| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Liu, Yujing Zhang, Aichun Liu, Jinghua Wang, Lianqiao Li, Xi Chen, Xinyu Gao, Yanming Xue, Xiaomin Zhang, Yao Li. Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells. International journal of molecular sciences. vol 17. issue 4. 2016-12-15. PMID:27070592. |
in addition, suppression of mtor activity by rapamycin decreased the level of activity of p70s6k, induced upregulation of p53 and caspase 3, and led to increase of apoptosis in k562r(imt) cells. |
2016-12-15 |
2023-08-13 |
human |
| Peng He, Lin Sun, Dan Zhu, Hong Zhang, Liang Zhang, Yujie Guo, Siwen Liu, Jingjing Zhou, Xiaoyan Xu, Peng Xi. Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells. International journal of molecular sciences. vol 17. issue 4. 2016-12-14. PMID:27023521. |
pathway analysis revealed that these differentially expressed genes were mainly involved in pathways related to the cell cycle, the mitogen-activated protein kinase pathway, p53 signaling, and apoptosis. |
2016-12-14 |
2023-08-13 |
human |
| Jiumao Lin, Youqin Chen, Qiaoyan Cai, Lihui Wei, Youzhi Zhan, Aling Shen, Thomas J Sferra, Jun Pen. Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways. Integrative cancer therapies. vol 13. issue 3. 2016-12-13. PMID:24231788. |
we previously reported that the ethanol extract of sb (eesb) is able to induce colon cancer cell apoptosis, inhibit cell proliferation and tumor angiogenesis via modulation of several pathways, including hedgehog, akt, and p53. |
2016-12-13 |
2023-08-12 |
mouse |
| Ali Zekri, Seyed H Ghaffari, Marjan Yaghmaie, Mehrdad Asghari Estiar, Kamran Alimoghaddam, Mohammad Hossein Modarressi, Ardeshir Ghavamzade. Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA. Molecular neurobiology. vol 53. issue 3. 2016-12-13. PMID:25752998. |
furthermore, lower concentrations of azd1152-hqpa profoundly induced apoptosis in u87gm (p53/p73 wild type) cells in parallel with an upregulation of p53 and its target genes bax, bad, apaf1, and puma. |
2016-12-13 |
2023-08-13 |
Not clear |
| Masayuki Kimura, Hajime Abe, Sayaka Mizukami, Takeshi Tanaka, Megu Itahashi, Nobuhiko Onda, Toshinori Yoshida, Makoto Shibutan. Onset of hepatocarcinogen-specific cell proliferation and cell cycle aberration during the early stage of repeated hepatocarcinogen administration in rats. Journal of applied toxicology : JAT. vol 36. issue 2. 2016-12-13. PMID:26011634. |
accumulation of dna damage probably in association with facilitation of p53 degradation by activation of mdm2 may be a prerequisite for aberrant p21(cip1) activation, which is responsible for apoptosis. |
2016-12-13 |
2023-08-13 |
rat |
| Elio A Cino, Iaci N Soares, Mônica S Freitas, Jerson L Silv. Backbone resonance assignments of the human p73 DNA binding domain. Biomolecular NMR assignments. vol 10. issue 1. 2016-12-13. PMID:26294377. |
p53, p63, p73 family of proteins are transcription factors with crucial roles in regulating cellular processes such apoptosis, proliferation, differentiation, and dna damage response. |
2016-12-13 |
2023-08-13 |
human |
| Loredana Urso, Fiorella Calabrese, Adolfo Favaretto, PierFranco Conte, Giulia Pasell. Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment. Critical reviews in oncology/hematology. vol 97. 2016-12-13. PMID:26358421. |
the tumor suppressor p53 regulates genes involved in dna repair, metabolism, cell cycle arrest, apoptosis and senescence. |
2016-12-13 |
2023-08-13 |
human |
