| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan-Li Wang, Dan Li, Hong-Dan Yang, Lin He, Wen-Juan Sun, Ze-Lin Duan, Qun Wan. The E3 Ubiquitin Ligase CRL4 Regulates Proliferation and Progression Through Meiosis in Chinese Mitten Crab Eriocheir sinensis. Biology of reproduction. vol 94. issue 3. 2016-12-13. PMID:26864195. |
we speculated that p53-mediated spontaneous germ cell apoptosis acts as a quality control mechanism to eliminate defective germ cells and that the cullin4 complex maintains p53, p21, and p27 homeostasis in primary spermatocytes to regulate spermatogenesis ofe. |
2016-12-13 |
2023-08-13 |
Not clear |
| Xiaofeng Liu, Yuqin Tan, Chunfeng Zhang, Ying Zhang, Liangliang Zhang, Pengwei Ren, Hongkui Deng, Jianyuan Luo, Yang Ke, Xiaojuan D. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO reports. vol 17. issue 3. 2016-12-13. PMID:26882543. |
as a genome guardian, p53 maintains genome stability by arresting cells for damage repair or inducing cell apoptosis to eliminate the damaged cells in stress response. |
2016-12-13 |
2023-08-13 |
human |
| Guoqian He, Wenming Xu, Linyan Tong, Shuaishuai Li, Shiceng Su, Xiaodan Tan, Changqing L. Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury. Apoptosis : an international journal on programmed cell death. vol 21. issue 4. 2016-12-13. PMID:26882903. |
neuron apoptosis was monitored by expression of bcl-2, bax, cleaved caspase3, p53 and tunel assay. |
2016-12-13 |
2023-08-13 |
rat |
| Weihua Yu, Xiaodi Zhang, Jiangzheng Liu, Xin Wang, Shuang Li, Rui Liu, Nai Liao, Tao Zhang, Chunxu Ha. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884717. |
cyclosporine a suppressed glucose oxidase induced p53 mitochondrial translocation and hepatic cell apoptosis through blocking mitochondrial permeability transition. |
2016-12-13 |
2023-08-13 |
mouse |
| Weihua Yu, Xiaodi Zhang, Jiangzheng Liu, Xin Wang, Shuang Li, Rui Liu, Nai Liao, Tao Zhang, Chunxu Ha. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884717. |
there is accumulating evidences show that p53 can directly induce cell apoptosis through transcription independent way at mitochondria. |
2016-12-13 |
2023-08-13 |
mouse |
| Weihua Yu, Xiaodi Zhang, Jiangzheng Liu, Xin Wang, Shuang Li, Rui Liu, Nai Liao, Tao Zhang, Chunxu Ha. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884717. |
taken together, these suggested that csa could suppress ros-mediated p53 mitochondrial distribution and cell apoptosis depended on its inhibition effect to mitochondrial permeability transition. |
2016-12-13 |
2023-08-13 |
mouse |
| Long Chen, Nihal Ahmad, Xiaoqi Li. Combining p53 stabilizers with metformin induces synergistic apoptosis through regulation of energy metabolism in castration-resistant prostate cancer. Cell cycle (Georgetown, Tex.). vol 15. issue 6. 2016-12-13. PMID:26900800. |
combining p53 stabilizers with metformin induces synergistic apoptosis through regulation of energy metabolism in castration-resistant prostate cancer. |
2016-12-13 |
2023-08-13 |
Not clear |
| Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David C S Huang, Lyubomir T Vassilev, Andreas Strasse. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells. Cell reports. vol 14. issue 8. 2016-12-13. PMID:26904937. |
therapeutic response to non-genotoxic activation of p53 by nutlin3a is driven by puma-mediated apoptosis in lymphoma cells. |
2016-12-13 |
2023-08-13 |
mouse |
| Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David C S Huang, Lyubomir T Vassilev, Andreas Strasse. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells. Cell reports. vol 14. issue 8. 2016-12-13. PMID:26904937. |
these results demonstrate that puma-mediated apoptosis, but not p21-mediated cell-cycle arrest or senescence, is a critical determinant of the therapeutic response to non-genotoxic p53 activation by nutlin3a. |
2016-12-13 |
2023-08-13 |
mouse |
| A-X Liu, D Zhang, Y-M Zhu, H-J Gao, J-Y Jiang, X-L Hu, P-P Lv, P C K Leung, H-F Huan. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. Current molecular medicine. vol 16. issue 3. 2016-12-13. PMID:26917260. |
