| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minh Truong Do, Hyung Gyun Kim, Jae Ho Choi, Hye Gwang Jeon. Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24970682. |
furthermore, upregulation of death receptor 5 by metformin-mediated sirt1 downregulation enhanced the sensitivity of wild-type p53 cancer cells to trail-induced apoptosis. |
2015-06-01 |
2023-08-13 |
human |
| Minh Truong Do, Hyung Gyun Kim, Jae Ho Choi, Hye Gwang Jeon. Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24970682. |
our results demonstrated that metformin induces mir-34a to suppress the sirt1/pgc-1α/nrf2 pathway and increases susceptibility of wild-type p53 cancer cells to oxidative stress and trail-induced apoptosis. |
2015-06-01 |
2023-08-13 |
human |
| Xu-Hui Zhou, Chao-Qun Yang, Cheng-Lin Zhang, Yang Gao, Hong-Bin Yuan, Ce Wan. RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling. Oncology reports. vol 32. issue 4. 2015-06-01. PMID:25109282. |
a gain-of-function approach was used to observe the effects of lentiviral vector-mediated overexpression of rassf5 (lv-rassf5) on cell growth, invasion and apoptosis, respectively, as indicated by mtt, transwell and flow cytometry assays, and the expression levels of mammalian sterile 20-like (mst1) kinase, large tumor suppressor 1 (lats1), proliferating cell nuclear antigen (pcna), matrix metallopeptidase-9 (mmp-9) and p53 were detected by real-time pcr and western blot assays in os cells (mg-63 and u-2 os). |
2015-06-01 |
2023-08-13 |
human |
| Xu-Hui Zhou, Chao-Qun Yang, Cheng-Lin Zhang, Yang Gao, Hong-Bin Yuan, Ce Wan. RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling. Oncology reports. vol 32. issue 4. 2015-06-01. PMID:25109282. |
overexpression of rassf5 markedly suppressed cell proliferation and invasion, and induced cell apoptosis in the os cell lines with increased expression of mst1, lats1 and p53 and decreased expression of pcna and mmp-9. |
2015-06-01 |
2023-08-13 |
human |
| Somnath Singha Roy, Pramita Chakraborty, Jaydip Biswas, Sudin Bhattachary. 2-[5-Selenocyanato-pentyl]-6-amino-benzo[de]isoquinoline-1,3-dione inhibits angiogenesis, induces p53 dependent mitochondrial apoptosis and enhances therapeutic efficacy of cyclophosphamide. Biochimie. vol 105. 2015-05-29. PMID:25038569. |
2-[5-selenocyanato-pentyl]-6-amino-benzo[de]isoquinoline-1,3-dione inhibits angiogenesis, induces p53 dependent mitochondrial apoptosis and enhances therapeutic efficacy of cyclophosphamide. |
2015-05-29 |
2023-08-13 |
mouse |
| Somnath Singha Roy, Pramita Chakraborty, Jaydip Biswas, Sudin Bhattachary. 2-[5-Selenocyanato-pentyl]-6-amino-benzo[de]isoquinoline-1,3-dione inhibits angiogenesis, induces p53 dependent mitochondrial apoptosis and enhances therapeutic efficacy of cyclophosphamide. Biochimie. vol 105. 2015-05-29. PMID:25038569. |
these results suggested that p53 dependent mitochondrial pathway was playing an important role in anos induced apoptosis of tumor cells. |
2015-05-29 |
2023-08-13 |
mouse |
| Alba Pérez-Perarnau, Sara Preciado, Claudia Mariela Palmeri, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Diana M González-Gironès, Miriam Miguel, Satoki Karasawa, Satoshi Sakamoto, Ana M Cosialls, Camila Rubio-Patiño, José Saura-Esteller, Rosario Ramón, Laia Caja, Isabel Fabregat, Gabriel Pons, Hiroshi Handa, Fernando Albericio, Joan Gil, Rodolfo Lavill. A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins. Angewandte Chemie (International ed. in English). vol 53. issue 38. 2015-05-29. PMID:25196378. |
with an ec50 in the low micromolar range, these compounds proved to be potent inducers of apoptosis in a broad spectrum of tumor cell lines, regardless of the functional status of p53. |
2015-05-29 |
2023-08-13 |
Not clear |
| Liyuan Zhang, Zhenhong Zhu, Jianhua Liu, Zhengqiu Zhu, Zhao H. Protective effect of N-acetylcysteine (NAC) on renal ischemia/reperfusion injury through Nrf2 signaling pathway. Journal of receptor and signal transduction research. vol 34. issue 5. 2015-05-28. PMID:24734887. |
furthermore, nac significantly decreased cleaved caspase 3, p53 and renal epithelial tubular cell apoptosis. |
2015-05-28 |
2023-08-13 |
Not clear |
| Maryam Kamarehei, Razieh Yazdanparas. Modulation of notch signaling pathway to prevent H2O2/menadione-induced SK-N-MC cells death by EUK134. Cellular and molecular neurobiology. vol 34. issue 7. 2015-05-28. PMID:25005833. |
inhibition of nicd production proved that notch signaling is involved in apoptosis through p53 activation. |
2015-05-28 |
2023-08-13 |
Not clear |
| Reiko Kurotani, Reika Shima, Yuki Miyano, Satoshi Sakahara, Yoshie Matsumoto, Yoko Shibata, Hiroyuki Abe, Shioko Kimur. SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation. Acta histochemica et cytochemica. vol 48. issue 2. 2015-05-28. PMID:26019375. |
scgb3a2 inhibits acrolein-induced apoptosis through decreased p53 phosphorylation. |
2015-05-28 |
