| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingxing He, Xinjuan Kong, Junwei Yan, Jingjun Yan, Yunan Zhang, Qian Wu, Ying Chang, Haitao Shang, Qian Dou, Yuhu Song, Fang Li. CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 3. 2015-06-15. PMID:25663456. |
cp-31398 induced p53 downstream target molecules in cultured ht-29 cells, which resulted in the inhibition of crc cell growth assessed by the determination of cell cycle, apoptosis, and cell proliferation. |
2015-06-15 |
2023-08-13 |
Not clear |
| Grazia Graziani, Simona Artuso, Anastasia De Luca, Alessia Muzi, Dante Rotili, Manuel Scimeca, Maria Grazia Atzori, Claudia Ceci, Antonello Mai, Carlo Leonetti, Lauretta Levati, Elena Bonanno, Lucio Tentori, Anna Maria Caccur. A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib. Biochemical pharmacology. vol 95. issue 1. 2015-06-15. PMID:25795251. |
both nbdhex and mc3181 induced marked antiproliferative and apoptotic effects in a375-vr8 cells and, at equitoxic concentrations, caused a strong phosphorylation of jnk, p38, and of the downstream mediators of apoptosis atf2 and p53. |
2015-06-15 |
2023-08-13 |
human |
| Saranyapin Potikanond, Natthakarn Chiranthanut, Parirat Khonsung, Supanimit Teekachunhatea. Cytotoxic Effect of Coscinium fenestratum on Human Head and Neck Cancer Cell Line (HN31). Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-06-15. PMID:26074999. |
in conclusion, the cytotoxicity of cf extract was associated with the modulation of p38 mapk, pakt, and p53 signal molecules, leading to inhibiting cell survival and increasing apoptosis. |
2015-06-15 |
2023-08-13 |
human |
| Christine Blattne. New tricks for p53 regulation - restraint by protein coding RNAs. Cell & bioscience. vol 5. 2015-06-15. PMID:26075053. |
a recent report demonstrates that p53 activity is regulated by a novel rna-containing negative feedback loop that promotes apoptosis specifically in escs. |
2015-06-15 |
2023-08-13 |
Not clear |
| Ignacio Vega-Naredo, Teresa Cunha-Oliveira, Teresa L Serafim, Vilma A Sardao, Paulo J Oliveir. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Methods in molecular biology (Clifton, N.J.). vol 1241. 2015-06-12. PMID:25308496. |
the permeabilization of the outer mitochondrial membrane which is mainly controlled by proteins of the bcl-2 family, is a key event that can be directly induced by p53 and results in the release of pro-apoptotic factors to the cytosol, such as cytochrome c, second mitochondria derived activator of caspases/direct inhibitor-of-apoptosis (iap) binding protein with low pi (smac/diablo), omi serine protease (omi/htra2), apoptosis inducing factor (aif), or endonuclease g (endo-g). |
2015-06-12 |
2023-08-13 |
Not clear |
| L A Baranova, E V Zhornik, I D Volotovsk. [Influence of silver and titanium dioxide nanoparticles on the expression of genes of biomarkers of inflammatory responses and apoptosis]. Biofizika. vol 60. issue 2. 2015-06-12. PMID:26016020. |
increased expression of il-6, il-8, tnf-α and p53 genes under the nanoparticles action indicates the stimulation of the immune system and of apoptosis, respectively. |
2015-06-12 |
2023-08-13 |
human |
| Sanjiv Neupane, Wern-Joo Sohn, Girdhari Rijal, Ye-Ji Lee, Sanggyu Lee, Hitoshi Yamamoto, Chang-Hyeon An, Sung-Won Cho, Youngkyun Lee, Hong-In Shin, Tae-Yub Kwon, Jae-Young Ki. Developmental regulations of Perp in mice molar morphogenesis. Cell and tissue research. vol 358. issue 1. 2015-06-11. PMID:24865245. |
