| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minyue Jiang, Guangpei Chen, Na Lu, Yongjie Zhang, Shulei Jin, Andrew Karaplis, David Goltzman, Dengshun Mia. Deficiency of the parathyroid hormone-related peptide nuclear localization and carboxyl terminal sequences leads to premature skin ageing partially mediated by the upregulation of p27. Experimental dermatology. vol 24. issue 11. 2016-10-27. PMID:26121068. |
these alternations were associated with higher expression of cdk2 and cyclin e, lower expression of p19 and p53, and enhanced antioxidant capacity with increased skin cell proliferation and inhibition of apoptosis. |
2016-10-27 |
2023-08-13 |
mouse |
| Thillainathan Natarajan, Manickam Anandhi, Dilipkumar Aiswarya, Rajendiran Ramkumar, Subramanian Kumar, Pachiappan Peruma. Idaein chloride induced p53 dependent apoptosis in cervical cancer cells through inhibition of viral oncoproteins. Biochimie. vol 121. 2016-10-25. PMID:26586108. |
idaein chloride induced p53 dependent apoptosis in cervical cancer cells through inhibition of viral oncoproteins. |
2016-10-25 |
2023-08-13 |
Not clear |
| Thillainathan Natarajan, Manickam Anandhi, Dilipkumar Aiswarya, Rajendiran Ramkumar, Subramanian Kumar, Pachiappan Peruma. Idaein chloride induced p53 dependent apoptosis in cervical cancer cells through inhibition of viral oncoproteins. Biochimie. vol 121. 2016-10-25. PMID:26586108. |
in addition, the idaein chloride significantly inhibited the expression of e6 and e7 proteins, resulting in p53 re-expression and hence triggering of p53 dependent apoptosis. |
2016-10-25 |
2023-08-13 |
Not clear |
| Yang Yang, Chongxi Fan, Chao Deng, Lin Zhao, Wei Hu, Shouyin Di, Zhiqiang Ma, Yu Zhang, Zhigang Qin, Zhenxiao Jin, Xiaolong Yan, Shuai Jiang, Yang Sun, Wei Y. Melatonin reverses flow shear stress-induced injury in bone marrow mesenchymal stem cells via activation of AMP-activated protein kinase signaling. Journal of pineal research. vol 60. issue 2. 2016-10-24. PMID:26707568. |
melatonin markedly reduced bmsc apoptotic death in a concentration-dependent manner while increasing the levels of transforming growth factor β (tgf-β), basic fibroblast growth factor (bfgf), vascular endothelial growth factor (vegf), platelet-derived growth factor (pdgf) and b-cell lymphoma 2 (bcl2), and decreasing those of bcl-2-associated x protein (bax), p53 upregulated modulator of apoptosis (puma), and caspase 3. |
2016-10-24 |
2023-08-13 |
Not clear |
| Daniel Radin, Arnold Lippa, Parth Patel, Donna Leonard. Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple-negative breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 77. 2016-10-24. PMID:26796280. |
cisplatin may initiate p73-dependent apoptosis in p53 mutant cell lines through fas trimerization and caspase-8 activation and bax up regulation and subsequent caspase-9 activation. |
2016-10-24 |
2023-08-13 |
Not clear |
| Xiaojun Song, Juan Du, Wei Zhu, Ping Jin, Fei M. Identification and characterization of an apoptosis-stimulating protein of p53 (ASPP) gene from Branchiostoma belcheri: Insights into evolution of ASPP gene family. Fish & shellfish immunology. vol 49. 2016-10-21. PMID:26747639. |
the aspp (apoptosis-stimulating protein of p53) protein family plays very key roles in apoptosis regulation, in both p53-dependent and p53-independent pathways. |
2016-10-21 |
2023-08-13 |
human |
| Catarina Vizetto-Duarte, Luísa Custódio, Katkam N Gangadhar, João Henrique G Lago, Catarina Dias, Ana Marta Matos, Nuno Neng, José Manuel Florêncio Nogueira, Luísa Barreira, Fernando Albericio, Amelia P Rauter, João Varel. Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 5. 2016-10-21. PMID:27064014. |
isololiolide, a carotenoid metabolite isolated from the brown alga cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased bcl-2 levels, increased p53 expression and parp cleavage. |
2016-10-21 |
2023-08-13 |
Not clear |
| Padmavathy Nandha Premnath, Sandra Craig, Campbell McInne. Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors. Journal of visualized experiments : JoVE. issue 105. 2016-10-20. PMID:26554946. |
inhibition of cdk2/cyclin a in s phase has been reported to promote selective apoptosis of cancer cells in a p53 independent manner through the e2f1 pathway. |
2016-10-20 |
2023-08-13 |
Not clear |
| Debarun Roy, Kaushik Das, Subhasish Mondal, Debajit Bhowmick, Souvik Dey, Gopal C Majumder, Biswajit Mukherjee, Debdas Bhattacharyy. Epididymal protein ASF is a D-galactose-specific lectin with apoptotic effect on human breast cancer cell line MCF7. International journal of biological macromolecules. vol 84. 2016-10-20. PMID:26706839. |
the effective anti-adhesive concentration of asf promotes p53 dependent apoptosis in mcf7, which was established by hoechst 33342 staining, dna fragmentation assay, fitc tagged annexin-v flowcytometry and western blot analysis. |
2016-10-20 |
2023-08-13 |
human |
| Alex A Philchenkov, Michael P Zavelevich, Volodymyr P Tryndyak, Ludmila M Kuiava, Dmitry Yu Blokhin, Koh Miura, Romano Silvestri, Igor P Pogribn. Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells. Cancer biology & therapy. vol 16. issue 12. 2016-10-20. PMID:26785947. |
