| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| In-Hu Hwang, Yong-Kyun Kwon, Chong-Kwan Cho, Yeon-Weol Lee, Jung-Suk Sung, Jong-Cheon Joo, Kyung-Bok Lee, Hwa-Seung Yoo, Ik-Soon Jan. Modified Panax ginseng Extract Inhibits uPAR-Mediated α[Formula: see text]β1-Integrin Signaling by Modulating Caveolin-1 to Induce Early Apoptosis in Lung Cancer Cells. The American journal of Chinese medicine. vol 44. issue 5. 2017-01-17. PMID:27430913. |
thus, these findings identify a novel mechanism whereby the inhibition of [formula: see text]1 integrin and the activation of p53 modulate the expression of the anti-apoptotic proteins that are crucially involved in inducing apoptosis in a549 lung cancer cells. |
2017-01-17 |
2023-08-13 |
human |
| Chiara Giacomelli, Letizia Natali, Maria Letizia Trincavelli, Simona Daniele, Alessandra Bertoli, Guido Flamini, Alessandra Braca, Claudia Martin. New insights into the anticancer activity of carnosol: p53 reactivation in the U87MG human glioblastoma cell line. The international journal of biochemistry & cell biology. vol 74. 2017-01-17. PMID:26939786. |
the p53 pathway is involved in the control of apoptosis and is often impaired in gbm. |
2017-01-17 |
2023-08-13 |
human |
| Chiara Giacomelli, Letizia Natali, Maria Letizia Trincavelli, Simona Daniele, Alessandra Bertoli, Guido Flamini, Alessandra Braca, Claudia Martin. New insights into the anticancer activity of carnosol: p53 reactivation in the U87MG human glioblastoma cell line. The international journal of biochemistry & cell biology. vol 74. 2017-01-17. PMID:26939786. |
accordingly, functional reactivation of p53 was demonstrated by the stimulation of p53 target genes' transcription, the induction of apoptosis and cell cycle blockade. |
2017-01-17 |
2023-08-13 |
human |
| Mohammad F Shaikh, William F Morano, John Lee, Elizabeth Gleeson, Blake D Babcock, Josef Michl, Ehsan Sarafraz-Yazdi, Matthew R Pincus, Wilbur B Bown. Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review. Annals of clinical and laboratory science. vol 46. issue 6. 2017-01-13. PMID:27993876. |
in normal, untransformed cells, mdm2 levels are tightly regulated to control expression of p53 and apoptosis. |
2017-01-13 |
2023-08-13 |
human |
| Mohammad F Shaikh, William F Morano, John Lee, Elizabeth Gleeson, Blake D Babcock, Josef Michl, Ehsan Sarafraz-Yazdi, Matthew R Pincus, Wilbur B Bown. Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review. Annals of clinical and laboratory science. vol 46. issue 6. 2017-01-13. PMID:27993876. |
disrupting mdm2-p53 interaction with resultant increase in p53 induces cancer cell cycle arrest and apoptosis. |
2017-01-13 |
2023-08-13 |
human |
| Li-Yuan Bai, Chang-Fang Chiu, Po-Chen Chu, Wei-Yu Lin, Shih-Jiuan Chiu, Jing-Ru Wen. A triterpenoid from wild bitter gourd inhibits breast cancer cells. Scientific reports. vol 6. 2017-01-13. PMID:26926586. |
tcd induced cell apoptosis accompanied with pleiotrophic biological modulations including down-regulation of akt-nf-κb signaling, up-regulation of p38 mitogen-activated protein kinase and p53, increased reactive oxygen species generation, inhibition of histone deacetylases protein expression, and cytoprotective autophagy. |
2017-01-13 |
2023-08-13 |
Not clear |
| Takako Yasuda, Yoshitaka Kimori, Kento Nagata, Kento Igarashi, Tomomi Watanabe-Asaka, Shoji Oda, Hiroshi Mitan. Irradiation-injured brain tissues can self-renew in the absence of the pivotal tumor suppressor p53 in the medaka (Oryzias latipes) embryo. Journal of radiation research. vol 57. issue 1. 2017-01-10. PMID:26410759. |
the tumor suppressor protein, p53, plays pivotal roles in regulating apoptosis and proliferation in the embryonic and adult central nervous system (cns) following neuronal injuries such as those induced by ionizing radiation. |
2017-01-10 |
2023-08-13 |
Not clear |
| Takako Yasuda, Yoshitaka Kimori, Kento Nagata, Kento Igarashi, Tomomi Watanabe-Asaka, Shoji Oda, Hiroshi Mitan. Irradiation-injured brain tissues can self-renew in the absence of the pivotal tumor suppressor p53 in the medaka (Oryzias latipes) embryo. Journal of radiation research. vol 57. issue 1. 2017-01-10. PMID:26410759. |
our present results demonstrated that self-renewal of the brain tissue completed faster in the absence of p53 than wild type at the time of hatching because p53 reduces the acute severe neural apoptosis induced by irradiation, suggesting that p53 is not essential for tissue self-renewal in developing brain. |
2017-01-10 |
2023-08-13 |
Not clear |
| Cen Zhang, Juan Liu, Chunwen Tan, Xuetian Yue, Yuhan Zhao, Jiaping Peng, Xiaolong Wang, Saurabh V Laddha, Chang S Chan, Shu Zheng, Wenwei Hu, Zhaohui Fen. microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. Oncotarget. vol 7. issue 8. 2017-01-09. PMID:26840028. |
mir-1827 negatively regulates mdm2, which in turn increases p53 protein levels to increase transcriptional activity of p53 and enhance p53-mediated stress responses, including apoptosis and senescence. |
