| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongyong Jiang, Jie Xion. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24845152. |
these results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, bax, and bcl-2 pathway. |
2015-07-02 |
2023-08-13 |
human |
| S Y Yan, M M Chen, J G Fan, Y Q Wang, Y Q Du, Y Hu, L M X. Therapeutic mechanism of treating SMMC-7721 liver cancer cells with magnetic fluid hyperthermia using Fe₂O₃ nanoparticles. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 47. issue 11. 2015-07-02. PMID:25296356. |
fe₂o₃ mfh can induce high hsp70 expression at an early stage, enhance the expression of bax, and decrease the expression of mutant p53, which promotes the apoptosis of tumor cells. |
2015-07-02 |
2023-08-13 |
Not clear |
| Meng Jie, Wan Man Cheung, Vivian Yu, Yanling Zhou, Pak Ho Tong, John W S H. Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats. PloS one. vol 9. issue 10. 2015-07-02. PMID:25329483. |
sinigrin induced apoptosis of liver cancer cells through up-regulation of p53 and down-regulation of bcl-2 family members and caspases. |
2015-07-02 |
2023-08-13 |
rat |
| Lizhu Jiang, Peng Wang, Lili Chen, Hongyan Che. Down-regulation of FoxM1 by thiostrepton or small interfering RNA inhibits proliferation, transformation ability and angiogenesis, and induces apoptosis of nasopharyngeal carcinoma cells. International journal of clinical and experimental pathology. vol 7. issue 9. 2015-07-02. PMID:25337187. |
foxm1 inhibition by thiostrepton induced apoptosis of npc cells by down-regulation of bcl-2, up-regulation of bax and p53, and inducing release of cytochrome c accompanied by activation of caspase-9, cleaved caspase-3 and cleaved parp. |
2015-07-02 |
2023-08-13 |
human |
| Xiaomei Fan, Yiming Jiang, Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen, Aijuan Qu, Frank J Gonzalez, Min Huang, Huichang B. Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug metabolism and disposition: the biological fate of chemicals. vol 42. issue 12. 2015-07-01. PMID:25217484. |
furthermore, apap increased the levels of p53 and its downstream gene p21 to trigger cell cycle arrest and apoptosis, whereas wz pretreatment could inhibit p53/p21 signaling to induce cell proliferation-associated proteins including cyclin d1, cdk4, pcna, and alr to promote hepatocyte proliferation. |
2015-07-01 |
2023-08-13 |
Not clear |
| Katerina Naka K, Patra Vezyraki, Alexandros Kalaitzakis, Stelios Zerikiotis, Lampros Michalis, Charalampos Angelidi. Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice. Cell stress & chaperones. vol 19. issue 6. 2015-06-30. PMID:24748476. |
the study in primary embryonic cell lines showed that the apoptosis after incubation with dox was reduced in cells overexpressing hsp70 (tg/tg), while the apoptotic pathway that was activated by dox administration involved activated protein factors such as p53, bax, caspase-9, caspase-3, and parp-1. |
2015-06-30 |
2023-08-13 |
mouse |
| Zhennan Zhao, Zuandi Luo, Qiong Wu, Wenjie Zheng, Yanxian Feng, Tianfeng Che. Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling. Dalton transactions (Cambridge, England : 2003). vol 43. issue 45. 2015-06-30. PMID:25087850. |
excess ros amplified apoptotic signals by activating many downstream pathways such as p53 and mapk pathways to promote cell apoptosis. |
2015-06-30 |
2023-08-13 |
Not clear |
| Yongshuai Jin, Baoping Cao, Meiying Zhang, Qimin Zhan, James G Herman, Miao Yu, Mingzhou Gu. RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker. Genes & cancer. vol 6. issue 5-6. 2015-06-30. PMID:26124922. |
restoration of rassf10 expression suppressed cell proliferation, induced apoptosis and g2/m phase arrest, as well as sensitized cells to docetaxel and activated p53 signaling in hepg2 and qgy7703 cells. |
2015-06-30 |
2023-08-13 |
human |
| S Karabulut, A Demiroğlu-Zergeroğlu, E Yılmaz, F Sağır, N Delikar. p53 and mitogen-activated protein kinase pathway protein profiles in fresh and frozen spermatozoa. Andrologia. vol 46. issue 10. 2015-06-29. PMID:24313628. |
according to our results, it may be suggested that cryopreservation process activates p53 via p38 mapk pathway that subsequently causes apoptosis, which may be related to sperm parameters. |
