| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongshi Chen, Lihua Ming, Fangdong Zou, Ye Peng, Bennett Van Houten, Jian Yu, Lin Zhan. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. vol 5. issue 18. 2015-06-25. PMID:25237903. |
extensive dna damage triggers tap73 depletion through ubiquitin/proteasome-mediated degradation of e2f1, leading to enhanced transcriptional activation by p53 and subsequent induction of apoptosis. |
2015-06-25 |
2023-08-13 |
Not clear |
| Min Huang, Dan Lou, Qian Cai, Xiuli Chang, Xinjin Wang, Zhijun Zho. Characterization of paraquat-induced miRNA profiling response in hNPCs undergoing proliferation. International journal of molecular sciences. vol 15. issue 10. 2015-06-25. PMID:25314302. |
the database for annotation, visualization and integrated discovery (david) bioinformatics analysis showed that target genes were enriched in regulation of cell proliferation and differentiation, cell cycle and apoptosis as well as tumor protein 53 (p53), wnt, notch and mitogen-activated protein kinases (mapk) signaling pathways (p < 0.001). |
2015-06-25 |
2023-08-13 |
human |
| Xin Li, Jun-Ming Huang, Jian-Ning Wang, Xi-Kun Xiong, Xing-Fen Yang, Fei Zo. Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53. Chemico-biological interactions. vol 232. 2015-06-25. PMID:25770930. |
combination of chrysin and cisplatin promotes the apoptosis of hep g2 cells by up-regulating p53. |
2015-06-25 |
2023-08-13 |
human |
| Paloma Alonso-Magdalena, Marta García-Arévalo, Iván Quesada, Ángel Nada. Bisphenol-A treatment during pregnancy in mice: a new window of susceptibility for the development of diabetes in mothers later in life. Endocrinology. vol 156. issue 5. 2015-06-25. PMID:25830705. |
in addition, the rate of β-cells apoptosis was increased as well as the expression of the cell cycle inhibitors p16 and p53. |
2015-06-25 |
2023-08-13 |
mouse |
| Su-Feng Zhou, Jing Yuan, Meng-Yang Liao, Ni Xia, Ting-Ting Tang, Jing-Jing Li, Jiao Jiao, Wen-Yong Dong, Shao-Fang Nie, Zheng-Feng Zhu, Wen-Cai Zhang, Bing-Jie Lv, Hong Xiao, Qing Wang, Xin Tu, Yu-Hua Liao, Guo-Ping Shi, Xiang Chen. IL-17A promotes ventricular remodeling after myocardial infarction. Journal of molecular medicine (Berlin, Germany). vol 92. issue 10. 2015-06-23. PMID:24965614. |
additional studies in vitro indicated that il-17a induces neonatal cardiomyocyte (from c57bl/6 mice) apoptosis through the activation of p38, p53 phosphorylation, and bax redistribution. |
2015-06-23 |
2023-08-13 |
mouse |
| Tomoyuki Sasaki, Shanshan Lian, Jie Qi, Peter E Bayliss, Christopher E Carr, Jennifer L Johnson, Sujay Guha, Patrick Kobler, Sergio D Catz, Matthew Gill, Kailiang Jia, Daniel J Klionsky, Shuji Kish. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. PLoS genetics. vol 10. issue 6. 2015-06-23. PMID:24967584. |
by contrast, in response to dna damage, 'activated p53' showed an apparent enhancement of the spns1-deficient phenotype, by inducing both autophagy and apoptosis. |
2015-06-23 |
2023-08-13 |
drosophila_melanogaster |
| Yang Yang-Hartwich, Jamie Bingham, Francesca Garofalo, Ayesha B Alvero, Gil Mo. Detection of p53 protein aggregation in cancer cell lines and tumor samples. Methods in molecular biology (Clifton, N.J.). vol 1219. 2015-06-23. PMID:25308263. |
the p53 protein plays a central role in regulating apoptosis. |
2015-06-23 |
2023-08-13 |
Not clear |
| Yang Yang-Hartwich, Emily Romanoff, Jamie Bingham, Ayesha B Alvero, Gil Mo. Detection of p53 protein transcriptional activity by chromatin immunoprecipitation. Methods in molecular biology (Clifton, N.J.). vol 1219. 2015-06-23. PMID:25308264. |
an important cellular function that is dependent on p53 transcriptional activity is apoptosis or programmed cell death. |
2015-06-23 |
2023-08-13 |
Not clear |
| Yang Yang-Hartwich, Emily Romanoff, Jamie Bingham, Ayesha B Alvero, Gil Mo. Detection of p53 protein transcriptional activity by chromatin immunoprecipitation. Methods in molecular biology (Clifton, N.J.). vol 1219. 2015-06-23. PMID:25308264. |
this technique enables the determination of the ability of p53 to bind to the promoter region of apoptotic genes and to evaluate the transcription-dependent activity of p53-induced apoptosis. |
2015-06-23 |
2023-08-13 |
Not clear |
| Mehran Mesgari Abbasi, Monir Moradzadeh Khiavi, Amir Monfaredan, Hamed Hamishehkar, Khaled Seidi, Rana Jahanban-Esfahla. DOX-MTX-NPs augment p53 mRNA expression in OSCC model in rat: effects of IV and oral routes. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 19. 2015-06-23. PMID:25339032. |
the well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. |
2015-06-23 |
2023-08-13 |
rat |
