| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinmei Xiang, Chunyun Wan, Rui Guo, Dingzong Gu. Is Hydrogen Peroxide a Suitable Apoptosis Inducer for All Cell Types? BioMed research international. vol 2016. 2017-02-15. PMID:27595106. |
times to apoptosis initiation and end were measured cytochemically and the changes in expression of caspase-9, p53, nf-κb, and rip were determined by rt-pcr. |
2017-02-15 |
2023-08-13 |
Not clear |
| Fang-Fang Yu, Yan-Xiang Zhang, Lian-He Zhang, Wen-Rong Li, Xiong Guo, Mikko J Lamm. Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease. Medicine. vol 95. issue 52. 2017-02-15. PMID:28033256. |
kegg pathway enrichment analysis found that 2 significant pathways were involved with pi3k-akt signaling pathway and p53 signaling pathway, and gene ontology function analysis found 3 bps involved with apoptosis, death, and cell death in kbd cartilage.according to previous results and our own research, we suggest that the trace element selenium and vitamin e induce pi3k-akt signaling pathway and the mycotoxins (t-2 toxin/ht-2 toxin and don) induce p53 signaling pathway, contributing to the development of kbd, and chondrocyte apoptosis and cell death. |
2017-02-15 |
2023-08-13 |
human |
| Sandra Liliana Vargas-Torres, Elyzabeth Avvad Portari, Amanda Lima Silva, Evandro Mendes Klumb, Heloísa Carneiro da Rocha Guillobel, Maria José de Camargo, Cíntia Barros Santos-Rebouças, Fábio Bastos Russomano, Jacyara Maria Brito Maced. Roles of CDKN1A gene polymorphisms (rs1801270 and rs1059234) in the development of cervical neoplasia. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-15. PMID:26846214. |
the cdkn1a gene product is a p53 downstream effector, which participates in cell differentiation, development process, repair, apoptosis, senescence, migration, and tumorigenesis. |
2017-02-15 |
2023-08-13 |
Not clear |
| Ramalingam Vaikundamoorthy, Revathidevi Sundaramoorthy, Varunkumar Krishnamoorthy, Ravikumar Vilwanathan, Rajaram Rajendra. Marine steroid derived from Acropora formosa enhances mitochondrial-mediated apoptosis in non-small cell lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-15. PMID:26852038. |
p53 pathway has been revealed to mediate cellular stress responses and trigger dna repair, cell cycle arrest, senescence, and apoptosis. |
2017-02-15 |
2023-08-13 |
human |
| Ramalingam Vaikundamoorthy, Revathidevi Sundaramoorthy, Varunkumar Krishnamoorthy, Ravikumar Vilwanathan, Rajaram Rajendra. Marine steroid derived from Acropora formosa enhances mitochondrial-mediated apoptosis in non-small cell lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-15. PMID:26852038. |
the tumor suppressor p53 was also observed to be upregulated during echc treatment in untransformed cells and was more likely to result in cell cycle arrest, senescence, and apoptosis. |
2017-02-15 |
2023-08-13 |
human |
| Yi Gou, Jun Wang, Shifang Chen, Zhan Zhang, Yao Zhang, Wei Zhang, Feng Yan. α-N-heterocyclic thiosemicarbazone Fe(III) complex: Characterization of its antitumor activity and identification of anticancer mechanism. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27487566. |
moreover, c1 induces production of reactive oxygen species (ros) and dna damage, resulting in activation of the p53 pathway, cell cycle arrest at the s phase, and mitochondria-mediated apoptosis by regulating the expression of bcl-2 family proteins. |
2017-02-13 |
2023-08-13 |
Not clear |
| Jelena Hrubik, Branka Glisic, Dragana Samardzija, Bojana Stanic, Kristina Pogrmic-Majkic, Svetlana Fa, Nebojsa Andri. Effect of PMA-induced protein kinase C activation on development and apoptosis in early zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 190. 2017-02-13. PMID:27521797. |
pma increased the number of apoptotic cells in the brain region as demonstrated by acridine orange staining and caused up-regulation of caspase 9 (casp9) and p53 up-regulated modulator of apoptosis (puma) mrna in whole embryos. |
2017-02-13 |
2023-08-13 |
zebrafish |
| Jing Wang, Yue Zhang, Qiuzhen Zhu, Yulan Liu, Hao Cheng, Yuefan Zhang, Tiejun L. Emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53. Environmental toxicology and pharmacology. vol 46. 2017-02-13. PMID:27525562. |
emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53. |
2017-02-13 |
2023-08-13 |
mouse |
| Jing Wang, Yue Zhang, Qiuzhen Zhu, Yulan Liu, Hao Cheng, Yuefan Zhang, Tiejun L. Emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53. Environmental toxicology and pharmacology. vol 46. 2017-02-13. PMID:27525562. |
mice were sacrificed at 1 week after 7gy tbi, we found that emodin attenuated intestinal morphological changes and increased villus height, crypt numbers, and reduced villus and crypt apoptosis as well as inhibited the expression of p53. |
2017-02-13 |
2023-08-13 |
mouse |
| Jing Wang, Yue Zhang, Qiuzhen Zhu, Yulan Liu, Hao Cheng, Yuefan Zhang, Tiejun L. Emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53. Environmental toxicology and pharmacology. vol 46. 2017-02-13. PMID:27525562. |
