| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janelle Rowell, Norimichi Koitabashi, David A Kass, Andreas S Bart. Dynamic gene expression patterns in animal models of early and late heart failure reveal biphasic-bidirectional transcriptional activation of signaling pathways. Physiological genomics. vol 46. issue 20. 2015-06-18. PMID:25159852. |
in contrast, most signaling pathways undergo a complex biphasic pattern: calcium signaling, p53, apoptosis, and mapk pathways displayed a bidirectional response, declining early but rising late. |
2015-06-18 |
2023-08-13 |
Not clear |
| A Kostecka, A Sznarkowska, K Meller, P Acedo, Y Shi, H A Mohammad Sakil, A Kawiak, M Lion, A Królicka, M Wilhelm, A Inga, J Zawacka-Panka. JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress. Cell death & disease. vol 5. 2015-06-18. PMID:25341038. |
taken that ups maintains the turnover of factors controlling cell cycle and apoptosis--such as p53 or p73, it represents a promising target for pharmaceutical intervention. |
2015-06-18 |
2023-08-13 |
Not clear |
| V Budhram-Mahadeo, R Fujita, S Bitsi, P Sicard, R Head. Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults. Cell death & disease. vol 5. 2015-06-18. PMID:25356872. |
the p53 protein can induce apoptosis or cell cycle arrest, but effects on cell fate depend on interactions with other regulators such as pou4f2/brn-3b (brn-3b), which co-operates with p53 to increase the expression of pro-apoptotic genes. |
2015-06-18 |
2023-08-13 |
mouse |
| V Budhram-Mahadeo, R Fujita, S Bitsi, P Sicard, R Head. Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults. Cell death & disease. vol 5. 2015-06-18. PMID:25356872. |
in contrast, the related pou4f1/brn-3a (brn-3a) blocks p53-mediated apoptosis but co-operates with p53 to enhance cell cycle arrest. |
2015-06-18 |
2023-08-13 |
mouse |
| V Budhram-Mahadeo, R Fujita, S Bitsi, P Sicard, R Head. Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults. Cell death & disease. vol 5. 2015-06-18. PMID:25356872. |
similarly, simulated ischaemia/reoxygenation (si/r) injury in neonatal rat ventricular cardiomyocytes (nrvm) and heart derived h9c2 myoblasts increased brn-3b, p53 as well as apoptotic genes, and this was associated with enhanced apoptosis. |
2015-06-18 |
2023-08-13 |
mouse |
| Shuo Chen, Xi Chen, Yin-Ling Xiu, Kai-Xuan Sun, Yang Zha. MicroRNA-490-3P targets CDK1 and inhibits ovarian epithelial carcinoma tumorigenesis and progression. Cancer letters. vol 362. issue 1. 2015-06-18. PMID:25819031. |
mir-490-3p overexpression promoted g1/s or g2/m arrest and apoptosis; reduced cell proliferation, migration and invasion; reduced cdk1, bcl-xl, mmp2/9, ccnd1, smarcd1 mrna or protein expression; and induced p53 expression. |
2015-06-18 |
2023-08-13 |
Not clear |
| Priyanka Bhatnagar, Soma Patnaik, Amit K Srivastava, Mohan K R Mudiam, Yogeshwer Shukla, Amulya K Panda, Aditya B Pant, Pradeep Kumar, Kailash C Gupt. Anti-cancer activity of bromelain nanoparticles by oral administration. Journal of biomedical nanotechnology. vol 10. issue 12. 2015-06-18. PMID:26000370. |
altered expression of marker proteins associated with apoptosis and cell death (p53, p21, bcl2, bax) also confirmed the enhanced anti-carcinogenic potential of formulated nps. |
2015-06-18 |
2023-08-13 |
mouse |
| Burak Cem Soner, Huseyin Aktug, Eda Acikgoz, Fahriye Duzagac, Ummu Guven, Sule Ayla, Cag Cal, Gulperi Okte. Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol. International journal of molecular medicine. vol 34. issue 5. 2015-06-17. PMID:25216351. |
flavopiridol induced growth inhibition and apoptosis at the ic(50) dose (500 nm), resulting in a significant increase in immunofluorescence staining of caspase‑3, caspase‑8 and p53. |
2015-06-17 |
2023-08-13 |
human |
| Zhixiong Long, Bin Wang, Dan Tao, Ying Huang, Zezhang Ta. Hypofractionated radiotherapy induces miR-34a expression and enhances apoptosis in human nasopharyngeal carcinoma cells. International journal of molecular medicine. vol 34. issue 5. 2015-06-17. PMID:25231528. |
the results revealed that hypofractionated radiotherapy enhanced apoptosis and increased the expression of mir-34a and p53 in the npc cells. |
2015-06-17 |
2023-08-13 |
human |
| Zhiyuan Li, Ming Ni, Jikun Li, Yuping Zhang, Qi Ouyang, Chao Tan. Decision making of the p53 network: death by integration. Journal of theoretical biology. vol 271. issue 1. 2015-06-16. PMID:21130774. |
