| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
the results showed that pfos could significantly reduce the cell viability and mediate cell apoptosis in hapi microglia, which was closely accompanied with ros production and p53 overexpression. |
2017-02-08 |
2023-08-13 |
Not clear |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
interestingly, nac, a ros inhibitor, inhibited p53 expression, and decreased the apoptosis of hapi microglia. |
2017-02-08 |
2023-08-13 |
Not clear |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
taken together, these findings suggest that upregulated production of ros plays a vital role in pfos-mediated apoptosis in hapi microglia via the modulation of p53 signaling. |
2017-02-08 |
2023-08-13 |
Not clear |
| Y Wei, F J Yuan, W B Zhou, L Wu, L Chen, J J Wang, Y S Zhan. Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax. Genetics and molecular research : GMR. vol 15. issue 2. 2017-02-08. PMID:27420953. |
borax-induced apoptosis in hepg2 cells involves p53, bcl-2, and bax. |
2017-02-08 |
2023-08-13 |
Not clear |
| Jade Dhananjay Dasiram, Ramamoorthi Ganesan, Janani Kannan, Venkatesan Kotteeswaran, Nageswaran Sivalinga. Curcumin inhibits growth potential by G1 cell cycle arrest and induces apoptosis in p53-mutated COLO 320DM human colon adenocarcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 86. 2017-02-08. PMID:28011386. |
together, these data suggest that curcumin exerts anticancer effects and induces apoptosis in p53 mutated colo 320dm human colon adenocarcinoma cells derived from dukes' type c metastatic stage. |
2017-02-08 |
2023-08-13 |
human |
| Yuan-Hua Liu, Guang-Hui Liu, Jing-Jing Mei, Jing Wan. The preventive effects of hyperoside on lung cancer in vitro by inducing apoptosis and inhibiting proliferation through Caspase-3 and P53 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27419887. |
the preventive effects of hyperoside on lung cancer in vitro by inducing apoptosis and inhibiting proliferation through caspase-3 and p53 signaling pathway. |
2017-02-07 |
2023-08-13 |
mouse |
| Elaheh Nooshinfar, Davood Bashash, Ava Safaroghli-Azar, Samaneh Bayati, Mostafa Rezaei-Tavirani, Seyed H Ghaffari, Mohammad Esmaeil Akbar. Melatonin promotes ATO-induced apoptosis in MCF-7 cells: Proposing novel therapeutic potential for breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27427852. |
real-time pcr analysis revealed that apoptosis induction by the drugs combination was associated with increased p53 transcriptional activity followed by the elevated molecular ratio of bax/bcl-2. |
2017-02-07 |
2023-08-13 |
Not clear |
| Irina Kaluzki, Igor Hrgovic, Tsige Hailemariam-Jahn, Monika Doll, Johannes Kleemann, Eva Maria Valesky, Stefan Kippenberger, Roland Kaufmann, Nadja Zoeller, Markus Meissne. Dimethylfumarate inhibits melanoma cell proliferation via p21 and p53 induction and bcl-2 and cyclin B1 downregulation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-07. PMID:27468725. |
the knockdown of dmf induced p53 via sirna led to significantly reduced apoptosis but had no influence on cell cycle arrest. |
2017-02-07 |
2023-08-13 |
Not clear |
| Irina Kaluzki, Igor Hrgovic, Tsige Hailemariam-Jahn, Monika Doll, Johannes Kleemann, Eva Maria Valesky, Stefan Kippenberger, Roland Kaufmann, Nadja Zoeller, Markus Meissne. Dimethylfumarate inhibits melanoma cell proliferation via p21 and p53 induction and bcl-2 and cyclin B1 downregulation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-07. PMID:27468725. |
these data provide evidence that dmf inhibits melanoma proliferation by reinduction of important cell cycle inhibitors leading to a concentration-dependent g0/g1 or g2/m cell cycle arrest and induction of apoptosis via downregulation of bcl-2 and induction of p53 and parp-1 cleavage. |
2017-02-07 |
2023-08-13 |
Not clear |
| Yuting Chen, Jiajia Chen, Lin Yun, Longmei Xu, Jiaxian Liu, Yongchun Xu, Hui Yang, Hairong Liang, Huanwen Tan. Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicology letters. vol 259. 2017-02-07. PMID:27515134. |
knockdown of sirt1 sensitized to the hq-induced apoptosis in vitro and increased the expression of p53, p21 and γ-h2ax. |
2017-02-07 |
2023-08-13 |
mouse |
| Sadegh Lotfalah Moradi, Gita Eslami, Hossein Goudarzi, Zahra Hajishafieeha, Masoud Soleimani, Adel Mohammadzadeh, Abdolreza Ardeshirylajim. Role of Helicobacter pylori on cancer of human adipose-derived mesenchymal stem cells and metastasis of tumor cells-an in vitro study. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 3. 2017-02-07. PMID:26446460. |