teraspanin transmembrane protein, perp (p53 apoptosis effector related to pmp22), which is found in the plasma membrane as a component of the desmosome, is reported to be involved in the morphogenesis of the epithelium and the enamel formation of the incisor. |
2015-06-11 |
2023-08-13 |
mouse |
| Judit Varga, Judit Bátor, Márton Péter, Zita Árvai, Marianna Pap, György Sétáló, József Szeberény. The role of the p53 protein in nitrosative stress-induced apoptosis of PC12 rat pheochromocytoma cells. Cell and tissue research. vol 358. issue 1. 2015-06-11. PMID:24962545. |
the role of the p53 protein in nitrosative stress-induced apoptosis of pc12 rat pheochromocytoma cells. |
2015-06-11 |
2023-08-13 |
rat |
| Judit Varga, Judit Bátor, Márton Péter, Zita Árvai, Marianna Pap, György Sétáló, József Szeberény. The role of the p53 protein in nitrosative stress-induced apoptosis of PC12 rat pheochromocytoma cells. Cell and tissue research. vol 358. issue 1. 2015-06-11. PMID:24962545. |
we thus conclude that (1) the main cause of the snp-induced apoptosis of pc12 cells is the repression of the bcl-2 gene, evoked through p53 stabilization, stress kinase activation, and chop induction; (2) the higher snp sensitivity of p143p53pc12 cells is the consequence of the stronger and earlier activation of the intrinsic apoptotic pathway. |
2015-06-11 |
2023-08-13 |
rat |
| Aaedah F Annooz, Alice K Melconian, Ban A Abdul-Majeed, Ali M Jawa. Detection p53 gene deletion in hematological malignancies using fluorescence in situ hybridization: a pilot study. . Pakistan journal of biological sciences : PJBS. vol 17. issue 7. 2015-06-11. PMID:26035937. |
detection p53 gene deletion in hematological malignancies using fluorescence in situ hybridization: a pilot study. . p53 as a tumor suppressor gene plays a major role in cancer development, it is essential for cell growth regulation and apoptosis. |
2015-06-11 |
2023-08-13 |
Not clear |
| Xia Ma, Jingling Han, Qiyun Wu, Hanzhang Liu, Shangshi Shi, Cheng Wang, Yueran Wang, Jing Xiao, Jianya Zhao, Junkang Jiang, Chunhua Wa. Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis. Toxicology letters. vol 235. issue 1. 2015-06-10. PMID:25791630. |
involvement of dysregulated wip1 in manganese-induced p53 signaling and neuronal apoptosis. |
2015-06-10 |
2023-08-13 |
rat |
| Xia Ma, Jingling Han, Qiyun Wu, Hanzhang Liu, Shangshi Shi, Cheng Wang, Yueran Wang, Jing Xiao, Jianya Zhao, Junkang Jiang, Chunhua Wa. Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis. Toxicology letters. vol 235. issue 1. 2015-06-10. PMID:25791630. |
in the present study, we established a mn-exposed rat model and found that downregulation of wild type p53-induced phosphatase 1 (wip1) might contribute to p53 activation and resultant neuronal apoptosis following mn exposure. |
2015-06-10 |
2023-08-13 |
rat |
| Xia Ma, Jingling Han, Qiyun Wu, Hanzhang Liu, Shangshi Shi, Cheng Wang, Yueran Wang, Jing Xiao, Jianya Zhao, Junkang Jiang, Chunhua Wa. Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis. Toxicology letters. vol 235. issue 1. 2015-06-10. PMID:25791630. |
in addition, ectopic expression of wip1 attenuated mn-induced p53 signaling as well as apoptosis in pc12 cells. |
2015-06-10 |
2023-08-13 |
rat |
| Patricia Izetti, Agnes Hautefeuille, Ana Lucia Abujamra, Caroline Brunetto de Farias, Juliana Giacomazzi, Bárbara Alemar, Guido Lenz, Rafael Roesler, Gilberto Schwartsmann, Alessandro Bersch Osvaldt, Pierre Hainaut, Patricia Ashton-Proll. PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. Investigational new drugs. vol 32. issue 5. 2015-06-09. PMID:24838627. |
