| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linbo Wang, Yang Zeng, Ye Liu, Xuansheng Hu, Shuhong Li, Yuepeng Wang, Ling Li, Zhongfang Lei, Zhenya Zhan. Fucoxanthin induces growth arrest and apoptosis in human bladder cancer T24 cells by up-regulation of p21 and down-regulation of mortalin. Acta biochimica et biophysica Sinica. vol 46. issue 10. 2015-06-09. PMID:25187415. |
mtt analysis results showed that 5 and 10 μm fucoxanthin inhibited the proliferation of t24 cells in a dose- and time-dependent manner accompanied by the growth arrest at g0/g1 phase of cell cycle, which is mediated by the up-regulation of p21, a cyclin-dependent kinase (cdk)-inhibitory protein and the down-regulation of cdk-2, cdk-4, cyclin d1, and cyclin e. in addition, 20 and 40 μm fucoxanthin induced apoptosis of t24 cells by the abrogation of mortalin-p53 complex and the reactivation of nuclear mutant-type p53, which also had tumor suppressor function as wild-type p53. |
2015-06-09 |
2023-08-13 |
human |
| Peimei Zou, Jian Song, Bei Jiang, Fei Pei, Binbin Chen, Xiangdong Yang, Guangyi Liu, Zhao H. Epigallocatechin-3-gallate protects against cisplatin nephrotoxicity by inhibiting the apoptosis in mouse. International journal of clinical and experimental pathology. vol 7. issue 8. 2015-06-09. PMID:25197333. |
egcg also inhibited the expression of the ligand of death receptor fas (fas-l), apoptosis regulator bax (bax) and tumor-suppressor protein p53, and increased the expression of b-cell lymphoma 2 (bcl-2). |
2015-06-09 |
2023-08-13 |
mouse |
| Ian Henry Lambert, Maria Stine Enghoff, Marie-Luise Brandi, Else Kay Hoffman. Regulation of p53 in NIH3T3 mouse fibroblasts following hyperosmotic stress. Physiological reports. vol 3. issue 6. 2015-06-09. PMID:26056062. |
caspase-3 activity increased gradually with hypertonicity and at 737 mosm both caspase-3 activity and annexin v binding are high even though p53 expression and activity are low, indicating that initiation of apoptosis under severe hypertonic conditions is not strictly controlled by p53. |
2015-06-09 |
2023-08-13 |
mouse |
| M P Fatt, G I Cancino, F D Miller, D R Kapla. p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells. Cell death and differentiation. vol 21. issue 10. 2015-06-08. PMID:24809925. |
together, these studies demonstrate that p63 and p73 cooperate to maintain adult npc pools through regulation of p53 function; p63 antagonizes p53 to promote cellular survival, whereas p73 regulates self-renewal and p53-mediated apoptosis versus senescence. |
2015-06-08 |
2023-08-13 |
mouse |
| Priyadharsini Nagarajan, Kathleen L Tober, Judith A Riggenbach, Donna F Kusewitt, Amy M Lehman, Thais Sielecki, James Pruitt, Abhay R Satoskar, Tatiana M Oberyszy. MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma. Molecular cancer research : MCR. vol 12. issue 9. 2015-06-05. PMID:24850900. |
in addition to decreasing skin thickness and myeloperoxidase (mpo) activity, cpsi-1306 pretreatment increased keratinocyte apoptosis and p53 expression, decreased proliferation and phosphohistone variant h2ax (γ-h2ax), and enhanced repair of cyclobutane pyrimidine dimers. |
2015-06-05 |
2023-08-13 |
mouse |
| Harish Potu, Luke F Peterson, Anupama Pal, Monique Verhaegen, Juxiang Cao, Moshe Talpaz, Nicholas J Donat. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. vol 5. issue 14. 2015-06-05. PMID:24980819. |
overall, our results demonstrate that braf activates usp5 to suppress cell cycle checkpoint control and apoptosis by blocking p53 and fas induction; all of which can be restored by small molecule-mediated usp5 inhibition. |
2015-06-05 |
2023-08-13 |
mouse |
| Mohammad-Taher Moradi, Zivar Salehi, Keyvan Aminian, Abbas Yazdanbo. Effects of p53 codon 72 and MDM2 SNP309 polymorphisms on gastric cancer risk among the Iranian population. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 17. 2015-06-05. PMID:25227851. |
the p53 tumor suppressor protein is involved in cell-cycle control, apoptosis and dna repair. |
2015-06-05 |
2023-08-13 |
Not clear |
| Yikai Zhang, Shanyuan Zheng, Sai-Ming Ngai, Wenjie Zheng, Jinying Li, Tianfeng Chen, Xueyun Zhon. A novel selenadiazole derivative induces apoptosis in human glioma cells by dephosphorylation of AKT. Chemical & pharmaceutical bulletin. vol 62. issue 10. 2015-06-05. PMID:25273058. |
further mechanistic investigation showed that bsbd treatment induced dephosphorylation of akt and dna damage-mediated activation of p53, leading to extensive apoptosis through the mitochondrial pathway. |
2015-06-05 |
2023-08-13 |
human |
| Frank Ziemann, Andrea Arenz, Stefanie Preising, Claus Wittekindt, Jens P Klussmann, Rita Engenhart-Cabillic, Andrea Witti. Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation ± Cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis. American journal of cancer research. vol 5. issue 3. 2015-06-05. PMID:26045983. |
therefore, the response of four hpv-positive (hpv+) (um-scc-47, um-scc-104, 93-vu-147t, upci:scc152) and four hpv-negative (hpv-) (ud-scc-1, um-scc-6, um-scc-11b, ut-scc-33) hnscc cell lines to x-irradiation ± cisplatin incubation in terms of clonogenic survival, cell cycle progression, protein expression (cyclin a2, cyclin e2, e6, e7, p53) and induction of apoptosis, was investigated. |