| Loredana Urso, Fiorella Calabrese, Adolfo Favaretto, PierFranco Conte, Giulia Pasell. Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment. Critical reviews in oncology/hematology. vol 97. 2016-12-13. PMID:26358421. |
p53 reactivation through mdm2 inhibitors seems to be a promising strategy to sensitize p53 wild-type cancer cells to apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| H Kim, J Zhao, Q Zhang, Y Wang, D Lee, X Bai, L Turrell, M Chen, W Gao, S Keshavjee, M Li. δV1-1 Reduces Pulmonary Ischemia Reperfusion-Induced Lung Injury by Inhibiting Necrosis and Mitochondrial Localization of PKCδ and p53. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 16. issue 1. 2016-12-13. PMID:26368845. |
δv1-1, a pkcδ peptide inhibitor, reduced translocation of pkcδ and p53 to the mitochondria after 18 h cit, rescued er stress protein expression, and converted the major mode of cell death from necrosis to apoptosis. |
2016-12-13 |
2023-08-13 |
rat |
| Dharmalingam Prakash, Ganapasam Sudhandira. Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain. The Journal of nutritional biochemistry. vol 26. issue 12. 2016-12-13. PMID:26411262. |
we found aggregation of amyloid beta (aβ 40-42), elevated expressions of apoptosis stimulating kinase (ask-1), p-jnk (c-jun n-terminal kinase), p53, cytochrome c, caspases-9 and 3, with altered bax/bcl-2 ratio in favour of apoptosis in cortex and hippocampus of alcl3-administered mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Hao Yu, Yong Yang, Qiaoyu Li, Tieliang Ma, Jun Xu, Taofeng Zhu, Jing Xie, Wenjiao Zhu, Zhihong Cao, Kun Dong, Jiancui Huang, Lei Ji. Ternary Dinuclear Copper(II) Complexes of a Reduced Schiff Base Ligand with Diimine Coligands: DNA Binding, Cytotoxic Cell Apoptosis, and Apoptotic Mechanism. Chemical biology & drug design. vol 87. issue 3. 2016-12-13. PMID:26427013. |
furthermore, cell apoptosis was detected by annexinv/pi flow cytometry and tunel assay and by western blotting to detect the protein expression of p53, bax, and bcl-2. |
2016-12-13 |
2023-08-13 |
human |
| Hao Yu, Yong Yang, Qiaoyu Li, Tieliang Ma, Jun Xu, Taofeng Zhu, Jing Xie, Wenjiao Zhu, Zhihong Cao, Kun Dong, Jiancui Huang, Lei Ji. Ternary Dinuclear Copper(II) Complexes of a Reduced Schiff Base Ligand with Diimine Coligands: DNA Binding, Cytotoxic Cell Apoptosis, and Apoptotic Mechanism. Chemical biology & drug design. vol 87. issue 3. 2016-12-13. PMID:26427013. |
all the three copper complexes can effectively induce apoptosis of the three human tumor cells, which was accompanied with upregulation of the expression of p53 and bax, while bcl-2 decreased. |
2016-12-13 |
2023-08-13 |
human |
| Lin Liu, Wenjun Lin, Qin Zhang, Wangsen Cao, Zhihong Li. TGF-β induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression. Journal of molecular medicine (Berlin, Germany). vol 94. issue 3. 2016-12-13. PMID:26432290. |
furthermore, tsa or rgfp966 treatment reversed tgf-β-induced up-regulation of mir-30d targets notch1 and p53 and alleviated the podocyte cytoskeleton damage and apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Mahadev Rao, Scott M Atay, Vivek Shukla, Young Hong, Trevor Upham, R Taylor Ripley, Julie A Hong, Mary Zhang, Emily Reardon, Patricia Fetsch, Markku Miettinen, Xinmin Li, Cody J Peer, Tristan Sissung, William D Figg, Assunta De Rienzo, Raphael Bueno, David S Schrum. Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 22. issue 5. 2016-12-13. PMID:26459178. |