| Pedro A Lazo, Claudio R Santo. Interference with p53 functions in human viral infections, a target for novel antiviral strategies? Reviews in medical virology. vol 21. issue 5. 2015-06-22. PMID:21726011. |
the cellular responses to stress are mediated by p53, which by deregulation of cell cycle and apoptosis, may also be part of the host cell reaction to fight infections. |
2015-06-22 |
2023-08-12 |
human |
| Jiang Ren, Chuanjiang Yu, Shifei Wu, Feng Peng, Qianqian Jiang, Xuechao Zhang, Guoxing Zhong, Huashan Shi, Xiang Chen, Xiaolan Su, Xinmei Luo, Wen Zhu, Yuquan We. Cationic liposome mediated delivery of FUS1 and hIL-12 coexpression plasmid demonstrates enhanced activity against human lung cancer. Current cancer drug targets. vol 14. issue 2. 2015-06-22. PMID:24410728. |
fus1-hil-12 coexpression could also obviously induce tumor cell apoptosis and inhibit tumor cell proliferation partly by higher activation of stat1 signal pathway and upregulation of p53. |
2015-06-22 |
2023-08-12 |
mouse |
| Rosa María Agra, Ángel Fernández-Trasancos, Juan Sierra, José Ramón González-Juanatey, Sonia Eira. Differential association of S100A9, an inflammatory marker, and p53, a cell cycle marker, expression with epicardial adipocyte size in patients with cardiovascular disease. Inflammation. vol 37. issue 5. 2015-06-22. PMID:24700313. |
one of the proteins that can regulate s100a9 transcription is p53, which is involved in cell cycle, apoptosis and adipogenesis. |
2015-06-22 |
2023-08-13 |
Not clear |
| Guiyun Song, Benigno C Valdez, Yang Li, Yan Liu, Richard E Champlin, Borje S Andersso. Synergistic cytotoxicity of sorafenib with busulfan and nucleoside analogs in human FMS-like tyrosine kinase 3 internal tandem duplications-positive acute myeloid leukemia cells. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 20. issue 11. 2015-06-22. PMID:25111583. |
the level of the proapoptotic protein p53 upregulated modulator of apoptosis (puma) increased, whereas the level of prosurvival protein mcl-1 decreased when cells were exposed to bu+clo+flu+sor. |
2015-06-22 |
2023-08-13 |
human |
| Nabil Mohsen El-Danasouri, Shadia Hassan Ragab, Maha Ameen Rasheed, Zainab Ali El Saadany, Safa Nabil Abd El-Fatta. MDM2 SNP309 and p53 codon 72 genetic polymorphisms and risk of AML: an Egyptian study. Annals of clinical and laboratory science. vol 44. issue 4. 2015-06-22. PMID:25361931. |
p53 is involved in multiple cellular pathways including apoptosis, transcriptional control, and cell cycle regulation. |
2015-06-22 |
2023-08-13 |
Not clear |
| Snezana Kojic, Aleksandra Nestorovic, Ljiljana Rakicevic, Olga Protic, Jovana Jasnic-Savovic, Georgine Faulkner, Dragica Radojkovi. Cardiac transcription factor Nkx2.5 interacts with p53 and modulates its activity. Archives of biochemistry and biophysics. vol 569. 2015-06-22. PMID:25677450. |
here we demonstrate that nkx2.5 and p53 synergistically activate the promoter of the striated muscle stress responsive transcriptional cofactor ankrd2, involved in coordination of proliferation and apoptosis during myogenic differentiation. |
2015-06-22 |
2023-08-13 |
Not clear |
| Debjani Ghosh, Subrata Kumar Dey, Chabita Sah. Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells. Radiation and environmental biophysics. vol 53. issue 4. 2015-06-19. PMID:24981250. |
the changes in the mrna expression of bax, bcl2, p53 and nrf2 were also followed to evaluate regulation of radiation-induced apoptosis by bte. |
2015-06-19 |
2023-08-13 |
Not clear |
| Sidra Ghani, Noureen Khan, Chihaya Koriyama, Suminori Akiba, Megumi Yamamot. N‑acetyl‑L‑cysteine reduces arsenite‑induced cytotoxicity through chelation in U937 monocytes and macrophages. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25310083. |
in the present study, in order to clarify the preventive mechanism of n‑acetyl‑l‑cysteine (nac) on arsenite‑induced apoptosis in u937 cells, which lack functional p53, the cytotoxicity among u937 cells [monocytes and 12‑o‑tetradecanoylphorbol‑13‑acetate (tpa)‑treated macrophages] receiving nac treatment at different times post arsenite treatment was examined. |
2015-06-19 |
2023-08-13 |
Not clear |
| Sung Min Ju, Jun Gue Kang, Jun Sang Bae, Hyun Ock Pae, Yeoung Su Lyu, Byung Hun Jeo. The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-06-19. PMID:26089934. |
cisplatin was known to exhibit cytotoxic effect to renal cells by inducing apoptosis through activation of p53. |
2015-06-19 |
2023-08-13 |
human |
| Sung Min Ju, Jun Gue Kang, Jun Sang Bae, Hyun Ock Pae, Yeoung Su Lyu, Byung Hun Jeo. The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-06-19. PMID:26089934. |
taken together, these results suggest that apigenin ameliorates cisplatin-induced apoptosis through reduction of p53 activation and promotion of pi3k/akt pathway in hk-2 cells. |
2015-06-19 |
2023-08-13 |
human |