| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Birce Akpinar, Ethiene V Bracht, Dorin Reijnders, Barbora Safarikova, Iva Jelinkova, Alf Grandien, Alena Hyrslova Vaculova, Boris Zhivotovsky, Magnus Olsso. 5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. Oncotarget. vol 6. issue 41. 2016-10-11. PMID:26544897. |
5-fluorouracil-induced rna stress engages a trail-disc-dependent apoptosis axis facilitated by p53. |
2016-10-11 |
2023-08-13 |
Not clear |
| Yunpeng Fan, Yuede Jiang, Jianjun Liu, Yongxiang Kang, Ruiqiao Li, Jingyu Wan. The anti-tumor activity and mechanism of alkaloids from Aconitum szechenyianum Gay. Bioorganic & medicinal chemistry letters. vol 26. issue 2. 2016-10-11. PMID:26711147. |
in addition, asa could led to a loss in the mitochondrial out membrane potential, up-regulate p53, phosphorylated p53 and bax, down-regulate bcl-2, release cytochrome c from the mitochondria to the cytoplasm, and activate caspase-9 and caspase-3 in a549 cells, which revealed that asa could also induce apoptosis through the mitochondria mediated pathway. |
2016-10-11 |
2023-08-13 |
human |
| Xiaodu Wang, Chunyan Shao, Luyan Wang, Qunjing Li, Houhui Song, Weihuan Fan. The viral non-structural protein 1 alpha (Nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells. Veterinary microbiology. vol 184. 2016-10-11. PMID:26854347. |
the viral non-structural protein 1 alpha (nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (prrsv) early-infected cells. |
2016-10-11 |
2023-08-13 |
Not clear |
| Xiaoyu Li, Limin Pan, Jianlin Sh. Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms. Advanced healthcare materials. vol 4. issue 17. 2016-10-10. PMID:26450832. |
it is interesting to find for the first time that dox@nt-msns down-regulate the expression of apoptosis suppressor genes and inhibit dna repair process by disturbing the p53 pathway. |
2016-10-10 |
2023-08-13 |
Not clear |
| Narayan Dolai, Ashish Kumar, Aminul Islam, Pallab K Halda. Apoptogenic effects of β-sitosterol glucoside from Castanopsis indica leaves. Natural product research. vol 30. issue 4. 2016-10-07. PMID:25790168. |
increase the expression of apoptotic protein p53 and p21 in eac, multiple downstream factors contributing to apoptosis pathway. |
2016-10-07 |
2023-08-13 |
mouse |
| Misook Oh, Ji Hoon Lee, Heejo Moon, Yu-Jung Hyun, Hyun-Suk Li. A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis. Angewandte Chemie (International ed. in English). vol 55. issue 2. 2016-10-07. PMID:26593157. |
besides the proteolytic activity, skp2 also blocks p53-mediated apoptosis by outcompeting p53 for binding p300. |
2016-10-07 |
2023-08-13 |
Not clear |
| Misook Oh, Ji Hoon Lee, Heejo Moon, Yu-Jung Hyun, Hyun-Suk Li. A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis. Angewandte Chemie (International ed. in English). vol 55. issue 2. 2016-10-07. PMID:26593157. |
we show that antagonism of the skp2/p300 interaction by the inhibitor leads to p300-mediated p53 acetylation, resulting in p53-mediated apoptosis in cancer cells, without affecting skp2 proteolytic activity. |
2016-10-07 |
2023-08-13 |
Not clear |
| Ruocan Qian, Yue Cao, Yi-Tao Lon. Dual-Targeting Nanovesicles for In Situ Intracellular Imaging of and Discrimination between Wild-type and Mutant p53. Angewandte Chemie (International ed. in English). vol 55. issue 2. 2016-10-07. PMID:26611768. |
p53 is a tumor-suppressor protein related to the cell cycle and programmed cell apoptosis. |
2016-10-07 |
2023-08-13 |
Not clear |
| Ying Hu, Wenjie Ge, Xingwen Wang, Gopinath Sutendra, Kunming Zhao, Zinaida Dedeić, Elizabeth A Slee, Caroline Baer, Xin L. Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB. Oncotarget. vol 6. issue 40. 2016-10-07. PMID:26646590. |
for example, the nf-κb subunit rela/p65 has been shown to inhibit apoptosis, whereas p53 induces apoptosis. |
2016-10-07 |
2023-08-13 |
zebrafish |
| Ying Hu, Wenjie Ge, Xingwen Wang, Gopinath Sutendra, Kunming Zhao, Zinaida Dedeić, Elizabeth A Slee, Caroline Baer, Xin L. Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB. Oncotarget. vol 6. issue 40. 2016-10-07. PMID:26646590. |
one potential explanation may be their co-regulation by common cellular factors: inhibitor of apoptosis stimulating p53 protein (iaspp) is one such common regulator of both rela/p65 and p53. |
2016-10-07 |
2023-08-13 |
zebrafish |
| Shoulin Zhang, Dongmei Zhang, Chunguang Yi, Yinping Wang, Hongan Wang, Jian Wan. MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma. Oncology reports. vol 35. issue 1. 2016-10-06. PMID:26499759. |