mithramycin depletes specificity protein 1 and activates p53 to mediate senescence and apoptosis of malignant pleural mesothelioma cells. |
2016-12-13 |
2023-08-13 |
human |
| G Renner, H Janouskova, F Noulet, V Koenig, E Guerin, S Bär, J Nuesch, F Rechenmacher, S Neubauer, H Kessler, A-F Blandin, L Choulier, N Etienne-Selloum, M Lehmann, I Lelong-Rebel, S Martin, M Dontenwil. Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell death and differentiation. vol 23. issue 4. 2016-12-13. PMID:26470725. |
however, p53-dependent apoptosis is not always achieved by p53-reactivating compounds such as nutlin-3a, although full transcriptional activity of p53 could be obtained. |
2016-12-13 |
2023-08-13 |
Not clear |
| G Renner, H Janouskova, F Noulet, V Koenig, E Guerin, S Bär, J Nuesch, F Rechenmacher, S Neubauer, H Kessler, A-F Blandin, L Choulier, N Etienne-Selloum, M Lehmann, I Lelong-Rebel, S Martin, M Dontenwil. Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell death and differentiation. vol 23. issue 4. 2016-12-13. PMID:26470725. |
we discovered that α5β1 integrin-specific blocking antibodies or small rgd-like antagonists in association with nutlin-3a triggered a caspase (casp) 8/casp 3-dependent strong apoptosis in glioma cells expressing a functional p53. |
2016-12-13 |
2023-08-13 |
Not clear |
| Mohamed Hassan, Abdelouahid El Khattouti, Ahmed Ejaeidi, Tangeng Ma, William A Day, Ingrid Espinoza, Srinivasan Vijayakumar, Christian R Gome. Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells. Journal of cellular biochemistry. vol 117. issue 6. 2016-12-13. PMID:26505164. |
γ-irradiation-induced apoptosis of pca cells is associated with expression of e2f1, p53, p21 proteins together with the phosphorylation of apoptosis signal-regulating kinase1 (ask1), c-jun-n-terminal kinase (jnk) and ataxia-telangiectasia mutated (atm) and histone family member x (h2ax). |
2016-12-13 |
2023-08-13 |
Not clear |
| Mohamed Hassan, Abdelouahid El Khattouti, Ahmed Ejaeidi, Tangeng Ma, William A Day, Ingrid Espinoza, Srinivasan Vijayakumar, Christian R Gome. Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells. Journal of cellular biochemistry. vol 117. issue 6. 2016-12-13. PMID:26505164. |
the observed radio-resistance of pca is thought to be the consequence of hurp-mediated destabilization of p53 and atm proteins that are essential for the modulation of γ-irradiation-induced apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| b' Barbora Brodsk\\xc3\\xa1, Ale\\xc5\\xa1 Holoubek, Petra Otev\\xc5\\x99elov\\xc3\\xa1, Kate\\xc5\\x99ina Ku\\xc5\\xbeelov\\xc3\\xa. Low-Dose Actinomycin-D Induces Redistribution of Wild-Type and Mutated Nucleophosmin Followed by Cell Death in Leukemic Cells. Journal of cellular biochemistry. vol 117. issue 6. 2016-12-13. PMID:26505272.' |
in cells expressing the tumor suppresor p53 (cml-t1, oci-aml3), cell cycle arrest in g1/g0 phase was followed by p53-dependent apoptosis while in p53-null hl60 cells, transient g2/m-phase arrest was followed by cell necrosis. |
2016-12-13 |
2023-08-13 |
human |
| Akshay Bhinge, Seema C Namboori, Angela Bithell, Chiara Soldati, Noel J Buckley, Lawrence W Stanto. MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration. Stem cells (Dayton, Ohio). vol 34. issue 1. 2016-12-13. PMID:26507573. |
additionally, mir-375 inhibits the tumor suppressor p53 and protects neurons from apoptosis in response to dna damage. |
2016-12-13 |
2023-08-13 |
mouse |