| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J I Belle, J C Petrov, D Langlais, F Robert, R Cencic, S Shen, J Pelletier, P Gros, A Nijni. Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance. Cell death and differentiation. vol 23. issue 5. 2016-12-28. PMID:26768662. |
mechanistically, we find that the mysm1 protein associates with p53 and colocalizes to promoters of classical p53-target genes bbc3/puma (p53 upregulated modulator of apoptosis) and cdkn1a/p21. |
2016-12-28 |
2023-08-13 |
mouse |
| Ruixuan Wang, Lijie Ma, Dan Weng, Jiahui Yao, Xueying Liu, Faguang Ji. Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:26987028. |
the results showed that both ga and cisplatin changed the morphology, inhibited the growth and induced apoptosis in the h446 cells by inducing generation of ros, disruption of mmp, downregulation of xiap expression, and upregulation of bax, apaf-1, diablo and p53 expression. |
2016-12-27 |
2023-08-13 |
human |
| Yi Mei Zheng, Amy Xiaoxu Lu, James Zheng Shen, Amy Ho Yan Kwok, Wing Shing H. Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26794238. |
imperatorin induced the apoptosis of colon cancer cells through upregulation of p53 and the caspase cascade. |
2016-12-26 |
2023-08-13 |
human |
| You-Zhi Xu, Yong-Huai Li, Wen-Jie Lu, Kun Lu, Chun-Ting Wang, Yan Li, Hong-Jun Lin, Li-Xin Kan, Sheng-Yong Yang, Si-Ying Wang, Ying-Lan Zha. YL4073 is a potent autophagy-stimulating antitumor agent in an in vivo model of Lewis lung carcinoma. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26847587. |
the anticancer and autophagy stimulating efficacy was confirmed by several factors, including the appearance of autophagic vacuoles, formation of acidic vesicular organelles, recruitment of microtubule-associated protein 1 light chain 3 ii (lc3-ii) to the autophagosomes, conversion and cleavage of lc3-i to lc3-ii, upregulation of beclin 1 expression, and formation of the atg12-atg5 conjugate in ll/2 cells after yl4073 treatment for 24 or 48 h. furthermore, p53 activation and p-histone h3 phosphorylation occurred after cell exposure to yl4073 for 48 h, suggesting that cell apoptosis had occurred. |
2016-12-26 |
2023-08-13 |
Not clear |
| Kyusik Shin, Ki Hyung Kim, Man Soo Yoon, Dong Soo Suh, Ji Young Lee, Ari Kim, Wankyu E. Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 25. issue 3. 2016-12-23. PMID:27629740. |
the tumor suppressor, p53, plays an important role in regulating cell cycles and apoptosis. |
2016-12-23 |
2023-08-13 |
Not clear |
| Yihao Zhu, Shu Li, Xiaohua Ten. The involvement of the mitochondrial pathway in manganese-induced apoptosis of chicken splenic lymphocytes. Chemosphere. vol 153. 2016-12-23. PMID:27035383. |
our research indicated that excess mn induced ros and mda content, inhibited mn-sod and gsh-px activities, induced bax and p53 mrna expression, inhibited bcl-2 and cam mrna expression, induced caspase-3 mrna and protein expression, upregulated [ca(2+)]i, inhibited ΔΨm, and induced apoptosis in a dose effect. |
2016-12-23 |
2023-08-13 |
chicken |
| Simona Daniele, Elisabetta Barresi, Elisa Zappelli, Luciana Marinelli, Ettore Novellino, Federico Da Settimo, Sabrina Taliani, Maria L Trincavelli, Claudia Martin. Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells. Oncotarget. vol 7. issue 7. 2016-12-21. PMID:26761214. |
the new compound elicited a tspo-mediated mitochondrial membrane dissipation and restored p53 activity, triggering a long-lasting apoptosis of gbm cells. |
2016-12-21 |
2023-08-13 |
human |
| D Cai, E Huang, B Luo, Y Yang, F Zhang, C Liu, Z Lin, W-B Xie, H Wan. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell death & disease. vol 7. 2016-12-21. PMID:27031958. |
elevated p53 expression raised up puma expression, which initiated mitochondrial apoptosis by downregulating antiapoptotic bcl-2, followed by upregulation of proapoptotic bax, resulting in translocation of cytochrome c (cyto c), an apoptogenic factor, from the mitochondria to cytoplasm and activation of caspase-dependent pathways. |
2016-12-21 |
2023-08-13 |
human |
| D Cai, E Huang, B Luo, Y Yang, F Zhang, C Liu, Z Lin, W-B Xie, H Wan. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell death & disease. vol 7. 2016-12-21. PMID:27031958. |
these findings were supported by data showing meth-induced apoptosis was significantly inhibited by silencing nupr1, chop or p53, or by puma or beclin1 knockdown. |
2016-12-21 |
2023-08-13 |
