| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pramita Chakraborty, Somnath Singha Roy, Abhishek Basu, Sudin Bhattachary. Sensitization of cancer cells to cyclophosphamide therapy by an organoselenium compound through ROS-mediated apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-01. PMID:27856111. |
all the above results together proposed that, dmse sensitized tumor cells to cyclophosphamide therapy through ros-induced p53 activation and mitochondria-mediated caspase dependent apoptosis. |
2017-02-01 |
2023-08-13 |
mouse |
| Xiaoqing Wang, Dazhong Wang, Yumei Zha. Effect and Mechanism of Resveratrol on the Apoptosis of Lung Adenocarcinoma Cell Line A549. Cell biochemistry and biophysics. vol 73. issue 2. 2017-01-31. PMID:27352348. |
our study demonstrates that res inhibits proliferation and induces apoptosis of a549 cells through regulation of p53, bax, bcl-2, and cleaved caspase-3 expression. |
2017-01-31 |
2023-08-13 |
Not clear |
| Rupamoni Thakur, Sudarshan Kini, Sillarine Kurkalang, Atanu Banerjee, Purba Chatterjee, Abhishek Chanda, Anupam Chatterjee, Dulal Panda, Ashis K Mukherje. Mechanism of apoptosis induction in human breast cancer MCF-7 cell by Ruviprase, a small peptide from Daboia russelii russelii venom. Chemico-biological interactions. vol 258. 2017-01-31. PMID:27613483. |
immunofluorescence microscopic analysis indicated ruviprase induced apoptosis in mcf-7 cells through p53 and p21-mediated pathways. |
2017-01-31 |
2023-08-13 |
human |
| Jianjun Wang, Yang Jiao, Lunmeng Cui, Lili Jian. miR-30 functions as an oncomiR in gastric cancer cells through regulation of P53-mediated mitochondrial apoptotic pathway. Bioscience, biotechnology, and biochemistry. vol 81. issue 1. 2017-01-31. PMID:27729002. |
knockdown of p53 inhibited mir-30-inhibitor-induced suppression of cell proliferation and increase of apoptosis. |
2017-01-31 |
2023-08-13 |
Not clear |
| Feng Zhang, Ming Zhang, Aixiu Wang, Mingcui Xu, Chen Wang, Guifang Xu, Bin Zhang, Xiaoping Zou, Yuzheng Zhug. TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence. Cell biology international. vol 41. issue 2. 2017-01-31. PMID:27888541. |
to detect the effects of tumor necrosis factor-like weak inducer of apoptosis (tweak) on sirt1 expression and p53 deacetylation, involving cell senescence, in activated human hepatic stellate cell (hsc) in vitro, human hsc lx-2 was cultured with tweak for 24 h. |
2017-01-31 |
2023-08-13 |
human |
| Xue-Ling Wang, Li-Yan Wu, Long Zhao, Li-Na Sun, Hai-Ying Liu, Gang Liu, Guang-Ju Gua. SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-01-30. PMID:27470548. |
additionally, the deacetylase activity of sirt1, and the expression levels of sirt1 and of representative apoptosis markers, such as p53, acetylated p53, cleaved caspase-3, caspase-9, and cleaved parp, were measured. |
2017-01-30 |
2023-08-13 |
human |
| Xia Wang, Xingli Gao, Bingnan He, Yuanxiang Jin, Zhengwei F. Cis-bifenthrin causes immunotoxicity in murine macrophages. Chemosphere. vol 168. 2017-01-27. PMID:27916261. |
we found that the expression of p53 and caspase-3 was up-regulated, while the expression of bcl-2 was down-regulated during cis-bf-induced apoptosis. |
2017-01-27 |
2023-08-13 |
human |
| Monika Kosacka, Irena Porębska, Anna Korzeniewska, Renata Rubinsztajn, Marcin Grabicki, Renata Jankowska, Halina Batura-Gabryel, Ryszarda Chaza. Serum levels of apoptosis-related markers (sFasL, TNF-a, p53 and bcl-2) in COPD patients. Pneumonologia i alergologia polska. vol 84. issue 1. 2017-01-27. PMID:26687668. |
taking into account important role of apoptosis in copd pathogenesis, we wanted to asses the serum levels of markers involved in apoptosis regulation, including apoptosis inducers such as tnf-a, sfasl or p53 protein and apoptosis inhibitor bcl-2 and, in addition, to compare these markers with selected copd parameters. |
2017-01-27 |
2023-08-13 |
Not clear |
| Vera Chesnokova, Svetlana Zonis, Cuiqi Zhou, Maria Victoria Recouvreux, Anat Ben-Shlomo, Takako Araki, Robert Barrett, Michael Workman, Kolja Wawrowsky, Vladimir A Ljubimov, Magdalena Uhart, Shlomo Melme. Growth hormone is permissive for neoplastic colon growth. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 23. 2017-01-27. PMID:27226307. |
we also demonstrate that gh suppresses p53 and reduces apoptosis in human colon cell lines as well as in induced human pluripotent stem cell-derived intestinal organoids, and confirm in vivo that gh suppresses colon mucosal p53/p21. |
2017-01-27 |
2023-08-13 |
mouse |
| Behzad Mansoori, Ali Mohammadi, Solmaz Shirjang, Elham Baghbani, Behzad Baradara. Micro RNA 34a and Let-7a Expression in Human Breast Cancers is Associated with Apoptotic Expression Genes. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 4. 2017-01-24. PMID:27221871. |
in this study, expression of mir-34a, let-7a and apoptosis pathway genes such as bcl-2, caspase-3 and p53 were evaluated using quantitative real-time pcr in 45 paired samples of normal margin and tumor tissue collected from breast cancer patient at advanced stage (3-4). |
