| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rizma Khan, Nadir Naveed Siddiqui, Ahtesham Ul Haq, M Ataur Rahma. Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26242269. |
the later included the interacting partner of hspb27, i.e., mitogen-activated protein kinase-3 and 5 (mapk3 and 5), ubiquitin c (ubc), v-akt murine thymoma viral oncogene homolog 1 (akt1), mitogen-activated protein kinase 14 (mapk14), and tumor protein p53 (tp53), which bestowed with critical capabilities, namely, apoptosis, cell cycling, stress activation, tumor suppression, cell survival, angiogenesis, proliferation, and stress resistance. |
2017-02-06 |
2023-08-13 |
human |
| Xing-Xing He, Yu-Nan Zhang, Jun-Wei Yan, Jing-Jun Yan, Qian Wu, Yu-Hu Son. CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26250460. |
the effects of cp-31398 on the characteristic of p53-mutated hcc cells were evaluated through analyzing cell cycle, cell apoptosis, cell proliferation, and the expression of p53 downstream genes. |
2017-02-06 |
2023-08-13 |
Not clear |
| Xing-Xing He, Yu-Nan Zhang, Jun-Wei Yan, Jing-Jun Yan, Qian Wu, Yu-Hu Son. CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26250460. |
then, further study showed that cp-31398 re-activated wild-type p53 function in p53-mutated hcc cells, which resulted in inhibitive response of cell proliferation and an induction of cell-cycle arrest and apoptosis. |
2017-02-06 |
2023-08-13 |
Not clear |
| Rui Kamada, Yu Toguchi, Takao Nomura, Toshiaki Imagawa, Kazuyasu Sakaguch. Tetramer formation of tumor suppressor protein p53: Structure, function, and applications. Biopolymers. vol 106. issue 4. 2017-02-06. PMID:26572807. |
p53 not only acts as a tumor suppressor protein by inducing cell cycle arrest and apoptosis in response to genotoxic stress, but it also regulates other cellular processes, including autophagy, stem cell self-renewal, and reprogramming of differentiated cells into stem cells, immune system, and metastasis. |
2017-02-06 |
2023-08-13 |
human |
| Manel Boussabbeh, Intidhar Ben Salem, Karima Rjiba-Touati, Chedy Bouyahya, Fadwa Neffati, Mohamed Fadhel Najjar, Hassen Bacha, Salwa Abid-Essef. The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect? Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26619846. |
this effect was evidenced by the activation of apoptosis which is supported by the increase in p53 and bax expressions, the downregulation of the protein levels of bcl2, and the increase in caspase-3 activity. |
2017-02-06 |
2023-08-13 |
mouse |
| Dipayan Bose, Somenath Banerjee, Subhadip Das, Nabanita Chatterjee, Krishna Das Sah. Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 38. issue 4. 2017-02-06. PMID:27010918. |
heat killed attenuated leishmania induces apoptosis of hepg2 cells through ros mediated p53 dependent mitochondrial pathway. |
2017-02-06 |
2023-08-13 |
Not clear |
| Yeongju Lee, Hyun-Suk Li. Skp2 Inhibitors: Novel Anticancer Strategies. Current medicinal chemistry. vol 23. issue 22. 2017-02-06. PMID:27160538. |
alternatively, skp2 suppresses p53-dependent apoptosis by outcompeting p53 for binding to p300, thereby perturbing p300-mediated p53 acetylation and stabilization. |
2017-02-06 |
2023-08-13 |
human |
| Åsa Fransson, Daria Glaessgen, Jessica Alfredsson, Klas G Wiman, Svetlana Bajalica-Lagercrantz, Nina Mohel. Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer. Journal of ovarian research. vol 9. issue 1. 2017-02-06. PMID:27179933. |
apr-246 (prima-1(met)) is the first clinical-stage compound that reactivates mutant p53 protein by refolding it to wild type conformation, thus inducing apoptosis. |
2017-02-06 |
2023-08-13 |
Not clear |
| Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Janusz Szemraj, Malgorzata Nieborowska-Skorska, Maciej Kolasa, Tomasz Skorski, Halina Wysokińska, Tomasz Śliwińsk. A preliminary study of apoptosis induction in glioma cells via alteration of the Bax/Bcl-2-p53 axis by transformed and non-transformed root extracts of Leonurus sibiricus L. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 7. 2017-02-03. PMID:26743778. |
in summary, our findings demonstrate that treatment of the glioma cells with nr and tr extracts resulted (a) in significant cell growth inhibition, (b) s- and g2/m-phase cell cycle arrest, and (c) apoptosis in a dose-dependent fashion by changing bax/bcl-2 ratio (about 4-fold increase) and p53 (5-fold increase) activation. |
2017-02-03 |
2023-08-13 |
human |
| Peiyan Hua, Mei Sun, Guangxin Zhang, Yifan Zhang, Ge Song, Zhenyu Liu, Xin Li, Xingyi Zhang, Bingjin L. Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells. Journal of biochemical and molecular toxicology. vol 30. issue 9. 2017-02-03. PMID:27078502. |
costunolide induces apoptosis through generation of ros and activation of p53 in human esophageal cancer eca-109 cells. |
2017-02-03 |
2023-08-13 |
human |