prima-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. |
2015-06-09 |
2023-08-13 |
Not clear |
| Patricia Izetti, Agnes Hautefeuille, Ana Lucia Abujamra, Caroline Brunetto de Farias, Juliana Giacomazzi, Bárbara Alemar, Guido Lenz, Rafael Roesler, Gilberto Schwartsmann, Alessandro Bersch Osvaldt, Pierre Hainaut, Patricia Ashton-Proll. PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. Investigational new drugs. vol 32. issue 5. 2015-06-09. PMID:24838627. |
in an effort to reactivate mutant p53 protein, several new drugs are being developed, including prima-1 and prima-1(met)/apr-246 (p53 reactivation and induction of massive apoptosis). |
2015-06-09 |
2023-08-13 |
Not clear |
| Patricia Izetti, Agnes Hautefeuille, Ana Lucia Abujamra, Caroline Brunetto de Farias, Juliana Giacomazzi, Bárbara Alemar, Guido Lenz, Rafael Roesler, Gilberto Schwartsmann, Alessandro Bersch Osvaldt, Pierre Hainaut, Patricia Ashton-Proll. PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. Investigational new drugs. vol 32. issue 5. 2015-06-09. PMID:24838627. |
prima-1 has been shown to induce apoptosis in tumor cells by reactivating p53 mutants, but its effect in pancreatic cancer remains unclear. |
2015-06-09 |
2023-08-13 |
Not clear |
| Patricia Izetti, Agnes Hautefeuille, Ana Lucia Abujamra, Caroline Brunetto de Farias, Juliana Giacomazzi, Bárbara Alemar, Guido Lenz, Rafael Roesler, Gilberto Schwartsmann, Alessandro Bersch Osvaldt, Pierre Hainaut, Patricia Ashton-Proll. PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. Investigational new drugs. vol 32. issue 5. 2015-06-09. PMID:24838627. |
treatment with prima-1 selectively induced apoptosis and cell cycle arrest in p53 mutant cells compared to capan-2 cells. |
2015-06-09 |
2023-08-13 |
Not clear |
| Patricia Izetti, Agnes Hautefeuille, Ana Lucia Abujamra, Caroline Brunetto de Farias, Juliana Giacomazzi, Bárbara Alemar, Guido Lenz, Rafael Roesler, Gilberto Schwartsmann, Alessandro Bersch Osvaldt, Pierre Hainaut, Patricia Ashton-Proll. PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. Investigational new drugs. vol 32. issue 5. 2015-06-09. PMID:24838627. |
taken together, our data indicate that prima-1 induces apoptosis in p53 mutant pancreatic cancer cells by promoting the re-activation of p53 and inducing proapoptotic signaling pathways, providing in vitro evidence for a potential therapeutic approach in pancreatic cancer. |
2015-06-09 |
2023-08-13 |
Not clear |
| See-Hyoung Park, Jung Han Lee, Jonathan S Berek, Mickey C-T H. Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53. International journal of oncology. vol 45. issue 4. 2015-06-09. PMID:25096914. |
the observed upregulation of pro-apoptotic genes and apoptosis in cancer cells without p53 in response to auranofin suggests a novel p53-independent mechanism underlying auranofin-induced apoptosis in ovarian cancer cells. |
2015-06-09 |
2023-08-13 |
Not clear |
| Taofeng Zhu, Ruhua Chen, Hao Yu, Yan Feng, Jianqiang Chen, Qin Lu, Jing Xie, Weiliang Ding, Tieliang M. Antitumor effect of a copper (II) complex of a coumarin derivative and phenanthroline on lung adenocarcinoma cells and the mechanism of action. Molecular medicine reports. vol 10. issue 5. 2015-06-09. PMID:25176185. |
in conclusion, the coumarin-copper drug may inhibit the proliferation of la795 cells through the induction of cell apoptosis, which may be associated with the upregulation of p53 and bax, with concurrent downregulation of bcl-2. |
2015-06-09 |
2023-08-13 |
mouse |