2017-01-24 |
2023-08-13 |
human |
| Su-Yu Chen, Chao-Lin Chang, Teng-Hai Chen, Ya-Wen Chang, Shwu-Bin Li. Colossolactone H, a new Ganoderma triterpenoid exhibits cytotoxicity and potentiates drug efficacy of gefitinib in lung cancer. Fitoterapia. vol 114. 2017-01-23. PMID:27575325. |
accordingly, colo h was found to halt cell growth and induce cell apoptosis via the elevation of cellular reactive oxygen species to cause dna damage and the increase of tumor suppressor p53 protein. |
2017-01-23 |
2023-08-13 |
mouse |
| Antonella Tramutola, Gilda Pupo, Fabio Di Domenico, Eugenio Barone, Andrea Arena, Chiara Lanzillotta, Diede Brokeaart, Carla Blarzino, Elizabeth Head, D Allan Butterfield, Marzia Perluig. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. Journal of Alzheimer's disease : JAD. vol 52. issue 1. 2017-01-23. PMID:26967221. |
we hypothesized that apoptosis may be activated in the presence of ad neuropathology in ds, thus we measured proteins associated with upstream and downstream pathways of p53 in the frontal cortex from ds cases with and without ad pathology and from ts65dn mice, at different ages. |
2017-01-23 |
2023-08-13 |
mouse |
| Yesim Negis, Arzu Karaba. Expression of cell cycle proteins in cortical neurons-Correlation with glutamate-induced neurotoxicity. BioFactors (Oxford, England). vol 42. issue 4. 2017-01-23. PMID:27040651. |
the results have shown that, glutamate treatment caused apoptosis by inducing active caspase-3 and p53 expression. |
2017-01-23 |
2023-08-13 |
rat |
| Sin-Gu Jeong, Goang-Won Ch. Accumulation of apoptosis-insensitive human bone marrow-mesenchymal stromal cells after long-term expansion. Cell biochemistry and function. vol 34. issue 5. 2017-01-23. PMID:27212655. |
the oxidative stress-sensitive proteins ataxia-telangiectasia mutated and p53 were phosphorylated, and the expression of apoptosis molecules bax increased, and bcl-2 decreased in early passage mscs; however, the expression of the apoptotic molecules did less change in response to apoptotic stimulation in late-passage mscs, suggesting that the intrinsic apoptotic signalling pathway was not induced by oxidative stress in long-term-cultured mscs. |
2017-01-23 |
2023-08-13 |
human |
| Devbrat Kumar, Soumya Basu, Lucy Parija, Deeptimayee Rout, Sanjeet Manna, Jagneshwar Dandapat, Priya Ranjan Debat. Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 81. 2017-01-23. PMID:27261574. |
curcumin and ellagic acid synergistically induce ros generation, dna damage, p53 accumulation and apoptosis in hela cervical carcinoma cells. |
2017-01-23 |
2023-08-13 |
Not clear |
| Muthuraman Pandurangan, P C Nagajyothi, Jaesool Shim, Doo Hwan Ki. Anti-Proliferative Effect of Copper Oxide Nanorods Against Human Cervical Carcinoma Cells. Biological trace element research. vol 173. issue 1. 2017-01-19. PMID:26811107. |
the messenger rna (mrna) expression of p53 and caspase 3 was increased, which further confirms the occurrence of apoptosis at the transcriptional level. |
2017-01-19 |
2023-08-13 |
human |
| Thantip Mitupatum, Kalaya Aree, Suthathip Kittisenachai, Sittiruk Roytrakul, Songchan Puthong, Sasichai Kangsadalampai, Panadda Rojpibulsti. mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 2. 2017-01-19. PMID:26925667. |
mrna expression of bax, bcl-2, p53, cathepsin b, caspase-3 and caspase-9 in the hepg2 cell line following induction by a novel monoclonal ab hep88 mab: cross-talk for paraptosis and apoptosis. |
2017-01-19 |
2023-08-13 |
Not clear |
| Thantip Mitupatum, Kalaya Aree, Suthathip Kittisenachai, Sittiruk Roytrakul, Songchan Puthong, Sasichai Kangsadalampai, Panadda Rojpibulsti. mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 2. 2017-01-19. PMID:26925667. |
the mrna expression results also suggested that the process triggered by hep88 mab involved up-regulation of tumor suppressor p53, pro-apoptotic bax, cathepsin b, caspase-3 and caspase-9, with a decrease of anti-apoptotic bcl-2 - thus confirming paraptosis and apoptosis programmed cell death. |
2017-01-19 |
2023-08-13 |
Not clear |
| Taweesak Tongtawee, Chavaboon Dechsukhum, Wilairat Leeanansaksiri, Soraya Kaewpitoon, Natthawut Kaewpitoon, Ryan A Loyd, Likit Matrakool, Sukij Panpimanma. Role of the Mdm2 SNIP 309 Polymorphism in Gastric Mucosal Morphologic Patterns of Patients with Helicobacter pylori Associated Gastritis. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 3. 2017-01-18. PMID:27039725. |
the tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. |
2017-01-18 |
2023-08-13 |
Not clear |
| Aneta Rogalska, Agnieszka Sliwinska, Jacek Kasznicki, Jozef Drzewoski, Agnieszka Marcza. Effects of Epothilone A in Combination with the Antidiabetic Drugs Metformin and Sitagliptin in HepG2 Human Hepatocellular Cancer Cells: Role of Transcriptional Factors NF-κB and p53. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 3. 2017-01-18. PMID:27039825. |
the epoa+met combination evoked the highest cytotoxic effect on hepg2 cells and led to apoptosis independent of p53, decreasing the level of nf-κb. |
2017-01-18 |
2023-08-13 |
human |