2017-01-09 |
2023-08-13 |
mouse |
| Yan Liu, Tingting Bi, Wei Dai, Gang Wang, Liqiang Qian, Genhai Shen, Quangen Ga. Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 5. 2017-01-09. PMID:26892272. |
co-treatment with lupeol and 5-fu induced apoptosis through up-regulating the expressions of bax and p53 and down-regulating the expressions of survivin and bcl-2. |
2017-01-09 |
2023-08-13 |
mouse |
| Wei Dai, Jingfeng Zhou, Bei Jin, Jingxuan Pa. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Scientific reports. vol 6. 2017-01-09. PMID:26940009. |
our results showed that inhibition of sirt1/2 by tenovin-6 induced apoptosis in um cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ros). |
2017-01-09 |
2023-08-13 |
Not clear |
| D A Il'in, S A Arkhipov, V A Shkurup. In Vitro Study of Cytophysiological Characteristics of Multinuclear Macrophages from Intact and BCG-Infected Mice. Bulletin of experimental biology and medicine. vol 160. issue 5. 2017-01-09. PMID:27021088. |
multinuclear macrophages formed in these cultures differed by the number of nuclei, expression of apoptosis inductors and regulators (tnf-α, p53 protein, caspase 3, and bcl-2 protein), and cytophysiological characteristics (phagocytic activity, ros generation, and antimycobacterial properties). |
2017-01-09 |
2023-08-13 |
mouse |
| D A Il'in, S A Arkhipov, V A Shkurup. In Vitro Study of Cytophysiological Characteristics of Multinuclear Macrophages from Intact and BCG-Infected Mice. Bulletin of experimental biology and medicine. vol 160. issue 5. 2017-01-09. PMID:27021088. |
our results indicate that the formation of multinuclear macrophages is accompanied by induction of apoptosis (p53 signaling pathway) and appearance of multinuclear macrophage-derived cells characterized by high phagocytic and antimycobacterial activity. |
2017-01-09 |
2023-08-13 |
mouse |
| Heran Wang, Ran Zhao, Chi Guo, Shihe Jiang, Jing Yang, Yang Xu, Yukun Liu, Liqing Fan, Wei Xiong, Jian Ma, Shuping Peng, Zhaoyang Zeng, Yanhong Zhou, Xiayu Li, Zheng Li, Xiaoling Li, David C Schmitt, Ming Tan, Guiyuan Li, Ming Zho. Knockout of BRD7 results in impaired spermatogenesis and male infertility. Scientific reports. vol 6. 2017-01-05. PMID:26878912. |
moreover, a high ratio of apoptosis was determined by tunel analysis, which was supported by high levels of the apoptosis markers annexin v and p53 in knockout testes. |
2017-01-05 |
2023-08-13 |
mouse |
| Si Chen, Lei Rong, Hui-Zhen Jia, Si-Yong Qin, Xuan Zeng, Ren-Xi Zhuo, Xian-Zheng Zhan. Co-delivery of proapoptotic peptide and p53 DNA by reduction-sensitive polypeptides for cancer therapy. Biomaterials science. vol 3. issue 5. 2017-01-04. PMID:26222594. |
the obtained xpolyr8-kla(tpp) could not only initiate tumor cell apoptosis by c-kla(tpp) with improved cell penetrating ability, but was also capable of loading and delivering the tumor cell suppressing p53 gene. |
2017-01-04 |
2023-08-13 |
Not clear |
| Nobuhisa Yoshikawa, Hiroaki Kajiyama, Kae Nakamura, Fumi Utsumi, Kaoru Niimi, Hiroko Mitsui, Ryuichiro Sekiya, Shiro Suzuki, Kiyosumi Shibata, David Callen, Fumitaka Kikkaw. PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells. Oncology reports. vol 35. issue 5. 2016-12-30. PMID:26986846. |
prima-1met induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells. |
2016-12-30 |
2023-08-13 |
Not clear |
| Nobuhisa Yoshikawa, Hiroaki Kajiyama, Kae Nakamura, Fumi Utsumi, Kaoru Niimi, Hiroko Mitsui, Ryuichiro Sekiya, Shiro Suzuki, Kiyosumi Shibata, David Callen, Fumitaka Kikkaw. PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells. Oncology reports. vol 35. issue 5. 2016-12-30. PMID:26986846. |
recently, prima-1 and prima‑1met (p53 reactivation and induction of massive apoptosis and its methylated form) were shown to have an antitumor effect on several types of cancer. |
2016-12-30 |
2023-08-13 |
Not clear |
| Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells. Oncology reports. vol 35. issue 5. 2016-12-29. PMID:26936454. |
taken together, the present study revealed that ca induced apoptosis in caki cells by induction of p53 and suppression of stat3 signaling. |
2016-12-29 |
2023-08-13 |
human |
| Yang Lu, Jun Wen, DaPeng Chen, LingLing Wu, QingGang Li, Yuansheng Xie, Di Wu, Xiaoluan Liu, XiangMei Che. Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis. Clinical and experimental nephrology. vol 20. issue 2. 2016-12-28. PMID:26359229. |
modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during habu nephritis. |
2016-12-28 |
2023-08-13 |
mouse |
| Yang Lu, Jun Wen, DaPeng Chen, LingLing Wu, QingGang Li, Yuansheng Xie, Di Wu, Xiaoluan Liu, XiangMei Che. Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis. Clinical and experimental nephrology. vol 20. issue 2. 2016-12-28. PMID:26359229. |
in this study, we explored the role of cyclins and p53 in modulating mc proliferation and apoptosis in a mouse model of habu nephritis. |
2016-12-28 |
2023-08-13 |
mouse |