| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie Hussmann, Kirsten Janke, Philip Kranz, Fabian Neumann, Evgenija Mersch, Melanie Baumann, Kirsten Goepelt, Ulf Brockmeier, Eric Metze. Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Oncotarget. vol 6. issue 36. 2016-12-13. PMID:26513173. |
in contrast, apoptosis was reduced in mda-mb-231 breast cancer cells harboring mutant p53. |
2016-12-13 |
2023-08-13 |
Not clear |
| Chi Zhang, Shunlin Qu, Xing Wei, Yansheng Feng, Honglin Zhu, Jia Deng, Kangkai Wang, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xia. HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis. Cell stress & chaperones. vol 21. issue 2. 2016-12-13. PMID:26515559. |
hsp25 down-regulation enhanced p53 acetylation by dissociation of sirt1 from p53 in doxorubicin-induced h9c2 cell apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Chi Zhang, Shunlin Qu, Xing Wei, Yansheng Feng, Honglin Zhu, Jia Deng, Kangkai Wang, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xia. HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis. Cell stress & chaperones. vol 21. issue 2. 2016-12-13. PMID:26515559. |
these findings indicated a novel mechanism by which hsp25 regulated p53 acetylation through dissociation of sirt1 from p53 in doxorubicin-induced h9c2 cell apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Nastasia Wilfinger, Shane Austin, Barbara Scheiber-Mojdehkar, Walter Berger, Siegfried Reipert, Monika Praschberger, Jakob Paur, Robert Trondl, Bernhard K Keppler, Christoph C Zielinski, Karin Nowikovsk. Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy. Oncotarget. vol 7. issue 2. 2016-12-13. PMID:26517689. |
accordingly, p53 accumulated in the nucleus where it activated its transcriptional target bnip3l, a bh3 only domain protein with functions in apoptosis and mitophagy. |
2016-12-13 |
2023-08-13 |
Not clear |
| Gunilla Olsson, Stefan Czene, Siamak Haghdoost, Mats Harms-Ringdah. Transient delay of radiation-induced apoptosis by phorbol acetate. Radiation and environmental biophysics. vol 55. issue 1. 2016-12-13. PMID:26581877. |
our results indicate that confinement of p53 in the cytoplasm is one of the potential mechanisms by which tpa interferes with the process of radiation-induced apoptosis in human lymphocytes. |
2016-12-13 |
2023-08-13 |
human |
| Min-Chi Yang, Ru-Wei Lin, Shih-Bo Huang, Shin-Yuan Huang, Wen-Jie Chen, Shiaw Wang, Yi-Ren Hong, Chihuei Wan. Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53. Cell cycle (Georgetown, Tex.). vol 15. issue 3. 2016-12-13. PMID:26694174. |
bim directly antagonizes bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53. |
2016-12-13 |
2023-08-13 |
Not clear |
| Min-Chi Yang, Ru-Wei Lin, Shih-Bo Huang, Shin-Yuan Huang, Wen-Jie Chen, Shiaw Wang, Yi-Ren Hong, Chihuei Wan. Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53. Cell cycle (Georgetown, Tex.). vol 15. issue 3. 2016-12-13. PMID:26694174. |
in the current study, we used lncap and pc3 prostate cancer cells, representing wild type p53 and a p53-null model, to determine if dna damage activates p53-mediated apoptosis in prostate cancers. |
2016-12-13 |
2023-08-13 |
Not clear |
| Min-Chi Yang, Ru-Wei Lin, Shih-Bo Huang, Shin-Yuan Huang, Wen-Jie Chen, Shiaw Wang, Yi-Ren Hong, Chihuei Wan. Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53. Cell cycle (Georgetown, Tex.). vol 15. issue 3. 2016-12-13. PMID:26694174. |
bcl-xl rather than p53, likely contributes to the differential response of lncap and pc3 to doxorubicin in apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Shengpeng Wang, Jinming Zhang, Yitao Wang, Meiwan Che. Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. vol 12. issue 2. 2016-12-13. PMID:26711968. |
mir-542-3p serves as a potent tumor suppressor molecule by targeting tumor suppressor p53 and apoptosis inhibitor survivin. |
2016-12-13 |
2023-08-13 |
Not clear |
| Shengpeng Wang, Jinming Zhang, Yitao Wang, Meiwan Che. Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. vol 12. issue 2. 2016-12-13. PMID:26711968. |
intracellular restoration of mir-542-3p further promoted tnbc cell apoptosis via activating p53 and inhibiting survivin expression. |
2016-12-13 |
2023-08-13 |
Not clear |
| Xiao-Li Xu, Qi-chao Bao, Jian-Min Jia, Fang Liu, Xiao-Ke Guo, Ming-ye Zhang, Jin-lian Wei, Meng-chen Lu, Li-li Xu, Xiao-Jin Zhang, Qi-Dong You, Hao-Peng Su. CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells. Scientific reports. vol 6. 2016-12-13. PMID:26743233. |