in particular, p53 is involved in both the pro-survival response of cell cycle arrest and dna repair, and the pro-death response of apoptosis. |
2015-06-16 |
2023-08-12 |
Not clear |
| Zhiyuan Li, Ming Ni, Jikun Li, Yuping Zhang, Qi Ouyang, Chao Tan. Decision making of the p53 network: death by integration. Journal of theoretical biology. vol 271. issue 1. 2015-06-16. PMID:21130774. |
to address these questions, we develop an integrated mathematical model that embraces three key modules of the p53 network: p53 core regulation, p53-induced cell cycle arrest and p53-dependent apoptosis initiation. |
2015-06-16 |
2023-08-12 |
Not clear |
| I G Chae, D-H Kim, J Kundu, C-H Jeong, J K Kundu, K-S Chu. Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. Free radical research. vol 48. issue 11. 2015-06-16. PMID:25096910. |
our study revealed that treatment with cay10598 significantly reduced the cell viability and induced apoptosis in hct116 cells, as evidenced by the induction of p53 and bax, release of cytochrome c, cleavage of caspase-9, -7, and -3, and parp, and the inhibition of bcl-2, bcl-xl and survivin expression. |
2015-06-16 |
2023-08-13 |
human |
| Yun-feng Qi, Yan-xin Huang, Yan Dong, Li-hua Zheng, Yong-li Bao, Lu-guo Sun, Yin Wu, Chun-lei Yu, Hong-yu Jiang, Yu-xin L. Systematic analysis of time-series gene expression data on tumor cell-selective apoptotic responses to HDAC inhibitors. Computational and mathematical methods in medicine. vol 2014. 2015-06-16. PMID:25371703. |
our analyses indicated that saha selectively disrupted the dna damage response, cell cycle, p53 expression, and mitochondrial integrity of tumor samples to induce selective tumor cell apoptosis. |
2015-06-16 |
2023-08-13 |
Not clear |
| Dan Xi. Ovarian cancer HO-8910 cell apoptosis induced by crocin in vitro. Natural product communications. vol 10. issue 2. 2015-06-16. PMID:25920253. |
crocin can also promote ovarian cancer ho-8910 cell apoptosis, most likely by increasing p53 and fas/apo-1 expression, and then activating the apoptotic pathway regulated by caspase-3. |
2015-06-16 |
2023-08-13 |
Not clear |
| Yu Liu, Liang Zhao, Wenya Ma, Xuefeng Cao, Hongyang Chen, Dan Feng, Jing Liang, Kun Yin, Xiaofeng Jian. The Blockage of KCa3.1 Channel Inhibited Proliferation, Migration and Promoted Apoptosis of Human Hepatocellular Carcinoma Cells. Journal of Cancer. vol 6. issue 7. 2015-06-16. PMID:26078795. |
collectively, inhibition of kca3.1 channel suppressed the growth and migration, and promoted the apoptosis of human hepatocellular carcinoma cells by regulating intracellular ros level and promoting p53 activation. |
2015-06-16 |
2023-08-13 |
human |
| Yanwei Qing, Haiyan Hu, Yuan Liu, Tao Feng, Wei Meng, Ling Jiang, Yongning Sun, Yang Ya. Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter. Cell biology international. vol 38. issue 5. 2015-06-15. PMID:24843889. |
berberine induces apoptosis in human multiple myeloma cell line u266 through hypomethylation of p53 promoter. |
2015-06-15 |
2023-08-13 |
human |
| A Okal, K J Matissek, S J Matissek, R Price, M E Salama, M M Janát-Amsbury, C S Li. Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model. Gene therapy. vol 21. issue 10. 2015-06-15. PMID:25077773. |
re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model. |
2015-06-15 |
2023-08-13 |
human |
| Kurataka Otsuka, Takahiro Ochiy. Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways. BioMed research international. vol 2014. 2015-06-15. PMID:25302307. |
genetic networks lead and follow tumor development: microrna regulation of cell cycle and apoptosis in the p53 pathways. |
2015-06-15 |
2023-08-13 |
Not clear |
| Kurataka Otsuka, Takahiro Ochiy. Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways. BioMed research international. vol 2014. 2015-06-15. PMID:25302307. |
recently, it has been demonstrated that a typical tumor suppressor p53, known as the guardian of the genome, regulates some kinds of mirnas to contribute to tumor suppression by the induction of cell-cycle arrest and apoptosis. |
2015-06-15 |
2023-08-13 |
Not clear |
| Xingxing He, Xinjuan Kong, Junwei Yan, Jingjun Yan, Yunan Zhang, Qian Wu, Ying Chang, Haitao Shang, Qian Dou, Yuhu Song, Fang Li. CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 3. 2015-06-15. PMID:25663456. |
crc cells which carry p53 mutation in codon 273 were treated with cp-31398 and the control, and the effects of cp-31398 on cell cycle, cell apoptosis, and proliferation were determined. |
2015-06-15 |
2023-08-13 |
Not clear |