier, Suqin Shen, Pingzhao Zhang, Long Y. The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly. Biochemical and biophysical research communications. vol 458. issue 3. 2015-05-12. PMID:25660448. |
here we report that aspp1 and aspp2, two members of the apoptosis stimulating proteins of p53 (aspp) family, are involved in centrosome linker reassembly. |
2015-05-12 |
2023-08-13 |
Not clear |
| Jason M Beckta, Syed Farhan Ahmad, Hu Yang, Kristoffer Valeri. Revisiting p53 for cancer-specific chemo- and radiotherapy: ten years after. Cell cycle (Georgetown, Tex.). vol 13. issue 5. 2015-05-11. PMID:24526114. |
at the time, the approach was to introduce a normal p53 gene into mutant p53 (mp53) tumor cells to induce cell cycle arrest and apoptosis. |
2015-05-11 |
2023-08-12 |
Not clear |