we prove that treating mcf-7 cells with cpuy201112 results in cell cycle arrest and apoptosis through the wild-type (wt) p53 pathway. |
2016-12-13 |
2023-08-13 |
mouse |
| Shi-Wei Huang, Shu-Hao Chang, Szu-Wei Mu, Hsin-Yi Jiang, Sin-Ting Wang, Jun-Kai Kao, Jau-Ling Huang, Chun-Ying Wu, Yi-Ju Chen, Jeng-Jer Shie. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of dermatological science. vol 81. issue 3. 2016-12-13. PMID:26775629. |
the tumor suppressor p53 controls dna repair, cell cycle, apoptosis, autophagy and numerous other cellular processes. |
2016-12-13 |
2023-08-13 |
human |
| Ingiridur Skirnisdottir, Tomas Seidal, Helena Åkeru. The relationship of the angiogenesis regulators VEGF-A, VEGF-R1 and VEGF-R2 to p53 status and prognostic factors in epithelial ovarian carcinoma in FIGO-stages I-II. International journal of oncology. vol 48. issue 3. 2016-12-13. PMID:26783205. |
the aim of this study was to evaluate prognostic effect of the angiogenesis regulators vegf-r1, vegf-r2 and vegf-a for recurrent disease and disease-free survival (dfs), and their relation to the apoptosis regulator p53, in 131 patients with figo-stages i-ii with epithelial ovarian cancer. |
2016-12-13 |
2023-08-13 |
Not clear |
| C-H Yuan, M Filippova, J L Krstenansky, P J Duerksen-Hughe. Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV⁺ cells. Cell death & disease. vol 7. 2016-12-13. PMID:26794656. |
hpv 16 e6, one of two major viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several proteins important in apoptotic signaling, including caspase 8 and p53. |
2016-12-13 |
2023-08-13 |
human |
| Arman Esfandiari, Thomas A Hawthorne, Sirintra Nakjang, John Lune. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. Molecular cancer therapeutics. vol 15. issue 3. 2016-12-13. PMID:26832796. |
we also assessed the effects of gsk2830371 on mdm2 inhibitor-induced p53(ser15) phosphorylation, p53-mediated global transcriptional activity, and apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Latif Reshi, Horng-Cherng Wu, Jen-Leih Wu, Hao-Ven Wang, Jiann-Ruey Hon. GSIV serine/threonine kinase can induce apoptotic cell death via p53 and pro-apoptotic gene Bax upregulation in fish cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 4. 2016-12-13. PMID:26833308. |
taken altogether, these results suggested that aquatic gsiv st kinase could induce apoptosis via upregulation of p53 and bax expression, resulting in mitochondrial disruption, which activated a downstream caspases-mediated cell death pathway. |
2016-12-13 |
2023-08-13 |
Not clear |
| Mingming Zhu, Cong Huang, Xiao Ma, Rui Wu, Weiwei Zhu, Xiaoting Li, Zhaofeng Liang, Feifei Deng, Jianyun Zhu, Wei Xie, Xue Yang, Ye Jiang, Shijia Wang, Jieshu Wu, Shanshan Geng, Chunfeng Xie, Caiyun Zhon. Modulation of miR-19 in Aluminum-Induced Neural Cell Apoptosis. Journal of Alzheimer's disease : JAD. vol 50. issue 4. 2016-12-13. PMID:26836165. |
in the present study, we showed that aluminum maltolate (al-malt), a lipophilic al complex which is a common component of human diet with the ability to facilitate the entry of al into the brain, induced apoptosis in human neuroblastoma sh-sy5y cells, along with downregulation of mir-19a/mir-19b, upregulation of mir-19-targeted pten, and alterations of its downstream apoptosis related proteins including akt, p53, bax, and bcl-2. |
2016-12-13 |
2023-08-13 |
human |
| Bhanu Priya Kilari, Venkata Subbaiah Kotakadi, Josthna Penchalanen. Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 1. 2016-12-13. PMID:26838257. |
this expression was reversed with apoptosis markers (p53 and caspase-3). |
2016-12-13 |
2023-08-13 |
rat |
| Binwei Zhou, Yanyu Huang, Fang Yang, Wenjie Zheng, Tianfeng Che. Dual-Functional Nanographene Oxide as Cancer-Targeted Drug-Delivery System to Selectively Induce Cancer-Cell Apoptosis. Chemistry, an Asian journal. vol 11. issue 7. 2016-12-13. PMID:26840531. |
moreover, tf-ngo@hpip effectively induced cancer-cell apoptosis through activation of superoxide-mediated p53 and mapk pathways along with inactivation of erk and akt. |
2016-12-13 |
2023-08-13 |
Not clear |
| Philippa Nuttall, Kidan Lee, Pietro Ciccarella, Marco Carminati, Giorgio Ferrari, Ki-Bum Kim, Tim Albrech. Single-Molecule Studies of Unlabeled Full-Length p53 Protein Binding to DNA. The journal of physical chemistry. B. vol 120. issue 9. 2016-12-13. PMID:26855037. |
p53 is an antitumor protein that plays an important role in apoptosis, preserving genomic stability and preventing angiogenesis, and it has been implicated in a large number of human cancers. |
2016-12-13 |
2023-08-13 |
human |