| Peiyan Hua, Mei Sun, Guangxin Zhang, Yifan Zhang, Ge Song, Zhenyu Liu, Xin Li, Xingyi Zhang, Bingjin L. Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells. Journal of biochemical and molecular toxicology. vol 30. issue 9. 2017-02-03. PMID:27078502. |
costunolide induced apoptosis of eca-109 cells as well as cell cycle arrest in g1/s phase by upregulation of p53 and p21. |
2017-02-03 |
2023-08-13 |
human |
| Andrei Alexandru Constantinescu, Malak Abbas, Mohamad Kassem, Céline Gleizes, Guillaume Kreutter, Valerie Schini-Kerth, Ioan Liviu Mitrea, Florence Toti, Laurence Kessle. Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27344165. |
cleaved caspase-3, bax apoptosis indicators, and p53, p21 cell cycle regulators were detected by western blot. |
2017-02-02 |
2023-08-13 |
human |
| Andrei Alexandru Constantinescu, Malak Abbas, Mohamad Kassem, Céline Gleizes, Guillaume Kreutter, Valerie Schini-Kerth, Ioan Liviu Mitrea, Florence Toti, Laurence Kessle. Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27344165. |
apoptosis was associated with up-regulated bax (threefold) and cleaved caspase-3 (fivefold) but only in panc-1, while p53 and p21 were up-regulated (twofold) in both cell lines. |
2017-02-02 |
2023-08-13 |
human |
| Gao Tianqin, Cheng Chunlei, Wang Jingjin. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biological & pharmaceutical bulletin. vol 39. issue 10. 2017-02-02. PMID:27431785. |
western blot revealed that the cell signaling pathways of proliferation and apoptosis were synergistically regulated, in which akt was synergistically inactivated, p53 was up-regulated with down-regulation of bcl-2. |
2017-02-02 |
2023-08-13 |
human |
| Gao Tianqin, Cheng Chunlei, Wang Jingjin. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biological & pharmaceutical bulletin. vol 39. issue 10. 2017-02-02. PMID:27431785. |
this study demonstrates that the combination of ncs and ptx can potentiate the effect on survival and apoptosis of glioma cells via suppression of akt, bcl-2, and activations of p53; meanwhile, the in vivo studies also confirmed that the combination of ncs and ptx synergistically inhibit the gliom growth. |
2017-02-02 |
2023-08-13 |
human |
| Yinghua Li, Min Guo, Zhengfang Lin, Mingqi Zhao, Misi Xiao, Changbing Wang, Tiantian Xu, Tianfeng Chen, Bing Zh. Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis. International journal of nanomedicine. vol 11. 2017-02-02. PMID:27994465. |
furthermore, ag@pei@ptx enhanced cytotoxic effects on hepg2 cells and triggered intracellular reactive oxygen species; the signaling pathways of akt, p53, and mapk were activated to advance cell apoptosis. |
2017-02-02 |
2023-08-13 |
Not clear |
| Satish K Raut, Gurinder B Singh, Bhawna Rastogi, Uma Nahar Saikia, Anupam Mittal, Nilambra Dogra, Sandeep Singh, Rishikesh Prasad, Madhu Khulla. miR-30c and miR-181a synergistically modulate p53-p21 pathway in diabetes induced cardiac hypertrophy. Molecular and cellular biochemistry. vol 417. issue 1-2. 2017-02-02. PMID:27221738. |
over-expression of mir-30c or mir-181a decreased expression of p53, p21, anp, cardiomyocyte cell size, and apoptosis in hg-treated cardiomyocytes. |
2017-02-02 |
2023-08-13 |
rat |
| Alexandra Iulia Irimie, Cornelia Braicu, Valentina Pileczki, Bobe Petrushev, Olga Soritau, Radu Septimiu Campian, Ioana Berindan-Neago. Knocking down of p53 triggers apoptosis and autophagy, concomitantly with inhibition of migration on SSC-4 oral squamous carcinoma cells. Molecular and cellular biochemistry. vol 419. issue 1-2. 2017-02-01. PMID:27370646. |
knocking down of p53 triggers apoptosis and autophagy, concomitantly with inhibition of migration on ssc-4 oral squamous carcinoma cells. |
2017-02-01 |
2023-08-13 |
Not clear |
| Alexandra Iulia Irimie, Cornelia Braicu, Valentina Pileczki, Bobe Petrushev, Olga Soritau, Radu Septimiu Campian, Ioana Berindan-Neago. Knocking down of p53 triggers apoptosis and autophagy, concomitantly with inhibition of migration on SSC-4 oral squamous carcinoma cells. Molecular and cellular biochemistry. vol 419. issue 1-2. 2017-02-01. PMID:27370646. |
p53 has a crucial role in proliferation and apoptosis during the occurrence and development of numerous malignant tumors. |
2017-02-01 |
2023-08-13 |
Not clear |
| Alexandra Iulia Irimie, Cornelia Braicu, Valentina Pileczki, Bobe Petrushev, Olga Soritau, Radu Septimiu Campian, Ioana Berindan-Neago. Knocking down of p53 triggers apoptosis and autophagy, concomitantly with inhibition of migration on SSC-4 oral squamous carcinoma cells. Molecular and cellular biochemistry. vol 419. issue 1-2. 2017-02-01. PMID:27370646. |
using an in vitro rna interference experiment, we have evaluated the impact of p53 knockdown on cell viability, apoptosis, migration, and gene expression for key genes involved in apoptosis and angiogenesis. |
2017-02-01 |
2023-08-13 |
Not clear |