2015-06-05 |
2023-08-13 |
human |
| A Weilbacher, M Gutekunst, M Oren, W E Aulitzky, H van der Kui. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38. Cell death & disease. vol 5. 2015-06-04. PMID:25010984. |
we investigated effects of rita on apoptosis, cell cycle and induction of 45 p53 target genes in a panel of 14 cell lines from different tumor entities with different p53 status as well as primary lymphocytes and fibroblasts. |
2015-06-04 |
2023-08-13 |
Not clear |
| K Liu, Y Shi, X Guo, S Wang, Y Ouyang, M Hao, D Liu, L Qiao, N Li, J Zheng, D Che. CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2. Cell death & disease. vol 5. 2015-06-04. PMID:25032846. |
apoptosis-stimulating protein of p53-2 (aspp2) induces apoptosis by promoting the expression of pro-apoptotic genes via binding to p53 or p73; however, the exact mechanisms by which aspp2 induces apoptotic death in hepatoma cells are still unclear. |
2015-06-04 |
2023-08-13 |
Not clear |
| S-L Peng, D-B Yao, Y Zhao, F Xu, C-J Jia, Y-Q Xu, C-L Da. Prognostic value of PUMA expression in patients with HBV-related hepatocellular carcinoma. European review for medical and pharmacological sciences. vol 19. issue 1. 2015-06-04. PMID:25635973. |
the p53 upregulated modulator of apoptosis (puma) is a potent apoptosis inducer that is downexpressed in various tumor types. |
2015-06-04 |
2023-08-13 |
Not clear |
| Karina J Matissek, Abood Okal, Mohanad Mossalam, Carol S Li. Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax. Pharmaceutical research. vol 31. issue 9. 2015-06-03. PMID:24633417. |
the purpose of this work was to determine if mitochondrial targeting signals (mtss) from pro-apoptotic bak and bax are capable of targeting p53 to the mitochondria and inducing rapid apoptosis. |
2015-06-03 |
2023-08-12 |
Not clear |
| Jing Gao, Jin Gao, Lan Qian, Xia Wang, Mingyuan Wu, Yang Zhang, Hao Ye, Shunying Zhu, Yan Yu, Wei Ha. Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil. Cancer biology & therapy. vol 15. issue 8. 2015-06-03. PMID:24800927. |
mechanistically, cxcl4mab reduced the apoptosis of the crypt epithelia by suppression of the 5-fu-induced expression of p53 and bax through its receptor cxcr3. |
2015-06-03 |
2023-08-13 |
mouse |
| Erin R Wissing, Justin G Boyer, Jennifer Q Kwong, Michelle A Sargent, Jason Karch, Elizabeth M McNally, Kinya Otsu, Jeffery D Molkenti. P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Human molecular genetics. vol 23. issue 20. 2015-06-03. PMID:24876160. |
indeed, muscle-specific deletion of bax, but not the apoptosis regulatory gene tp53 (encoding p53), significantly reduced dystrophic pathology in the muscles of mkk6 transgenic mice. |
2015-06-03 |
2023-08-13 |
mouse |
| Mikkel A Rasmussen, Bjørn Holst, Zeynep Tümer, Mads G Johnsen, Shuling Zhou, Tina C Stummann, Poul Hyttel, Christian Clause. Transient p53 suppression increases reprogramming of human fibroblasts without affecting apoptosis and DNA damage. Stem cell reports. vol 3. issue 3. 2015-06-03. PMID:25241739. |
transient p53 suppression increases reprogramming of human fibroblasts without affecting apoptosis and dna damage. |
2015-06-03 |
2023-08-13 |
human |
| Mikkel A Rasmussen, Bjørn Holst, Zeynep Tümer, Mads G Johnsen, Shuling Zhou, Tina C Stummann, Poul Hyttel, Christian Clause. Transient p53 suppression increases reprogramming of human fibroblasts without affecting apoptosis and DNA damage. Stem cell reports. vol 3. issue 3. 2015-06-03. PMID:25241739. |
here, we report that transient suppression of p53 during nonintegrative reprogramming of human fibroblasts leads to a significant increase in expression of pluripotency markers and overall number of ipsc colonies, due to downstream suppression of p21, without affecting apoptosis and dna damage. |
2015-06-03 |
2023-08-13 |
human |
| Yao-Tsung Yeh, Hua Yeh, Shu-Hui Su, Jian-Sheng Lin, Kuo-Jui Lee, Huey-Wen Shyu, Zi-Feng Chen, Sheng-Yun Huang, Shu-Jem S. Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24952138. |
phenethyl isothiocyanate induces dna damage-associated g2/m arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. |
2015-06-01 |
2023-08-13 |
Not clear |
| Yao-Tsung Yeh, Hua Yeh, Shu-Hui Su, Jian-Sheng Lin, Kuo-Jui Lee, Huey-Wen Shyu, Zi-Feng Chen, Sheng-Yun Huang, Shu-Jem S. Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24952138. |
the p53 inhibitor pifithrin-α and the antioxidants n-acetylcysteine and glutathione (gsh) protected the cells from peitc-mediated apoptosis. |
2015-06-01 |
2023-08-13 |
Not clear |
| Yao-Tsung Yeh, Hua Yeh, Shu-Hui Su, Jian-Sheng Lin, Kuo-Jui Lee, Huey-Wen Shyu, Zi-Feng Chen, Sheng-Yun Huang, Shu-Jem S. Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24952138. |
these results provide new insights into the critical roles of both gsh redox stress and p53 in the regulation of peitc-induced g2/m cell cycle arrest and apoptosis in osccs. |
2015-06-01 |
2023-08-13 |
Not clear |