mtt assay, flow cytometry, hoechst 33258 staining, real-time pcr, and western blotting indicated that emodin pretreatment can effectively increase human umbilical venous endothelial cells (huvecs) viability and attenuate cell apoptosis; it also inhibited the expression of p53, bax, and caspase3 in huvecs after irradiation. |
2017-02-13 |
2023-08-13 |
mouse |
| Ankita Kumari, Charu Bahl, Navneet Singh, Digambar Behera, Siddharth Sharm. Association of p53 codon 72 polymorphism and survival of North Indian lung cancer patients treated with platinum-based chemotherapy. Molecular biology reports. vol 43. issue 12. 2017-02-13. PMID:27614750. |
p53 helps in maintaining genomic stability by undergoing cellular arrest, dna repair or cellular apoptosis during dna damage. |
2017-02-13 |
2023-08-13 |
Not clear |
| Anna Lewinska, Jagoda Adamczyk-Grochala, Ewa Kwasniewicz, Anna Deregowska, Maciej Wnu. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. Toxicology letters. vol 265. 2017-02-13. PMID:27890807. |
diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and erk activity. |
2017-02-13 |
2023-08-13 |
Not clear |
| Birendra Behera, Debasish Mishra, Bibhas Roy, K Sanjana P Devi, Rajan Narayan, Joyjyoti Das, Sudip K Ghosh, Tapas K Mait. Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells. Chemico-biological interactions. vol 222. 2017-02-13. PMID:25305377. |
ros further led to symptoms of early apoptosis by deregulating akt (protein kinase b) and activating c-jun n-terminal kinase (jnk), p38 mitogen activated protein kinase (mapk), p53, and autophagy starting from ∼8h of incubation. |
2017-02-13 |
2023-08-13 |
mouse |
| Ying-Ying Cui, Li Yan, Jing Zhou, Shan Zhao, Ya-Bing Zheng, Bing-Hui Sun, Hong-Tao Lv, Feng-Nian Rong, Xiao-Tian Chan. The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 4. 2017-02-13. PMID:26563365. |
these results suggest an important role for padi4 in the p53 pathway and the regulation of the proliferation, apoptosis, invasion and migration of ovarian cancer cells. |
2017-02-13 |
2023-08-13 |
Not clear |
| Neha Rani, Saurabh Bharti, Ameesha Tomar, Amit Kumar Dinda, D S Arya, Jagriti Bhati. Inhibition of PARP activation by enalapril is crucial for its renoprotective effect in cisplatin-induced nephrotoxicity in rats. Free radical research. vol 50. issue 11. 2017-02-09. PMID:27571604. |
moreover, enalapril dose dependently inhibited cisplatin-induced inflammation (nf-κb/ikk-β/il-6/cox-2/tnf-α expressions), apoptosis (increased bcl-2 and reduced p53, cytochrome c, bax and caspase-3 expressions, and tunel/dapi positivity) and preserved the structural integrity of the kidney. |
2017-02-09 |
2023-08-13 |
rat |
| Hui Yang, Ling Qiu, Li Zhang, Gaochao Lv, Ke Li, Huixin Yu, Minhao Xie, Jianguo Li. Platinum-zoledronate complex blocks gastric cancer cell proliferation by inducing cell cycle arrest and apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-09. PMID:26891667. |
the expressions of cell cycle regulators (p53, p21, cyclin d1, cyclin e, and cyclin-dependent kinase (cdk)2) and apoptosis-related proteins (bcl-2, bax, caspase-3, poly adp ribose polymerase (parp), and survivin) were regulated by the treatment of [pt(en)]2zl, resulting in the cell cycle arrest and apoptosis. |
2017-02-09 |
2023-08-13 |
human |
| Yanhua Fan, Hongyuan Lu, Li An, Changli Wang, Zhipeng Zhou, Fan Feng, Hongda Ma, Yongnan Xu, Qingchun Zha. Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction. Environmental toxicology and pharmacology. vol 43. 2017-02-09. PMID:26923230. |
our findings suggested that the fraction e3 of e. sieboldianum could effectively inhibit the activity of aurora kinase and induce apoptosis via blocking cell cycle, up-regulating the expression of proapoptotic proteins including p53 and bax and reducing the expression of bcl-2. |
2017-02-09 |
2023-08-13 |
human |
| Yağmur Kiraz, Aysun Adan, Melis Kartal Yandim, Yusuf Bara. Major apoptotic mechanisms and genes involved in apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 7. 2017-02-09. PMID:27059734. |
different gene families such as caspases, inhibitor of apoptosis proteins, b cell lymphoma (bcl)-2 family of genes, tumor necrosis factor (tnf) receptor gene superfamily, or p53 gene are involved and/or collaborate in the process of apoptosis. |
2017-02-09 |
2023-08-13 |
Not clear |
| Shaghayegh Amirijavid, Maliheh Entezari, Abolfazl Movafagh, Mehrdad Hashemi, Alireza Mosavi-Jarahi, Hossein Dehghan. Cytotoxicity Effects of Mouse IgG Produced against Three Nanoliposomal Human DR5 Receptor Epitopes on Breast Cancer Cells. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue S3. 2017-02-09. PMID:27165235. |
of the two main apoptosis inducing pathways in cells, the first has p53 protein as the main initiating factor in the cascade. |
2017-02-09 |
2023-08-13 |
mouse |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
ros-mediated apoptosis of hapi microglia through p53 signaling following pfos exposure. |
2017-02-08 |
2023-08-13 |
Not clear |