2015-06-29 |
2023-08-12 |
Not clear |
| Odelya Hartung, Meredyth M Forbes, Florence L Marlo. Zebrafish vasa is required for germ-cell differentiation and maintenance. Molecular reproduction and development. vol 81. issue 10. 2015-06-29. PMID:25257909. |
furthermore, phenotypes of vasa;p53 compound mutants are indistinguishable from those of vasa mutants, therefore the failure of vasa mutants to differentiate as females and to support germ-cell development in the testis is not due to p53-mediated apoptosis. |
2015-06-29 |
2023-08-13 |
zebrafish |
| Xiuyuan Ou, Yan Chen, Xinxin Cheng, Xumeng Zhang, Qiyang H. Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells. Oncology reports. vol 32. issue 6. 2015-06-29. PMID:25269486. |
resveratrol inhibited proliferation and induced apoptosis in hepg2 cells via activation of caspase-9 and caspase-3, upregulation of the bax/bcl-2 ratio and induction of p53 expression. |
2015-06-29 |
2023-08-13 |
human |
| Xiufang Xiong, Yongchao Zhao, Fei Tang, Dongping Wei, Daffyd Thomas, Xiang Wang, Yang Liu, Pan Zheng, Yi Su. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. vol 3. 2015-06-26. PMID:25144937. |
thus, rps27l has dual functions in p53 regulation: under trp53⁺/⁺ background, rps27l disruption triggers ribosomal stress to induce p53 and apoptosis, whereas under trp53⁺/⁻ background, rps27l disruption triggers genomic instability and trp53 deletion to promote tumorigenesis. |
2015-06-26 |
2023-08-13 |
mouse |
| Liqun Huang, Chi C Wong, Ka W Cheng, Basil Riga. Phospho-aspirin-2 (MDC-22) inhibits estrogen receptor positive breast cancer growth both in vitro and in vivo by a redox-dependent effect. PloS one. vol 9. issue 11. 2015-06-26. PMID:25369051. |
pa-2 triggered the activation of p53-dependent apoptosis via two distinct mechanisms: 1) acetylation of p53 (at k373), which disrupts its interaction with its transcription repressor mdm2, and 2) translocation of p53 to the mitochondria leading to the dissipation of mitochondrial transmembrane potential (ΔΨ(m)). |
2015-06-26 |
2023-08-13 |
mouse |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
interrelationships between sirtuin 1 and transcription factors p53 and nf-κb (p50/p65) in the control of ovarian cell apoptosis and proliferation. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
we examine, in vitro, the involvement of sirt1, p53 and the p65 and p50 subunits of nfκb and their interrelationships in the control of the apoptosis and proliferation of porcine ovarian granulosa cells. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
transfection of cells with gene constructs encoding p53, p50 or p65 decreased the expression of proliferation markers but not the apoptosis marker. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
thus, sirt1, p53 and nf-κb are involved in the control of both the proliferation and the apoptosis of ovarian cells. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
these novel data on the cross-talk between the mtor/sirt1 system and the transcription factors p53 and nf-κb show both the inhibitory (proliferation) and stimulatory (apoptosis) influences of sirt1 on transcription factor action in ovarian cells. |
2015-06-25 |
2023-08-13 |
Not clear |
| Ju Liu, C Zhang, X L Wang, P Ly, V Belyi, Z Y Xu-Monette, K H Young, W Hu, Z Fen. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell death and differentiation. vol 21. issue 11. 2015-06-25. PMID:25146927. |
tumor suppressor p53 has a key role in maintaining genomic stability and preventing tumorigenesis through its regulation of cellular stress responses, including apoptosis, cell cycle arrest and senescence. |
2015-06-25 |
2023-08-13 |
mouse |
| Dongshi Chen, Lihua Ming, Fangdong Zou, Ye Peng, Bennett Van Houten, Jian Yu, Lin Zhan. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. vol 5. issue 18. 2015-06-25. PMID:25237903. |
p53 plays a key role in regulating dna damage response by suppressing cell cycle progression or inducing apoptosis depending on extent of dna damage. |
2015-06-25 |
2023-08-13 |
Not clear |