overexpression of mir-22 activated p53 and its downstream target p21 and puma, and the apoptosis markers cleaved casp3 and parp, and inhibited epithelial-mesenchymal transition (emt). |
2016-10-06 |
2023-08-13 |
mouse |
| Xuechao Li, Tao Li, Dehong Chen, Peng Zhang, Yarong Song, Hongxue Zhu, Yajun Xiao, Yifei Xin. Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway. Oncology reports. vol 35. issue 1. 2016-10-06. PMID:26534764. |
furthermore, lsd1 was found to regulate the androgen receptor (ar) and p53 signaling pathways via demethylation, subsequently influencing apoptosis and cell cycle progression. |
2016-10-06 |
2023-08-13 |
human |
| Guangwei Zhong, Xi Chen, Xia Fang, Dongsheng Wang, Mingxuan Xie, Qiong Che. Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway. Oncology reports. vol 35. issue 1. 2016-10-06. PMID:26549498. |
fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the p53 signaling pathway. |
2016-10-06 |
2023-08-13 |
Not clear |
| Namrata Rastogi, Shivali Duggal, Shailendra Kumar Singh, Konica Porwal, Vikas Kumar Srivastava, Rakesh Maurya, M L B Bhatt, Durga Prasad Mishr. Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells. Oncotarget. vol 6. issue 41. 2016-10-06. PMID:26621832. |
therefore, use of small molecules for inhibition of proteasome function and induction of p53 reactivation is a promising strategy for induction of apoptosis in cervical cancer cells. |
2016-10-06 |
2023-08-13 |
human |
| Yinsong Zhu, Wenjuan He, Xiujuan Gao, Bin Li, Chenghan Mei, Rong Xu, Hui Che. Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells. Scientific reports. vol 5. 2016-10-06. PMID:26635117. |
meanwhile, the cotreatment significantly induced cell apoptosis, autophagy, cell cycle arrest and senescence accompanied by increased expression of cleaved caspase-3, lc3b-ii, p53 and p21. |
2016-10-06 |
2023-08-13 |
Not clear |
| He Shen, Min Liu, Zhijun Zhan. Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy. Journal of nanoscience and nanotechnology. vol 16. issue 3. 2016-10-05. PMID:27455620. |
furthermore, the therapeutic gene (p53) was translated into the breast cancer cell line (mcf-7), and then induced cell apoptosis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Farrah Ali, Rehan Khan, Abdul Quaiyoom Khan, Md Abdul Lateef, Tahir Maqbool, Sarwat Sultan. Assessment of Augmented Immune Surveillance and Tumor Cell Death by Cytoplasmic Stabilization of p53 as a Chemopreventive Strategy of 3 Promising Medicinal Herbs in Murine 2-Stage Skin Carcinogenesis. Integrative cancer therapies. vol 13. issue 4. 2016-10-05. PMID:24363284. |
finally, all 3 medicinal extracts induced stable expression of p53 within the tumors, confirmed by the cfda-cy3 apoptosis assay. |
2016-10-05 |
2023-08-12 |
mouse |
| Marco Antonio Bassi, Victor Arias, Nicolau D'Amico Filho, Bárbara Yasmin Gueuvoghlanian-Silva, Mauricio Simoes Abrao, Sergio Podgae. Deep Invasive Endometriosis Lesions of the Rectosigmoid May Be Related to Alterations in Cell Kinetics. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 9. 2016-10-05. PMID:25721913. |
the aim of this study was to analyze cell kinetics through expression and apoptosis of topoisomerase 2-α (top2a), p53, and c-erb2 in rectosigmoid endometriotic lesions and in healthy endometrial tissue and to establish correlations between such findings and clinical data in patients with rectosigmoid endometriosis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Xinxin Song, Ashok-Kumar Dilly, Haroon Asif Choudry, David L Bartlett, Yong Tae Kwon, Yong J Le. Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53. Molecular cancer research : MCR. vol 13. issue 12. 2016-10-05. PMID:26354682. |
the coordinated action of bcl-xl phosphorylation and p53 translocation to the mitochondria resulted in conformational activation of bak oligomerization, facilitating cytochrome c release and apoptosis induction. |
2016-10-05 |
2023-08-13 |
Not clear |
| Luiz Gustavo A Chuffa, Michelly S Alves, Marcelo Martinez, Isabel Cristina C Camargo, Patricia F F Pinheiro, Raquel F Domeniconi, Luiz Antonio L Júnior, Francisco Eduardo Martine. Apoptosis is triggered by melatonin in an in vivo model of ovarian carcinoma. Endocrine-related cancer. vol 23. issue 2. 2016-10-05. PMID:26555801. |
to accomplish oc-related apoptosis, we first observed that p53, bax, caspase-3, and cleaved caspase-3 were downregulated in oc tissue while bcl-2 and survivin were overexpressed. |
2016-10-05 |
2023-08-13 |
rat |