2023-08-13 |
mouse |
| Reiko Kurotani, Reika Shima, Yuki Miyano, Satoshi Sakahara, Yoshie Matsumoto, Yoko Shibata, Hiroyuki Abe, Shioko Kimur. SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation. Acta histochemica et cytochemica. vol 48. issue 2. 2015-05-28. PMID:26019375. |
it causes lung injury through altering apoptosis and causes inflammation by augmenting p53 phosphorylation and producing reactive oxygen species (ros). |
2015-05-28 |
2023-08-13 |
mouse |
| Reiko Kurotani, Reika Shima, Yuki Miyano, Satoshi Sakahara, Yoshie Matsumoto, Yoko Shibata, Hiroyuki Abe, Shioko Kimur. SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation. Acta histochemica et cytochemica. vol 48. issue 2. 2015-05-28. PMID:26019375. |
acrolein increased the production of ros and phosphorylation of p53 and induced apoptosis in mlg cells. |
2015-05-28 |
2023-08-13 |
mouse |
| Reiko Kurotani, Reika Shima, Yuki Miyano, Satoshi Sakahara, Yoshie Matsumoto, Yoko Shibata, Hiroyuki Abe, Shioko Kimur. SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation. Acta histochemica et cytochemica. vol 48. issue 2. 2015-05-28. PMID:26019375. |
these results demonstrate that scgb3a2 inhibited acrolein-induced apoptosis through decreased p53 phosphorylation, not altered ros levels. |
2015-05-28 |
2023-08-13 |
mouse |
| Lili Wei, Dave Hoole, Baojian Su. Identification of apoptosis-related genes and transcription variations in response to microcystin-LR in zebrafish liver. Toxicology and industrial health. vol 30. issue 9. 2015-05-27. PMID:23064767. |
the messenger rna abundance of some apoptosis-related genes was found to be increased, including five tumor necrosis factor (tnf)-related members (apoptosis regulatory protein siva, tumor necrosis factor-α (tnfa) tnf (ligand) superfamily member 10 (tnfsf10), tnf-inducible protein 6 (tnfaip6) and tnf receptor associated factor 2 binding protein (traf2bp)), three p53-related genes (tumor protein p53 inducible nuclear protein 1 (tp53inp1), p53-induced protein phosphatase 1 (ppm1d) and a novel apoptosis stimulating protein of p53 (aspp2)), bcl 2 family members (proapoptosis gene bax and antiapoptosis gene mcl 1), caspases (caspase y (caspy) and a pyd and card domain-containing protein (pycard)) and the transforming growth factor beta (tgf-β) induced apoptosis protein 2 (taip2). |
2015-05-27 |
2023-08-12 |
zebrafish |
| Marilù Sinisi, Valentina Gandin, Teresa Saltarella, Francesco P Intini, Concetta Pacifico, Christine Marzano, Giovanni Natil. Synthesis, characterization, and biological activity of platinum II, III, and IV pivaloamidine complexes. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 19. issue 7. 2015-05-27. PMID:24850131. |
in addition, cellular uptake and dna binding, perturbations of cell cycle progression, induction of apoptosis, and p53 activation were investigated for the most promising compound trans-[ptcl2(nh3){z-hn=c(t-bu)nh2}]. |
2015-05-27 |
2023-08-13 |
Not clear |
| Shobhan Gaddameedhi, Christopher P Selby, Michael G Kemp, Rui Ye, Aziz Sanca. The circadian clock controls sunburn apoptosis and erythema in mouse skin. The Journal of investigative dermatology. vol 135. issue 4. 2015-05-27. PMID:25431853. |
early-morning exposure to uv also produced maximal activation of ataxia telangiectasia mutated and rad3-related (atr)-mediated dna damage checkpoint signaling, including activation of the tumor suppressor p53, which is known to control the process of sunburn apoptosis. |
2015-05-27 |
2023-08-13 |
mouse |
| Tarun Keswani, Soham Mitra, Arindam Bhattacharyy. Copper-induced immunotoxicity involves cell cycle arrest and cell death in the liver. Environmental toxicology. vol 30. issue 4. 2015-05-26. PMID:24170445. |
in addition, the copper treatments altered the expression of apoptotic markers, further ros generation and mitochondrial trans-membrane potential changes promote intrinsic pathway of apoptosis that was p53 independent. |
2015-05-26 |
2023-08-12 |
mouse |
| Kimberly M Sutton, Anna L Greenshields, David W Hoski. Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53. Nutrition and cancer. vol 66. issue 3. 2015-05-26. PMID:24579801. |
thymoquinone, a bioactive component of black caraway seeds, causes g1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53. |
2015-05-26 |
2023-08-12 |
Not clear |
| Pinaki B Patel, Vasudev R Thakka. L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines. Nutrition and cancer. vol 66. issue 3. 2015-05-26. PMID:24611509. |
l-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines. |
2015-05-26 |
2023-08-12 |
Not clear |
| Pinaki B Patel, Vasudev R Thakka. L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines. Nutrition and cancer. vol 66. issue 3. 2015-05-26. PMID:24611509. |
the increased level of p53, bad, cleaved caspase 3, and cleaved parp explained p53 and caspase-mediated apoptosis. |
2015-05-26 |
2023-08-12 |
Not clear |