our results demonstrated that h. pylori tries to improve the ha-mscs carcinogenic activities by overexpression of bcl2 gene as an anti-apoptosis agent against the p53 gene expression as main apoptosis agent. |
2017-02-07 |
2023-08-13 |
human |
| Wei Liu, Haidong Yao, Wenchao Zhao, Yuguang Shi, Ziwei Zhang, Shiwen X. Selenoprotein W was Correlated with the Protective Effect of Selenium on Chicken Myocardial Cells from Oxidative Damage. Biological trace element research. vol 171. issue 2. 2017-02-07. PMID:26463750. |
in contrast, h2o2 increased the expression of p53, nf-κb, tnf-α, and ldh (p < 0.05) and induced early cell apoptosis, which was alleviated by treatment with se. |
2017-02-07 |
2023-08-13 |
chicken |
| Çağrı Şakalar, Kenan İzgi, Banu İskender, Sedat Sezen, Huriye Aksu, Mustafa Çakır, Büşra Kurt, Ali Turan, Halit Canata. The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 4. 2017-02-07. PMID:26500095. |
after bioinformatic analysis, genes in apoptosis, cytokine, and p53 signaling categories were found to be modulated with a high significance in tq-treated cells (p < 10(-28), p < 10(-8), and p < 10(-6), respectively). |
2017-02-07 |
2023-08-13 |
mouse |
| Çağrı Şakalar, Kenan İzgi, Banu İskender, Sedat Sezen, Huriye Aksu, Mustafa Çakır, Büşra Kurt, Ali Turan, Halit Canata. The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 4. 2017-02-07. PMID:26500095. |
in cells treated with the combination of tq and pac, genes in apoptosis cascade (p < 10(-12)), p53 signaling (p = 10(-5)), and jak-stat signaling (p < 10(-3)) were differentially expressed. |
2017-02-07 |
2023-08-13 |
mouse |
| Yunmao Huang, Wanyan Li, Danning Xu, Bingxin Li, Yunbo Tian, Linsen Za. Effect of Dietary Selenium Deficiency on the Cell Apoptosis and the Level of Thyroid Hormones in Chicken. Biological trace element research. vol 171. issue 2. 2017-02-07. PMID:26507440. |
these results suggested that dietary se deficiency exerts significant harmful effects on male reproductive organ and that the intrinsic and extrinsic pathways and the upstream regulators such as p53, bax, and bcl-2 were all involved in se deficiency-induced testicular apoptosis. |
2017-02-07 |
2023-08-13 |
chicken |
| S Parenti, G Casagrande, M Montanari, M Espahbodinia, R Ettari, A Grande, L Cors. A novel 2,3-benzodiazepine-4-one derivative AMPA antagonist inhibits G2/M transition and induces apoptosis in human leukemia Jurkat T cell line. Life sciences. vol 152. 2017-02-07. PMID:27178220. |
the molecule also induced apoptosis through the enhanced expression of the pro-apoptotic p53, and the inhibition of bcl-2, and bcl-xl, followed by the activation of caspase-3. |
2017-02-07 |
2023-08-13 |
human |
| Grégoire Philippe, Yen-Hua Huang, Olivier Cheneval, Nicole Lawrence, Zhen Zhang, David P Fairlie, David J Craik, Aline Dantas de Araujo, Sónia Troeira Henrique. Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers. vol 106. issue 6. 2017-02-06. PMID:27287767. |
the transcription factor p53 has a tumor suppressor role in leading damaged cells to apoptosis. |
2017-02-06 |
2023-08-13 |
Not clear |
| Weixin Zhang, Lianhong Yin, Xufeng Tao, Lina Xu, Lingli Zheng, Xu Han, Youwei Xu, Changyuan Wang, Jinyong Pen. Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. Environmental toxicology and pharmacology. vol 45. 2017-02-06. PMID:27317992. |
furthermore, dioscin significantly decreased the expression levels of fasl, fas, p53, bak, caspase-3/9, and upregulated bcl-2 level through decreasing irf9 level against apoptosis. |
2017-02-06 |
2023-08-13 |
Not clear |
| Zhisen Shen, Chongchang Zhou, Jinyun Li, Dong Ye, Qun Li, Jian Wang, Xiang Cui, Xiaoying Chen, Tianlian Bao, Shiwei Dua. Promoter hypermethylation of miR-34a contributes to the risk, progression, metastasis and poor survival of laryngeal squamous cell carcinoma. Gene. vol 593. issue 2. 2017-02-06. PMID:27450916. |
mir-34a is a direct transcriptional target of p53, which induces cell cycle arrest, senescence, and apoptosis. |
2017-02-06 |
2023-08-13 |
Not clear |
| Rizma Khan, Nadir Naveed Siddiqui, Ahtesham Ul Haq, M Ataur Rahma. Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26242269. |
the later included the interacting partner of hspb27, i.e., mitogen-activated protein kinase-3 and 5 (mapk3 and 5), ubiquitin c (ubc), v-akt murine thymoma viral oncogene homolog 1 (akt1), mitogen-activated protein kinase 14 (mapk14), and tumor protein p53 (tp53), which bestowed with critical capabilities, namely, apoptosis, cell cycling, stress activation, tumor suppression, cell survival, angiogenesis, proliferation, and stress resistance. |
2017-02-06 |
2023-08-13 |
human |