human |
| J H Kang, J-S Lee, D Hong, S-H Lee, N Kim, W-K Lee, T-W Sung, Y-D Gong, S-Y Ki. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell death & disease. vol 7. 2016-12-21. PMID:27031960. |
in renal cell carcinoma, transglutaminase 2 (tgase 2) crosslinks p53 in autophagosomes, resulting in p53 depletion and the tumor's evasion of apoptosis. |
2016-12-21 |
2023-08-13 |
human |
| J H Kang, J-S Lee, D Hong, S-H Lee, N Kim, W-K Lee, T-W Sung, Y-D Gong, S-Y Ki. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell death & disease. vol 7. 2016-12-21. PMID:27031960. |
inhibition of tgase 2 stabilizes p53 and induces tumor cells to enter apoptosis. |
2016-12-21 |
2023-08-13 |
human |
| J H Kang, J-S Lee, D Hong, S-H Lee, N Kim, W-K Lee, T-W Sung, Y-D Gong, S-Y Ki. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell death & disease. vol 7. 2016-12-21. PMID:27031960. |
in addition to the increase in p53 stability due to tgase 2 inhibition, the administration of a dna-damaging anti-cancer drug such as doxorubicin-induced apoptosis in rcc cell lines and synergistically reduced tumor volume in a xenograft model. |
2016-12-21 |
2023-08-13 |
human |
| Jin-Yong Lee, Maki Tokumoto, Yasuyuki Fujiwara, Tatsuya Hasegawa, Yoshiyuki Seko, Akinori Shimada, Masahiko Sato. Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity. Scientific reports. vol 6. 2016-12-20. PMID:26912277. |
double knockdown of ube2d2 and ube2d4 caused an increase in p53 protein levels, and knockdown of p53 attenuated not only cd-induced apoptosis, but also cd-induced apoptosis-related gene expression (bax and puma). |
2016-12-20 |
2023-08-13 |
mouse |
| Jin-Yong Lee, Maki Tokumoto, Yasuyuki Fujiwara, Tatsuya Hasegawa, Yoshiyuki Seko, Akinori Shimada, Masahiko Sato. Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity. Scientific reports. vol 6. 2016-12-20. PMID:26912277. |
additionally, the mice exposed to cd for 6 months resulted in increased levels of p53 and induction of apoptosis in proximal tubular cells. |
2016-12-20 |
2023-08-13 |
mouse |
| Constance Qiao Xin Yeo, Irina Alexander, Zhaoru Lin, Shuhui Lim, Obed Akwasi Aning, Ramesh Kumar, Kanda Sangthongpitag, Vishal Pendharkar, Vincent H B Ho, Chit Fang Cheo. p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication. Cell reports. vol 15. issue 1. 2016-12-20. PMID:27052176. |
p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. |
2016-12-20 |
2023-08-13 |
Not clear |
| Lu Chen, Zhuyun Jiang, Hui Ma, Ling Ning, Hongdan Chen, Li Li, Hongyi Q. Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells. Scientific reports. vol 6. 2016-12-19. PMID:26892186. |
volatile oil of acori graminei rhizoma-induced apoptosis and autophagy are dependent on p53 status in human glioma cells. |
2016-12-19 |
2023-08-13 |
human |
| Lu Chen, Zhuyun Jiang, Hui Ma, Ling Ning, Hongdan Chen, Li Li, Hongyi Q. Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells. Scientific reports. vol 6. 2016-12-19. PMID:26892186. |
apoptosis was triggered by voa with a caspase-dependent way in p53 wild-type a172 cells, while a caspase-independent way in p53 mutant u251 cells. |
2016-12-19 |
2023-08-13 |
human |
| Lu Chen, Zhuyun Jiang, Hui Ma, Ling Ning, Hongdan Chen, Li Li, Hongyi Q. Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells. Scientific reports. vol 6. 2016-12-19. PMID:26892186. |
furthermore, p53 decrease was observed along with voa-induced apoptosis and autophagy in a172 cells. |
2016-12-19 |
2023-08-13 |
human |
| Gustavo Tomas Diaz-Gerevini, Gaston Repossi, Alejandro Dain, María Cristina Tarres, Undurti Narasimha Das, Aldo Renato Eynar. Beneficial action of resveratrol: How and why? Nutrition (Burbank, Los Angeles County, Calif.). vol 32. issue 2. 2016-12-15. PMID:26706021. |
flavonoid resveratrol modulates the transcription factor nf-κb; inhibits the cytochrome p450 isoenzyme cyp1 a1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates fas/fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases. |
2016-12-15 |
2023-08-13 |
Not clear |
| Jinhua Jiang, Yanhong Chen, Ruixian Yu, Xueping Zhao, Qiang Wang, Leiming Ca. Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Environmental toxicology and pharmacology. vol 42. 2016-12-15. PMID:26851375. |
moreover, the up-regulation of p53, mdm2, bbc3 expression and caspase3 and caspase9 activities in the apoptosis pathway suggested pretilachlor might trigger cell apoptosis in zebrafish. |
2016-12-15 |
2023-08-13 |
cat |