more importantly, findings showing that ati5 treatment induced p53-independent apoptosis are of great importance from a therapeutic point of view since p53 mutations are common genetic alterations in human neoplasms. |
2016-10-20 |
2023-08-13 |
human |
| H Zhang, X Zhou, C Xu, J Yang, J Xiang, M Tao, Y Xi. Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer. Cancer gene therapy. vol 23. issue 1. 2016-10-19. PMID:26564429. |
the synergistic tumor suppression elicited by adving4/pten was closely associated with the synergistic induction of apoptosis possibly via enhancement of endogenous p53 responses through cooperatively facilitating p53's stability and acetylation, and the synergistic inhibition of tumor angiogenesis probably via overlapping reduction of vegf through cooperatively downregulating hypoxia inducible factor-1α's level and transcription activity. |
2016-10-19 |
2023-08-13 |
mouse |
| Alka Choudhary, Brittany Zachek, Robert F Lera, Lauren M Zasadil, Amber Lasek, Ryan A Denu, Hyunjung Kim, Craig Kanugh, Jennifer J Laffin, Josephine M Harter, Kari B Wisinski, Sandeep Saha, Beth A Weaver, Mark E Burkar. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Molecular cancer therapeutics. vol 15. issue 1. 2016-10-18. PMID:26586723. |
dpbq activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind dna. |
2016-10-18 |
2023-08-13 |
human |
| Yongmei Cao, Zhen Jiang, Zhen Zeng, Yujing Liu, Yuchun Gu, Yingying Ji, Yupeng Zhao, Yingchuan L. Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 1. 2016-10-14. PMID:26456506. |
in normal pmvecs, bcl-2-shrna or hre combined with bcl-2-shrna transduction successfully decreased bcl-2 expression, while increasing apoptosis as well as caspase-3 and p53 expression in a normoxic environment. |
2016-10-14 |
2023-08-13 |
rat |
| Yongmei Cao, Zhen Jiang, Zhen Zeng, Yujing Liu, Yuchun Gu, Yingying Ji, Yupeng Zhao, Yingchuan L. Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 1. 2016-10-14. PMID:26456506. |
in a hypoxic environment, the effects of bcl-2-shrna treatment on cell apoptosis, and on bcl-2, caspase-3, p53 expression were significantly suppressed. |
2016-10-14 |
2023-08-13 |
rat |
| Yongmei Cao, Zhen Jiang, Zhen Zeng, Yujing Liu, Yuchun Gu, Yingying Ji, Yupeng Zhao, Yingchuan L. Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 1. 2016-10-14. PMID:26456506. |
conversely, hre activation combined with bcl-2-shrna transduction markedly enhanced cell apoptosis and upregulated caspase-3 and p53 expression, while decreasing bcl-2 expression. |
2016-10-14 |
2023-08-13 |
rat |
| Yongmei Cao, Zhen Jiang, Zhen Zeng, Yujing Liu, Yuchun Gu, Yingying Ji, Yupeng Zhao, Yingchuan L. Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 1. 2016-10-14. PMID:26456506. |
these results suggest that hre-mediated bcl-2 inhibition can effectively attenuate hypoxia-induced apoptosis resistance in pmvecs by downregulating bcl-2 expression and upregulating caspase-3 and p53 expression. |
2016-10-14 |
2023-08-13 |
rat |
| Malabika Banerjee, Subrata Chattopadhyay, Tathagata Choudhuri, Rammohan Bera, Sanjay Kumar, Biswajit Chakraborty, Samir Kumar Mukherje. Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line. Journal of biomedical science. vol 23. 2016-10-14. PMID:27084510. |
this study reports on andrographolide induced apoptosis and its possible mechanism in highly proliferative, invasive breast cancer cells, mda-mb-231 lacking a functional p53 and estrogen receptor (er). |
2016-10-14 |
2023-08-13 |
mouse |
| Wenqian Yu, Guochuang Chen, Pengying Zhang, Kaoshan Che. Purification, partial characterization and antitumor effect of an exopolysaccharide from Rhizopus nigricans. International journal of biological macromolecules. vol 82. 2016-10-13. PMID:26449531. |
eps1-1 caused dissipation of mitochondrial membrane potential, accumulation of reactive oxygen species, up-regulation of bax and p53 mrna expression and down-regulation of bcl-2 mrna expression, which suggested that mitochondrial pathway was involved in the eps1-1-induced apoptosis. |
2016-10-13 |
2023-08-13 |
human |
| Sumit Kumar, Ashu Bhan Tik. Biochemical and Molecular Mechanisms of Radioprotective Effects of Naringenin, a Phytochemical from Citrus Fruits. Journal of agricultural and food chemistry. vol 64. issue 8. 2016-10-13. PMID:26881453. |
although naringenin induces apoptosis in cancer cells we found that it can protect against radiation-induced apoptosis in normal cells by modulating the expression of p53, bax, and bcl-2. |
2016-10-13 |
2023-08-13 |
mouse |
| Jie Wu, Yanbo Zhu, Chun Xu, Hong Xu, Xiumin Zhou, Jicheng Yang, Yufeng Xie, Min Ta. Adenovirus-mediated p53 and ING4 gene co-transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer. Oncology reports. vol 35. issue 1. 2016-10-12. PMID:26530780. |
we demonstrated that adving4/p53-mediated p53 and ing4 co-expression induced synergistic growth inhibition and apoptosis as well as enhanced effects on upregulation of acetylated p53, p21, bax, puma, noxa, cleaved caspase-9, cleaved caspase-3 and cleaved parp, and downregulation of bcl-2, cd31 and microvessel density (mvd) in mda-mb-231 breast cancer in vitro and/or in vivo subcutaneous (s.c.) xenografted tumors. |
2016-10-12 |
2023-08-13 |
human |