jmr-132 inhibited cellular viability and induced apoptosis in jeg-3 cell in a time and dosedependent manners through activation of caspase-3, p38, and p53, as well as inhibition of phosphorylation of akt. |
2016-12-13 |
2023-08-13 |
human |
| M Harsha Raj, B Yashaswini, Jochen Rössler, Bharathi P Salimat. Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways. Apoptosis : an international journal on programmed cell death. vol 21. issue 5. 2016-12-13. PMID:26921178. |
combinatorial treatment with anacardic acid followed by trail augments induction of apoptosis in trail resistant cancer cells by the regulation of p53, mapk and nfκβ pathways. |
2016-12-13 |
2023-08-13 |
mouse |
| Jiandong Che. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harbor perspectives in medicine. vol 6. issue 3. 2016-12-13. PMID:26931810. |
cell-cycle arrest and apoptosis are the most prominent outcomes of p53 activation. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jiandong Che. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harbor perspectives in medicine. vol 6. issue 3. 2016-12-13. PMID:26931810. |
many studies showed that p53 cell-cycle and apoptosis functions are important for preventing tumor development. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jiandong Che. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harbor perspectives in medicine. vol 6. issue 3. 2016-12-13. PMID:26931810. |
this review focuses on the cell-cycle arrest and apoptosis functions of p53, their roles in tumor suppression, and the regulation of cell fate decision after p53 activation. |
2016-12-13 |
2023-08-13 |
Not clear |
| Sathish Kumar Mungamuri, Rui F Qiao, Shen Yao, James J Manfredi, Wei Gu, Stuart A Aaronso. USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Cell reports. vol 14. issue 11. 2016-12-13. PMID:26971997. |
finally, usp7 blocking cooperates with p53 in inducing apoptosis by enhancing p53 promoter occupancy and dependent transactivation of target genes. |
2016-12-13 |
2023-08-13 |
Not clear |
| Shalini Srivastava, Satyendra Mishra, Avadhesha Surolia, Dulal Pand. C1, a highly potent novel curcumin derivative, binds to tubulin, disrupts microtubule network and induces apoptosis. Bioscience reports. vol 36. issue 2. 2016-12-13. PMID:26980197. |
c1 appeared to induce p53 mediated apoptosis in mcf-7 cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Andrew L Paek, Julia C Liu, Alexander Loewer, William C Forrester, Galit Laha. Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell. vol 165. issue 3. 2016-12-13. PMID:27062928. |
cells must reach a threshold level of p53 to execute apoptosis, and this threshold increases with time. |
2016-12-13 |
2023-08-13 |
Not clear |
| Andrew L Paek, Julia C Liu, Alexander Loewer, William C Forrester, Galit Laha. Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell. vol 165. issue 3. 2016-12-13. PMID:27062928. |
the increase in p53 apoptotic threshold is due to drug-dependent induction of anti-apoptotic genes, predominantly in the inhibitors of apoptosis (iap) family. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yueqiang Wen, Peilan Zhou, Lingling Liu, Zebin Wang, Yajie Zhang, Jianbo Lian. Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. Journal of receptor and signal transduction research. vol 36. issue 2. 2016-11-14. PMID:26400065. |
moreover, cabin1 retards tumor cell apoptosis by regulating p53. |
2016-11-14 |
2023-08-13 |
rat |
| Ji-Sue Baik, Seo-Won Mun, Kyoung-Sook Kim, Shin-Ji Park, Hyun-Kyoung Yoon, Dong-Hyun Kim, Min-Kyu Park, Cheorl-Ho Kim, Young-Choon Le. Apoptotic Effects of Cordycepin Through the Extrinsic Pathway and p38 MAPK Activation in Human Glioblastoma U87MG Cells. Journal of microbiology and biotechnology. vol 26. issue 2. 2016-11-11. PMID:26597532. |
we first demonstrated that cordycepin inhibited cell growth and triggered apoptosis in u87mg cells with wild-type p53, but not in t98g cells with mutant-type p53. |
2016-11-11 |
2023-08-13 |
human |